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(Faculty Division of Natural Sciences Research Group of Chemistry)｜Researchers' Profile Teacher performance management system

KONDO Masato

Faculty Division of Natural Sciences Research Group of ChemistryAssociate Professor
Last Updated :2025/06/13

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Profile Information

  • Name (Japanese)

    Kondo

  • Name (Kana)

    Masato

Degree

  • Ph.D, Kyoto University, Mar. 2011

Research Interests

  • 分子拡散
  • 界面
  • 過渡回折格子法
  • 振動分光

Research Areas

  • Nanotechnology/Materials, Basic physical chemistry

Research History

  • May 2024 - Present, Nara Women's University, 自然科学系化学領域, 准教授
  • Oct. 2015 - Apr. 2024, University of Tsukuba, 数理物質系化学域, 助教
  • Apr. 2014 - Oct. 2015, Osaka University, Graduate School of Science Department of Chemistry, 特任研究員
  • Apr. 2011 - Mar. 2014, Japan Atomic Energy Agency, 量子ビーム応用研究部門, Postdoctoral fellow

Education

  • Apr. 2007 - Mar. 2011, Kyoto University, Graduate School of Science, Division of Chemistry, 博士後期課程
  • Apr. 2005 - Mar. 2007, Kyoto University, Graduate School of Science, Division of Chemistry, 修士課程
  • Apr. 2001 - Mar. 2005, Kyoto University, Faculty of Science, Faculty of Science

Professional Memberships

  • The Japan Association of Solution Chemistry
    Oct. 2024 - Present
  • The Society for Molecular Science
    Jun. 2008 - Present
  • The Chemical Society of Japan
    Jan. 2008 - Present
  • The Spectroscopical Society of Japan
    Mar. 2007 - Present
  • The Japanese Photochemistry Association
    May 2008 - Dec. 2022

■Ⅱ．研究活動実績

Published Papers

  • Refereed, Journal of Physical Organic Chemistry, Wiley, Substituted effects on bonding characteristics of cyclopentane‐1,3‐diyl diradicals monitored by time‐resolved infrared spectroscopy, Masato Kondoh; Shunsuke Kuboki; Hidetaka Kume; Eriku Oda; Manabu Abe; Taka‐aki Ishibashi, Abstract

    Cyclopentane‐1,3‐diyl diradicals (DRs) provide excellent opportunities to study the properties of diradicals because their lifetimes can be significantly lengthened to up to milliseconds with the introduction of proper substituents. This study investigated the bonding characteristics of singlet and triplet DRs having C=O and p‐cyanophenyl groups (S‐DR3 and T‐DR3) by monitoring the photo‐induced formation of the diradicals from their precursor azo compounds using time‐resolved IR (TR‐IR) spectroscopy. Upon the formation of S‐DR3, a C=O stretching wavenumber was upshifted by 22 cm−1, whereas a C≡N stretching one was downshifted by 12 cm−1. The observed shifts indicate that the unpaired electrons increase and decrease the C=O and C≡N bond orders, respectively. The effects of the unpaired electrons in S‐DR3 were similar to those observed in our previous TR‐IR studies on a singlet cyclopentane‐1,3‐diyl diradical having C=O but no C≡N groups (S‐DR2) and on that having C≡N but no C=O groups (S‐DR1), respectively. Contrastingly, upon the formation of T‐DR3, the C=O wavenumber was downshifted by 16 cm−1, indicating that the unpaired electrons decrease the C=O bond order. More notably, no detectable shifts were observed in the C≡N stretching wavenumber. These observations are not clearly explained by a model suggested in the previous studies on S‐DRs. Here, we discuss and propose a more elaborated resonance hybrid of DRs that can explain the directions and relative magnitudes of the observed wavenumber shifts irrespective of spin multiplicities. We expect that the findings and suggestions presented here will stimulate research in both organic and theoretical chemistry., 11 Oct. 2023, 37, 2, Scientific journal, 10.1002/poc.4575
    URLDOI URL
  • Refereed, Accounts of Materials & Surface Research, Photoinduced ring opening and closure reactions in chalcones monitored by time-resolved IR spectroscopy, Masato Kondoh; Taka-aki Ishibashi, Apr. 2023, 8, 1, 46, 57, Scientific journal
  • Refereed, The Journal of Physical Chemistry B, American Chemical Society (ACS), Total Internal Reflection Raman Spectra of Alamethicin Interacting with Supported Lipid Bilayers at a Silica/Water Interface, Masato Kondoh; Arisa Sano; Izuru Kawamura; Taka-aki Ishibashi, 28 Nov. 2022, 126, 50, 10712, 10720, Scientific journal, 10.1021/acs.jpcb.2c06371
    URLDOI URL
  • JOURNAL OF PHYSICAL CHEMISTRY B, Time-Resolved Infrared Spectroscopy with Multivariate Analysis on Photoinduced Proton Transfer in Aromatic Urea-Acetate Anion Complexes, Masato Kondoh; Hayato Honda; Kei Togasaki; Yoshinobu Nishimura; Tatsuo Arai; Taka-aki Ishibashi, Feb. 2022, 126, 4, 912, 921, Scientific journal, 10.1021/acs.jpcb.1c09526
    DOI URL
  • Not Refereed, JOURNAL OF PHYSICAL CHEMISTRY LETTERS, Quadrupole Contribution of C=O Vibrational Band in Sum Frequency Generation Spectra of Organic Carbonates, Wang, Lin; Mori, Wataru; Morita, Akihiro; Kondoh, Masato; Okuno, Masanari; Ishibashi, Taka-aki, Oct. 2020, 11, 20, 8527, 8531, Scientific journal, 10.1021/acs.jpclett.0c02453
    DOI URL
  • Refereed, Bulletin of the Chemical Society of Japan, Observation of translational diffusion in a planer supported lipid bilayer membrane by total internal reflection-transient grating method, Kondoh, Masato; Moritani, Hidekazu; Ishibashi, Taka-aki, May 2020, 93, 5, 671, 675, Scientific journal, 10.1246/bcsj.20200019
    DOI URL
  • Refereed, Journal of Photochemistry and Photobiology A: Chemistry, Time-resolved infrared study of photo-induced ring-closure reaction of trans-2-hydroxychalcone, Kondoh, Masato; Takizawa, Chinatsu; Okazawa, Kazuki; Akase, Dai; Aida, Misako; Ishibashi, Taka-aki, Dec. 2019, 389, 112280, Scientific journal, 10.1016/j.jphotochem.2019.112280
    DOI URL
  • The Journal of Physical Chemistry B, Photo-Induced Ring-Opening Reaction of Flav-3-en-2-ol Monitored by Time-Resolved Infrared Spectroscopy, Masato Kondoh; Akira Sakuta; Kazuki Okazawa; Dai Akase; Misako Aida; Taka-aki Ishibashi, 27 Sep. 2019, 123, 40, 8499, 8504, Scientific journal, 10.1021/acs.jpcb.9b07108
    DOI URL
  • Not Refereed, PHOTOCHEMISTRY AND PHOTOBIOLOGY, Conformational and Intermolecular Interaction Dynamics of Photolyase/Cryptochrome Proteins Monitored by the Time-Resolved Diffusion Technique, Masato Kondoh; Masahide Terazima, Jan. 2017, 93, 1, 15, 25, Scientific journal, 10.1111/php.12681
    DOI URL
  • The Journal of Physical Chemistry Letters, Importance of Atomic Contacts in Vibrational Energy Flow in Proteins, Masato Kondoh; Misao Mizuno; Yasuhisa Mizutani, 12 May 2016, 7, 11, 1950, 1954, Scientific journal, 10.1021/acs.jpclett.6b00785
    DOI URL
  • OPTICS EXPRESS, Liquid-sheet jets for terahertz spectroscopy, Masato Kondoh; Masaaki Tsubouchi, Jun. 2014, 22, 12, 14135, 14147, Scientific journal, 10.1364/OE.22.014135
    DOI URL
  • CHEMICAL PHYSICS LETTERS, Ion effects on the structure of water studied by terahertz time-domain spectroscopy, Masato Kondoh; Yasuhiro Ohshima; Masaaki Tsubouchi, Jan. 2014, 591, 317, 322, Scientific journal, 10.1016/j.cplett.2013.11.055
    DOI URL
  • 2013 38TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER, AND TERAHERTZ WAVES (IRMMW-THZ), Ion Effects on Liquid Structure of Water Monitored by Terahertz Time-Domain Spectroscopy, Masato Kondoh; Yasuhiro Ohshima; Masaaki Tsubouchi, 2013, International conference proceedings
  • JOURNAL OF MOLECULAR BIOLOGY, Light-Induced Conformational Changes in Full-Length Arabidopsis thaliana Cryptochrome, Masato Kondoh; Chiaki Shiraishi; Pavel Mueller; Margaret Ahmad; Kenichi Hitomi; Elizabeth D. Getzoff; Masahide Terazima, Oct. 2011, 413, 1, 128, 137, Scientific journal, 10.1016/j.jmb.2011.08.031
    DOI URL
  • JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Transient Dissociation of the Transducer Protein from Anabaena Sensory Rhodopsin Concomitant with Formation of the M State Produced upon Photoactivation, Masato Kondoh; Keiichi Inoue; Jun Sasaki; John L. Spudich; Masahide Terazime, Aug. 2011, 133, 34, 13406, 13412, Scientific journal, 10.1021/ja202329u
    DOI URL
  • JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Light-Induced Conformational Change and Product Release in DNA Repair by (6-4) Photolyase, Masato Kondoh; Kenichi Hitomi; Junpei Yamamoto; Takeshi Todo; Shigenori Iwai; Elizabeth D. Getzoff; Masahide Terazima, Feb. 2011, 133, 7, 2183, 2191, Scientific journal, 10.1021/ja107691w
    DOI URL
  • CHEMICAL PHYSICS LETTERS, Photochemical reaction and diffusion of caged calcium studied by the transient grating, Masato Kondoh; Naoki Baden; Masahide Terazima, Sep. 2008, 462, 1-3, 58, 63, Scientific journal, 10.1016/j.cplett.2008.07.032
    DOI URL

MISC

  • Not Refereed, Apr. 2025, 7, 14, 17, Introduction other
  • Apr. 2021, 12, 7, 11, Report research institution

Presentations

  • Masato Kondoh, 46th Symposium on Solution Chemistry of Japan (Pre-Symposium), Structure and orientation of membrane-binding dyes and peptides interacting with lipid membranes monitored by interface-sensitive vibrational spectroscopy, Invited oral presentation, 22 Oct. 2024, 22 Oct. 2024 - 22 Oct. 2024
  • Takumi Kameyama; Masato Kondoh; Taka-aki Ishibashi, The 18th Annual Meeting of Japan Society for Molecular Science, Orientation of SHG-active dye Ap3 in lipid monolayers at the air/water interface studied by HD-VSFG spectroscopy, Oral presentation, 21 Sep. 2024, 18 Sep. 2024 - 21 Sep. 2024
  • Ayaka Omuro; Masato Kondoh; Taka-aki Ishibashi, The 18th Annual Meeting of Japan Society for Molecular Science, HD-VSFG spectra of Penetratin interacting with lipid monolayers at the air/water interface, Poster presentation, 20 Sep. 2024, 18 Sep. 2024 - 21 Sep. 2024
  • Takumi Kameyama; Masato Kondoh; Atsuya Momotake; Taka-aki Ishibashi, 9th SFG symposium, Measurement of HD-VSFG spectra of SHG active dye Ap3 in lipid monolayers on water, 13 Nov. 2023
  • 14 Sep. 2023
  • 12 Sep. 2023
  • 12 Sep. 2023
  • 12 Sep. 2023
  • 鈴木, 沙弥; 近藤, 正人; 石橋, 孝章, 分子科学討論会, リン脂質二分子膜中のグラミシジンAの全内部反射ラマンスペクトル測定, 19 Sep. 2022 - 22 Sep. 2022
  • 篠田, 亮介; 近藤, 正人; 百武 篤也; 石橋, 孝章, 分子科学討論会, 4'-ジヘキシルアミノ-4-スルホアゾベンゼン水溶液上の脂質単分子膜のHD-VSFG分光, 19 Sep. 2022 - 22 Sep. 2022
  • Sep. 2022
  • Kondoh, Masato; Ishibashi, Taka-aki, The Pacifichem 2021 meeting, Time-resolved IR spectroscopy of photo-induced ring opening and closure reactions between 2-hydroxychalcone and flav-3-en-2-ol, 21 Dec. 2021, 21 Dec. 2021, True
  • 佐野, 有里紗; 近藤, 正人; 川村出; 石橋, 孝章, 日本分光学会年次講演会, 全内部反射ラマン分光による固液界面リン脂質二重膜とアラメチシンの相互作用観測の試み, 13 Oct. 2021, 13 Oct. 2021, False
  • 佐野, 有里紗; 近藤, 正人; 川村, 出; 石橋, 孝章, 分子科学討論会, 固液界面におけるリン脂質二重膜と膜透過ペプチドの全内部反射ラマンスペクトル測定, 21 Sep. 2021, 21 Sep. 2021, False
  • 近藤, 正人; 新井, 達郎; 中島, 晃希; 石橋, 孝章, 分子科学討論会, VSFG分光で観るSHG活性色素Ap3の平面支持脂質二重膜への吸脱着過程, 21 Sep. 2021, 21 Sep. 2021, False
  • 永山, 弘季; 近藤, 正人; 田島, 優衣; 石橋, 孝章, 分子科学討論会, 非光反応性タンパク質の紫外光励起過渡回折格子信号とその起源の検討, 19 Sep. 2021, 19 Sep. 2021, False
  • 中島, 晃希; 近藤, 正人; 石橋, 孝章, 日本分光学会年次講演会, HD-VSFG分光法で観るSHGプローブ色素AP3と水上脂質単分子膜の相互作用, 26 Oct. 2020, 26 Oct. 2020 - 28 Oct. 2020, 日本分光学会, False
  • 筑波, 標; 近藤, 正人; 石橋, 孝章, 日本分光学会年次講演会, HD-VSFG分光で観る脂質二重膜の構造に対するコレステロールの影響, 26 Oct. 2020, 26 Oct. 2020 - 28 Oct. 2020, 日本分光学会, False
  • 近藤, 正人; 田島, 優衣; 永山, 弘季; 石橋, 孝章, 日本分光学会年次講演会, 非光反応性タンパク質水溶液の紫外光励起過渡回折格子信号, 26 Oct. 2020, 26 Oct. 2020 - 28 Oct. 2020, 日本分光学会, False
  • 佐野, 有里紗; 近藤, 正人; 江波, 静夏; 石橋, 孝章, 日本分光学会年次講演会, HD-VSFG分光で観る脂質二重膜の構造に対するコレステロールの影響, 26 Oct. 2020, 日本分光学会, False
  • 近藤, 正人; 本多, 駿斗; 東ヶ崎, 慶; 西村, 賢宣; 新井, 達郎; 石橋, 孝章, 第13回分子科学討論会, 芳香族ウレア－酢酸イオン会合体の光誘起プロトン移動の時間分解赤外分光と多変量解析, 17 Sep. 2019, 17 Sep. 2019 - 21 Sep. 2019, False
  • 森谷, 英和; 近藤, 正人; 石橋, 孝章, 第13回分子科学討論会, 全内部反射過渡回折格子法による脂質二重膜中の分子拡散係数の測定, 17 Sep. 2019, 17 Sep. 2019 - 21 Sep. 2019, False
  • Moritani, Hidekazu; Kondoh, Masato; Ishibashi, Taka-aki, MANA International Symposium, Measurement of molecular diffusion coefficient and reaction rate constant at solid-liquid interface by total internal reflection - transient grating, 04 Mar. 2019, 04 Mar. 2019 - 06 Mar. 2019, Tsukuba, False
  • 森渉; 近藤正人; 奥野, 将成; 王琳; 石橋孝章; 森田明弘, 第12回分子科学討論会, Investigation of bulk quadrupole effect in sum frequency generation spectroscopy, 10 Sep. 2018, 10 Sep. 2018 - 13 Sep. 2018, 福岡, False
  • 近藤, 正人; 作田, 光; 岡澤, 一樹; 赤瀬, 大; 相田, 美砂子; 石橋, 孝章, The 12th Annual Meeting of Japan Society for Molecular Science, Photochromic reaction of hydroxychalcone and flavenol monitored by time-resolved infrared spectroscopy, 10 Sep. 2018, 10 Sep. 2018 - 13 Sep. 2018, 分子化学会, 日本 福岡県博多市, Photochromic reaction of hydroxychalcone and flavenol has been studied by
    time-resolved infrared (TR-IR) spectroscopy and quantum chemical calculations. Here, the
    photo-induced ring-opening reaction from flav-3-en-2-ol to trans-2-hydroxychalcone is
    discussed. A vibrational band due to a C=O stretching mode of an intermediate species, enol
    form of 2-hydroxychalcone, was detected at 1632 cm-1 in TR-IR spectra obtained after
    photoexcitation of flav-3-en-2-ol. We also found that a vibrational band at 1664 cm-1, where a
    C=O stretching mode of trans-2-hydroxychalcone appears, appeared immediately after the
    photoexcitation and increased in intensity upon depletion of the enol intermediate. The DFT
    calculation showed that the enol intermediate has no vibrational modes at around the 1664
    cm-1. These findings indicate that trans-2-hydroxychalcone is produced not only via the enol
    intermediate but also directly from flav-3-en2-ol without via the enol intermediate., False
  • 森谷, 英和; 近藤, 正人; 石橋, 孝章, 第12回分子科学討論会, 全内部反射過渡回折格子法による固液界面近傍の分子拡散係数や反応速度定数の測定, 10 Sep. 2018, 10 Sep. 2018 - 13 Sep. 2018, False
  • 近藤, 正人; 本多, 駿斗; 東ヶ崎, 慶; 西村, 賢宣; 新井, 達郎; 石橋, 孝章, 第12回分子科学討論会, 時間分解赤外分光で観る芳香族ウレア-アセテートアニオン会合体の光誘起プロトン移動, 10 Sep. 2018, 10 Sep. 2018 - 13 Sep. 2018, False
  • 森谷, 英和; 近藤, 正人; 石橋, 孝章, 平成30年度 日本分光学会年次講演会, 固液界面における分子拡散や化学反応を測定するための全内部反射過渡回折格子装置の製作, 22 May 2018, 22 May 2018 - 25 May 2018, False
  • 近藤正人; Okuno, Masanari; 井上圭一; 神取秀樹; 石橋孝章, 第11回分子科学討論会, Dynamics of conformational and orientational change in sodium pump rhodopsin at the air/water interface monitored by vibrational sum frequency generation spectroscopy, 15 Sep. 2017, 15 Sep. 2017 - 18 Sep. 2017, 仙台, False
  • 本多, 駿斗; 近藤, 正人; 東ヶ崎, 慶; 西村, 賢宣; 新井, 達郎; 石橋, 孝章, 第11回分子科学討論会, 時間分解赤外分光による1-anthracen-2-yl-3-phenylurea-酢酸イオン会合体の光誘起プロトン移動の研究, 15 Sep. 2017, 15 Sep. 2017 - 18 Sep. 2017, False
  • 山下, 聡; 近藤, 正人; 水野, 操; 水谷, 泰久, 第11回分子科学討論会, タンパク質における振動エネルギー移動経路, 15 Sep. 2017, 15 Sep. 2017 - 18 Sep. 2017, False
  • 近藤, 正人; 井上圭一; 神取秀樹; 石橋, 孝章, 平成29年度 日本分光学会年次講演会, 気水界面におけるナトリウムポンプロドプシンの振動和周波発生分光, 23 May 2017, 23 May 2017 - 25 May 2017, False
  • 本多, 駿斗; 近藤, 正人; 東ヶ崎, 慶; 西村, 賢宣; 新井, 達郎; 石橋, 孝章, 平成29年度 日本分光学会年次講演会, 時間分解赤外分光による1-anthracen-2-yl-3-phenylurea-酢酸イオン会合体の光励起プロトン移動の研究, 23 May 2017, 23 May 2017 - 25 May 2017, False
  • 10 Mar. 2016, 10 Mar. 2016 - 10 Mar. 2016
  • Masato Kondoh; Misao Mizuno; Yasuhisa Mizutani, 9th Asian Conference on Ultrafast Phenomena, Vibrational energy flow in hemeprotein monitored by time-resolved anti-Stokes ultraviolet resonance Raman spectroscopy, 22 Feb. 2016, 22 Feb. 2016 - 24 Feb. 2016

Awards

  • BCSJ Award Article, Masato Kondoh;Hidekazu Moritani;Taka-aki Ishibashi, May 2020
  • Jun. 2015
  • Oct. 2012
  • Nov. 2010
  • Sep. 2010
  • Oct. 2009
  • Best presentation award, 10th KAIST-KYOTO Chemistry Symposium (First KAIST-KYOTO-TSING HUA Chemistry Symposium), Dec. 2008
  • Oct. 2007

Research Projects

  • 基盤研究(C), 01 Apr. 2023 - 31 Mar. 2026, 23K04661, 全内部反射ラマン分光で観るゲル－液晶相転移に伴う脂質膜中の抗菌ペプチドの構造変化, 近藤 正人, 日本学術振興会, 科学研究費助成事業 基盤研究(C), 筑波大学, 4680000, 3600000, 1080000, kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (C), 01 Apr. 2022 - 31 Mar. 2025, 22K05016, Vibrational spectroscopic study of supported lipid bilayers with peptides, 石橋 孝章; 近藤 正人; 野嶋 優妃, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), University of Tsukuba, 4290000, 3300000, 990000, kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (C), 01 Apr. 2020 - 31 Mar. 2023, 20K05415, Method to measure vibrational spectra of proteins in aqueous solution for detection of intermolecular interactions using solid/liquid interface, 近藤正人, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), University of Tsukuba, 4290000, 3300000, 990000, 本研究では，固体と液体の界面を利用して，水溶液中のタンパク質の振動スペクトルを水和水のものまで含めて高感度に得る新しい方法論を確立することを目的としている．その基本的なアイデアは，界面敏感な振動分光法である振動和周波発生（VSFG）分光法を，固液界面に向きを制御した上で固定したタンパク質の系に適用することである．この用途に用いるための基板として，シリカ薄膜をコートしたCaF2基板に着目した．この基板では，シリカに試料分子をシランカップリング反応により化学的に固定できる．固液界面のVSFG測定は，水の強い赤外吸収を避けるため，赤外光を基板側から入射する内部反射配置で行う必要がある．シリカは2000 cm-1以下の赤外領域で不透明であるが，薄膜としたうえで赤外領域で透明なCaF2にコートすることで，この配置での測定も可能となる．初年度は，このシリカコートCaF2基板上での有機単分子膜について，内部反射配置でヘテロダイン検出（HD）-VSFG測定を行うための取り組みを行った．
    まず，ゾルゲル法によってCaF2（Φ20×t5）上にシリカ薄膜（厚み~100 nm）をコートした．この基板上の有機単分子膜を内部反射配置でHD-VSFG測定するには，試料と同じ面に，参照試料を準備する必要がある．そこでシリカコート面の一部に，スパッタ法で銀薄膜を蒸着した．試料の絶対配向の情報を含んだ量である絶対的な非線形感受率を得るには，その基準となる銀の絶対的な感受率が必要である．そこで，リン脂質DPPCの脂質膜を用いて銀の絶対的な感受率を決定した．DPPCのアルキル鎖が上を向けた脂質膜の絶対的な感受率と，下を向けた膜のものでは，その符号が反転する．このことを利用して，それぞれの膜を，外部および内部反射配置でHD-VSFG測定した結果から，シリカコートCaF2に蒸着した銀薄膜の感受率の値を決定した．, Competitive research funding, kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (C), 01 Apr. 2019 - 31 Mar. 2022, 19K05362, Study on structures and orientations of proteins in lipid bilayers by heterodyne-detected vibrational SFG spectroscopy, Ishibashi Taka-aki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), University of Tsukuba, 4290000, 3300000, 990000, Heterodyne-detected vibrational sum frequency generation (HD-VSFG) spectroscopy and total internal reflection Raman (TR-Raman) spectroscopy were used to study the interaction of substrate-supported lipid bilayers (SLBs) with peptides and small molecules. Cholesterol, the cell membrane staining dye AP3, gramicidin, and alamethicin were examined as molecules that interact with the membrane. In particular, the interaction between SBLs and peptides was captured for the first time by Raman spectroscopy using TR-Raman spectroscopy, as a result of the improvement of the measurement system., kaken
    対象リソースIRI
  • Grant-in-Aid for Early-Career Scientists, 01 Apr. 2018 - 31 Mar. 2020, 18K14175, Principal investigator, Development of total internal reflection transient grating system to monitor ion pump dynamics of rhodopsin in a lipid bilayer, Kondoh Masato, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, University of Tsukuba, 4160000, 3200000, 960000, A method based on the transient grating (TG) technique with total internal reflection geometry for probe light (TIR-TG) has been developed to detect conformational and ion transportation dynamics of rhodopsin proteins in a lipid bilayer membrane. In this study, we constructed a TIR-TG apparatus and applied it to diffusion coefficient measurements of stilbene in a dimyristoylphosphatidylcholine (DMPC) lipid bilayer membrane at a silica/water interface. As a result, we found that the stilbene molecules in the DMPC bilayer membrane show two different diffusion coefficients. This result indicates that the DMPC membrane is an inhomogeneous environment that can be described with two different effective viscosities., Competitive research funding, url
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  • Grant-in-Aid for Young Scientists (B), 01 Apr. 2012 - 31 Mar. 2014, 24750027, Interaction dynamics of solvated electron with water investigated by terahertz time-resolved dielectric spectroscopy, KONDOH Masato, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), 独立行政法人日本原子力研究開発機構, 4030000, 3100000, 930000, Experimental and technical developments for the time-resolved terahertz (THz) spectroscopy on aqueous solutions have been made in this study. First, we performed the steady-state THz spectroscopy on aqueous ionic solutions. As a result, we successfully obtained an experimental evidence for the existence of the ion effects that weaken hydrogen bonding structure in solution, demonstrating the effectiveness of THz spectroscopy for studies on a solution sample. Second, a window-less method using a liquid sheet was developed. This method salves the problem of damaging windows due to a strong pump laser pulse in the conventional method using a solution sample cell. Here, a nozzle which can produce a liquid sheet with controllable thickness from 50 to 120 micrometer has been developed and optimized to THz spectroscopy., url
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