MIZUHARA Hiroaki

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Profile and Settings

• Profile

  I am engaging in non-invasive human brain functional measurements such as EEG and fMRI. In particular, I am developing simultaneous recordings of fMRI and EEG to achieve fMRI spatial resolution with EEG temporal resolution. Our simultaneous fMRI and EEG techniques have been evaluated worldwide, for example, receiving an award from the top international journal “NeuroImage”. I am working on elucidating the mechanisms of various functions related to human communication, for example, the functions that form the basis of communication such as speech recognition and self-other segregation, by using these functional brain measurements.

• Name (Japanese)

  Mizuhara

• Name (Kana)

  Hiroaki

Degree

• Ph.D, Mar. 2002

Research Interests

• Phase Synchronization
• fMRI
• EEG
• 脳波
• 脳機能イメージング
• 計測工学
• 認知科学
• 脳・神経
• 生物・生体工学
• 認知神経科学
• 機能的MRI
• MRI
• 神経科学
• 位相同期
• 神経回路
• 情報統合
• コミュニケーション

Research Areas

• Informatics, Perceptual information processing
• Life sciences, Cognitive neuroscience
• Life sciences, Basic brain sciences
• Humanities & social sciences, Cognitive sciences

Research Experience

• Apr. 2024, 9999, Nara Women's University, Faculty Division of Human Life and Environmental Sciences, Professor
• Mar. 2022, Mar. 2024, Graduate School of Informatics, Kyoto University, Japan, Associate Professor
• Apr. 2007, Feb. 2022, Graduate School of Informatics, Kyoto University, Japan, Senior Lecturer
• Sep. 2018, Mar. 2019, University of Glasgow, Institute of Neuroscience & Psychology, Visiting Researcher
• Sep. 2005, Mar. 2011, RIKEN Brain Science Institute, Japan, Visiting Research Scientist
• Sep. 2005, Mar. 2007, Graduate School of Natural Science and Technology, Okayama University, Japan, Senior Lecturer
• Apr. 2002, Aug. 2005, RIKEN Brain Science Institute, Japan, Research Scientist
• Mar. 2002, Graduate School of Science and Engineering, Yamaguchi University, 博士後期課程 早期修了 博士（工学）

Ⅱ．研究活動実績

Published Papers

• Neuroscience research, Neural activity related to productive vocabulary knowledge effects during second language comprehension., Takara Kenza Allal-Sumoto; Duygu Şahin; Hiroaki Mizuhara, Second language learners and educators often believe that improving one's listening ability hinges on acquiring an extensive vocabulary and engaging in thorough listening practice. Our previous study suggested that listening comprehension is also impacted by the ability to produce vocabulary. Nevertheless, it remained uncertain whether quick comprehension could be attributed to a simple acceleration of processing or to changes in neural activity. To identify neural activity changes during sentence listening comprehension according to different levels of lexical knowledge (productive, only comprehensive, uncomprehensive), we measured participants' electrical activity in the brain via electroencephalography (EEG) and conducted a time-frequency-based EEG power analysis. Additionally, we employed a decoding model to verify the predictability of vocabulary knowledge levels based on neural activity. The decoding results showed that EEG activity could discriminate between listening to sentences containing phrases that include productive knowledge and ones without. The positive impact of productive vocabulary knowledge on sentence comprehension, driven by distinctive neural processing during sentence comprehension, was unequivocally evident. Our study emphasizes the importance of productive vocabulary knowledge acquisition to enhance the process of second language listening comprehension., 18 Jan. 2024, Scientific journal, True, 10.1016/j.neures.2024.01.002

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• Refereed, Frontiers in Psychology, The effect of productive vocabulary knowledge on second language comprehension, Takara Kenza Allal-Sumoto; Kiyofumi Miyoshi; Hiroaki Mizuhara, 2023, Scientific journal
• Refereed, Cerebral cortex (New York, N.Y. : 1991), Frequency-Dependent Cortical Interactions during Semantic Processing: An Electrocorticogram Cross-spectrum Analysis Using a Semantic Space Model., Naoyuki Sato; Riki Matsumoto; Akihiro Shimotake; Masao Matsuhashi; Mayumi Otani; Takayuki Kikuchi; Takeharu Kunieda; Hiroaki Mizuhara; Susumu Miyamoto; Ryosuke Takahashi; Akio Ikeda, Convergent evidence has demonstrated that semantics are represented by the interaction between a multimodal semantic hub at the anterior temporal lobe (ATL) and other modality-specific association cortical areas. Electrocorticogram (ECoG) recording with high spatiotemporal resolutions is efficient in evaluating such cortical interactions; however, this has not been a focus of preceding studies. The present study evaluated cortical interactions during picture naming using a novel ECoG cross-spectrum analysis, which was formulated from a computational simulation of neuronal networks and combined with a vector space model of semantics. The results clarified three types of frequency-dependent cortical networks: 1) an earlier-period (0.2-0.8 s from stimulus onset) high-gamma-band (90-150 Hz) network with a hub at the posterior fusiform gyrus, 2) a later-period (0.4-1.0 s) beta-band (15-40 Hz) network with multiple hubs at the ventral ATL and posterior middle temporal gyrus, and 3) a pre-articulation theta-band (4-7 Hz) network distributed over widely located cortical regions. These results suggest that frequency-dependent cortical interactions can characterize the underlying processes of semantic cognition, and the beta-band network with a hub at the ventral ATL is especially associated with the formation of semantic representation., 29 Jul. 2021, 31, 9, 4329, 4339, Scientific journal, True, 10.1093/cercor/bhab089

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• Refereed, Frontiers in psychology, The Role of Temporal Contingency and Integrity of Visual Inputs in the Sense of Agency: A Psychophysical Study., Hiroaki Mizuhara; Peter Uhlhaas, The sense of agency is a subjective feeling that one's own actions drive action outcomes. Previous studies have focused primarily on the temporal contingency between actions and sensory inputs as a possible mechanism for the sense of agency. However, the contribution of the integrity of visual inputs has not been systematically addressed. In the current study, we developed a psychophysical task to examine the role of visual inputs as well as temporal contingencies toward the sense of agency. Specifically, participants were required to track a target on a sinusoidal curve on a computer screen. Visual integrity of sensory inputs was manipulated by gradually occluding a computer cursor, and participants were asked to report the sense of agency on a nine-point Likert scale. Temporal contingency was manipulated by varying the delay between finger movements on a touchpad and cursor movements. The results showed that the sense of agency was influenced by both visual integrity and temporal contingency. These results are discussed in the context of current models that have proposed that the sense of agency emerges from the comparison of visual inputs with motor commands., 2021, 12, 635202, 635202, Scientific journal, True, 10.3389/fpsyg.2021.635202

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• Refereed, eNeuro, Successful Encoding during Natural Reading Is Associated with Fixation-Related Potentials and Large-Scale Network Deactivation., Sato N; Mizuhara H, Sep. 2018, 5, 5, 10.1523/ENEURO.0122-18.2018

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• Refereed, Scientific reports, Open monitoring meditation reduces the involvement of brain regions related to memory function., Masahiro Fujino; Yoshiyuki Ueda; Hiroaki Mizuhara; Jun Saiki; Michio Nomura, Mindfulness meditation consists of focused attention meditation (FAM) and open monitoring meditation (OMM), both of which reduce activation of the default mode network (DMN) and mind-wandering. Although it is known that FAM requires intentional focused attention, the mechanisms of OMM remain largely unknown. To investigate this, we examined striatal functional connectivity in 17 experienced meditators (mean total practice hours = 920.6) during pre-resting, meditation, and post-resting states comparing OMM with FAM, using functional magnetic resonance imaging. Both FAM and OMM reduced functional connectivity between the striatum and posterior cingulate cortex, which is a core hub region of the DMN. Furthermore, OMM reduced functional connectivity of the ventral striatum with both the visual cortex related to intentional focused attention in the attentional network and retrosplenial cortex related to memory function in the DMN. In contrast, FAM increased functional connectivity in these regions. Our findings suggest that OMM reduces intentional focused attention and increases detachment from autobiographical memory. This detachment may play an important role in non-judgmental and non-reactive attitude during OMM. These findings provide new insights into the mechanisms underlying the contribution of OMM to well-being and happiness., 02 Jul. 2018, 8, 1, 9968, 9968, Scientific journal, True, 10.1038/s41598-018-28274-4

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• Refereed, PLoS computational biology, A dynamical systems approach for estimating phase interactions between rhythms of different frequencies from experimental data., Takayuki Onojima; Takahiro Goto; Hiroaki Mizuhara; Toshio Aoyagi, Synchronization of neural oscillations as a mechanism of brain function is attracting increasing attention. Neural oscillation is a rhythmic neural activity that can be easily observed by noninvasive electroencephalography (EEG). Neural oscillations show the same frequency and cross-frequency synchronization for various cognitive and perceptual functions. However, it is unclear how this neural synchronization is achieved by a dynamical system. If neural oscillations are weakly coupled oscillators, the dynamics of neural synchronization can be described theoretically using a phase oscillator model. We propose an estimation method to identify the phase oscillator model from real data of cross-frequency synchronized activities. The proposed method can estimate the coupling function governing the properties of synchronization. Furthermore, we examine the reliability of the proposed method using time-series data obtained from numerical simulation and an electronic circuit experiment, and show that our method can estimate the coupling function correctly. Finally, we estimate the coupling function between EEG oscillation and the speech sound envelope, and discuss the validity of these results., Jan. 2018, 14, 1, e1005928, Scientific journal, True, 10.1371/journal.pcbi.1005928

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• Refereed, PloS one, Ongoing slow oscillatory phase modulates speech intelligibility in cooperation with motor cortical activity., Takayuki Onojima; Keiichi Kitajo; Hiroaki Mizuhara, Neural oscillation is attracting attention as an underlying mechanism for speech recognition. Speech intelligibility is enhanced by the synchronization of speech rhythms and slow neural oscillation, which is typically observed as human scalp electroencephalography (EEG). In addition to the effect of neural oscillation, it has been proposed that speech recognition is enhanced by the identification of a speaker's motor signals, which are used for speech production. To verify the relationship between the effect of neural oscillation and motor cortical activity, we measured scalp EEG, and simultaneous EEG and functional magnetic resonance imaging (fMRI) during a speech recognition task in which participants were required to recognize spoken words embedded in noise sound. We proposed an index to quantitatively evaluate the EEG phase effect on behavioral performance. The results showed that the delta and theta EEG phase before speech inputs modulated the participant's response time when conducting speech recognition tasks. The simultaneous EEG-fMRI experiment showed that slow EEG activity was correlated with motor cortical activity. These results suggested that the effect of the slow oscillatory phase was associated with the activity of the motor cortex during speech recognition., 2017, 12, 8, e0183146, Scientific journal, True, 10.1371/journal.pone.0183146

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• Refereed, EBIOMEDICINE, ELSEVIER SCIENCE BV, Increased BOLD Signals Elicited by High Gamma Auditory Stimulation of the Left Auditory Cortex in Acute State Schizophrenia, Hironori Kuga; Toshiaki Onitsuka; Yoji Hirano; Itta Nakamura; Naoya Oribe; Hiroaki Mizuhara; Ryota Kanai; Shigenobu Kanba; Takefumi Ueno, Recent MRI studies have shown that schizophrenia is characterized by reductions in brain gray matter, which progress in the acute state of the disease. Cortical circuitry abnormalities in gamma oscillations, such as deficits in the auditory steady state response (ASSR) to gamma frequency (N30-Hz) stimulation, have also been reported in schizophrenia patients. In the current study, we investigated neural responses during click stimulation by BOLD signals. We acquired BOLD responses elicited by click trains of 20, 30, 40 and 80-Hz frequencies from 15 patients with acute episode schizophrenia (AESZ), 14 symptom-severity-matched patients with non-acute episode schizophrenia (NASZ), and 24 healthy controls (HC), assessed via a standard general linear-model-based analysis. The AESZ group showed significantly increased ASSR-BOLD signals to 80-Hz stimuli in the left auditory cortex compared with the HC and NASZ groups. In addition, enhanced 80-Hz ASSR-BOLD signals were associated with more severe auditory hallucination experiences in AESZ participants. The present results indicate that neural over activation occurs during 80-Hz auditory stimulation of the left auditory cortex in individuals with acute state schizophrenia. Given the possible association between abnormal gamma activity and increased glutamate levels, our data may reflect glutamate toxicity in the auditory cortex in the acute state of schizophrenia, which might lead to progressive changes in the left transverse temporal gyrus. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)., Oct. 2016, 12, 143, 149, Scientific journal, 10.1016/j.ebiom.2016.09.008

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• Refereed, NEUROREPORT, LIPPINCOTT WILLIAMS & WILKINS, Top-down and bottom-up attention cause the ventriloquism effect with distinct electroencephalography modulations, Toshihiro Kumagai; Hiroaki Mizuhara, The ventriloquism effect is a critical phenomenon for understanding the underlying mechanisms of multisensory integration. Cross-modal spatial attention causes a distortion of sound localization, although the neural basis of the effect remains an unanswered question. We hypothesized that top-down and bottom-up visual-spatial attention causes the ventriloquism effect with different modulations of ongoing neural oscillation. To test this hypothesis, human scalp electroencephalography (EEG) was measured during a sound localization task. Top-down attention suppressed the EEG amplitude in the alpha frequency (10 Hz) over the contralateral temporal electrode sites to visual cue hemifields. Bottom-up attention shifted the EEG phase to the theta frequency (7 Hz), rather than suppressing the amplitude. Two different neural mechanisms of ongoing neural oscillation contributed toward the ventriloquism effect, with different spatial attention. NeuroReport Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved., Jun. 2016, 27, 9, 647, 651, Scientific journal, 10.1097/WNR.0000000000000590

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• Refereed, NEUROIMAGE, ACADEMIC PRESS INC ELSEVIER SCIENCE, Cortical networks dynamically emerge with the interplay of slow and fast oscillations for memory of a natural scene, Hiroaki Mizuhara; Naoyuki Sato; Yoko Yamaguchi, Neural oscillations are crucial for revealing dynamic cortical networks and for serving as a possible mechanism of inter-cortical communication, especially in association with mnemonic function. The interplay of the slow and fast oscillations might dynamically coordinate the mnemonic cortical circuits to rehearse stored items during working memory retention. We recorded simultaneous EEG-fMRI during a working memory task involving a natural scene to verify whether the cortical networks emerge with the neural oscillations for memory of the natural scene. The slow EEG power was enhanced in association with the better accuracy of working memory retention, and accompanied cortical activities in the mnemonic circuits for the natural scene. Fast oscillation showed a phase-amplitude coupling to the slow oscillation, and its power was tightly coupled with the cortical activities for representing the visual images of natural scenes. The mnemonic cortical circuit with the slow neural oscillations would rehearse the distributed natural scene representations with the fast oscillation for working memory retention. The coincidence of the natural scene representations could be obtained by the slow oscillation phase to create a coherent whole of the natural scene in the working memory. (C) 2015 Elsevier Inc. All rights reserved., May 2015, 111, 76, 84, Scientific journal, 10.1016/j.neuroimage.2015.02.019

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• Refereed, JOURNAL OF COGNITIVE NEUROSCIENCE, MIT PRESS, Dynamic Parieto-premotor Network for Mental Image Transformation Revealed by Simultaneous EEG and fMRI Measurement, Takafumi Sasaoka; Hiroaki Mizuhara; Toshio Inui, Previous studies have suggested that the posterior parietal cortices and premotor areas are involved in mental image transformation. However, it remains unknown whether these regions really cooperate to realize mental image transformation. In this study, simultaneous EEG and fMRI were performed to clarify the spatio-temporal properties of neural networks engaged in mental image transformation. We adopted a modified version of the mental clock task used by Sack et al. [Sack, A. T., Camprodon, J. A., Pascual-Leone, A., & Goebel, R. The dynamics of interhemispheric compensatory processes in mental imagery. Science, 308, 702-704, 2005; Sack, A. T., Sperling, J. M., Prvulovic, D., Formisano, E., Goebel, R., Di Salle, F., et al. Tracking the mind's image in the brain II: Transcranial magnetic stimulation reveals parietal asymmetry in visuospatial imagery. Neuron, 35, 195-204, 2002]. In the modified mental clock task, participants mentally rotated clock hands from the position initially presented at a learned speed for various durations. Subsequently, they matched the position to the visually presented clock hands. During mental rotation of the clock hands, we observed significant beta EEG suppression with respect to the amount of mental rotation at the right parietal electrode. The beta EEG suppression accompanied activity in the bilateral parietal cortices and left premotor cortex, representing a dynamic cortical network for mental image transformation. These results suggest that motor signals from the premotor area were utilized for mental image transformation in the parietal areas and for updating the imagined clock hands represented in the right posterior parietal cortex., Feb. 2014, 26, 2, 232, 246, Scientific journal, 10.1162/jocn_a_00493

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• Refereed, NEUROIMAGE, ACADEMIC PRESS INC ELSEVIER SCIENCE, Cortical dynamics of human scalp EEG origins in a visually guided motor execution, Hiroaki Mizuhara, The EEG mu rhythm is often used as an index of activation in the sensorimotor cortex. However, the blur caused by volume conduction makes it difficult to identify the exact origin of the EEG rhythm in the brain using only the human scalp EEG. In this study, simultaneous fMRI and EEG measurements were performed during a visually guided motor execution task in order to investigate whether the mu rhythm in the scalp EEG is an indication of the activity in the sensorimotor cortex. In addition, a new method was proposed for reconstruction of the cortical EEG activity through the fusion of fMRI and EEG data. A suppression of mu rhythm appeared around the lateral central electrode sites, just above the sensorimotor cortex, in association with the activity in that region. During a visually guided motor execution task, the alpha rhythms at the occipital electrode sites and the alpha rhythm at the central electrode sites also showed a correlation with the fMRI signal in the occipital and the supplementary motor cortices, respectively. This method allows the investigation of the scalp EEG origin with the spatial precision of fMRI, while retaining dynamic properties of the cortex with the temporal precision of EEG. (c) 2012 Elsevier Inc. All rights reserved., Sep. 2012, 62, 3, 1884, 1895, Scientific journal, 10.1016/j.neuroimage.2012.05.072

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• Refereed, COGNITIVE NEURODYNAMICS, SPRINGER, Traveling EEG slow oscillation along the dorsal attention network initiates spontaneous perceptual switching, Takashi J. Ozaki; Naoyuki Sato; Keiichi Kitajo; Yoshiaki Someya; Kimitaka Anami; Hiroaki Mizuhara; Seiji Ogawa; Yoko Yamaguchi, An ambiguous figure such as the Necker cube causes spontaneous perceptual switching (SPS). The mechanism of SPS in multistable perception has not yet been determined. Although early psychological studies suggested that SPS may be caused by fatigue or satiation of orientation, the neural mechanism of SPS is still unknown. Functional magnetic resonance imaging (fMRI) has shown that the dorsal attention network (DAN), which mainly controls voluntary attention, is involved in bistable perception of the Necker cube. To determine whether neural dynamics along the DAN cause SPS, we performed simultaneous electroencephalography (EEG) and fMRI during an SPS task with the Necker cube, with every SPS reported by pressing a button. This EEG-fMRI integrated analysis showed that (a) 3-4 Hz spectral EEG power modulation at fronto-central, parietal, and centro-parietal electrode sites sequentially appeared from 750 to 350 ms prior to the button press; and (b) activations correlating with the EEG modulation traveled along the DAN from the frontal to the parietal regions. These findings suggest that slow oscillation initiates SPS through global dynamics along the attentional system such as the DAN., Apr. 2012, 6, 2, 185, 198, Scientific journal, 10.1007/s11571-012-9196-y

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• Proceedings of the Japanese Society for Cognitive Psychology, The Japanese Society for Cognitive Psychology, Reward system modulation induced by partner's cooperative state: An fMRI study, SHIKAUCHI Manabu; MIZUHARA Hiroaki, Abstract, 2012, 2012, 14, 14, 10.14875/cogpsy.2012.0_14

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• Proceedings of the Japanese Society for Cognitive Psychology, The Japanese Society for Cognitive Psychology, Mirror neuron system enhances the human vocal communication, Mizuhara Hiroaki; Inoue Suguru; Sasaoka Takafumi; Shikauchi Manabu, Seeing speaker's face is known as a crucial factor to enhance the intelligibility of speaker's voice. We hypothesized that the visual amplification of the speech perception could be realized by the motor prediction in the mirror neuron system for the speech production. Here we measured the human scalp EEG during a voice listening task to elucidate this hypothesis. The task consisted of a voice-lip asynchrony condition, and a mosaic image condition to allow us to elucidate the effect of mirror neuron system. The results showed that the intelligibility of voice perception was enhanced by seeing the speaker's face, accompanying the EEG mu rhythm suppression, which is an index of the activity in the mirror neuron system. This supports our hypothesis that the motor prediction by the mirror neuron system enhances the vocal communication., 2012, 2012, 12, 12, 10.14875/cogpsy.2012.0_12

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• Proceedings of the Japanese Society for Cognitive Psychology, The Japanese Society for Cognitive Psychology, EEG dynamics related to semantic unification on processing of simple sentences in Japanese, ARAI SHOMA; IWABUCHI TOSHIKI; MIZUHARA HIROAKI; ASAKURA NOBUHIKO; INUI TOSHIO, Abstract, 2012, 2012, 31, 31, 10.14875/cogpsy.2012.0_31

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• Refereed, EUROPEAN JOURNAL OF NEUROSCIENCE, WILEY-BLACKWELL, Neuronal ensemble for visual working memory via interplay of slow and fast oscillations, Hiroaki Mizuhara; Yoko Yamaguchi, The current focus of studies on neural entities for memory maintenance is on the interplay between fast neuronal oscillations in the gamma band and slow oscillations in the theta or delta band. The hierarchical coupling of slow and fast oscillations is crucial for the rehearsal of sensory inputs for short-term storage, as well as for binding sensory inputs that are represented in spatially segregated cortical areas. However, no experimental evidence for the binding of spatially segregated information has yet been presented for memory maintenance in humans. In the present study, we actively manipulated memory maintenance performance with an attentional blink procedure during human scalp electroencephalography (EEG) recordings and identified that slow oscillations are enhanced when memory maintenance is successful. These slow oscillations accompanied fast oscillations in the gamma frequency range that appeared at spatially segregated scalp sites. The amplitude of the gamma oscillation at these scalp sites was simultaneously enhanced at an EEG phase of the slow oscillation. Successful memory maintenance appears to be achieved by a rehearsal of sensory inputs together with a coordination of distributed fast oscillations at a preferred timing of the slow oscillations., May 2011, 33, 10, 1925, 1934, Scientific journal, 10.1111/j.1460-9568.2011.07681.x

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• Refereed, ADVANCES IN COGNITIVE NEURODYNAMICS (II), SPRINGER-VERLAG BERLIN, Is Mu Rhythm an Index of the Human Mirror Neuron System? A Study of Simultaneous fMRI and EEG, Hiroaki Mizuhara; Toshio Inui, EEG mu rhythm is one of the prominent oscillatory patterns for investigating the dynamics of the human mirror system. However, because of the blurring effect caused by the volume conduction in EEG measures, the origin of this rhythm remains an open question. Here we propose a novel method to identify the EEG distribution on the scalp by using the simultaneous fMRI and EEG recording. The results indicate that the mu rhythm appeared on the lateral central sites indexes as activities in the sensorimotor cortex, while the contamination from activities in other cortices also appears as the mu rhythm., 2011, 123, 127, International conference proceedings, 10.1007/978-90-481-9695-1_19

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• Refereed, ADVANCES IN COGNITIVE NEURODYNAMICS (II), SPRINGER-VERLAG BERLIN, The Interaction Between the Parietal and Motor Areas in Dynamic Imagery Manipulation: An fMRI Study, Takafumi Sasaoka; Hiroaki Mizuhara; Toshio Inui, Mental imagery is a cognitive function that includes sub-functions such as generation, transformation, and matching. However, the neural substrates for each sub-function are not yet clear. In the present study, we used event-related functional MRI during a modified version of a mental clock task to investigate these neural substrates. While participants were mentally transforming the clock hands, we found activations in the left inferior parietal lobule, left motor related regions (premotor area and supplementary motor area), and left insula, which were contra-lateral to the right hand used to manipulate a 3-D mouse in the learning phase. These results suggest that motor imagery was utilized for transformation of mental imagery., 2011, 345, 349, International conference proceedings, 10.1007/978-90-481-9695-1_55

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• Refereed, NEUROREPORT, LIPPINCOTT WILLIAMS & WILKINS, Subsequent memory-dependent EEG theta correlates to parahippocampal blood oxygenation level-dependent response, Naoyuki Sato; Takashi J. Ozaki; Yoshiaki Someya; Kimitaka Anami; Seiji Ogawa; Hiroaki Mizuhara; Yoko Yamaguchi, The 4-12 Hz (theta rhythm)-dependent neural dynamics play a fundamental role in the memory formation of the rat hippocampus. Although the power of human scalp electroencephalography theta (EEG theta) is known to be associated with a hippocampus-dependent memory encoding, it remains unclear whether the human hippocampus uses theta rhythm. In this study, we aim to identify the scalp EEG theta-related neural regions during memory encoding by using a simultaneous EEG-functional magnetic resonance imaging recording. We showed that the parahippocampal and the medial frontal and posterior regions were significantly correlated to subsequent memory-dependent EEG theta power. This evidence suggests that the human parahippocampal region and associated structures use theta rhythm during hippocampal memory encoding as in rodents. NeuroReport 21:168-172 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins., Feb. 2010, 21, 3, 168, 172, Scientific journal, 10.1097/WNR.0b013e328332072a

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• Refereed, PAIN MEDICINE, WILEY-BLACKWELL PUBLISHING, INC, Nonimmersive Virtual Reality Mirror Visual Feedback Therapy and Its Application for the Treatment of Complex Regional Pain Syndrome: An Open-Label Pilot Study, Kenji Sato; Satoshi Fukumori; Takashi Matsusaki; Tomoko Maruo; Shinichi Ishikawa; Hiroyuki Nishie; Ken Takata; Hiroaki Mizuhara; Satoshi Mizobuchi; Hideki Nakatsuka; Masaki Matsumi; Akio Gofuku; Masataka Yokoyama; Kiyoshi Morita, Objective. Chronic pain conditions such as phantom limb pain and complex regional pain syndrome are difficult to treat, and traditional pharmacological treatment and invasive neural block are not always effective. Plasticity in the central nervous system occurs in these conditions and may be associated with pain. Mirror visual feedback therapy aims to restore normal cortical organization and is applied in the treatment of chronic pain conditions. However, not all patients benefit from this treatment. Virtual reality technology is increasingly attracting attention for medical application, including as an analgesic modality. An advanced mirror visual feedback system with virtual reality technology may have increased analgesic efficacy and benefit a wider patient population. In this preliminary work, we developed a virtual reality mirror visual feedback system and applied it to the treatment of complex regional pain syndrome. Design. A small open-label case series. Five patients with complex regional pain syndrome received virtual reality mirror visual feedback therapy once a week for five to eight sessions on an outpatient basis. Patients were monitored for continued medication use and pain intensity. Results. Four of the five patients showed > 50% reduction in pain intensity. Two of these patients ended their visits to our pain clinic after five sessions. Conclusion. Our results indicate that virtual reality mirror visual feedback therapy is a promising alternative treatment for complex regional pain syndrome. Further studies are necessary before concluding that analgesia provided from virtual reality mirror visual feedback therapy is the result of reversing maladaptive changes in pain perception., 2010, 11, 4, 622, 629, Scientific journal, 10.1111/j.1526-4637.2010.00819.x

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• Refereed, NEURAL INFORMATION PROCESSING, PART I, SPRINGER-VERLAG BERLIN, Decomposing EEG data into space-time-frequency components using Parallel Factor Analysis and its relation with cerebral blood flow, Fumikazu Miwakeichi; Pedro A. Valdes-Sosa; Eduardo Aubert-Vazquez; Jorge Bosch Bayard; Jobu Watanabe; Hiroaki Mizuhara; Yoko Yamaguchi, Finding the means to efficiently summarize electroencephalographic data has been a long-standing problem in electrophysiology. Our previous works showed that Parallel Factor Analysis (PARAFAC) can effectively perform atomic decomposition of the time-varying EEG spectrum in space/frequency/time domain. In this study, we propose to use PARAFAC for extracting significant activities in EEG data that is concurrently recorded with functional Magnetic Resonance Imaging (fMRI), and employ the temporal signature of the atom for investigating the relation between brain electrical activity and the changing of BOLD signal that reflects cerebral blood flow. We evaluated the statistical significance of dynamical effect of BOLD respect to EEG based on the modeling of BOLD signal by plain autoregressive model (AR), its AR with exogenous EEG input (ARX) and ARX with nonlinear term (ARNX)., 2008, 4984, PART 1, 802, +, International conference proceedings, 10.1007/978-3-540-69158-7_83

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• Refereed, NEUROIMAGE, ACADEMIC PRESS INC ELSEVIER SCIENCE, Human cortical circuits for central executive function emerge by theta phase synchronization, Hiroaki Mizuhara; Yoko Yamaguchi, Dynamic networking of brain regions is suggested to be one of the key factors involved in various brain computations. Central executive function typically requires instantaneous coordination among the medial prefrontal regions and other distant regions, depending on the on-going task situation. In human scalp-recorded electroencephalography (EEG), the medial prefrontal area is estimated to be the current source of the theta rhythm, while there is no direct evidence that the theta rhythm is involved in the dynamic networking of central executive circuits. Here we hypothesize that the central executive circuit over the prefrontal and task-related cortices is dynamically linked by theta synchronization. By using simultaneous functional magnetic resonance imaging (fMRI) and EEG, we elucidated cortical circuits emerging with theta phase synchronization during free pacing repeated subtraction. Theta phase synchronization in the scalp EEG was found to emerge at two major clusters of electrode pairs, between the right frontal and left parietal sites and between the frontal and right parietal sites. The phase synchronization of two clusters is accompanied by fMRI responses in the cortical regions responsible for central executive function, working memory, visual imagery and cognitive action sequence. Here we report the first evidence that theta phase synchronization dynamically coordinates the central executive circuits, including the medial prefrontal cortex and relevant cortical regions. (C) 2007 Elsevier Inc. All rights reserved., May 2007, 36, 1, 232, 244, Scientific journal, 10.1016/j.neuroimage.2007.02.026

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• Not Refereed, Human interface. The Transaction of Human Interface Society, ヒュ-マンインタフェ-ス学会, Interactive Explanation Presentation of Causal Reasoning Process Considering Simplification Tendency of Human, GOFUKU Akio; SHIMADA Yusuke; MIZUHARA Hiroaki, 25 Aug. 2006, 8, 3, 321, 330
• Refereed, NEUROIMAGE, ACADEMIC PRESS INC ELSEVIER SCIENCE, Long-range EEG phase synchronization during an arithmetic task indexes a coherent cortical network simultaneously measured by fMRI, H Mizuhara; LQ Wang; K Kobayashi; Y Yamaguchi, An open question lies in whether or not distributed activities in the distant brain regions are integrated into a coherent ensemble for cognitive information processing. Long-range phase synchronization is often observed by scalp EEG measurements during cognitive tasks and is considered to provide a possible neural principle for the functional integration of distributed neural activities. Synchronization could be reflected at the neuron firing level or at the local field potential and could appear in the scalp EEG under certain conditions on neural spatial and temporal coherence. To examine if phase synchronization is concerned with the integration of distant regions, we proposed a method to extract brain activities associated with task-dependent phase synchronization by combining simultaneous fMRI and EEG. By applying this method in a mental arithmetic task, we found a dominant task-dependent increase of phase synchronization around 14 Hz (in beta frequency) across bilateral parietal sites that were associated with both negative and positive BOLD responses. Functional connectivity analyses of these regions demonstrated that an increase in hemispheric beta synchronization was associated with a linking between the cross-hemispheric regions (left angular gyrus and right superior parietal gyros) and also among the anterior-posterior regions (right dorsolateral prefrontal cortex, putamen, and right superior temporal gyrus). These findings indicate that the positive BOLD regions (dorsolateral prefrontal cortex and superior parietal lobule) are linked with other negative BOLD regions. We also discussed the possible importance of beta synchronization in the formation of a working memory network. (c) 2005 Elsevier Inc. All rights reserved., Sep. 2005, 27, 3, 553, 563, Scientific journal, 10.1016/j.neuroimage.2005.04.030

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• Refereed, Cognitive Systems Research, Peculiarity oriented fMRI brain data analysis for studying human multi-perception mechanism, Ning Zhong; Jing-Long Wu; Akio Nakamaru; Muneaki Ohshima; Hiroaki Mizuhara, Although many cognitive and brain scientists have already studied human information processing mechanism of auditory and visual, separately, the relevance between auditory and visual information processing needs to be investigated in depth. We investigate human multi-perception mechanism by combining various psychological experiments, physiological measurements, data cleaning, modeling, transformation and mining techniques for developing artificial systems which match human ability in specific aspects. In particular, we observe fMRI (functional magnetic resonance imaging) brain activations from the view point of peculiarity oriented mining and propose a way of peculiarity oriented mining for knowledge discovery in multiple human brain data. We present an interesting result on modeling, transforming, and mining multiple human brain data obtained from visual and auditory psychological experiments by using the fMRI. The proposed methodology attempts to change the perspective of cognitive scientists from a single type of experimental data analysis towards a holistic view. © 2004 Elsevier B.V. All rights reserved., Sep. 2004, 5, 3, 241, 256, Scientific journal, 10.1016/j.cogsys.2004.03.005

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• Refereed, NEUROIMAGE, ACADEMIC PRESS INC ELSEVIER SCIENCE, Decomposing EEG data into space-time-frequency components using Parallel Factor Analysis, F Miwakeichi; E Martinez-Montes; PA Valdes-Sosa; N Nishiyama; H Mizuhara; Y Yamaguchia, Finding the means to efficiently summarize electroencephalographic data has been a long-standing problem in electrophysiology. A popular approach is identification of component modes on the basis of the time-varying spectrum of multichannel EEG recordings-in other words, a space/frequency/time atomic decomposition of the time-varying EEG spectrum. Previous work has been limited to only two of these dimensions. Principal Component Analysis (PCA) and Independent Component Analysis (ICA) have been used to create space/time decompositions; suffering an inherent lack of uniqueness that is overcome only by imposing constraints of orthogonality or independence of atoms. Conventional frequency/time decompositions ignore the spatial aspects of the EEG. Framing of the data being as a three-way array indexed by channel, frequency, and time allows the application of a unique decomposition that is known as Parallel Factor Analysis (PARAFAC). Each atom is the tri-linear decomposition into a spatial, spectral, and temporal signature. We applied this decomposition to the EEG recordings of five subjects during the resting state and during mental arithmetic. Common to all subjects were two atoms with spectra signatures whose peaks were in the theta and alpha range. These signatures were modulated by physiological state, increasing during the resting stage for alpha and during mental arithmetic for theta. Furthermore, we describe a new method (Source Spectra Imaging or SSI) to estimate the location of electric current sources from the EEG spectrum. The topography of the theta atom is frontal and the maximum of the corresponding SSI solution is in the anterior frontal cortex. The topography of the alpha atom is occipital with maximum of the SSI solution in the visual cortex. We show that the proposed decomposition can be used to search for activity with a given spectral and topographic profile in new recordings, and that the method may be useful for artifact recognition and removal. (C) 2004 Elsevier Inc. All rights reserved., Jul. 2004, 22, 3, 1035, 1045, Scientific journal, 10.1016/j.neuroimage.2004.03.039

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• Refereed, NEUROREPORT, LIPPINCOTT WILLIAMS & WILKINS, A long-range cortical network emerging with theta oscillation in a mental task, H Mizuhara; LQ Wang; K Kobayashi; Y Yamaguchi, Human scalp EEG has demonstrated that global coherence among distant areas increases during cognitive tasks, suggesting that oscillating neural activities work to generate global neuronal assemblies for cognitive functions. The theta oscillation in a frequency range of 4-8 Hz with large amplitudes which emerges during mental tasks around the frontal midline region is called fm theta. If theta oscillation concerns the global neuronal assemblies, fm theta should be associated with regional activities that depend on task conditions. In the present study, we examine the EEG-related brain activities by developing simultaneous EEG and fMRI during a mental calculation task. EEG-related negative BOLD was dominant over anterior medial regions, suggesting a major contribution of negative BOLD to fm theta. Negative and positive BOLD were found over distant regions. Functional connectivity analyses revealed that the connectivity varied remarkably according to mental conditions. In the rest condition, the connectivity was localized, whereas in the task condition, a long-range coherent network was formed by the anterior midline, posterior cingulate and right middle temporal cortices with linking between the right middle temporal and left lateral cortices during numerical processing. Further EEG analyses indicate that the long-range coherent network executing cognitive functions is coordinated in the time window of theta oscillations., Jun. 2004, 15, 8, 1233, 1238, Scientific journal, 10.1097/01.wnr.0000126755.09715.b3

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• Refereed, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Peculiarity oriented mining in multiple human brain data, N. Zhong; A. Nakamaru; M. Ohshima; J.-L. Wu; H. Mizuhara, 2004, 2690, 742, 750
• Refereed, 計測自動制御学会論文集, Measurement on Human Visual and Auditory Advanced Function of Brain Calculation Processing by Psychological Experiment and Functional Magnetic Resonance Imaging., WU J-L; 水原啓暁; 根来清; 橋田昌弘; 小笠原淳一; 山内秀一; 松永尚文; 斉藤俊, 30 Nov. 2001, 37, 11, 1003, 1011, 10.9746/sicetr1965.37.1003

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• Refereed, Japanese Journal of Radiological Technology, Japanese Society of Radiological Technology, Measurement of Human Advanced Brain Function in Calculation Processing Using Functional Magnetic Resonance Imaging(fMRI), HASHIDA MASAHIRO; YAMAUCHI SYUICHI; WU JING-LONG; MIZUHARA HIROAKI; NEGORO KIYOSHI; OGASAWARA JUNICHI; SANO YUUICHI; KITAZAWA MASAYUKI; YAMANE SATORU; SANADA TAIZOH, Using functional magnetic resonance imaging (fMRI), we investigated the activated areas of the human brain related with calculation processing as an advanced function of the human brain. Furthermore, we investigated differences in activation between visual and auditory calculation processing. The eight subjects (all healthy men)were examined on a clinical MR unit (1.5 tesla)with a gradient echo-type EPI sequence. SPM99 software was used for data processing. Arithmetic problems were used for the visual stimulus (visual image)as well as for the auditory stimulus (audible voice). The stimuli were presented to the subjects as follows: no stimulation, presentation of random figures, and presentation of arithmetic problems. Activated areas of the human brain related with calculation processing were the inferior parietal lobule, middle frontal gyrus, and inferior frontal gyrus. Comparing the arithmetic problems with the presentation of random figures, we found that the activated areas of the human brain were not differently affected by visual and auditory systems. The areas activated in the visual and auditory experiments were observed at nearly the same place in the brain. It is possible to study advanced functions of the human brain such as calculation processing in a general clinical hospital when adequate tasks and methods of presentation are used., 20 Jun. 2001, 57, 6, 605, 610, 10.6009/jjrt.KJ00001357584

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• Refereed, Transactions of the Institute of Systems, Control and Information Engineers, THE INSTITUTE OF SYSTEMS, CONTROL AND INFORMATION ENGINEERS (ISCIE), Characteristic of Reaction Time in Parallel Information Processing of Human Visual and Auditory System, WU Jing-Long; MIZUHARA Hiroaki; NISHIKAWA Yoshikazu, In previous studies of human information processing, the visual separate system and the auditory separate system have been frequently studied. However, human related characteristic between visual and auditory systems has not been investigated substantially. If the mechanisms of human visual and auditory parallel information processing are elucidated, the finding will contribute to improving technical systems. In our previous studies, human related characteristic between visual search and speech perception is studied. The results showed the mutual effect between visual information processing and auditory information processing in the visual and the auditory parallel information processing. However, to clarify the cause of many car accidents lies in the use of car-phone on driving, it is necessary to use the same kind of visual and auditory stimuli in psychological experiments. In this paper, characteristic of reaction time in parallel information processing of human visual and auditory system is measured by using the same kind of stimuli. The experimental results show the factors that influence the visual and the auditory reaction time are the difficulty of the visual and the auditory stimuli and the timing of the visual and the auditory inputs. The experimental results also suggest that one of the causes of car accidents (to use car-phone while driving) is that the human visual information processing is affected by the auditory information., 15 Jan. 2001, 14, 1, 18, 25, 10.5687/iscie.14.18

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• Refereed, Artificial Life and Robotics, The degree of human visual attention in the visual search., Mizuhara H; Wu JL; Nishikawa Y, 2000, 4, 57, 61, 10.1007/BF02480857

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• Refereed, Transactions of the Institute of Systems, Control and Information Engineers, THE INSTITUTE OF SYSTEMS, CONTROL AND INFORMATION ENGINEERS (ISCIE), On Human Related Characteristic between Visual Search and Speach Perception, WU Jing-Long; MIZUHARA Hiroaki; NISHIKAWA Yoshikazu, Recently, the cause of many car accidents is to use car-phone while driving. We hypothesize that one of the causes of such traffic accidents is that the human visual information processing is affected by the auditory information. In order to evidence the hypothesis, human characteristics between visual search and speech perception have been measured by psychological experiments. On the measurement results, in the case of the auditory information is presented concurrently, the visual reaction time is longer than that in the case of the visual information is presented only. The results of fundamental experiments with human visual and auditory characteristic suggest one of the cause of traffic accidents in using car-phone is that the human visual information processing is affected by the auditory information., 15 Feb. 1999, 12, 2, 98, 105, 10.5687/iscie.12.98

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MISC

• Not Refereed, Program ID: 339.18, Annual meeting of Society for Neuroscience 2019, Predictability of electrocorticogram coherence using distributed semantic representation, Naoyuki Sato; Riki Matsumoto; Akihiro Shimotake; Masao Matsuhashi; Mayumi Otani; Takayuki Kikuchi; Takeharu Kunieda; Hiroaki Mizuhara; Ryosuke Takahashi; Akio Ikeda, Oct. 2019, Meeting report
• Not Refereed, 日本物理学会講演概要集(CD-ROM), The Physical Society of Japan, 位相振動子モデルを用いた異なる周波数間の結合推定, 小野島隆之; 後藤貴宏; 水原啓暁; 青柳富誌生, 23 Mar. 2018, 73, 1, ROMBUNNO.25aK703‐10, 2855, 10.11316/jpsgaiyo.73.1.0_2855

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• Not Refereed, EBIOMEDICINE, ELSEVIER SCIENCE BV, Increased BOLD Signals Elicited by High Gamma Auditory Stimulation of the Left Auditory Cortex in Acute State Schizophrenia (vol 12, pg 143, 2016), Hironori Kuga; Toshiaki Onitsuka; Yoji Hirano; Itta Nakamura; Naoya Oribe; Hiroaki Mizuhara; Ryota Kanai; Shigenobu Kanba; Takefumi Ueno, Feb. 2017, 16, 312, 312, Others, 10.1016/j.ebiom.2017.01.002

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• Refereed, INTERNATIONAL JOURNAL OF PSYCHOLOGY, ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, How do Focused attention meditation and Open monitoring meditation regulate the default mode network activity?, Masahiro Fujino; Yoshiyuki Ueda; Hiroaki Mizuhara; Jun Saiki; Michio Nomura, Jul. 2016, 51, 883, 883, Summary international conference
• Not Refereed, 22st Annual Meeting of the Organization for Human Brain Mapping, Geneva, Switzerland, Subsequent memory-dependent BOLD activation during the natural reading of literature., Naoyuki Sato; Hiroaki Mizuhara, Jun. 2016, Summary international conference
• Not Refereed, 日本ヒト脳機能マッピング学会プログラム・抄録集, 脳波データにおける振動子間ネットワークの推定, 小野島隆之; 大田絵一郎; 後藤貴宏; 水原啓暁; 青柳富誌生, 2016, 18th, 62

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• Not Refereed, 日本物理学会講演概要集, 一般社団法人日本物理学会, 21pBL-5 Estimation of interaction functions in neural oscillator networks from EEG data, Onojima T; Mizuhara H; Aoyagi T, 21 Mar. 2015, 70, 1, 2931, 2931, 10.11316/jpsgaiyo.70.1.0_2931

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• Not Refereed, 電子情報通信学会技術研究報告, 脳波データにおける位相振動子ネットワークの推定,, 小野島隆之; 太田絵一郎; 後藤貴宏; 水原啓暁; 青柳富誌生, 2015, 115, 300, 11, 15, Summary national conference
• Not Refereed, IEICE technical report. Neurocomputing, 一般社団法人電子情報通信学会, Interplay of pre- and post-stimulus EEG phase enhances human vocal communication, ONOJIMA Takayuki; KITAJO Keiichi; MIZUHARA Hiroaki, Neural synchrony is a crucial mechanism of emerging a dynamic cortical network for various cognitive processing. The neural synchrony was often observed in the scalp EEG measure for a speech perception. The performance of auditory perception also depends on a phase of scalp EEG appearing prior to the stimulus input. Together with these previous studies, we hypothesized that the interplay of the EEG phase between pre- and post-stimulus presentation determines an optimal condition to emerge a cortical network for the speech perception. To verify our hypothesis, we measured the scalp EEG during a speech perception task. The results showed that the EEG phase locking during the speech perception was manipulated by the pre-stimulus EEG phase. The appropriate cortical network for the speech processing was emerged by the optimal EEG phase before the stimulus input., 22 Nov. 2013, 113, 315, 23, 28
• Not Refereed, IEICE technical report. Neurocomputing, The Institute of Electronics, Information and Communication Engineers, Brain activity by partner's selfishness modulates an effective connectivity between reward-related regions, SHIKAUCHI MANABU; MIZUHARA HIROAKI, We are living in interactions with many people and there is also much collaboration in our social environment. Although it may sometimes be forced collaboration work with a selfish partner, we can act stably reluctantly. We think that our brain had been adapted for the dynamic cooperativeness change. We used a centipede game as an experimental task in the functional Magnetic Resonance Imaging (fMRI). We investigated task-related regions by using a General Linear Model analysis (GLM analysis). Results of GLM analysis showed that the caudate as the reward value and that the middle cingulate cortex (MCC) and putamen activated in the case of a selfish partner. To investigate the network of these regions, we estimated effective connectivity by Dynamic Causal Modeling (DCM). Results of DCM analysis showed that there is an effective connectivity from the caudate to the putamen and that this connectivity in reward system was modulated by the effect of the MCC activity so that the putamen activity was enhanced in the case of selfish partner. These results suggest that caudate-putamen connectivity as the reward system can be modulated by selfishness-related activity. Our view would be also that the network modulation system could achieve stable decision-making and action, even if the partner is selfish., Jul. 2013, 113, 148, 23, 28
• Not Refereed, 日本認知心理学会第11回大会, 単文の意味理解における位相ロッキングの機能的役割：EEG研究, 岩渕 俊樹; 荒井 翔真; 水原 啓暁; 朝倉 暢彦; 乾 敏郎, Jun. 2013
• Refereed, Measuring Consciousness - Theory and Experiments, Neural synchronization of the intra-/inter-brain for hetero systems communication, Hiroaki Mizuhara, Mar. 2013
• Not Refereed, Proceedings of the Japanese Society for Cognitive Psychology, 日本認知心理学会, Ongoing EEG phase modulates the intelligibility of speech perception, Onojima Takayuki; Kitajo Keiichi; Mizuhara Hiroaki, 人間の音声知覚において，聴覚野の周期的な脳活動が音声聴取時の知覚成績に影響を与えている．この周期的な脳活動には，知覚を促進させる最適な状態と阻害する非最適な状態が存在する可能性が指摘されている．また音声聴取時の脳波位相によって音の検出精度が変化する可能性も報告されている．これらのことから音声提示前の自発脳波により，音声聴取時の脳活動の最適・非最適状態が決定されるのではないかと考えた．本研究では，聞き取れるか聞き取れないかの音声を呈示することにより，その時の脳波位相によって聴取成績が変化することを実験により確かめた．この実験により，音声を呈示するよりも早い時点での脳波位相の状態が音声知覚の確信度に関係していることが明らかになった．, 2013, 2013, 0, 26, 26, 10.14875/cogpsy.2013.0_26

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• Not Refereed, 電子情報通信学会技術研究報告 : 信学技報, 電子情報通信学会, EEG dynamics during semantic unification of simple sentences, 荒井翔真; 岩渕俊樹; 水原啓暁; 朝倉暢彦; 乾敏郎, Dec. 2012, 112, 345, 89, 94
• Not Refereed, Dynamic Brain Forum 2012, Boosting the intelligibility of vocal communication via inter-individual entrainment of neuronal oscillations, Mizuhara H; Inoue S; Sasaoka T; Shikauchi M, Sep. 2012
• Not Refereed, IEICE technical report. Neurocomputing, The Institute of Electronics, Information and Communication Engineers, Reward system modulation induced by partner's cooperative behavior : An fMRI study, SHIKAUCHI MANABU; MIZUHARA HIROAKI, The reward-related cortical areas can be activated by various stimuli, including not only monetary rewards, but also social interaction (e.g., admiration etc.). These led us a hypothesis that reward system should be dynamically modulated for adapting to fluid environments with social interaction. Peoples must obtain their reward with keeping interaction to cooperative/selfish partners. Here we assumed that the partners' cooperative behavior would be a crucial factor in the modulation of neural reward system. We used a modified version of centipede game as a task in the fMRI. This task is a dynamic version of prisoner's dilemma game. To obtain more monetary rewards, participants must decide their strategy depend on their partner's cooperativeness. Our results showed that the dorsomedial prefrontal cortex (DMPFC) and the insula activated significantly in an estimation of cooperativeness. The middle cingulate cortex (MCC) activated significantly in a competitive partner condition. The anterior cingulate cortex (ACC) and the caudate activated significantly as reward-related regions., 07 Mar. 2012, 111, 483(NC2011 121-190), 287, 292

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• Not Refereed, IEICE technical report. Neurocomputing, The Institute of Electronics, Information and Communication Engineers, Brain mechanisms of dynamic image generation based on body schema (4) : Recognition of self and objects based on body movement, ASAKURA Nobuhiko; MIZUHARA Hiroaki; SASAOKA Takafumi; INUI Toshio, We present a framework for the recognition of self and objects based on the execution and imagination of body movement. First, we show that delayed visual feedback of moving fingers results in a diminished sense of self agency and causes an increase in the activity of the right parietal lobe. Next, we show that a parietal-occipital-parahippocampal network is recruited to perform updating of an object-place memory by imagined body translation. We then demonstrate the perception of bistable object rotation related to mental transformations of an observer's egocentric reference frame. Finally, we propose a self-organizing neural network model of multiple object representation in inferotemporal cortex., 07 Mar. 2012, 111, 483(NC2011 121-190), 275, 280

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• Not Refereed, IEICE technical report. Neurocomputing, The Institute of Electronics, Information and Communication Engineers, Brain mechanisms of dynamic image generation based on body schema 4 : Recognition of self and objects based on body movement, ASAKURA Nobuhiko; MIZUHARA Hiroaki; SASAOKA Takafumi; INUI Toshio, We present a framework for the recognition of self and objects based on the execution and imagination of body movement. First, we show that delayed visual feedback of moving fingers results in a diminished sense of self agency and causes an increase in the activity of the right parietal lobe. Next, we show that a parietal-occipital-parahippocampal network is recruited to perform updating of an object-place memory by imagined body translation. We then demonstrate the perception of bistable object rotation related to mental transformations of an observer's egocentric reference frame. Finally, we propose a self-organizing neural network model of multiple object representation in inferotemporal cortex., Mar. 2012, 111, 483, 275, 280
• Not Refereed, IEICE technical report. Neurocomputing, The Institute of Electronics, Information and Communication Engineers, Reward system modulation induced by partner's cooperative behavior : An fMRI study, SHIKAUCHI MANABU; MIZUHARA HIROAKI, The reward-related cortical areas can be activated by various stimuli, including not only monetary rewards, but also social interaction (e.g., admiration etc.). These led us a hypothesis that reward system should be dynamically modulated for adapting to fluid environments with social interaction. Peoples must obtain their reward with keeping interaction to cooperative/selfish partners. Here we assumed that the partners' cooperative behavior would be a crucial factor in the modulation of neural reward system. We used a modified version of centipede game as a task in the fMRI. This task is a dynamic version of prisoner's dilemma game. To obtain more monetary rewards, participants must decide their strategy depend on their partner's cooperativeness. Our results showed that the dorsomedial prefrontal cortex (DMPFC) and the insula activated significantly in an estimation of cooperativeness. The middle cingulate cortex (MCC) activated significantly in a competitive partner condition. The anterior cingulate cortex (ACC) and the caudate activated significantly as reward-related regions., Mar. 2012, 111, 483, 287, 292
• Not Refereed, 神経心理学 : Japanese journal of neuropsychology, Information integration via global neuronal ensemble and synchronization in brain disorders, MIZUHARA Hiroaki, 25 Jun. 2011, 27, 2, 90, 96
• Not Refereed, IEICE technical report, 電子情報通信学会, Brain mechanisms of dynamic image generation based on body schema (2) Recognition and mental imagery of objects, 朝倉 暢彦; 水原 啓暁; 笹岡 貴史; 乾敏郎, Mar. 2011, 110, 461, 119, 124
• Not Refereed, 日本認知心理学会第9回大会, 全身移動運動をともなう物－場所記憶表象形成の脳内機構 －機能的MRIによる実験的検証－, 水原 啓暁; 乾 敏郎, 2011
• Not Refereed, 日本神経回路学会誌 = The Brain & neural networks, 日本神経回路学会, 時限研究会「身体知機構研究会」実施報告, 水原 啓暁, 05 Mar. 2010, 17, 1, 43, 45, 10.3902/jnns.17.43

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• Not Refereed, 日本認知心理学会第8回大会, 心的回転に関わる脳内ネットワークの時空間特性, 笹岡 貴史; 水原 啓暁; 乾 敏郎, 2010
• Not Refereed, 日本認知心理学会第8回大会, 把持運動における皮質間のグレンジャー因果性の動特性, 水原 啓暁; 乾 敏郎, 2010
• Not Refereed, IEICE technical report. Neurocomputing, The Institute of Electronics, Information and Communication Engineers, Brain mechanisms of dynamic image generation based on body schema (1), INUI Toshio; YAMAGUCHI Yoko; SATO Naoyuki; MIZUHARA Hiroaki; SASAOKA Takafumi; ASAKURA Nobuhiko, We propose body-schema-based neural network models for mental transformations of object and scene representations. For the mental transformations of an object, a parietal-premotor network is exploited to perform mental rotation using stored object representations in the inferotemporal cortex. For mental transformations of a scene, a hippocampal network is recruited to perform viewer rotation to update an egocentric representation of multiple objects in a scene encoded by theta phase precession. We present neuroimaging and behavioral studies that provide support for the proposed models. Our fMRI study on mental rotation reveals significant activations within the premotor cortex and the inferior parietal lobe. In addition, activity in the right parieto-occipital region is consistently related to the amount of mental rotation. Our behavioral experiment further shows that the environmental vertical axis is preferentially used for imagined object rotations. This result suggests that body-environment interactions in a gravitational world are incorporated into the process of mental rotation. Finally, by using simultaneous fMRI and EEG, we show that theta oscillation dynamically binds the frontal eye field and the medial temporal lobe into a coherent whole during object-place memory retention., Jan. 2010, 109, 363, 13, 18
• Refereed, The 16th Annual Meeting of the Organization for Human Brain Mapping., Dynamic parieto-premotor network for mental imagery transformation: A simultaneous EEG-fMRI study., Sasaoka, T; Mizuhara, H; Inui, T, 2010
• Refereed, 16th Annual Meeting of the Organization for Human Brain Mapping, The origin of scalp EEG during a motor execution task: A new method for simultaneous fMRI and EEG., Mizuhara H; Inui T, 2010
• Not Refereed, 日本神経回路学会誌 = The Brain & neural networks, Japanese Neural Network Society, 時限研究会「身体知機構研究会」実施報告, 水原 啓暁, 05 Mar. 2009, 16, 1, 37, 39, 10.3902/jnns.16.37

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• Not Refereed, 計測と制御 = Journal of the Society of Instrument and Control Engineers, 計測自動制御学会, Neuronal Dynamics and Emergent Intelligence, MIZUHARA Hiroaki, 10 Jan. 2009, 48, 1, 94, 99
• Not Refereed, 日本認知心理学会第７回大会, メンタルクロック課題による心的イメージ操作の神経基盤の検討, 笹岡 貴史; 水原 啓暁; 乾 敏郎, 2009
• Refereed, The 2nd International Conference on Cognitive Neurodynamics, Is mu rhythm an index of the human mirror neuron system? A study of simultaneous fMRI and EEG, Mizuhara, H; Inui, T, 2009
• Refereed, The 2nd International Conference on Cognitive Neurodynamics, The interaction between the parietal and motor areas in dynamic imagery manipulation: an fMRI study, Sasaoka, T; Mizuhara, H; Inui, T, 2009
• Refereed, Society for Neuroscience, Dorsal attention network correlated with EEG slow oscillations initiates spontaneous perceptual switching, Ozaki, TJ; Sato, N; Kitajo, K; Someya, Y; Anami, K; Mizuhara, H; Ogawa, S; Yamaguchi, Y, 2009
• Refereed, Society for Neuroscience, Dynamic cortical networks with theta oscillation for the scene memory maintenance: A simultaneous fMRI and EEG study, Mizuhara, H; Sato, N; Yamaguchi, Y, 2009
• Refereed, Human Brain Mapping, Human frontal EEG theta oscillation encodes the visual input sequence of novel scenes into the medial temporal lobe, Mizuhara, H; Sato, N; Yamaguchi, Y, 2009
• Refereed, NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, An episodic memory encoding pathway emerges with subsequent memory dependent EEG theta synchronization, Naoyuki Sato; Takashi Ozaki; Yoshiaki Someya; Kimitaka Anami; Seiji Ogawa; Hiroaki Mizuhara; Yoko Yamaguchi, 2008, 61, S255, S255, Summary international conference
• Refereed, Human Brain Mapping, A cortico-hippocampal network emerging with subsequent memory dependent theta oscillation, Sato, N; Ozaki, T; Someya, Y; Anami, K; Ogawa, S; Mizuhara, H; Yamaguchi, Y, 2008
• Refereed, Human Brain Mapping, EEG theta-gamma coupling during explicit memory retention., Mizuhara, H; Yamaguchi, Y, 2008
• Refereed, NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, A dynamic fronto-parietal network emerges with EEG slow oscillation during bistable perception: A simultaneous EEG-fMRI study, Takashi J. Ozaki; Naoyuki Sato; Keiichi Kitajo; Yoshiaki Someya; Kimitaka Anami; Hiroaki Mizuhara; Seiji Ogawa; Yoko Yamaguchi, 2008, 61, S66, S66, Summary international conference
• Not Refereed, 講演論文集, The Japan Society of Mechanical Engineers, 106 PARAFAC decomposition of EEG signal during self-initiated finger movement task, YONEHARA Etsuji; MIZUHARA Hiroaki; GOFUKU Akio, 07 Mar. 2007, 2007, 45, 11, 12
• Not Refereed, 講演論文集, The Japan Society of Mechanical Engineers, 110 A real-time EEG system for distracting mnemonic processing with human theta oscillation, ENZAKI Daiki; MIZUHARA Hiroaki; SHIBATA Mitunobu; GOFUKU Akio, 07 Mar. 2007, 2007, 45, 19, 20
• Not Refereed, 講演論文集, The Japan Society of Mechanical Engineers, 105 Investigation of EEG activity induced by self-initiated finger movement : A brain computer interface study, TIAN Xuxin; MIZUHARA Hiroaki; GOFUKU Akio, 07 Mar. 2007, 2007, 45, 9, 10
• Refereed, PROCEEDINGS OF SICE ANNUAL CONFERENCE, VOLS 1-8, IEEE, Parallel Factor Analysis can decompose human EEG during a finger movement task, Hiroaki Mizuhara; Etsuji YoneharW; Akio Gofilku, To achieve a non-invasive brain computer interface by using the human scalp EEG, we applied the parallel factor analysis (PARAFAC) decomposition to the EEG data measured during the self-initiated and externally cued finger movement tasks. The results showed that the PARAFAC model can decompose the human scalp EEG and identify the intention, which concerns with the finger movement. By applying the core consistency diagnostic to the PARAFAC model, we discussed the feasible method for identifying the appropriate number of the components. Our results suggest that the combination of the EEG and other neuroimaging modality should be applied for producing the appropriate number of the components of the PARAFAC model for the purpose of the non-invasive brain computer interface, while the core consistency diagnostic could decide the minimum number of the components., 2007, 1940, +, 10.1109/SICE.2007.4421305

  DOI URL
• Refereed, Society for Neuroscience, 37th annual meeting., Virtual reality based visual feedback therapy modulates the cortical circuits for pain perception in the patient with complex regional pain syndrome., Sato K; Sato T; Mizobuchi S; Nakatsuka H; Morita K; Mizuhara H; Maruo T; Gofuku A, 2007
• Refereed, Society for Neuroscience, 37th annual meeting., Theta synchronization networks observed by simultaneous EEG-fMRI measurement during bistable perception., Ozaki T; Sato N; Kitajo K; Someya Y; Anami K; Mizuhara H; Ogawa S; Yamaguchi Y, 2007
• Refereed, Society for Neuroscience, 37th annual meeting., Subsequent memory dependent EEG theta correlates with hippocampal BOLD response in human, Sato N; Ozaki T; Someya Y; Anami K; Ogawa S; Mizuhara H; Yamaguchi Y, 2007
• Refereed, Society for Neuroscience, 37th annual meeting, Neuronal networks with theta and gamma oscillations for encoding novel events in attentional blink task., Mizuhara H; Yamaguchi Y, 2007
• Refereed, The 30th annual meeting of Japan Neuroscience Society., A hypothesis of oscillation networks with multiple frequency synchronization for cognitive control., Yamaguchi Y; Kitajo K; Mizuhara H; Sato N; Ozaki T, 2007
• Refereed, PROCEEDINGS OF SICE ANNUAL CONFERENCE, VOLS 1-8, IEEE, Parallel Factor Analysis can decompose human EEG during a finger movement task, Hiroaki Mizuhara; Etsuji YoneharW; Akio Gofilku, To achieve a non-invasive brain computer interface by using the human scalp EEG, we applied the parallel factor analysis (PARAFAC) decomposition to the EEG data measured during the self-initiated and externally cued finger movement tasks. The results showed that the PARAFAC model can decompose the human scalp EEG and identify the intention, which concerns with the finger movement. By applying the core consistency diagnostic to the PARAFAC model, we discussed the feasible method for identifying the appropriate number of the components. Our results suggest that the combination of the EEG and other neuroimaging modality should be applied for producing the appropriate number of the components of the PARAFAC model for the purpose of the non-invasive brain computer interface, while the core consistency diagnostic could decide the minimum number of the components., 2007, 1940, +, 10.1109/SICE.2007.4421305

  DOI URL
• Refereed, NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, Theta EEG power enhancement for encoding novel scene at attentional blink period, Hiroaki Mizuhara; Yoko Yamaguchi, 2007, 58, S109, S109, Summary international conference, 10.1016/j.neures.2007.06.1206

  DOI URL
• Refereed, FOURTH INTERNATIONAL CONFERENCE ON PHOTONICS AND IMAGING IN BIOLOGY AND MEDICINE, PTS 1 AND 2, SPIE-INT SOC OPTICAL ENGINEERING, An event-related analysis of P300 by simultaneous EEG/fMRI, Li-qun Wang; Mingshi Wang; Hiroaki Mizuhara, In this study, P300 that induced by visual stimuli was examined with simultaneous EEG/fMRI. For the purpose of combine the best temporary resolution with the best special resolution together to estimate the brain function, event-related analysis contributed to this methodological trial. A 64 channel MRI-compatible MR EEG amplifier (BrainAmp: made of Brain Production GmbH, Germany) was used in the measurement simultaneously with fMRI scanning. The reference channel is between Fz, Cz and Pz. Sampling rate of raw EEG was 5 kHz, and the MRI noise reduction was performed. EEG recording synchronized with MRI scan by our original stimulus system, and an oddball paradigm (four-oriented Landolt Ring presentation) was performed. in the official manner. After P300 segmentation, the timing of P300 was exported to event-related analysis of fMRI data with SPM99 software. In single subject study, the significant activations appear in the left superior frontal, Broca's area and on both sides of the parietal lobule when P300 occurred. It is suggest that P300 may be an integration carried out by top-down signal from frontal to the parietal lobule, which regulates an Attention-Logical Judgment process. Compared with other current methods, the event related analysis by simultaneous EEG/fMRI is excellent in the point that can describe the cognitive process with reality unifying further temporary and spatial information. It is expected that examination and demonstration of the obtained result will supply with the promotion of this powerful methods., 2006, 6047, 10.1117/12.710992

  DOI URL
• Not Refereed, 分子精神医学, 先端医学社, 神経リズムによる脳のモジュールリンク:認知機能とその障害の理解へ (特集 認知障害--解析への新たな挑戦), 山口 陽子; 水原 啓暁, Jul. 2005, 5, 3, 261, 268
• Refereed, 35th Annual Meeting of Society for Neuroscience, Human long-range theta phase synchronization is networking distant cortices during a mental task: A simultaneous EEG and fMRI study., Hiroaki Mizuhara; Yoko Yamaguchi, 2005
• Refereed, 11th Annual Meeting of the Organization for Human Brain Mapping (HBM2005), Estimation of Hemodynamic Response Function using Partially Linear Models in concurrent EEG/fMRI data., Fumikazu Miwakeichi; Pedro A. Valdes-Sosa; Jorge Bosch-Byard; Eduardo Aubert-Vazquez; Hiroaki Mizuhara, 2005
• Refereed, International Conference on Complex Medical Engineering, Multivariate Partial Linear Models for concurrent EEG/fMRI., Fumikazu Miwakeichi; Pedro A. Valdes-Sosa; Jorge Bosch-Byard; Eduardo Aubert-Vazquez; Hiroaki Mizuhara, 2005
• Not Refereed, Biophysics, The Biophysical Society of Japan General Incorporated Association, 3P243 Linear and non-linear hemodynamic response to EEG, Miwakeichi F; Valdes-Sosa Pedro; Mizuhara H; Yamaguchi Y, 10 Nov. 2004, 44, 1, S250, 10.2142/biophys.44.S250_3

  DOI URL
• Not Refereed, NeuroImage, The Institute of Electronics, Information and Communication Engineers, Decomposing EEG data into space-time-frequency components using Parallel Factor Analysis, Fumikazu Miwakeichi; Eduardo Martínez-Montes; Pedro A. Valdés-Sosa; Nobuaki Nishiyama; Hiroaki Mizuhara; Yoko Yamaguchi, Finding the means to efficiently summarize electroencephalographic data has been a long-standing problem in electrophysiology. A popular approach is identification of component modes on the basis of the time-varying spectrum of multichannel EEG recordings - in other words, a space/frequency/time atomic decomposition of the time-varying EEG spectrum. Previous work has been limited to only two of these dimensions. Principal Component Analysis (PCA) and Independent Component Analysis (ICA) have been used to create space/time decompositions suffering an inherent lack of uniqueness that is overcome only by imposing constraints of orthogonality or independence of atoms. Conventional frequency/time decompositions ignore the spatial aspects of the EEG. Framing of the data being as a three-way array indexed by channel, frequency, and time allows the application of a unique decomposition that is known as Parallel Factor Analysis (PARAFAC). Each atom is the tri-linear decomposition into a spatial, spectral, and temporal signature. We applied this decomposition to the EEG recordings of five subjects during the resting state and during mental arithmetic. Common to all subjects were two atoms with spectral signatures whose peaks were in the theta and alpha range. These signatures were modulated by physiological state, increasing during the resting stage for alpha and during mental arithmetic for theta. Furthermore, we describe a new method (Source Spectra Imaging or SSI) to estimate the location of electric current sources from the EEG spectrum. The topography of the theta atom is frontal and the maximum of the corresponding SSI solution is in the anterior frontal cortex. The topography of the alpha atom is occipital with maximum of the SSI solution in the visual cortex. We show that the proposed decomposition can be used to search for activity with a given spectral and topographic profile in new recordings, and that the method may be useful for artifact recognition and removal. © 2004 Elsevier Inc. All rights reserved., Jul. 2004, 22, 3, 1035, 1045, 10.1016/j.neuroimage.2004.03.039

  DOI URL
• Refereed, 34th Annual Meeting of Society for Neuroscience, Phase synchronization of scalp theta rhythm is associated with networkingof positive and negative regional responses in a human mental task, Hiroaki Mizuhara; Li-Qun Wang; Koichiro Kobayashi; Yoko Yamaguchi, 2004
• Refereed, 10th Annual Meeting of the Organization for Human Brain Mapping, Emergence of distributed BOLD related with long- range phase synchronization during a mental task studied by human simultaneous fMRI and EEG., Hiroaki Mizuhara; Li-Qun Wang; Koichiro Kobayashi; Yoko Yamaguchi, 2004
• Refereed, 10th Annual Meeting of the Organization for Human Brain Mapping, How nonlinear is the hemodyanmic response?: analysis of EEG/fMRI with semiparametric autoregression., Fumikazu Miwakeichi; Pedro A. Valdes-Sosa; Hiroaki Mizuhara; Li-Qun Wang; Koichiro Kobayashi; Yoko Yamaguchi, 2004
• Refereed, 9th International Conference on Functional Mapping of the Human Brain, Parallel Factor Analysis can extract significant activities in multi channel EEG., Fumikazu Miwakeichi; Eduardo Martinez-Montes; Pedro A. Valdes-Sosa; Hiroaki Mizuhara; Nobuaki Nishiyama; Yoko Yamaguchi, 2003
• Not Refereed, Biophysics, The Biophysical Society of Japan General Incorporated Association, 3J1045 Human EEG theta synchronization during virtual maze navigation, Nishiyama N; Mizuhara H; Miwakeichi F; Yamaguchi Y, 10 Oct. 2002, 42, 2, S178, 10.2142/biophys.42.S178_3

  DOI URL
• Not Refereed, Dynamics and Design Conference : 機械力学・計測制御講演論文集 : D & D, The Japan Society of Mechanical Engineers, An Approach of a Determination Model about Autonomous Action using the Depth Cue from T-junctions, KURIHARA Yoshitaka; SAITO Takashi; MIZUHARA Hiroaki, The depth estimation from the binocular parallax has mainly used in usual autonomous moving methods. It requires high resolution, and doesn't always coincide with the human visual characteristic. So, the proposed-method uses the depth cue from "T-junctions". In order to make processing faster, we used a single eye and low resolution pictures(32×32pixcel). By this method that enables to move in the direction of most depth, we built "Determination Model about Autonomous Action". The validity of this model was confirmed by the simulations using the pictures assuming ideal and real environments., 13 Sep. 2002, 2002, 0
• Refereed, ICONIP'02: PROCEEDINGS OF THE 9TH INTERNATIONAL CONFERENCE ON NEURAL INFORMATION PROCESSING, NANYANG TECHNOLOGICAL UNIV, Theta episodes observed in human scalp EEG during virtual navigation - Spatial distribution and task dependence, N Nishiyama; H Mizuhara; F Miwakeichi; Y Yamaguchi, We investigated the theta oscillation in human scalp EEG during virtual spatial navigation task in order to elucidate the functional role of theta oscillation and contributory cortical areas. It was found that prominent theta activity appears over the frontal midline (Fm). The significant change of the theta amplitude is found not only around the Fm region but also over the centro-parietal region during learning the route to a goal in a novel maze. It is concluded that both the frontal cortex. and the centro-parietal cortical areas contribute to learning during spatial navigation. These results suggest that the development of the brain network during spatial learning is managed by the cooperation between the frontal cortex and the hippocampus, possibly by synchronization., 2002, 428, 432, 10.1109/ICONIP.2002.1202206

  DOI URL
• Refereed, International Conference on Information, Relation of fMRI signal suppression to human selective attention., Hiroaki Mizuhara; Takashi Saito; Jing-Long Wu; Jun-ichi Ogasawara; Shuichi Yamauchi; Kiyoshi Negoro; Masahiro Hashida; Taizo Sanada; Naofumi Matsunaga, 2002
• Not Refereed, 知能メカトロニクスワークショップ講演論文集, 〔精密工学会〕, 人間の視覚情報処理機能を模した画像からのエッジ抽出モデル (第6回 知能メカトロニクスワークショップ--人間を支援するメカトロニクス技術) -- (特別セッション 非整備環境におけるパターン認識1), 水原 啓暁; 田代 裕樹; 斉藤 俊, 30 Aug. 2001, 6, 118, 123
• Not Refereed, Dynamics and Design Conference : 機械力学・計測制御講演論文集 : D & D, The Japan Society of Mechanical Engineers, 416 An Edge Detection Model Simulating Human Visual Characteristics, Mizuhara Hiroaki; Tashiro Yuki; Saito Takashi, Human visual system has the superior ability as the visual information processing. Therefore, it is able to construct the advanced method as the image processing, if the human ability is simulated on the artificial systems. In this study, authors dealt with the edge detection buried under the impulsive noise as one of the human ability, and proposed a model using the nonlinear behavior, which is observed at the activity of brain in the visual processing. The characteristics of the proposed model show the similarly results to those of the human subjects measured by the psychological experiments. Using the proposed model, the fine results of the edge detection are obtained., 03 Aug. 2001, 2001, 0
• Not Refereed, ロボティクス・メカトロニクス講演会講演概要集, The Japan Society of Mechanical Engineers, 1P1-H6 Measurement of Human Visual and Auditory Interactive Function by Psychological Experiment and fMRI, Wu J; Mizuhara H; Nobuki O; Kitazawa M; Negoro K; Hashida M; Ogasawara J; Yamauchi S; Matsunaga N; Saito T, 08 Jun. 2001, 2001, 27, 27
• Not Refereed, 講演論文集, The Japan Society of Mechanical Engineers, 702 Construction of Edge Detection Method Using Chaos Oscillators, Tashiro Yuki; Mizuhara Hiroaki; Saito Takashi; Wu Jing-Long, 21 Feb. 2001, 2001, 39, 245, 246
• Refereed, The Sixth International Symposium on Artificial Life and Robotics (AROB '01), A chaos oscillator model of temporal-frequency characteristics on human visual search., Hiroaki Mizuhara; Takashi Saito; Jing-Long Wu, 2001
• Refereed, 5th World Multiconference on Systemics, Cybernetics and Informatics (SCI 2001), Effect of task-difficulty on human attentional blink between visual and auditory systems in the calculation processing., Hiroaki Mizuhara; Jing-Long Wu; Takashi Saito, 2001
• Refereed, The Fifth International Symposium on Artificial Life and Robotics (AROB '00), Measurement of human visual and auditory calculate processing by functional magnetic resonance imaging (fMRI)., Hiroaki Mizuhara; Jing-long Wu; Kiyoshi Negoro; Masahiro Hashida; Jun-ichi Ogasawara; Syuichi Yamauchi; Naofumi Matsunaga, 2000
• Not Refereed, Memoirs of the Faculty of Engineering, Yamaguchi University, 山口大学, CHARACTERISTICS OF REACTION TIME IN HUMAN VISUAL AND AUDITORY INFORMATION PROCESSING, WU Jing-Long; MIZUHARA Hiroaki; NISHIKAWA Yoshikazu, In order to investigate interactive characteristics between human visual and auditory information processing, human visual and auditory characteristics have been measured by our previous studies. In our previous investigations, the visual search and the speech perception (mental arithmetic) were used as visual and auditory stimuli. respectively. The experimental results suggested that human visual information processing is affected by the auditory information. In the present study, human visual and auditory characteristics of reaction time are measured, and the tasks of mental arithmetic are used as the both of visual and auditory stimuli. The measurement results suggest that the visual information processing is affected by the auditory information. Furthermore, the experimental results clarify that the auditory information is affected by the visual information., Mar. 1999, 49, 2, 189, 196
• Not Refereed, Transactions of the Institute of Systems, Control and Information Engineers, THE INSTITUTE OF SYSTEMS, CONTROL AND INFORMATION ENGINEERS (ISCIE), On Human Related Characteristic between Visual Search and Speach Perception, WU Jing-Long; MIZUHARA Hiroaki; NISHIKAWA Yoshikazu, Recently, the cause of many car accidents is to use car-phone while driving. We hypothesize that one of the causes of such traffic accidents is that the human visual information processing is affected by the auditory information. In order to evidence the hypothesis, human characteristics between visual search and speech perception have been measured by psychological experiments. On the measurement results, in the case of the auditory information is presented concurrently, the visual reaction time is longer than that in the case of the visual information is presented only. The results of fundamental experiments with human visual and auditory characteristic suggest one of the cause of traffic accidents in using car-phone is that the human visual information processing is affected by the auditory information., 15 Feb. 1999, 12, 2, 98, 105, 10.5687/iscie.12.98

  DOI URL
• Refereed, The Forth International Symposium on Artificial Life and Robotics (AROB '99), The Degree of Human Visual Attention in the Visual Search., Hiroaki Mizuhara; Jing-long Wu; Yoshikazu Nishikawa, 1999, 10.1007/BF02480857

  DOI URL
• Refereed, IEEE International Conference on Systems, Man and Cybernetics (SMC '99), Human characteristics of parallel information processing on visual and auditory systems., Jing-Long Wu; Hiroaki Mizuhara; Yoshikazu Nishikawa, 1999
• Refereed, 電子情報通信学会技術研究報告 : 信学技報 112(345) 89-94, Measurement of human visual and auditory characteristics for a virtual driving system., Jing-long Wu; Hiroaki Mizuhara; Yoshikazu Nishikawa, 1998

Books etc

• 有斐閣現代心理学辞典 (子安増生，丹野義彦，箱田裕司 監修), 有斐閣, 水原啓暁, 機能的磁気共鳴画像法, 脳波, 磁気共鳴画像法, 拡散テンソル映像法, PET／SPECT, CT, 経頭蓋磁気刺激, 局所血流量, デフォルト･モード･ネットワーク, ガンマ波, シータ波, デルタ波, 徐波, 神経同期, Feb. 2021, 996p, 図版 [18] p, 9784641002661

  CiNii Books URL
• よくわかる認知科学（乾敏郎・吉川左紀子・川口潤編）, ミネルヴァ書房, 水原啓暁, 情報の統合2（生理）, 2010, Not Refereed

Presentations

• Takara K. Allal-Sumoto; Hiroaki Mizuhara, Neuro2022, The Effects of Productive and Comprehensive Vocabulary Knowledge on Second Language Comprehension Processing, 02 Jul. 2022, 30 Jun. 2022, 03 Jul. 2022

  共同研究・競争的資金等URL
• Duygu Sahin; Hiroaki Mizuhara, Neuro2022, Spatiotemporal Reconstruction Accuracies of M/EEG Inverse Solution Models, 02 Jul. 2022, 30 Jun. 2022, 03 Jul. 2022

  共同研究・競争的資金等URL
• Hiroaki Mizuhara, Akiyuki Kamiura, Naoyuki Sato, FENS Forum 2020, Neural oscillations for the dynamic integration of spoken words, Jul. 2020, 11 Jul. 2020, 15 Jul. 2020

  共同研究・競争的資金等URL
• Hiroaki Mizuhara, NOLTA2019, Neural Oscillations Are a Common Mechanism to Explain Multiscale Communication within/Between the Brains, 03 Dec. 2019, True
• Hiroaki Mizuhara; Peter Uhlhaas, EuroCogSci2019, The impact of predictions and sensory input on the sense of agency: Development of a new psychophysical paradigm, 02 Sep. 2019, True
• Tomomi Hida; Hiroaki Mizuhara, Cognitive Neuroscience Society 25th Annual Meeting, Language and music do and do not share the merging operations in syntax, 26 Mar. 2018, True
• 水原啓暁, 大阪大学 数理・データ科学アドバンストセミナー「生体情報の数理モデリングと統計解析」, 脳情報のダイナミクス解析, 15 Feb. 2018, False
• Tomomi Hida; Hiroaki Mizuhara, Language, Music, and Cognition: Organizing Events in Time, Language and music use the subassembly-type as universal, but not the pot-type merging operation, Feb. 2018, True
• Hiroaki Mizuhara; Toshihiro Kumagai; Atsushi Oozono, Society for Neuroscience 2017, Two different phase coding mechanisms for integrating audio-visual information via slow neural oscillation, 15 Nov. 2017, True
• Tomomi Hida; Hiroaki Mizuhara, The 6th Conference of the Asia-Pacific Society for the Cognitive Sciences of Music (APSCOM 6), Learning triggers pot-merge emergence in the syntactic hierarchy, 26 Aug. 2017, True
• Tomomi Hida; Hiroaki Mizuhara, Cognitive Neuroscience Annual Meeting, Compounds emerge from the merge operation in human language syntax., 27 Mar. 2017, True
• Atsushi Oozono; Hiroaki Mizuhara, Cell Symposia: Big Questions in Neuroscience, Phase shift of neural oscillation induces asymmetric integration in audio-visual speech perception, Nov. 2016, True
• Ueno T; Kuga H; Oribe N; Takao K; Hayashida R; Nakayama N; Mizuhara H; Yuzuriha T, Society for Neuroscience, Cognitive functions negatively correlate to the angular gray matter volume in schizophrenia, Nov. 2016, True
• Toshihiro Kumagai; Hiroaki Mizuhara, Society for Neuroscience, EEG phase shift caused by visual-spatial attention accompanies ventriloquism effect., Nov. 2015, True
• 水原啓暁, 日本認知科学会 第32回大会, リズムの協調による脳間コミュニケーション, 18 Sep. 2015
• Hiroaki Mizuhara, 12th World Congress of the World Federation of Societies of Biological Psychiatry (WFSBP 2015), Neural dynamics with simultaneous EEG and fMRI measurements, 18 Jun. 2015
• Hiroaki Mizuhara, 第15回 冬のワークショップ 心の統合 "Integration of mind", Dynamic integration of distributed information via neural synchrony, 08 Jan. 2015
• 水原啓暁, 生理研研究会：コミュニケーションを可能にする神経機構の解明, コミュニケーションを促進する神経オシレーションの位相協調, 2015, False
• 水原啓暁, 第4回社会神経科学研究会 「社会認知とコミュニケーション」, 神経振動子協調による脳内/脳間コミュニケーション, 31 Oct. 2014
• Hiroaki Mizuhara, Symposium on Human Cognitive Neuroscience: Neural Dynamics of Internal Switching, Neural Synchrony: Common Framework for Understanding Inter-cortical and Inter-brain Communication, 23 Jan. 2014
• Hiroaki Mizuhara, Conference on Neural Oscillation 2013, Spatiotemporal analysis of human neural oscillation by simultaneous fMRI-EEG, Jul. 2013, False
• Hiroaki Mizuhara; Takafumi Sasaoka; Yutaka Yamaguti; Hiroshi Watanabe; Ichiro Tsuda, International Conference on Cognitive Neurodynamics 2013, EEG (de-)synchronization of the intra/inter-brain during cooperative finger tapping, Jun. 2013, True
• Hiroaki Mizuhara, Monthly Meeting of the TOKUSUI Project, Osaka University, Neural Synchrony: Common Framework for Understanding Inter-cortical and Inter-brain Communication, 26 Apr. 2013
• Hiroaki Mizuhara, Measuring Consciousness - Theory and Experiments, Neural synchronization of the intra-/inter-brain for hetero systems communication, Mar. 2013, False
• Mizuhara H; Inoue S; Sasaoka T; Shikauchi M, Dynamic Brain Forum 2012, Boosting the intelligibility of vocal communication via inter-individual entrainment of neuronal oscillations, Sep. 2012, True
• 水原啓暁, ダイナミックブレインワークショップ, fMRIとEEGの同時計測による皮質脳波の再構築, Dec. 2011, False
• 水原啓暁, 京都大学大学院医学研究科 神経科学セミナー, 神経振動子の階層カップリングによる皮質間/個体間コミュニケーション： fMRIとEEGの同時計測によるアプローチ, Nov. 2011
• 水原啓暁, コンポン研究所・人間社会科学セミナー「コミュニケーションの脳内メカニズム」, 脳内コミュニケーションの時空間特性, Mar. 2011
• 第2回神経ダイナミクス研究会, 皮質活動に関連した頭皮脳波分布の同定, 29 Jan. 2011, 神経ダイナミクス研究会
• 水原啓暁, 九州大学大学院医学研究院 精神病態医学 精神病態医学セミナー, 皮質間の同期的神経活動による動的な情報統合, Oct. 2010
• 水原啓暁, 日本神経心理学会第34回総会・学術集会, グローバルな神経協調による情報統合と機能障害., Sep. 2010
• Mizuhara H; Inui T, 16th Annual Meeting of the Organization for Human Brain Mapping, The origin of scalp EEG during a motor execution task: A new method for simultaneous fMRI and EEG., 2010
• 水原啓暁, 日本心理学会2009WS「心理学研究におけるfMRI研究の最前線」, θ波により創発するエピソード記憶ネットワーク：fMRIとEEGの同時計測を用いて, 2009
• Ozaki, TJ; Sato, N; Kitajo, K; Someya, Y; Anami, K; Mizuhara, H; Ogawa, S; Yamaguchi, Y, Society for Neuroscience, 2009, Dorsal attention network correlated with EEG slow oscillations initiates spontaneous perceptual switching., 2009
• Mizuhara, H; Sato, N; Yamaguchi, Y, Society for Neuroscience, 2009, Dynamic cortical networks with theta oscillation for the scene memory maintenance: A simultaneous fMRI and EEG study., 2009
• Mizuhara, H; Sato, N; Yamaguchi, Y, Human Brain Mapping 2009, Human frontal EEG theta oscillation encodes the visual input sequence of novel scenes into the medial temporal lobe., 2009
• Mizuhara, H, 11th Tamagawa Dynamic Brain Forum '09, Dynamic human cortical networks by neuronal phase synchronization., 2009
• Sasaoka, T; Mizuhara, H; Inui, T, he 2nd International Conference on Cognitive Neurodynamics, The interaction between the parietal and motor areas in dynamic imagery manipulation: an fMRI study., 2009
• Mizuhara, H; Inui, T, The 2nd International Conference on Cognitive Neurodynamics, Is mu rhythm an index of the human mirror neuron system? A study of simultaneous fMRI and EEG., 2009
• 平成20年度 計測自動制御学会関西支部講習会「パワーアシスト技術の現状と展望」, 最新の脳機能計測技術と福祉工学応用, 2008, 計測自動制御学会関西支部
• 水原啓暁, 日本認知科学会「パターン認識と知覚モデル研究分科会」, 脳波位相同期による動的な皮質ネットワーク形成．, 2008
• Sato, N; Ozaki, T; Someya, Y; Anami, K; Ogawa, S; Mizuhara, H; Yamaguchi, Y, The 31st Annual Meeting of the Japan Neuroscience Society, An episodic memory encoding pathway emerges with subsequent memory dependent EEG theta synchronization., 2008
• Ozaki, T; Sato, N; Kitajo, K; Someya, Y; Anami, K; Mizuhara, H; Ogawa, S; Yamaguchi, Y, The 31st Annual Meeting of the Japan Neuroscience Society, A fronto-parietal network emerges with EEG slow oscillation during bistable perception: a simultaneous EEG-fMRI study., 2008
• Sato, N; Ozaki, T; Someya, Y; Anami, K; Ogawa, S; Mizuhara, H; Yamaguchi, Y, Human Brain Mapping, 14th Annual Meeting, Melbourne, A cortico-hippocampal network emerging with subsequent memory dependent theta oscillation., 2008
• Mizuhara, H; Yamaguchi, Y, 14th Annual Meeting, Melbourne, EEG theta-gamma coupling during explicit memory retention., 2008
• 日本機械学会中国四国支部第104回講習会, 最近の脳機能計測技術の動向と医療診断支援への応用, 2007, 日本機械学会
• 水原啓暁, 日本機械学会中国四国支部第104回講習会, 最近の脳機能計測技術の動向と医療診断支援への応用, 2007
• Sato K; Sato T; Mizobuchi S; Nakatsuka H; Morita K; Mizuhara H; Maruo T; Gofuku A, Society for Neuroscience, 37th annual meeting, Virtual reality based visual feedback therapy modulates the cortical circuits for pain perception in the patient with complex regional pain syndrome., 2007
• Ozaki T; Sato N; Kitajo K; Someya Y; Anami K; Mizuhara H; Ogawa S; Yamaguchi Y, Society for Neuroscience, 37th annual meeting, Theta synchronization networks observed by simultaneous EEG-fMRI measurement during bistable perception., 2007
• Sato N; Ozaki T; Someya Y; Anami K; Ogawa S; Mizuhara H; Yamaguchi Y, Society for Neuroscience, 37th annual meeting, Subsequent memory dependent EEG theta correlates with hippocampal BOLD response in human., 2007
• Mizuhara H; Yamaguchi Y, Society for Neuroscience, 37th annual meeting, Neuronal networks with theta and gamma oscillations for encoding novel events in attentional blink task., 2007
• Hiroaki Mizuhara; Etsuji Yonehara; Akio Gofuku, SICE annual conference, Parallel Factor Analysis can decompose human EEG during a finger movement task., 2007
• Mizuhara H; Yamaguchi Y, RIKEN SYMPOSIUM "Brain activity and information integration", Cortical circuits for human ececutive function revealed by simultaneous fMRI and EEG., 2007
• Mizuhara H; Yamaguchi Y, The 30th annual meeting of Japan Neuroscience Society, Theta EEG power enhancement for encoding novel scene at attentional blink period., 2007
• Yamaguchi Y; Kitajo K; Mizuhara H; Sato N; Ozaki T, The 30th annual meeting of Japan Neuroscience Society, A hypothesis of oscillation networks with multiple frequency synchronization for cognitive control., 2007
• Hiroaki Mizuhara; Yoko Yamaguchi, 35th Annual Meeting of Society for Neuroscience, Human long-range theta phase synchronization is networking distant cortices during a mental task: A simultaneous EEG and fMRI study., 2005
• Fumikazu Miwakeichi; Pedro A. Valdes-Sosa; Jorge Bosch-Byard; Eduardo Aubert-Vazquez; Hiroaki Mizuhara, 11th Annual Meeting of the Organization for Human Brain Mapping (HBM2005), Estimation of Hemodynamic Response Function using Partially Linear Models in concurrent EEG/fMRI data., 2005
• Fumikazu Miwakeichi; Pedro A. Valdes-Sosa; Jorge Bosch-Byard; Eduardo Aubert-Vazquez; Hiroaki Mizuhara, International Conference on Complex Medical Engineering, Multivariate Partial Linear Models for concurrent EEG/fMRI., 2005
• Hiroaki Mizuhara; Li-Qun Wang; Koichiro Kobayashi; Yoko Yamaguchi, CREST-RIKEN Workshop 2005 on Real-Time Computing and Neural Dynamics in the Brain, Cortical coherent ensemble revealed by simultaneous fMRI and spontaneous EEG during a mental task, 2005
• Hiroaki Mizuhara; Li-Qun Wang; Koichiro Kobayashi; Yoko Yamaguchi, 34th Annual Meeting of Society for Neuroscience, Phase synchronization of scalp theta rhythm is associated with networkingof positive and negative regional responses in a human mental task, 2004
• Hiroaki Mizuhara; Li-Qun Wang; Koichiro Kobayashi; Yoko Yamaguchi, 10th Annual Meeting of the Organization for Human Brain Mapping, Emergence of distributed BOLD related with long- range phase synchronization during a mental task studied by human simultaneous fMRI and EEG., 2004
• Fumikazu Miwakeichi; Pedro A. Valdes-Sosa; Hiroaki Mizuhara; Li-Qun Wang; Koichiro Kobayashi; Yoko Yamaguchi, 10th Annual Meeting of the Organization for Human Brain Mapping, How nonlinear is the hemodyanmic response?: analysis of EEG/fMRI with semiparametric autoregression., 2004
• Fumikazu Miwakeichi; Eduardo Martinez-Montes; Pedro A. Valdes-Sosa; Hiroaki Mizuhara; Nobuaki Nishiyama; Yoko Yamaguchi, 9th International Conference on Functional Mapping of the Human Brain, Parallel Factor Analysis can extract significant activities in multi channel EEG., 2003
• Nobuaki Nishiyama; Hiroaki Mizuhara; Fumikazu Miwakeichi; Yoko Yamaguchi, 9th International Conference on Neural Information Processing (ICONIP'02), Theta episodes observed in human scalp EEG during virtual navigation: Spatial distribution and task dependence., 2002
• Hiroaki Mizuhara; Takashi Saito; Jing-Long Wu; Jun-ichi Ogasawara; Shuichi Yamauchi; Kiyoshi Negoro; Masahiro Hashida; Taizo Sanada; Naofumi Matsunaga, International Conference on Information, Relation of fMRI signal suppression to human selective attention., 2002
• Hiroaki Mizuhara; Jing-Long Wu; Takashi Saito, 5th World Multiconference on Systemics, Cybernetics and Informatics (SCI 2001), Effect of task-difficulty on human attentional blink between visual and auditory systems in the calculation processing., 2001
• Hiroaki Mizuhara; Takashi Saito; Jing-Long Wu, The Sixth International Symposium on Artificial Life and Robotics (AROB '01), A chaos oscillator model of temporal-frequency characteristics on human visual search., 2001
• Hiroaki Mizuhara; Jing-long Wu; Kiyoshi Negoro; Masahiro Hashida; Jun-ichi Ogasawara; Syuichi Yamauchi; Naofumi Matsunaga, The Fifth International Symposium on Artificial Life and Robotics (AROB '00), Measurement of human visual and auditory calculate processing by functional magnetic resonance imaging (fMRI)., 2000
• Jing-Long Wu; Hiroaki Mizuhara; Yoshikazu Nishikawa, IEEE International Conference on Systems, Man and Cybernetics (SMC '99), Human characteristics of parallel information processing on visual and auditory systems., 1999
• Jing-Long Wu; Hiroaki Mizuhara; Kiyoshi Negoro; Masahiro Hashida; Jun-ichi Ogasawara; Shuichi Yamauchi; Naofumi Matsunaga, 2nd International Conference on Cognitive Science (ICCS/JCSS '99), Measurement of human interactive characteristic between visual and auditory system by psychological experiment and functional magnetic resonance imaging (fMRI)., 1999
• Hiroaki Mizuhara; Jing-long Wu; Yoshikazu Nishikawa, The Forth International Symposium on Artificial Life and Robotics (AROB '99), The Degree of Human Visual Attention in the Visual Search., 1999
• Jing-long Wu; Hiroaki Mizuhara; Yoshikazu Nishikawa, The Third International Symposium on Artificial Life and Robotics (AROB '98), Measurement of human visual and auditory characteristics for a virtual driving system. The Third International Symposium on Artificial Life and Robotics (AROB '98), 1998

Awards

• 優秀発表賞新規性評価部門, 日本認知心理学会, 水原啓暁, Jun. 2013
• 優秀研究賞, 日本神経回路学会, Jun. 2013
• 科学研究費補助金第一段審査委員表彰, 日本学術振興会, 水原啓暁, Sep. 2011
• 優秀発表賞技術性評価部門, 日本認知心理学会, 水原啓暁, May 2010
• SICE2007 Annual Conference Young Author's Award, Hiroaki Mizuhara, Sep. 2007
• NeuroImage Section Editors Choice Award, Hiroaki Mizuhara, Jun. 2007
• 論文賞, ヒューマンインタフェース学会, Mar. 2007
• 研究科長賞, 山口大学大学院理工学研究科, 水原啓暁, Mar. 2002
• 奨励賞, システム制御情報学会, 水原啓暁, May 2000

Industrial Property Rights

• Patent right, 脳波－運動指令変換装置, 水原啓暁, 五福明夫, 特許特許第4411442号, 27 Nov. 2009

Research Projects

• Grant-in-Aid for Scientific Research (B), Apr. 2022, Mar. 2025, 22H03913, Self-body consciousness transformed by EEG manipulation, 水原 啓暁, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Kyoto University, 17030000, 13100000, 3930000, kaken

  対象リソースIRI
• Grant-in-Aid for Scientific Research (C), 01 Apr. 2021, 31 Mar. 2024, 21K12610, Development of an electroencephalographic index measuring text comprehension, 佐藤 直行; 水原 啓暁, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Future University-Hakodate, 4160000, 3200000, 960000, 本研究の目的は、文章読解中の「理解の程度」を推定するための脳波解析技術を開発することである。私たちは先行研究において、文章読解中に計測した脳波データの解析により、読解した文章のどこの部分を「覚えているかどうか」を予測できることを示しており、「理解」を伴う記憶かどうかが明らかになれば、より応用価値のある技術となると考えた。令和３年度は、（１）頭部が非拘束の場合でもアーチファクトに影響を受けづらい脳波指標の検討、及び（２）オンライン及び対面講義の理解に関わる脳波計測・解析を行った。（１）体動や眼電位などのアーチファクトは全電極に同時的に混入すると想定されるため、頭皮上の時空間パターンである脳波進行波を解析すれば、自然な講義受講中の脳波を解析できると考えた。そこで、コネクトームを用いた全脳神経回路シミュレーション行い、脳波進行波パターンの特性を調べた。結果として、進行波は特定のパターンを示しやすいものの、全体的な脳活動パターンの推移に伴い、進行波パターンが即時的に変化することが明らかになった。（２）オンライン及び対面講義の理解に関わる脳波計測を行い、脳波進行波が受講状態の違いを反映するかどうかを調べた。結果として、両条件でβ波帯域（15-30 Hz）の脳波進行波パターンには差異があることを確認した。これは、講義受講に注意状態の違いを反映していると考えられた。今回の計測では条件間で理解度の差がない課題だったが、同解析手法は理解度に差異のある課題でも同様に適用可能である。以上の結果は、理解度定量の脳波解析技術開発の点で有用な結果である。, kaken

  対象リソースIRI
• Grant-in-Aid for Challenging Research (Exploratory), 30 Jul. 2020, 31 Mar. 2022, 20K20860, Predictive motor signals propagating to others beyond individual brain, 水原 啓暁, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Kyoto University, 6370000, 4900000, 1470000, 二人一組で参加した被験者の一方に痛みを感じる刺激を加えたとき，恋人同士が手をつないでいる場合には，その痛みが軽減することが最近の研究で次々に報告されている．この結果の脳メカニズムは，感覚減衰で説明可能かもしれない．感覚減衰とは，自身の行動予測により，感覚の感度が低下する現象である．例えば，他人が自分の掌をくすぐった場合にはくすぐったく感じるが，自分でくすぐった場合にはくすぐったく感じない．通常は，自分の運動を予測することで，これから入力される刺激への感度を落とすために，くすぐったく感じなくなる． くすぐり実験のようなself-initiated actionに対して感覚感度が下がる場合については，そのメカニズムの第一候補に運動指令の遠心性コピーがある．遠心性コピーは，運動を実行する際に作成される運動指令信号のフィードフォワード信号である．つまり，自分の行為のフィードバックとして刺激が入力される場合には，そのフィードバック刺激に先回りして，運動指令信号のコピーが予測信号として使われることで，感覚反応をつかさどる神経活動を抑制する．ただし，感覚減衰には遠心性コピーだけでは不十分で，これに加えて文脈に依存したトップダウン的な予測が必要とされる可能性も指摘されている． そこで本研究では，感覚減衰パラダイムを用いて，恋人とのソーシャルタッチにより感覚減衰が発生するかを検証する．特に，対人関係のトップダウン情報は，感覚モダリティを超えて初期感覚皮質に作用することが示されており，本研究では痛み刺激を直接的に用いるのではなく，異なるモダリティ(聴覚)への刺激に対する感覚減衰を検証する．感覚減衰は頭皮脳波計測により検証する．本年度までに予定していた頭皮脳波計測を完了している．, kaken;rm:presentations;rm:presentations

  対象リソースIRI
• Apr. 2018, Mar. 2021, Principal investigator, 神経リズムの引き込み協調により実現する脳コミュニケーション, Hiroaki Mizuhara, JSPS, KAKENHI (Basic research (B)), 0, 0, 0, Competitive research funding, rm:presentations

  対象リソースIRI
• 2016, 2017, Principal investigator, コミュニケーションを実現する神経オシレーションの階層協調, 水原啓暁, 文部科学省, 科学研究費補助金(新学術領域研究(研究領域提案型)), 0, 0, 0, Competitive research funding
• Grant-in-Aid for Scientific Research (A), 2013, 2017, 25240019, Principal investigator, Underlying mechanism of verbal communication by phase-resetting of neural oscillations, Mizuhara Hiroaki; ONITSUKA Toshiaki; HIRANO Shogo; ONOJIMA Takayuki; KUMAGAI Toshihiro; OOZONO Atsushi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Kyoto University, 8060000, 6200000, 1860000, We measured human scalp EEG, and simultaneous fMRI-EEG to investigate the neural mechanisms of communication. In this project, we assumed that the communication, ranging from cortical networks in the brain to social networks between humans, can be explained by a common theoretical framework on the neural oscillations. The results indicated that the dynamic cortical networks in the brain were achieved by a hierarchical synchrony of neural oscillations between the theta and gamma EEGs. The hierarchical synchrony of neural oscillations also enhanced the communication between humans, where the slower oscillation in delta EEG conveyed information represented by the theta EEG in the brain to others. We demonstrated that the underlying mechanism of communication can be described by a common theoretical framework on the neural oscillations ranging from cortical networks in the brain to real human-human interaction., Competitive research funding, url;kaken

  対象リソースIRI
• 新学術領域研究(研究領域提案型), 2014, 2015, 26119516, Principal investigator, コミュニケーションの時間窓を決定する周期的脳活動, 水原 啓暁, 文部科学省, 科学研究費補助金(新学術領域研究(研究領域提案型)), 京都大学, 4940000, 3800000, 1140000, 周期的脳活動の一つである脳波の神経振動子協調が，脳内の動的な神経ネットワーク形成を実現していることが指摘されている．この神経振動子協調は，脳内の情報伝達のみに留まらず，脳と脳の間の情報伝達，つまりコミュニケーションにおいても重要な戦略であるとして，近年，注目を集め始めている．例えば音声コミュニケーションにおいては，話者の発話のリズムと，音声聴取中の聞き手の脳内の神経振動子が位相協調することが報告されている．さらに，音声提示前の脳波位相によって聴取成績が変化することも示されており，この脳波位相が話者の音声発話タイミングの予測に関与しているものと考えられる．つまり，音声コミュニケーションにおいて適切な時間窓を実現する脳内メカニズムが，神経振動子の音声提示前後における位相協調であると考えられる．そこで本申請課題では，ヒトを対象とした脳波計測，および脳波と機能的MRIの同時計測を実施することで，脳波の位相に依存して音声聴取成績が変化することを示すとともに，そのときの皮質回路の音声提示前後の変化を検証することを目的とした． 本研究課題では，音声聴取課題遂行中の脳波計測を実施することで，音声提示前後の神経ネットワークの切り替えに関与している脳波成分を同定した．この脳波成分の発生に関連する脳部位の同定を目的として，音声聴取課題遂行中の脳波と機能的MRIの同時計測を実施した．その結果，音声提示前後の神経ネットワークとして， 音声の生成に関連する運動皮質の活動が明らかになった．この部位はミラーニューロンシステムと呼ばれる他者の運動を予測する部位であり，他者の運動予測を脳波の位相情報を用いて実施することにより，コミュニケーションの時間窓を調整していることが明らかになった．, Competitive research funding, url;kaken

  対象リソースIRI
• 2013, 2015, Principal investigator, 高時空間分解能を実現する脳神経ダイナミクス解析技術の開発, 水原啓暁, 栢森情報科学振興財団, 研究助成, 0, 0, 0, Competitive research funding
• Grant-in-Aid for Scientific Research (C), 2011, 2013, 23592290, an application of on-demand virtual reality mirror visual feedback therapy to patients with intractable chronic pain, SATO kenji; GOFUKU Akio; NISHIE Hiroyuki; KAKU Ryuji; MIZUHARA Hiroaki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Okayama University, 5590000, 4300000, 1290000, Since the equipment of virtual reality mirror visual feedback therapy( VR-MVR) is too expensive for individual purchase, so system are only available in hospital. It results into the limitation of patients treatment opportunity. In this study, we resolved this problem with developing the remote personal VR-MVR system. Patients with chronic hand pain have been treated by this system which is installed at patient home., kaken

  対象リソースIRI
• Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), 2009, 2013, 21120008, Principal investigator, Verbal and non-verbal communication principle revealed by neural synchrony, MIZUHARA Hiroaki; SASAOKA Takafumi; INUI Toshio, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Kyoto University, 0, 0, 0, Neural synchrony is a crucial mechanism to dynamically communicate between cortices in the brain. The neural synchrony is usually observed as the EEG activity, and has been often elucidated in the term of mnemonic function. We used the scalp EEG recordings during a sentence comprehension task and a vocal communication task, in order to elucidate the underlying mechanism of the verbal communication in the current project. Here we assumed that the neural synchrony is the common mechanism to explain the verbal and non-verbal communications. For investigating the mechanism of non-verbal communication, the causal relationship analysis of fMRI was used to verify the dynamical modulation of the cortical networks caused by non-verbal interaction to others. We also elucidated the mechanism of the inter-personal communication emerges with the neural synchrony of EEGs from two brains., Competitive research funding, url;kaken

  対象リソースIRI
• 2009, 2013, ヘテロ複雑システムによるコミュニケーション理解のための神経機構の解明, 津田一郎, 文部科学省, 科学研究費補助金(新学術領域研究(研究領域提案型)), 0, 0, 0, Competitive research funding
• 2008, 2012, 身体図式を基礎とした動的イメージ生成の脳内メカニズムの解明, 乾敏郎, 日本学術振興会, 科学研究費補助金(基盤研究(S)), 0, 0, 0, Competitive research funding
• Grant-in-Aid for Young Scientists (A), 2009, 2011, 21680024, Principal investigator, Underlying mechanisms of information integration via interplay of Multiple scale neuronal oscillators, MIZUHARA Hiroaki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Kyoto University, 0, 0, 0, To investigate the underlying mechanisms of the cortical networks which dynamically emerge for the episodic memory, we measured the simultaneous fMRI and EEG. The task was the memory for the association of objects and places information, which would be processed in the hippocampus. The results showed that the medial prefrontal cortex, the frontal eye field, the visual cortex and the parahippocampal place area emerge a cortical network for the successful memory retention, when the theta EEG oscillation appeared on the front-central scalp sites. Furthermore, we developed a method for combining the simultaneously recorded fMRI and EEG. This method enables to identifying the cortical EEG activity with the fMRI spatial and EEG temporal precisions., Competitive research funding, url;kaken

  対象リソースIRI
• Grant-in-Aid for Scientific Research (C), 2008, 2010, 20591831, The validation of virtual reality mirror visual feedback therapy as an analgesic modality for intractable pain, SATOU Kenji; MIZOBUCHI Satoshi; NISHIE Hiroyuki; NAKATSUKA Hideki; SATO Tetsufumi; MIZUHARA Hiroaki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Okayama University, 4940000, 3800000, 1140000, We developed and introduced The Virtual Reality Mirror Visual Feedback Therapy (VR/MVF) to patients with intractable pain, such as phantom limb pain and complex regional pain syndrome (CRPS).We have already confirmed and reported its analgesic efficacy and speculated that VR/MVF would provide its analgesic effect through the activation of intrinsic opioid system. In the present study we developed the system which could link VR/MVF with this intrinsic opioid system and is easy to take outside of the hospital (where VR/MVF was set). The system converts VR/MVF into music. When patients hear this music、their intrinsic opioid system could be activated just like during VR/MVF therapy, they can enjoy analgesia anytime he/she wants., kaken

  対象リソースIRI
• 2006, 2008, Principal investigator, 多自由度・実時間制御機構を有するブレイン・コンピュータインタフェースの研究開発, 水原啓暁, 総務省, 戦略的情報通信研究開発推進制度(SCOPE-R)), 0, 0, 0, Competitive research funding
• Grant-in-Aid for Young Scientists (A), 2006, 2008, 18680027, Principal investigator, A study on the emergent mechanism of neuronal circuits for memory formation by simultaneous fMRI and EEG, MIZUHARA Hiroaki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 岡山大学->京都大学, 0, 0, 0, 本年度は,平成18年度において構築した記憶関連課題を用いて,機能的磁気共鳴画像と脳波の同時計測を開始した.また測定する脳波データと機能的磁気共鳴画像の統合化解析手法の構築を行う.同時測定する脳波データには磁気共鳴画像装置の高磁場環境(1.5テスラ)に由来するアーチファクトが重畳する.そこで,測定後の脳波データから重畳するアーチファクトを除去することで連続的な脳波データを抽出する.アーチファクトを除去した脳波データをウェーブレット変換することにより,記憶関連課題を遂行中に頭皮上に出現する脳波イベントを抽出を実施した.さらに,電気活動である脳波イベントは時間的に早い活動(数百ミリ秒)であり,機能的磁気共鳴画像で測定する血流活動に由来する信号値は遅い活動(数十秒)であるため,両者を直接的に比較することは困難である.この問題を解決するために,血流反応動態関数と呼ばれる二つのガンマ関数の和で表現される時間遅れ関数を脳波イベントに畳み込み積分することにより,対応する機能的磁気共鳴画像信号の期待値を導出した.得られた期待値と実測値との回帰解析を実施することで,脳波の発生に関連して活動する空間部位の同定を行なった.なお,平成19年度においては当初予定通り,20名の同時計測を実施した.計測した機能的磁気共鳴画像や頭皮脳波の中には,上述したアーチファクトの除去手法において不完全なものや被験者の課..., Competitive research funding, url;kaken

  対象リソースIRI
• 萌芽研究, 2006, 2007, 18650065, Principal investigator, ヒト脳波の実時間処理システム構築によるθ波位相の生理機能の解明, 水原啓暁, 文部科学省, 科学研究費補助金(萌芽研究), 岡山大学->京都大学, 0, 0, 0, θ波と呼ばれる4〜8Hzの電気的神経活動はラットやヒトなどの脳内における重要な振動現象として考えられており,そのメカニズムや機能との関連はホットトピックの一つとなっている.近年,ラットやヒトの研究において海馬以外の皮質などからもθ波が観察されることが報告され始めている.また近年の報告により,海馬でのθ波活動の特定の位相に関係して,前頭葉内側面におけるスパイク活動が発生することが報告されており,θ波活動の位相情報が脳内における情報処理過程において重要な役割を果たしていることが考えられる.ヒトにおける従来のθ波に関する研究では,頭皮脳波の測定により前頭正中線上から発生するθ波が注意や記憶などの認知課題時に多く発生することが報告されているとともに,てんかん患者の皮質に直接埋め込んだ電極(皮質脳波)により,空間性認知課題において前頭のみならず頭頂・側頭の複数の皮質からθ波が観察されることが指摘されている.しかしながら,ヒト頭皮上における脳波活動と機能的活動の因果関係に関して疑問視する研究者は多く,頭皮上で観察される脳波活動が情報処理を実施するために必要不可欠な神経活動か否かの結論には未だに至っていない.そこで本研究では,ヒトの頭皮上で観察される脳波のひとつであるθ波活動が,情報処理機能に不可欠な神経活動であることを示すことを目的として,新たな非侵襲脳機能計測システムを構築した.構築し..., Competitive research funding, url;kaken

  対象リソースIRI
• 2006, 2006, Principal investigator, ブレイン・コンピュータインタフェースによる内骨格型パワーアシストグローブの多自由度・実時間制御, 水原啓暁, 財団法人三菱財団, 自然科学研究助成, 0, 0, 0, Competitive research funding

Ⅲ．社会連携活動実績

１．公的団体の委員等（審議会、国家試験委員、他大学評価委員，科研費審査委員等）

• Frontiers in Computational Neuroscience, Topic Editor, Mar. 2023, 9999, Society
• Neuroscience Research, Associate Editor, Mar. 2023, 9999, Society
• Frontiers in Human Neuroscience, Review Editor, Feb. 2023, 9999, Society
• Jan. 2023, 9999, Society
• Mar. 2022, Jun. 2022, Society
• Jul. 2020, Jun. 2022, Government
• May 2008, Mar. 2019, Society
• Dec. 2016, Nov. 2018, Society
• May 2015, Oct. 2016, Society
• May 2014, May 2016, Society
• Jul. 2010, Mar. 2014, Society
• Apr. 2008, Mar. 2014, Society
• Dec. 2011, Nov. 2012, Government
• Dec. 2009, Nov. 2011, Government
• Dec. 2009, Nov. 2010, Government
• Oct. 2007, Jul. 2010, Society
• Mar. 2008, Mar. 2010, Society
• Jul. 2007, Society
• Apr. 2006, Sep. 2006, Society
• Apr. 2006, Sep. 2006, Society
• May 2005, Aug. 2005, Society