FUJIWARA Motoko
| Faculty Division of Human Life and Environmental Sciences Research Group of Sport and Health Sciences | Professor |
Last Updated :2025/05/10
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Profile Information
Name (Japanese)
FujiwaraName (Kana)
Motoko
Research History
- Apr. 2014 - Present, 奈良女子大学生活環境学部・教授
- Apr. 2022 - Mar. 2024, 奈良女子大学副学長（企画担当）
- Apr. 2000 - Mar. 2022, 奈良女子大学理事（研究・財務担当）・副学長
- Apr. 2017 - Mar. 2020, 奈良女子大学 理事（研究・情報担当）・副学長
- Dec. 2015 - Mar. 2017, 奈良女子大学 学長補佐（地域創生担当）
- Apr. 2006 - Mar. 2014, 奈良女子大学教授文学部
- Apr. 2009 - Mar. 2011, 奈良女子大学附属幼稚園長
- 2003 - 2006, 奈良女子大学大学院助教授人間文化研究科
- 1998 - 2003, 奈良女子大学助教授文学部
- 1995 - 1998, 奈良女子大学講師文学部
- 1989 - 1995, 大阪大学助手医学部
Education
- 1989, Osaka University, 医学研究科, 生理系, Japan
- 1989, Osaka University, Graduate School, Division of Medicine
- 1985, Nara Women's University, 文学研究科, 体育学, Japan
- 1985, Nara Women's University, Graduate School, Division of Letters
- 1983, Nara Women's University, Faculty of Letters, 教育学科, Japan
- 1983, Nara Women's University, Faculty of Literature
Academic Activities
■Ⅱ．研究活動実績
Published Papers
- Refereed, Acta Psychologica, Elsevier BV, Comparison of force and timing control in periodic isometric leg extension, Hasebe H; Ohtaka C; Fujiwara M, Jun. 2024, 246, 1, 11, Scientific journal, 10.1016/j.actpsy.2024.104258
- Refereed, Journal of Motor Learning and Development, Ability of adjusting grip strength from childhood to adulthood, Ohtaka C; Fujiwara M, Dec. 2023, 12, 142, 154, Scientific journal, Ability of adjusting grip strength from childhood to adulthood（J Motor Learninng and Development 2024）.pdf, False, 10.1123/jmld.2022-0036
- Refereed, Journal of Physical Fitness and Sports Medicine, Effects of subjective effort on overground and treadmill running: A comparative analysis, Hasebe F, Miura M, Ono K, Goto Y, Nakata H, Ohtaka C, Fujiwara M, Aug. 2023, 12, 2, 45, 57, Scientific journal, Effects of subjective effort on overground and treadmill running（2023） (2).pdf, False
- Refereed, 2023, 95, 42, 51, 運動出力のグレーディング能力における発達過程（2023）発育発達研究.pdf, False, 10.5332/hatsuhatsu.2023.95_42
- Refereed, Isokinetics and Exercise Science, Effect of force adjustment modalities on characteristics for force generation and relaxation, Ohtaka C; Fujiwara M, 2023, Scientific journal
- Refereed, Journal of Physical Fitness and Sports Medicine, Motor control characteristics for simultaneous bilateral asymmetrical tasks performed by upper limbs, Ono K, Hasebe F, Miura M, Ohtaka C, Fujiwara M, May 2022, 11, 2, 97, 106, Motor control characteristics for simultaneous bilateral asymmetrical tasks performed by upper limbs（2022）.pdf, Published, False
- Refereed, Mar. 2022, 93, 32, 44, Scientific journal, 学童期における運動出力のグレーディング能力の発達特性（2022）.pdf, False
- Refereed, Characteristics of motor function in terms of the relationship between coordination ability and degree of locomotion: For the participants of Mukogawa Womenʼs University Open College, 2022, Research institution, 調整力とロコモ度の関係性からみた運動機能の特徴（武庫川女子大学女性活躍総合研究所紀要 2022）.pdf, False
- Refereed, Journal of Motor Learning and Development, The developmental progression and sex differences in agility during continuous two-footed jumping among children aged 4 to 16 years, Muro A; Takatoku N; Ohtaka C; Fujiwara M; Nakata H, 2022, Scientific journal
- Not Refereed, 2022, 24, 12, 23
- Refereed, Journal of Human Sport and Exercise, Force control characteristics for generation and relazation compared between the upper and lower limbs, Ohtaka C, Fujiwara M, 2022, 17, 1, 181, 196, Scientific journal, Force control characteristics for generation and relazation compared between the upper and lower limbs（ J Human Sport and Exer 2020）.pdf, False
- Refereed, May 2021, 23, 1, 1, 10, Research institution
- Journal of Motor Learning and Development, Kinematic characteristics of standing long jump in young children aged 4 to 5 years old, Ogawa M, Ohtaka C, Fujiwara M, Nakata H, 2021, 9, 80, 94
- Refereed, 2021, 57, 34, 41, Scientific journal, 始めに保持する力の有無が出力のグレーディング特性に及ぼす影響（2021）.pdf, False
- Refereed, Journal of Human Sport and Exercise, The relationship between free-throw accuracy and performance variables in male wheelchair basketball players, Shigematsu S; Ogawa M; Neya M; Fujiwara M; Nakata H, 2020, Scientific journal, The relationship between free-throw accuracy and performance variables in male wheelchair basketball players（2021）Journal of Human Sport and Exercise.pdf, False, 10.14198/jhse.2022.174.18
- Refereed, 2020, 22, 1, 11, Research institution
- Refereed, Research Journal of Sport Science in Nara Women's University, Relationship between the subjective and objective parameters for accurate force generation and relaxation, Ohtaka C; Fujiwara M, 2020, 22, 1, 11, Research institution, Relationship between the subjective and objective_ parameters for accurate force generation and relaxation（スポーツ科学研究 2020）.pdf, False
- Refereed,
The relationship between continuous bilateral hop and basic exercise ability among young children, Continuous bilateral hop has been used to evaluate a person's agility by focusing on the movement time. In the present study, we examined the movement time as well as hopping pattern score on continuous bilateral hop, and investigated the relationship between continuous bilateral hop and basic motor ability (25-m sprint, tennis ball throwing and standing long jumping) among 131 young children aged 4 to 5 years. The movement time was significantly shorter in 5- than in 4-year-old children, but the hopping pattern score did not change with increasing age. The score was significantly higher in girls than in boys, while the movement time was significantly shorter in boys than in girls. Moreover, a significant correlation was observed between the movement time and basic motor ability (25-m sprint and standing long jumping), the score and basic motor ability (25-m sprint, tennis ball throwing and standing long jumping). These data suggest that continuous bilateral hop can be used as indexes for agility as well motor coordination in young children., 2020, 22, 1, 12, 21, Research institution - Refereed, J Phys Fitness Sports Med, Effect of switching force control direction on consecutive compared to discrete adjustment., Ohtaka C, Fujiwara M, 20 Jun. 2019, 8, 4, 127, 136, Scientific journal, Effect of switchint force control direction on consecutive compared to discrete adjustment（2019 JPFSM）.pdf, False
- Refereed, Journal of Physical Fitness and Sports Medicine, The relationship between basketball free-throw accuracy and other performance variables among collegiate female players., Ogawa M; Hoshino S; Fujiwara M; Nakata H, May 2019, 8, 127, 136, 掲載論文.pdf, False
- Refereed, 2019, 幼児の握力発揮における出力調節（体育学研究）.pdf, False
- Refereed,
Usefulness of the "Shimoichi Raku-Raku Exercise" DVD : The PPK Group Report of `The Development of the "Raku-Raku Farming Method", 2019, 21, 2, 10, 16 - Not Refereed, 2018, 69, 0, 161_3, 161_3, 10.20693/jspehss.69.161_3
- Refereed, Journal of Motor Behavior, Force Control Characteristics for Generation and Relaxation in the Lower Limb, Chiaki Ohtaka; Motoko Fujiwara, 2018, 早期公開, Force Control Characteristics for Generation and Relaxation in the Lower Limb（JMB 2018）.pdf, False
- Refereed, 2018, 63, 281, 290, 幼児の目安跳び動作における距離調節方略（体育学研究 2018）.pdf, False
- Refereed, Perceptual and Motor Skills, SAGE PUBLICATIONS INC, Relative Age Effect in Physical Fitness Among Elementary and Junior High School Students, Nakata H; Akido M; Naruse K; Fujiwara M, The present study investigated characteristics of the relative age effect (RAE) among a general sample of Japanese elementary and junior high school students. Japan applies a unique annual age-grouping by birthdates between April 1 and March 31 of the following year for sport and education. Anthropometric and physical fitness data were obtained from 3,610 Japanese students, including height, weight, the 50-m sprint, standing long jump, grip strength, bent-leg sit-ups, sit and reach, side steps, 20-m shuttle run, and ball throw. We examined RAE-related differences in these data using a one-way analysis of variance by comparing students with birthdates in the first (April-September) versus second (October-March of the following year) semesters. We observed a significant RAE for boys aged 7 to 15 years on both anthropometric and fitness data, but a significant RAE for girls was only evident for physical fitness tests among elementary school and not junior high school students. Thus, a significant RAE in anthropometry and physical fitness was evident in a general sample of school children, and there were RAE gender differences among adolescents., Oct. 2017, 124, 5, 900, 911, Scientific journal, 10.1177/0031512517722284
- Refereed, Perceptual and Motor Skills, SAGE PUBLICATIONS INC, Control Strategies for Accurate Force Generation and Relaxation, Ohtaka C; Fujiwara M, Characteristics and motor strategies for force generation and force relaxation were examined using graded tasks during isometric force control. Ten female college students (M age=20.2 yr., SD=1.1) were instructed to accurately control the force of isometric elbow flexion using their right arm to match a target force level as quickly as possible. They performed: (1) a generation task, wherein they increased their force from 0% maximum voluntary force to 20% maximum voluntary force (0%-20%), 40% maximum voluntary force (0%-40%), or 60% maximum voluntary force (0%-60%) and (2) and a relaxation task, in which they decreased their force from 60% maximum voluntary force to 40% maximum voluntary force (60%-40%), 20% maximum voluntary force (60%-20%), or to 0% maximum voluntary force (60%-0%). Produced force parameters of point of accuracy (force level, error), quickness (reaction time, adjustment time, rate of force development), and strategy (force wave, rate of force development) were analyzed. Errors of force relaxation were all greater, and reaction times shorter, than those of force generation. Adjustment time depended on the magnitude of force and peak rates of force development and force relaxation differed. Controlled relaxation of force is more difficult with low magnitude of force control., Oct. 2016, 123, 2, 489, 507, Scientific journal, Control Strategies for Accurate Force Generation and Relaxation（PMS 2016）.pdf, False, 10.1177/0031512516664778
- Refereed, Taiikugaku kenkyu (Japan Journal of Physical Education, Health and Sport Sciences), Japan Society of Physical Education, Health and Sport Sciences, Effect of switching the control direction on force control using isometric leg extension, Otaka Chiaki; Fujiwara Motoko, In this study, we investigated the effects of differing control processes on the duration of zero-velocity in force control and force level control accuracy and quickness using isometric leg contraction tasks. Eleven participants were instructed to adjust the target force from 20% maximal voluntary contraction (MVC: 20% task) or from 60%MVC (60% task) to 20%, 40%, or 60%MVC after relaxing completely. The participants were instructed to control their force as quickly and as accurately as possible on receiving a visual stimulus, and the force produced by the participants was recorded. We investigated the differences in the task (20% or 60%MVC) and target (20%, 40%, or 60%MVC) force levels. We found that the target force level in the 20% task was higher than during the other target force levels for both tasks. The duration of zero-velocity was longer during the 60% task than in the 20% task for all target force levels. Before and after the period of zero-velocity, relaxation and re-adjustment time were longer during the 60% task than during the 20% task for all target force levels. Furthermore, the re-adjustment time was longer in the 60% task than in the 20% task for all target force levels; re-adjustment time was also found increase successively for the 20%, 40% and 60% MVC target force levels. Therefore, our findings suggest that during control the slight magnitude, accurate control of the force was difficult, irrespective of the magnitude of the force before relaxing completely. Moreover, the duration of zero-velocity became longer with greater magnitudes of force before relaxing completely, which affected the quickness at which force control was achieved after switching the control direction.
, 07 Jun. 2016, 61, 2, 489, 501, 等尺性脚伸展動作における脱力を介した出力の切り換え（体育学研究 2016）.pdf, False, 10.5432/jjpehss.15102 - Refereed, 2016, 7, 71, 9, 17, 幼児の目安跳び動作における認知とパフォーマンスの関係（発育発達研究 2016）.pdf, False
- 2015, 66, 247, 247, 10.20693/jspehss.66.247_1
- 2015, 66, 218, 218, 10.20693/jspehss.66.218_2
- 2015, 66, 216, 216, 10.20693/jspehss.66.216_1
- 2015, 66, 201, 201, 10.20693/jspehss.66.201_1
- 2015, 66, 201, 201, 10.20693/jspehss.66.201_2
- Refereed, Football Science, The relarionship between positive thinking and individual characteristics: Development of the Soccer positive thinking scale., Kaori Tsutsui; Motoko Fujiwara, 2015, 12, 74, 83, The relationship between positive thinking and individeal characteristics（Football Science 2015）.pdf, False
- 2014, 65, 201, 201, 10.20693/jspehss.65.201_1
- 2014, 65, 166, 166, 10.20693/jspehss.65.166_2
- Refereed, JJSP, Japanese Society of Sport Psychology, Diversity of the Role of Positive Thinking According to Individual Characteristics:A Triaxial Analysis of Objects of Attention, Tsutsui Kaori; Fujiwara Motoko, This research clarified the concrete contents of positive thinking and explored how positive thinking differs according to individual characteristics. Levels of trait anxiety and concerns about evaluation from others and the coaching environment, were defined as individual characteristics. The State-Trait Anxiety Inventory (STAI) for measuring trait anxiety was administered to a university male baseball team. Subsequently, one baseball player with high trait anxiety and one baseball player with low trait anxiety were interviewed. Semi-structured interviews focused on their thoughts during their baseball games and their individual characteristics. Interview data were transcribed verbatim and analyzed qualitatively. Positive thinking was classified according to eight patterns associated with the objects of attention, on 3 axes (emotional expression, body consciousness, and external concern), and the relationship between individual characteristics and positive thinking was considered. Greater trait anxiety and concern about evaluation from others seemed to indicate that self-control thinking contributed to performance. In contrast, when trait anxiety and concern about evaluation from others was lower, self-encouragement thinking was more likely to contribute to performance., 2014, 41, 2, 115, 130, 個人特性によるポジティブシンキングの役割の多様性（スポーツ心理学研究 2014）.pdf, False, 10.4146/jjspopsy.2014-1404
- Not Refereed, Journal of Motor Behavior, ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, Control of Arm Movements for Quick Change of Movement Direction, Nozomi Takatoku; Motoko Fujiwara, The authors investigated the control strategy for changing movement direction during arm movements by analyzing the changes in a triphasic electromyographic pattern. Subjects performed a 40 degrees flexion (basic) and a 40 degrees flexion-extension to return to the start position (return) under two conditions: performing a predetermined task (SF) and performing each task in response to a signal (ST). The results revealed the agonist burst for the return task under the ST condition resembled that of the basic task under the SF condition, and the antagonist burst increased after presenting the modification signal. In conclusion, the strategy for quick change of movement direction was to increase the antagonist burst by an additional command from the central nervous system without cancelling the planned movement., Jan. 2014, 46, 1, 25, 32, Scientific journal, 10.1080/00222895.2013.840554
- Refereed, Perceptual and Motor Skills, Postural control during pushing movement with risk of forward perturbation, Rika Okai; Motoko Fujiwara, The purpose of this study was to investigate the effect of a forward bilateral pushing movement on postural control in a situation where known, unknown, and unpredictable perturbations may be induced. Participants stood upright and voluntarily pushed a handle with both hands. In the first task, the handle was free to be moved by the participant (perturbation
movable task) and in the second task, the handle was locked (stationary task). For each task, body displacement and observed applied force were recorded. Anticipatory postural control adjustment plays a vital role in body stability
however, in contrast to its role in maintaining stability, adjustment can generate a restricted voluntary movement because motor programming selects a postural control that gives priority to body stability over the target movement. © Perceptual &
Motor Skills 2013., Jun. 2013, 116, 3, 969, 979, Scientific journal, 10.2466/26.22.PMS.116.3.969-979 - 2013, 64, 218, 219, 10.20693/jspehss.64.218_3
- Refereed, Muscle activities during pushing movement with risk of forward disturbance, 2012, 16, 3, 118, 127
- 2011, 62, 153, 153, 10.20693/jspehss.62.153_3
- 2011, 62, 153, 153, 10.20693/jspehss.62.153_1
- 2011, 62, 152, 152, 10.20693/jspehss.62.152_2
- Refereed, JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY, ELSEVIER SCI LTD, Muscle activity patterns during quick increase of movement amplitude in rapid elbow extensions, Nozomi Takatoku; Motoko Fujiwara, In this study, we investigated a motor strategy for increasing the amplitude of movement in rapid extensions at the elbow joint. This study focused on the changes in a triphasic electromyographic (EMG) pattern, i.e., the first agonist burst (AG1), the second agonist burst (AG2) and the antagonist burst (ANT), for increasing the amplitude of movement required after the initiation of movement. Subjects performed 40 degrees (Basic task) and 80 degrees of extension (Wide task). These tasks were performed under two conditions; performing a predetermined task (SF condition) and performing a task in response to a visual stimulus immediately after movement commencement (ST condition). Kinematic parameters and EMG activity from the agonist (triceps brachii) and the antagonist (biceps brachii) muscles were recorded. As a result, the onset latency of AG1 and AG2 and the duration of AG1 were longer under the ST condition than the SF condition. No difference was observed between the SF and ST condition with respect to ANT activity. It is concluded that the motor strategy for increasing the amplitude of movement after the initiation of movement was to control the movement velocity and the timing to stop movement by the coactivation duration of AG1 and ANT and to stop the desired position accurately by AG2 activity. (C) 2009 Elsevier Ltd. All rights reserved., Apr. 2010, 20, 2, 290, 297, Scientific journal, 10.1016/j.jelekin.2009.03.007
- 2010, 61, 154, 154, 10.20693/jspehss.61.154_3
- 2010, 61, 155, 155, 10.20693/jspehss.61.155_2
- 2010, 61, 157, 157, 10.20693/jspehss.61.157_2
- 2010, 61, 160, 160, 10.20693/jspehss.61.160_2
- 2009, 60, 152, 152, 10.20693/jspehss.60.152_2
- 2009, 14, 1, 57, 57, 10.18977/jspog.14.1_57_2
- 2009, 49, 6, 659, 659, 10.15064/jjpm.49.6_659_2
- Refereed, Taiikugaku kenkyu (Japan Journal of Physical Education, Health and Sport Sciences), Japan Society of Physical Education, Health and Sport Sciences, Muscle activity patterns during quick change in elbow extensions, Takatoku Nozomi; Fujiwara Motoko, In this study, we investigated a motor strategy for changing the amplitude or direction of movement during rapid extensions of the elbow joint. We focused on changes in the triphasic electromyographic (EMG) pattern, i.e. the first agonist burst (AG1), the second agonist burst (AG2) and the antagonist burst (ANT), in relation to changes in the amplitude and direction of movement required after the initiation of movement. Ten seated subjects extended the elbow 40 degrees in the Basic task and 80 degrees in the Wide task, and then returned to the starting position after reaching for a target in the Basic task (Return task). The tasks were performed under two conditions: while performing a predetermined task (SF condition), and while performing a task in response to a visual stimulus after movement commencement (ST-BW condition—the subject performed either the Basic task or the Wide task; ST-BR condition—the subject performed either the Basic task or the Return task). Kinematic and temporal parameters, and EMG activity from the agonist (triceps brachii) and the antagonist (biceps brachii) muscles were recorded. Comparing the Wide task with the Basic task, the onset latency of AG2 increased, and the duration in all bursts increased. In the ST-BW condition, the onset latency of AG1 and AG2 and the duration of AG1 increased compared with the SF condition. Comparing the Return task with the Basic task, the onset latency of ANT and AG2 increased. The duration of all bursts and the average EMG (a-EMG) of ANT in the Return task increased compared with the Basic task. There was no difference between the SF and ST-BR conditions. It is concluded that the motor strategy for changing the amplitude of initiated movement is to control the duration of AG1 depending on the amplitude of movement in order to change the timing to stop movement, and that the motor strategy for changing the direction of initiated movement is to increase the duration and amplitude of ANT in order to stop at the target and flex continuously., 2009, 54, 2, 293, 306, 10.5432/jjpehss.a540201
- 2007, 58, 228, 228, 10.20693/jspehss.58.228_2
- 2007, 58, 220, 220, 10.20693/jspehss.58.220_3
- 2005, 56, 264, 264, 10.20693/jspehss.56.264_3
- Refereed, Proceedings of the 7th World Congress of Perinatal Medicine, MEDIMOND PUBLISHING CO, Does general medical knowledge affect prevalence and severity of premenstrual syndrome in young Japanese women?, A Suetake; T Hosono; Y Sugita; M Yanase-Fujiwara; M Takada, It is generally known that the spread of medical knowledge promotes actions to improve health but this has not been well investigated for premenstrual syndrome (PMS). We investigated whether accumulation of general medical knowledge would affect the prevalence of PMS and the severity of physical and mental symptoms of PMS. We carried out questionnaire investigation about PMS with 402 female students. We divided the respondents into two groups; a group with medical knowledge (n=117) and a group without medical knowledge (n=285). Women with medical knowledge had a high prevalence ratio of PMS and severity of PMS symptoms, sought medical advice to relive severe PMS symptoms. Medical knowledge promotes not only the prevalence ratio of PMS and its severity but also the motivation for medical treatment of PMS., 2005, 407, 411, International conference proceedings
- Refereed, Sports Sciences, Muscle activity patterns in the Hikiwake movement of Kyudo, Aki Konishi; Motoko Fujiwara, 2005, 2, 51, 62
- Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, Effects of estrogen on thermoregulatory tail vasomotion and heat-escape behavior in freely moving female rats, T Hosono; XM Chen; A Miyatsuji; T Yoda; K Yoshida; M Yanase-Fujiwara; K Kanosue, Effects of estrogen on thermoregulatory vasomotion and heat-escape behavior were investigated in ovariectomized female rats supplemented with estrogen (replaced estrogen rats) or control saline (low estrogen rats). First, we measured tail temperature of freely moving rats at ambient temperatures (T-a) between 13 and 31 degreesC. Tail temperature of the low estrogen rats was higher than that of the replaced estrogen rats at T-a between 19 and 25 degreesC, indicating that the low estrogen rats exhibit more skin vasodilation than the replaced estrogen rats. There was no significant difference in oxygen consumption and core temperature between the two groups. Second, we analyzed heat-escape behaviors in a hot chamber where rats could obtain cold air by moving in and out of a reward area. The low estrogen rats kept Ta at a lower level than did the replaced estrogen rats. These results imply that the lack of estrogen facilitates heat dissipation both by skin vasodilation and by heat-escape behavior. Ovariectomized rats may mimic climacteric hot flushes not only for autonomic skin vasomotor activity but also for thermoregulatory behavior., May 2001, 280, 5, R1341, R1347, Scientific journal
- Refereed, Japanese Journal of Physiology, PHYSIOLOGICAL SOCIETY OF JAPAN, Hypothalamic region facilitating shivering in rats "jointly worked", Tanaka, M; Tonouchi, M; Hosono, T; Nagashima, K; Yanase-Fujiwara, M; Kanosue, K, Although the posterior part of the hypothalamus has long been considered important for thermoregulatory shivering, it is unknown whether the neurons there or the passing fibers are implicated in the response. Exposure of urethane-anesthetized rats to cold (15-21°C) elicits shivering. An injection of muscimol (0.5 mM), a GABAA receptor agonist, into the medial part of the hypothalamus, including the dorsomedial and posterior nuclei, suppressed the cold-induced shivering. This result suggests that neurons having an excitatory effect on shivering are in this region of the hypothalamus.
, 2001, 51, 5, 625, 629, 10.2170/jjphysiol.51.625 - Refereed, JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, Effect of midbrain stimulations on thermoregulatory vasomotor responses in rats, YH Zhang; T Hosono; M YanaseFujiwara; XM Chen; K Kanosue, 1. Efferent projections eliciting vasodilatation when the preoptic area is warmed were investigated by monitoring tail vasomotor responses of ketamine-anaesthetized rats when brain areas mere stimulated electrically (0.2 mA, 200 mu s, 30 Hz) or with the excitatory amino acid D,L-homocysteic acid (1 mM, 0.3 mu l).
2. Both stimulations elicited vasodilatation when applied within a region extending from the most caudal part of the lateral hypothalamus to the ventrolateral periaqueductal grey mat ter (PAG) and the reticular formation ventrolateral to the PAG.
3. Vasodilatation elicited by preoptic warming was suppressed when either stimulation was applied within the rostral part of the ventral tegmental area (VTA).
4. Sustained vasodilatation was elicited by knife cuts caudal to the VTA, and vasodilatation elicited by preoptic warming was suppressed by cuts either rostral to the VTA or in the region including the FAG and the reticular formation ventrolateral to it.
5. These results, together with the results of earlier physiological and histological studies, suggest that warm-sensitive neurones in the preoptic area send excitatory signals to vasodilatative neurones in the caudal part of the lateral hypothalamus, ventrolateral PAG and reticular formation, and send inhibitory signals to vasoconstrictive neurones in the rostral part of the VTA., Aug. 1997, 503, 1, 177, 186, Scientific journal, 10.1111/j.1469-7793.1997.177bi.x - JES Ergonomics, Japan Ergonomics Society, Study on Timing Control of Moving Target Catching Task by Forward Step, FUJIWARA Motoko, 16 May 1997, 38, 318, 319, 10.5100/jje.33.Supplement_318
- Refereed, BRAIN RESEARCH, ELSEVIER SCIENCE BV, Effect of gonadotropin releasing hormone on thermoregulatory vasomotor activity in ovariectomized female rats, T Hosono; M YanaseFujiwara; YH Zhang; XM Chen; Y Fukuda; Y Asaki; K Yamaji; K Kanosue, To investigate the effect of gonadotropin releasing hormone (GnRH) on thermoregulatory skin vasomotion, we injected GnRH into various brain regions in both anesthetized and unanesthetized ovariectomized female rats. Local warming of preoptic area (PO) elicited skin vasodilation in anesthetized rats, Injection of 2 mu g GnRH into the septal area lowered the threshold hypothalamic temperature for skin vasodilation at least for 2 h. Similar injections of 2 mu g GnRH into the lateral ventricle (LV) and PO were ineffective. Although this vasodilative effect was also obtained after the injection of 20 ng GnRH into the septal area, injections of 2 ng GnRH were without effect. Not only injections of 20 ng Antide, a potent GnRH antagonist, but also injections of the mixed solution of 20 ng GnRH and 20 ng Antide were also without effect. In unanesthetized and unrestrained rats at an ambient temperature of 17 degrees C, injections of 20 ng GnRH into the septal area elicited tail vasodilation lasting for 30 minutes, whereas vehicle injections were ineffective. Injections of 20 ng GnRH into LV and PO were also ineffective. These results indicate that GnRH can elicit thermoregulatory skin vasomotion by acting on GnRH receptors in the septal area, This thermoregulatory vasodilative effect of GnRH might be possibly related to the etiology of climacteric hot flush., Apr. 1997, 754, 1-2, 88, 94, Scientific journal, 10.1016/S0006-8993(97)00060-7
- Refereed, JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, WARM AND COLD SIGNALS FROM THE PREOPTIC AREA - WHICH CONTRIBUTE MORE TO THE CONTROL OF SHIVERING IN RATS, YH ZHANG; M YANASEFUJIWARA; T HOSONO; K KANOSUE, 1. To find out whether the thermosensitive neurones in the preoptic area that control shivering are predominantly warm or cold sensitive, we tested the effects of injecting the excitatory amino acid L-glutamate at various sites in and adjacent to the preoptic area of anaesthetized rats shivering at ambient temperatures of 15-21 degrees C.
2. L-Glutamate injections (0.2 mM in 0.5-1.0 mu l), as well as preoptic warming and electrical stimulation, suppressed shivering, whereas central saline injections had no effect. Effective sites were restricted to the anterior part of the preoptic area, and a tenfold lower concentration of L-glutamate did not influence shivering.
3. Injections of procaine (0.2 M) into the sites where L-glutamate suppressed shivering did not affect strong shivering activity, but facilitated shivering in three out of seven cases when shivering was weak or absent at higher ambient temperatures (25-30 degrees C).
4. L-Glutamate injections, as well as preoptic warming and electrical stimulation, also elicited vasodilatation of the paw skin and the tail. Procaine elicited vasoconstriction when it was applied during vasodilatation induced by local preoptic warming.
5. These results indicate that the contribution of the preoptic area to the control of shivering and vasomotion is influenced more by signals from warm-sensitive neurones than by signals from cold-sensitive neurones., May 1995, 485, 1, 195, 202, Scientific journal - Refereed, AMERICAN JOURNAL OF PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, HYPOTHALAMIC NETWORK FOR THERMOREGULATORY SHIVERING, K KANOSUE; YH ZHANG; M YANASEFUJIWARA; T HOSONO, Warming one side of a rat's preoptic area and anterior hypothalamus (POAH) suppresses shivering on both sides of the body, and the present study evaluated the extent to which signals mediating this suppression cross the midline within and below the POAH. Hind paw shivering during unilateral POAH thermal stimulation was measured for rats in which the POAH had been midsagittally transected and for rats in which one side of the hypothalamus had been coronally transected just caudal to the POAH. In midsagittally transected rats, unilateral warming on either side of the POAH suppressed shivering equally on both sides of the body. In unilaterally transected rats, POAH warming on the transected side did not affect shivering, but warming the intact side suppressed shivering equally on both sides of the body. When a unilateral transection of only the lateral part of the hypothalamus included the medial forebrain bundle, the effect was the same as that of a unilateral transection of the whole hypothalamus. These results indicate that no information controlling shivering is exchanged between the left and right POAH and that efferent signals from the POAH, descending through the medial forebrain bundle, cross the midline somewhere below the hypothalamus to innervate both sides of the body equally., Jul. 1994, 267, 1, R275, R282, Scientific journal
- Refereed, AMERICAN JOURNAL OF PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, HYPOTHALAMIC NETWORK FOR THERMOREGULATORY VASOMOTOR CONTROL, K KANOSUE; M YANASEFUJIWARA; T HOSONO, Warming one side of a rat's preoptic area and anterior hypothalamus (POAH) causes skin vasodilation on both sides of the body, and the present study evaluated the extent to which signals mediating this vasodilation cross the midline within and below the POAH, Hind paw vasomotion during unilateral POAH thermal or electrical stimulation was measured for rats in which the POAH had been midsagittally transected and for rats in which one side of the hypothalamus had been coronally transected just below the POAH. In midsagittally transected rats, unilateral POAH thermal or electrical stimulation produced bilateral paw vasodilation, but the ipsilateral dilation occurred at a hypothalamic temperature lower than that at which contralateral dilation occurred. In the unilaterally transected rats, unilateral POAH warming produced bilateral vasodilation and, regardless of which side of the POAH was warmed, the threshold stimulus temperature was always lower for vasodilation on the intact side. Unilateral transection of a part of the hypothalamus that included the medial forebrain bundle had the same effect as did unilateral transection of the whole hypothalamus. Information controlling thermoregulatory vasomotion thus crosses the midline both within and below the POAH. Although efferent signals descending through the medial forebrain bundle innervate skin blood vessels on both sides of the body, this innervation is stronger on the ipsilateral side., Jul. 1994, 267, 1, R283, R288, Scientific journal
- Refereed, American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Hypothalamic network for thermoregulatory shivering, K. Kanosue; Y. H. Zhang; M. Yanase-Fujiwara; T. Hosono, Warming one side of a rat's preoptic area and anterior hypothalamus (POAH) suppresses shivering on both sides of the body, and the present study evaluated the extent to which signals mediating this suppression cross the midline within and below the POAH. Hind paw shivering during unilateral POAH thermal stimulation was measured for rats in which the POAH had been midsagittally transected and for rats in which one side of the hypothalamus had been coronally transected just caudal to the POAH. In midsagittally transected rats, unilateral warming on either side of the POAH suppressed shivering equally on both sides of the body. In unilaterally transected rats, POAH warming on the transected side did not affect shivering, but warming the intact side suppressed shivering equally on both sides of the body. When a unilateral transection of only the lateral part of the hypothalamus included the medial forebrain bundle, the effect was the same as that of a unilateral transection of the whole hypothalamus. These results indicate that no information controlling shivering is exchanged between the left and right POAH and that efferent signals from the POAH, descending through the medial forebrain bundle, cross the midline somewhere below the hypothalamus to innervate both sides of the body equally., 1994, 267, 1, R275, R282, Scientific journal
- Refereed, American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Hypothalamic network for thermoregulatory vasomotor control, K. Kanosue; M. Yanase-Fujiwara; T. Hosono, Warming one side of a rat's preoptic area and anterior hypothalamus (POAH) causes skin vasodilation on both sides of the body, and the present study evaluated the extent to which signals mediating this vasodilation cross the midline within and below the POAH. Hind paw vasomotion during unilateral POAH thermal or electrical stimulation was measured for rats in which the POAH had been midsagittally transected and for rats in which one side of the hypothalamus had been coronally transected just below the POAH. In midsagittally transected rats, unilateral POAH thermal or electrical stimulation produced bilateral paw vasodilation, but the ipsilateral dilation occurred at a hypothalamic temperature lower than that at which contralateral dilation occurred. In the unilaterally transected rats, unilateral POAH warming produced bilateral vasodilation and, regardless of which side of the POAH was warmed, the threshold stimulus temperature was always lower for vasodilation on the intact side. Unilateral transection of a part of the hypothalamus that included the medial forebrain bundle had the same effect as did unilateral transection of the whole hypothalamus. Information controlling thermoregulatory vasomotion thus crosses the midline both within and below the POAH. Although efferent signals descending through the medial forebrain bundle innervate skin blood vessels on both sides of the body, this innervation is stronger on the ipsilateral side., 1994, 267, 1, R283, R288, Scientific journal
- Refereed, INTEGRATIVE AND CELLULAR ASPECTS OF AUTONOMIC FUNCTIONS: TEMPERATURE AND OSMOREGULATION, JOHN LIBBEY EUROTEXT LTD, HYPOTHALAMIC NETWORK FOR THERMOREGULATION - OLD BUT STILL UNANSWERED QUESTION, K KANOSUE; M YANASEFUJIWARA; T HOSONO; YH ZHANG, 1994, 253, 257, International conference proceedings
- Refereed, AMERICAN JOURNAL OF PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, MARKED REDUCTION OF ACYL-COA SYNTHETASE-ACTIVITY AND MESSENGER-RNA IN INTRAABDOMINAL VISCERAL FAT BY PHYSICAL EXERCISE, SHIMOMURA, I; K TOKUNAGA; K KOTANI; Y KENO; M YANASEFUJIWARA; K KANOSUE; S JIAO; T FUNAHASHI; T KOBATAKE; T YAMAMOTO; Y MATSUZAWA, Several reports have suggested that the reduction of intra-abdominal visceral fat after physical exercise is more prominent than that of subcutaneous fat. We compared some parameters in mesenteric and subcutaneous fats between sedentary and exercised rats (treadmill running; 10-20 m/min, 60 min/day, 7 days). Tissue weight and cell volume were decreased in mesenteric fat by the exercise. The exercise reduced activity and mRNA levels of acyl-CoA synthetase (ACS; 67 and 26% of those of the sedentary group, respectively), mRNA levels of lipoprotein lipase (LPL; 49% of those of the sedentary group), and GLUT-4 (38% of those of the sedentary group) in the mesenteric fat. In contrast, all of these parameters did not change significantly in the subcutaneous fat. Gastrocnemius muscle was heavier in exercised rats. ACS activity was elevated in the gastrocnemius muscle of the exercised rats (137% of those of sedentary group), although mRNA levels of ACS, LPL, and GLUT-4 did not change in the muscle by the exercise. These observations suggest that mesenteric fat may contribute to switching of distribution of plasma energy flux, including lipid and glucose, from fat tissue to muscle in physical exercise., Jul. 1993, 265, 1, E44, E50, Scientific journal
- Refereed, AMERICAN JOURNAL OF PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, EFFECTS OF CENTRALLY AND SYSTEMICALLY ADMINISTERED INDOMETHACIN ON BODY-TEMPERATURE IN EXERCISING RATS, H TANAKA; M YANASEFUJIWARA; K KANOSUE, Subcutaneous and intracerebroventricular (icv) injections of indomethacin were used to test whether prostaglandin synthesis is essential for the exercise-induced increase in a rat's body temperature. At an air temperature of 24-degrees-C, male Wistar rats ran on a treadmill at 10-15 m/min 20 min after 300-mug icv injection or 60 min after 15-mg/kg sc injection of indomethacin or of control vehicle. The rectal temperature (T(re)) of control rats in 17 control experiments increased by 1.0-degrees-C during exercise, whereas the T(re) of the rats pretreated with intracerebroventricular indomethacin increased creased by only 0.4-degrees-C. Threshold T(re) for tail vasodilation was significantly lower in rats pretreated with indomethacin than the control rats (38.4 +/- 0.1 vs. 38.9 +/- 0.1-degrees-C), but O2 uptake did not differ between indomethacin-pretreated and control rats. Subcutaneous injection of indomethacin did not affect the body temperature, tail vasomotor activity, or O2 uptake of exercising rats. Intracerebroventricular indomethacin did not affect T(re) or tail vasomotor activity of rats resting at ambient temperatures of 24 and 28-degrees-C. Present results suggest that prostaglandin synthesis is required for the vasoconstrictive effect of exercise on skin blood vessels and thus for the exercise-induced elevation of body temperature., Jul. 1993, 265, 1, R230, R234, Scientific journal
- Bulletin of the Physical Fitness Research Institute, Involvement of fever mechanisms in exercise-induced hyperthermia, K. Kanosue; M. Yanase-Fujiwara; H. Tanaka, 1992, 80, 40, 46, Scientific journal
- Not Refereed, 1992, 80, 40, 46, Scientific journal
- Refereed, AMERICAN JOURNAL OF PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, LATERAL DISTRIBUTION OF HYPOTHALAMIC SIGNALS CONTROLLING THERMOREGULATORY VASOMOTOR ACTIVITY AND SHIVERING IN RATS, K KANOSUE; K NIWA; PD ANDREW; H YASUDA; M YANASE; H TANAKA; K MATSUMURA, The present study explored the laterality of central nervous thermoregulatory control in anesthetized rats by measuring paw skin vasomotor activity and cold-induced shivering in hind leg muscles during unilateral preoptic area and anterior hypothalamus (POAH) warming and electrical stimulation or during unilateral thermal stimulation of abdominal skin. Unilateral POAH warming produced vasodilation on both sides of the body, but vasodilation on the ipsilateral side always either occurred at a lower threshold hypothalamic temperature or was stronger than on the contralateral side. In a cold environment (5-degrees-C), shivering was suppressed simultaneously in both hind legs when one side of the POAH was warmed, and shivering reappeared simultaneously on both sides when POAH warming stopped. These results suggest that different thermoregulatory effectors are regulated in a different way by each side of the POAH. Unilateral thermal stimulation of the abdominal skin, on the other hand, affected vasomotor activity and shivering equally on both sides of the body, as previously reported for its influence on salivary secretion. Skin thermal signals from both sides of the body therefore seem to converge before they act on different thermoregulatory effector systems., Mar. 1991, 260, 3, R486, R493, Scientific journal
- Refereed, JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, SALIVARY SECRETION AND GROOMING BEHAVIOR DURING HEAT EXPOSURE IN FREELY MOVING RATS, M YANASE; K KANOSUE; H YASUDA; H TANAKA, 1. At neutral (24-degrees-C) and at hot (40-degrees-C) ambient temperatures (T(a)) salivary secretion from the submandibular gland of freely moving rats was recorded, together with simultaneous observation of saliva-spreading behaviour (grooming).
2. At a T(a) of 24-degrees-C, basal salivary flow was less than 2-mu-l/min. When rats were first placed in the experimental chamber, brief grooming bouts often occurred. Transient secretion at more than 10-mu-l/min was associated with this grooming, and the rate of salivary flow was positively correlated with the duration of grooming activity.
3. At a Ta of 40-degrees-C, grooming appeared frequently and salivary secretion at more than 20-mu-l/min continued even between grooming bouts. Threshold rectal temperatures (T(re)) for thermally induced grooming (38.2 +/- 0.2-degrees-C) and for salivary secretion (38.2 +/- 0.1-degrees-C) were similar, and for eleven of sixteen rats the two thresholds coincided.
4. At the threshold T(re) both the rate of salivary secretion and the duration of grooming increased in a stepwise fashion. Above the threshold, there was no correlation between the duration of grooming and the rate of salivary flow.
5. Thermally induced salivary secretion and grooming behaviour appear to be controlled by independent mechanisms., Jan. 1991, 432, 585, 592, Scientific journal - Refereed, JOURNAL OF PHYSIOLOGY-LONDON, CAMBRIDGE UNIV PRESS, MODES OF ACTION OF LOCAL HYPOTHALAMIC AND SKIN THERMAL-STIMULATION ON SALIVARY SECRETION IN RATS, K KANOSUE; T NAKAYAMA; H TANAKA; M YANASE; H YASUDA, May 1990, 424, 459, 471, Scientific journal
- Refereed, AMERICAN JOURNAL OF PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, EFFECTS OF PYROGEN ADMINISTRATION ON TEMPERATURE REGULATION IN EXERCISING RATS, H TANAKA; K KANOSUE; M YANASE; T NAKAYAMA, Apr. 1990, 258, 4, R842, R847, Scientific journal
- Refereed, AMERICAN JOURNAL OF PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, CIRCADIAN VARIATION OF THERMOREGULATORY RESPONSES DURING EXERCISE IN RATS, H TANAKA; M YANASE; K KANOSUE; T NAKAYAMA, Apr. 1990, 258, 4, R836, R841, Scientific journal
- Refereed, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, SPRINGER VERLAG, EFFECTS OF ESTRUS CYCLE ON THERMOREGULATORY RESPONSES DURING EXERCISE IN RATS, M YANASE; H TANAKA; T NAKAYAMA, Jan. 1989, 58, 4, 446, 451, Scientific journal
- Refereed, JAPANESE JOURNAL OF PHYSIOLOGY, CENTER ACADEMIC PUBL JAPAN, BODY-TEMPERATURE REGULATION IN RATS DURING EXERCISE OF VARIOUS INTENSITIES AT DIFFERENT AMBIENT-TEMPERATURES, H TANAKA; M YANASE; T NAKAYAMA, 1988, 38, 2, 167, 177, Scientific journal, 10.2170/jjphysiol.38.167
- Refereed, 2024, 12, 142, 154, https://doi.org/10.1123/jmld.2022-0036
- 2023, 12, 2, 45, 57, 10.7600/jpfsm.12.45
- Refereed, 2023, 95, 42, 51
- Refereed, 2023
- Refereed, 2018, 20, 1, 13
- Not Refereed, 24, 12, 23
- Refereed, 11, 71, 85
- Refereed
- Refereed, 2023, 12, 2, 45, 57
- Refereed, 2022, 93, 32, 44
MISC
- Not Refereed, 01 Jul. 2024, 22, 2, 96, 100, Introduction scientific journal
- Not Refereed, Mar. 2024, 28, 1, 1, Summary national conference
- Not Refereed, 01 Jan. 2023, 20, 4, 220, 222, Introduction scientific journal
- Not Refereed, 2020, 41, 244, 251, Others
- Not Refereed, 2018, 22, 2, 3, Introduction scientific journal
- Not Refereed, 2018, 22, 25, 30
- Refereed, 2018, 20, 1, 13
- 【Reports】Production process of the "Shimoichi Raku-Raku Excercise" : The PPK Group report of "The Development of the "Raku-Raku Farming Method", 31 Mar. 2017, 19, 49, 54
- The developmental process of the "foresee-movement" among young children in catching a bouncing ball : data from a two-year longitudinal survey, Mar. 2017, 74, 45, 55
- Production process of the "Shimoichi Raku-Raku Exercise" : The PPK Group report of 'The Development of the "Raku-Raku Farming Method"', 2017, 19, 49, 54
- 2017, 21, 3, 130, 136
- Not Refereed, 2017, 10, 3, 5, 7
- Not Refereed, 2017, 165, 171
- Refereed, Developmental process of "foresee-movement" in young children catching a bouncing ball : Comparison of two tasks with different orbits, 2016, 18, 1, 12
- Refereed, The motion characteristics of the forehand stroke on ball speed in tennis, 2016, 18, 13, 24
- Refereed, 2016, 18, 35, 46
- Not Refereed, Japan Journal of Human Growth and Development Research, FUJIWARA Motoko, 2016, 7, 71, 9, 17
- Not Refereed, 2015, 17, 1, 8
- Refereed, Developmental process of "foresee-movement" in young children catching a bouncing ball : Analyzing of catching movement for parabolic-line task, 2015, 17, 9, 19
- Research journal of sport science in Nara Women's University, Nara Women's University, Reserch of the posture during the harvesting operations for advanced age people cultivating persimmons : The PPK Group report of 'The Development of the "Raku-Raku Farming Method" to Support Farming by Elderly People', 2014, 16, 47, 56
- Refereed, Research journal of sport science in Nara Women's University, Nara Women's University, The effestd of "Forse relaxation" on quickness of force control, 2014, 16, 1, 8
- Refereed, 2013, 15, 37, 46
- Refereed, 2013, 15, 1, 15
- Refereed, The strategy of rapid running direction change movement from a side step, 2013, 15, 17, 27
- Not Refereed, 2013, 15, 59, 68
- Not Refereed, 2013, 15, 79, 82
- Not Refereed, 2013, 15, 91, 96
- Not Refereed, 2012, 34, 86, 94
- Not Refereed, 2012, 14, 1, 11
- Not Refereed, 2012, 14, 13, 23
- Not Refereed, 2011, 13, 1, 11
- Not Refereed, 2011, 13, 13, 22
- 01 Sep. 2010, 47, 3, S66
- Not Refereed, 2010, 60, 733, 738
- Not Refereed, 2010, 12, 11, 18
- Muscle activity patterns during quick change of movement amplitude in rapid elbow flexions, ln this study, we investigated control of muscle activity for changing the amplitude of movement in rapid flexions at the elbow joint. This study focused on the changes in a triphasic electromyographic(EMG) pattern, i.e., the first agonist burst(AG1), the second agonist burst (AG2) and the antagonist burst (ANT), for increasing the amplitude of movement requires after the initiation of movement. Subjects performed 40 degree (Basic task) and 80 degree of flexion (Wide task). These tasks were performed under two conditions; performing a predetermined task (SF condition) and performing a task in response to a visual stimulus immediately after movement commencement (ST condition). Kinematic parameters (movement amplitude, movement velocity and movement time) and EMG activity (onset latency, duration and average EMG) from the agonist(biceps brachii) and the antagonist(triceps brachii) muscles were recorded. As a result, in both tasks, the onset latency of AG1, ANT and AG2 in the ST condition increased compared with those in the SF condition. In addition, the duration of ANT and AG2 and the a-EMG of AG2 increased in the ST condition. It is concluded that the control of muscle activity for changing the amplitude of movement in the ongoing movement was to control the onset and duration of ANT for changing the timing of stop movement and the duration and amplitude of AG2 for stopping the desired position accurately., 31 Mar. 2009, 11, 1, 11
- Not Refereed, 2008, 10, 97, 106
- Not Refereed, 2008, 10, 117, 127
- Not Refereed, Research journal of sport science in Nara Women's University, Nara Women's University, Timing control of pass movement, Fujiwara Motoko; Nishiyama Momoko; Takatoku Nozomi, 2007, 9, 19, 28
- Not Refereed, Research journal of sport science in Nara Women's University, Nara Women's University, Second report on instruction of the movement method aiming at the health for middle and old age people in the region, Fujiwara Motoko; Hoshino Satoko; Naruse Kumi, 2007, 9, 1, 17
- Not Refereed, Research journal of sport science in Nara Women's University, Nara Women's University, Planter pressrure during quick change of derections at initiation of running, Nozomi Takatoku; Motko Fujiwara, 2006, 8, 19, 28
- Not Refereed, Research journal of sport science in Nara Women's University, Nara Women's University, Instruction of yhe movement method aiming at the health for middle and ald age people in the region, Kumi Naruse; Motoko Fujiwara; Satoko Hosihino, 2006, 8, 49, 53
- Not Refereed, 2005, 7, 37, 45
- Not Refereed, 2005, 2, 25, 33
- 01 Sep. 2004, 55, 328, 328
- 01 Sep. 2004, 55, 327, 327
- Not Refereed, 2003, 52, 6, 810, 810
- Not Refereed, Research journal of sport science in Nara Women's University, Nara Women's University, Shock absorption during catching in lacrosse, Fujiwara Motoko; Maruyama Eiko, 2003, 5, 69, 76
- Not Refereed, Research journal of sport science in Nara Women's University, Nara Women's University, Motor control during unilateral stopping in bilateral coordination of elbow joints, Tomatu Saeka; Fujiwara Motoko, 2002, 4, 76, 84
- Not Refereed, Research journal of sport science in Nara Women's University, Nara Women's University, Electromyographic activity for two types of modification of rapid wrist flexion movement, Todo Fukuko; Fujiwara Motoko, 2002, 4, 85, 92
- 10 Aug. 2001, 52, 353, 353
- Not Refereed, Abstract of the 18th Congress of the International Society of Biomechanics, Effects of trial importance on the accurate ball-stroking movements, FUJIWARA Motoko; Matsumoto N; Yanase-Fujiwara M; Ohtsuki T, 2001, 246, 247
- 25 Aug. 2000, 51, 177, 177
- Not Refereed, 2000, 2, 40
- Not Refereed, 1999, 4, 4, 287, 293
- Not Refereed, Japanese Journal of Biomechanics in Sports & Exercise., Timing control and vision., FUJIWARA Motoko, 1999, 4, 287
- Not Refereed, 1998, 2, 2, 109, 115
- Not Refereed, Japanese Journal of Biomechanics in Sports & Exercise, Quick change of the forward running divection., FUJIWARA Motoko, 1998, 2, 2, 109, 115
- 29 Aug. 1997, 48, 341, 341
- 29 Aug. 1997, 48, 324, 324
- 29 Aug. 1997, 48, 350, 350
- Not Refereed, 1996, 91, 142
- Not Refereed, Bulletin of the Physical Fitness Research Institute., A fundamental research on cold constitution., FUJIWARA Motoko, 1996, 91, 142
- Not Refereed, Annual report of studies in humanities and social sciences, Nara Women's University, Exercise and Body Temperature, Fujiwara Motoko, 1995, 39, 97, 114
- Not Refereed, Annual report of studies in humanities and social sciences., Exercise and body temperature., FUJIWARA Motoko, 1995, 39, 97
- Not Refereed, 2024, 28, 1, 1
- Not Refereed, 2022, 20, 4, 220, 222
- Not Refereed, 2020, 41, 244, 251
- Not Refereed, 2018, 22, 2, 3
- Not Refereed, 2019, 21, 10, 16
Books etc
Presentations
- 15 Mar. 2025, 15 Mar. 2025 - 16 Mar. 2025
- Mar. 2024
- Nov. 2023
- Characteristics of muscle stiffness during isometric contraction and relaxation by shear wave elastography, Jul. 2023
- Mar. 2023
- Nov. 2022
- Nov. 2022
- Nov. 2022
- Jul. 2022
- Mar. 2022
- Sep. 2021
- Sep. 2021
- Sep. 2021
- Sep. 2021
- Sep. 2021
- Mar. 2021
- Sep. 2020
- Sep. 2020
- Sep. 2020
- Sep. 2020
- Sep. 2020
- Jun. 2020
- Mar. 2020
- Sep. 2019
- Sep. 2019
- Mar. 2019
- Mar. 2019
- Sep. 2018
- Aug. 2018
- Aug. 2018
- Aug. 2018
- Mar. 2018
- Mar. 2018
- Ohtaka C; Fujiwara M, The 17th International Conference on Environmental Ergonomics, Control strategies for accurate force generation and relaxation in isometric contraction of lower limb, Nov. 2017
- Sep. 2017
- Sep. 2017
- Sep. 2016
- Sep. 2016
- Sep. 2016
- Aug. 2016
- Mar. 2016
- Mar. 2016
- Mar. 2016
- Aug. 2015
- Aug. 2015
- Aug. 2015
- Aug. 2015
- Jul. 2015
- Jul. 2015
- Mar. 2015
- Mar. 2015
- 2015
- Sep. 2014
- Sep. 2014
- Aug. 2014
- Aug. 2014
- Tsutsui; K. Fujiwara, M, The 7th Asian-South Pacific Association of Sport Psychology, Positive thinking according to individual characteristics, 2014
- 2014
- Aug. 2013
- Aug. 2013
- 2013
- 2013
- Sep. 2012
- Sep. 2012
- Sep. 2012
- Sep. 2012
- Sep. 2012
- 2012
- Sep. 2011
- Sep. 2011
- Sep. 2011
- Sep. 2011
- Sep. 2011
- Sep. 2011
- Fujiwara M, The 5th Asia-Pacific Conference on Exercise and Sports Science, Central control mechanism in rapid variation of muscle output during isometric elbow flexion., 2011
- Nov. 2010
- Sep. 2010
- Sep. 2010
- Sep. 2010
- Sep. 2010
- Aug. 2010
- Aug. 2010
- Aug. 2010
- Aug. 2010
- Dec. 2009
- Aug. 2009
- Aug. 2009
- Aug. 2008
- Aug. 2008
- Aug. 2008
- Sep. 2007
- Sep. 2007
- Fujiwara M. Okai R; Takatoku N, The 3rd Asia-Pacific Conference on Exercise and Sports Science, Postural control in response to disturbance during pushing movements., 2007
- Takatoku N; Fujiwara M, 21th Congress of the International Society of Biomechanics, Muscle activity patterns during quick change of elbow joint movement., 2007
- Sep. 2006
- Nov. 2005
- Sep. 2004
- Sep. 2004
- Sep. 2003
- Jul. 2002
- Sep. 2001
- Matsumoto N; Yanase-Fujiwara M; Ohtsuki T, 18th Congress of the International Society of Biomechanics, Effects of trial importance on the accurate ball-stroking movements., 2001
- Oct. 2000
- Oct. 2000
- Oct. 1999
- Oct. 1999
- Yanase-Fujiwara, M; Maruyama E; Kido A, 17th Congress of the International Society of Biomechanics, Muscle activity patterns during quick change of stroking distance in response to anunexpected situation., 1999
- Matsumoto N; Yanase-Fujiwara M; Ohtsuki T, 17th Congress of the International Society of Biomechanics, Effects of success demand on EMG activities of ball-stroking movements., 1999
- Kido, A; Yanase-Fujiwara M, 17th Congress of the International Society of Biomechanics, Movement moduration to perturbation in ball striking., 1999
- Taniguchi, A; Kido, A; Yanase-Fujiwara M, 17th Congress of the International Society of Biomechanics, Electromyographic analysis of drawing in Japanese archery., 1999
- Oct. 1998
- Sep. 1998
- Oct. 1997
- Oct. 1997
- Oct. 1997
- May 1997
- Mar. 1997
- Mar. 1997
- Matsumoto N; Yanase-Fujiwara M; Ohtsuki T, 16th Congress of the International Society of Biomechanics, Effects of psychological pressure on ball-stroking movements., 1997
- Yanase-Fujiwara, M; Maruyama E; Kido A; Yaoi Y, 16th Congress of the International Society of Biomechanics, Biomechanical analysis of catching in lacrosse., 1997
- Sep. 1996
- Apr. 1996
- 1996
- Hosono, T; Yamada, K; Zhang, Y-H; Yanase-Fujiwara, M; Yamaji, K; Kanosue, K, Fourth IBRO world congress of neuroscience, Effect of gonadotropin releasing hormone on thermoregulatory vasomotion in rats., 1995
- Hosono, T; Yanase-Fujiwara, M; Zhang, Y-H; Yamada, K; Yamaji, K; Kanosue, K, The second joint meeting of the Physiological Societies of Japan and and Eire, Thermoregulatory vasodilation induced by septal gonadotoropin releasing hormone in anaesthetized and unanaesthetized female rats., 1995
- Kanosue, K; Zhang, Y-H; Yamada, K; Yanase-Fujiwara M; Hosono,T, The second joint meeting of the Physiological Societies of Japan and and Eire, Neural network for thermoregulatory vasomotion in rats., 1995
- Mar. 1994
- Mar. 1994
- Hales, J. S. R; Nielsen, B; Yanase, M, Thermal Physiology (A Satellite Symposium of the 17th International Congress of Physiological Sciences), Skin blood flow during severe heat stress: regional variations & failure to maintain maximal levels., Aug. 1993
- Hosono, T; Yanase-Fujiwara, M; Zhang, Y-H; Fukuda, Y; Tanizawa, O, Thermal Physiology (A Satellite Symposium of the 17th International Congress of Physiological Sciences), Effect of gonadotropin on thermoregulatory vasomotor activity., Aug. 1993
- Kanosue, K; Yanase-Fujiwara, M; Zhang, Y-H; Hosono, T; Tanaka, H, Thermal Physiology (A Satellite Symposium of the 17th International Congress of Physiological Sciences), Independence of hypothalamic neuronal modules for thermoregulatory effector control., Aug. 1993
- Tanaka, H; Yanase-Fujiwara, M; Kanosue, K, Thermal Physiology (A Satellite Symposium of the 17th International Congress of Physiological Sciences), Effect of intracerebroventricular indomethacin administration on body temperature during exercise in rats., Aug. 1993
- Yanase-Fujiwara, M; Kanosue, K; Zhang, Y-H; Hosono, T, Thermal Physiology (A Satellite Symposium of the 17th International Congress of Physiological Sciences), Efferent pathways from the preoptic area for thermoregulatory vasomotion and shivering., Aug. 1993
- Apr. 1993
- Apr. 1993
- Dec. 1992
- Dec. 1992
- Apr. 1992
- Apr. 1992
- Nov. 1991
- Oct. 1991
- Kanosue, K; Tanaka, H; Yanase, M; Matsumura, K, Regional Meeting of the International Union of Physiological Sciences, Body temperature change during exercise is mediated by prostaglandin synthesis inside the blood brain barrier., Jul. 1991
- Mar. 1991
- Apr. 1990
- Apr. 1990
- Apr. 1990
- Sep. 1989
- Effects of Interleukin; administration on; body; mperature rise during exercise in rats, Thermal Physiology (A Satellite Symposium of the 16th International Congress of Physiological Sciences), Tanaka, H., Yanase, M., Kanosue, K. & Nakayama, T., Jul. 1989
- Yanase, M; Tanaka, H; Kanosue, K; Nakayama, T, Thermal Physiology (A Satellite Symposium of the 16th International Congress of Physiological Sciences), Circadian and estrus variationsof thermoregulatory responses during exercise in rats., Jul. 1989
- Apr. 1989
- Apr. 1989
- Nov. 1988
- Oct. 1988
- Oct. 1988
- Apr. 1988
- Apr. 1988
- Oct. 1987
- Apr. 1987
- Oct. 1986
- Sep. 1986
- Kanosue, K; Nakayama, T; Tanaka, H; Yanase, M; Matsuo, R, Thermal Physiology (A Satellite Symposium of the 15th International Congress of Physiological Sciences), Salivary secretion in response to thermal stimulation in rats., Jul. 1986
- Dec. 1985
- Oct. 1985
- Oct. 1984
- May 1984
- Aug. 1983
- Poster presentation, 30 Nov. 2024 - 01 Dec. 2024
- Poster presentation, 30 Aug. 2024 - 31 Aug. 2024
- Poster presentation, 16 Mar. 2024 - 17 Mar. 2024
- Oral presentation, 25 Nov. 2023 - 25 Nov. 2023
- Poster presentation, 04 Jul. 2023 - 07 Jul. 2023
- Poster presentation, Aug. 2018 - Aug. 2018
- Poster presentation, Aug. 2018 - Aug. 2018
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- Poster presentation, 09 Mar. 2019 - 10 Mar. 2013
- Poster presentation, 09 Mar. 2019 - 10 Mar. 2019
- Poster presentation, Sep. 2019 - Sep. 2019
- Poster presentation, Sep. 2019 - Sep. 2021
- Poster presentation, 14 Mar. 2020 - 15 Mar. 2020
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- Poster presentation, 13 Mar. 2021 - 14 Mar. 2021
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Research Projects
- Grant-in-Aid for Scientific Research (C), Apr. 2023 - Mar. 2026, 23K10713, Motor control characteristics for simultaneous bilateral asymmetrical tasks performed by left and right limbs, 藤原 素子, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Nara Women's University, 2600000, 2000000, 600000, ヒトの随意動作遂行時の素早い筋出力調節に関わる中枢制御機構について、左右で異なる筋出力を行う場合のメカニズムに着目した実験を行った。
研究の目的は、日常生活及びスポーツ場面で重要となる素早く正確な出力調節について、実際の場面では左右肢で異なる出力調節をすることが多いことから、そのような場面での出力調節が左右で独立して制御されているのか否かを明らかにすることである。これまでに上肢による出力増加時には、小さな出力を行う側が大きな出力を行う側の動作に引き込まれることを見出しており、今年度の研究では、出力を減らす場合でも同じ制御が見られるかどうかを検討するための実験を行った。
まず、今年度は初年度として、実験システムの構築を行った。その後、女子大学生12名を被験者とし、座位で上肢の等尺性肘関節屈曲動作による筋出力発揮を左右肢それぞれ一側条件と両側同時条件で行った。
具体的な被験者の課題は、左右の上肢による最大発揮張力（MVF）を計測し、この値をもとに50％MVCを保持した状態から、目標％MVF（30%あるいは10％）を示すLED点灯に対して、できるだけ素早く筋出力を減少させた。一側条件では、左右それぞれの上肢により目標％MVFへの筋出力減少を行った。両側同時条件では、左右肢で異なる目標％MVC（一側が30%で対側が10％MVF、またその逆）への筋出力減少を行った。指標として、発揮張力に加えて上腕二頭筋及び上腕三頭筋から筋電図を導出した。, kaken - Grant-in-Aid for Scientific Research (B), 01 Apr. 2018 - 31 Mar. 2022, 18H03166, Effects of central and peripheral fatigue on muscle output regulation and circulatory regulation during exercise in a hot environment, Shibasaki Manabu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Nara Women's University, 17160000, 13200000, 3960000, We investigated the effects of central and peripheral fatigues on motor control and cardiovascular responses during exercise in a hot environment using electroencephalographic event-related potentials, near-infrared spectroscopy, and middle cerebral artery blood velocity. In addition, to investigate the motor skill with muscle fatigue, we examined the interlocking of upper and lower limbs movements. The results of hyperthermia-induced central fatigue showed that the mode of exercise is capable of modulating the central motor command. Also, the peripheral fatigue affects the output of the central motor command, which is brain activity. Finally, "how to relax" due to muscle fatigue was numerically presented., kaken
- 基盤研究(C), 21 Oct. 2016 - 31 Mar. 2020, 16K01661, 上肢と下肢の協応による素早い筋出力調節メカニズム, 藤原 素子, 日本学術振興会, 科学研究費助成事業, 奈良女子大学, 4680000, 3600000, 1080000, kaken
- Grant-in-Aid for Scientific Research (C), 01 Apr. 2013 - 31 Mar. 2016, 25350762, Coordinate strategy during quick regulation of voluntary muscle output by right and left legs, FUJIWARA MOTOKO, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Nara Women's University, 4550000, 3500000, 1050000, This study aimed to investigate the central control mechanism behind the rapid adjustment of muscle output during isometric knee extension by analyzing tension as an indicator. In particular, attentions were focused on rapid increase or decrease in muscle output, muscle output was adjusted by unilateral or bilateral, and coordinate of muscle output by leg with arm. In the case of bilateral muscle output by leg, moreover, accuracy and quickness were compared between output level were same or not same among legs. The characteristics of muscle output control manner by leg were clarified., kaken
- 2011 - 2014, 柿栽培における作業負荷の測定, ＪＳＴ戦略的創造研究推進制度（研究チーム型） （戦略的基礎研究推進事業：ＣＲＥＳＴ）, 0, 0, 0, 「高齢者の営農を支える『らくらく農法』の開発」, Competitive research funding
- 2013, 幼児の調整力の発達, 0, 0, 0, Competitive research funding
- Grant-in-Aid for Scientific Research (C), 2010 - 2012, 22500577, Central Control Mechanism during quick regulation of voluntary Muscle Output, FUJIWARA Motoko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Nara Women's University, 3900000, 3000000, 900000, This study aimed to investigate the central control mechanism behind the rapid adjustment of muscle output during isometric elbow flexion by analyzing tension and muscle activity as an indicator. In particular, attentions were focused on rapid decrease or increase in muscle output and muscle output was adjusted by unilateral or bilateral. In conclusion, characteristics of motor units mobilized during increase and decrease muscle output and extension in adjustment time when muscle output was decreased were revealed., kaken
- 2005 - 2012, ソックスの着圧が運動時の血流に及ぼす影響, 0, 0, 0, Competitive research funding
- 2005 - 2012, Effects of pressure of socks on blood flow during exercise., 0, 0, 0, Competitive research funding
- 奨励研究(A), 1998 - 1999, 10770026, 筋出力の変化からみた左右への打球動作に対する打ち分け指示時刻の影響, 藤原 素子, 日本学術振興会, 科学研究費助成事業, 奈良女子大学, 2100000, 2100000, テニスに代表されるネットスポーツでは、相手の動きの認知時刻が打球動作のパフォーマンスに影響を与えることが多い。本研究では、左右への打球打ち分け動作に打ち分け指示時刻の違いが与える影響について、主に筋出力を指標として調べることを目的とした。
今年度は、前年度と同じ装置を用い、女子大学生10名(テニス経験者を含む、全員右利き)を被験者として、ボールガイド上を転がってくる硬式テニスボールを、実験台上で特別に作製した小型ラケットで打球し、左右前方に設置した的に入れる課題を行なわせた。打球方向はボールガイドの左右に設けた刺激LEDを、ボールスタートから1000ms,1250ms,1500msの3種類のいずれかのタイミングで点灯させることにより指示した。右上肢から、三角筋前部、三角筋後部、橈側手根屈筋、尺側手根伸筋の計4カ所について、表面筋電図をテレメーターシステム(日本光電WEB-5000)を介して導出し、生体現象取り込み装置(BIOPAC社MP100)によりコンピュータ(Macintosh)に取り込んだ。
結果として、指示時刻が最も遅い場合に他の条件に比べて、橈側手根屈筋の活動に次のような顕著な違いがみられた。1)右方向へ打つ場合、尺側手根伸筋と同時に放電を開始した。2)左方向へ打つ場合、動き始めてからインパクトまでのスイング期に大きな放電がみられた。これらの結果より、相手の動きの認知が遅い場合の打球動作の特徴として、右方向へ打球するときには、前腕の屈筋を伸筋と同時に活動させ、共収縮による手関節の固定を行なうことが、また左方向へ打球するときには、より素早い手関節の屈曲によるスナップ動作を行なうことが示唆された。, kaken - 1995, 随意運動の中枢制御機構, 0, 0, 0, Competitive research funding
- 1995, Motor Control in Voluntary Movement, 0, 0, 0, Competitive research funding
- 奨励研究(A), 1994 - 1994, 06770053, 運動時体温調節への脳内プロスタグランジンの関与, 藤原 素子, 日本学術振興会, 科学研究費助成事業, 大阪大学, 900000, 900000, 運動時の体温上昇機構を解明するために、我々はこれまでにラットを用いて実験を行ない、いくつかの興味深い結果を得てきた。例えば運動時に発熱物質を投与すると、運動による体温上昇と発熱による体温上昇が加算される。また、発熱物質であるプロスタグランジン(PGE2)の合成阻害剤であるインドメタシンを脳室内あるいは皮下に投与して運動を行なわせたところ、脳室内投与時のみ運動による体温上昇が抑えられた。これらの結果は、運動時には体温の調節レベルが新たな値にリセットされること、またこれには血液-脳関門の脳側でのPGE2合成が関与していることを示唆する。今回我々は実際に運動中に脳内でPGE2が合成されているか否かを検討した。ラットに30分間の運動で直腸温が0.8℃-1.0℃上昇するような強度のトレッドミル走を行なわせ、運動終了後ネンブタール麻酔下で脳脊髄液を採取し、凍結、-80℃で保存した。ラジオイムノアッセイキットにより脳脊髄液中のPGE2を測定した。対象群として30分間トレッドミル内で安静にしているラットからも脳脊髄液を採取し、同様にPGE2を測定した。今回の実験では、運動終了直後のラット脳脊髄液中のPGE2レベルは、運動していないラットのそれと差がなかった。脳脊髄液中においてPGE2レベルの上昇が見られなかったことから、脳組織、特に体温調節中枢である視床下部、また最近発熱に関与していると注目されている脳室周囲器官などで、PGE2レベルが上昇している可能性が考えられる。今回の実験では脳組織でのPGE2レベルを測定するには至らなかったが、今後引き続き検討していく予定である。, kaken
- Grant-in-Aid for Developmental Scientific Research (B), 1992 - 1994, 05557006, Optical recordings from hypothalamic neurons., KANOSUE Kazuyuki; SHIONO Satoru; FUZIWARA Motoko; KOSAKA Jun, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Osaka University, 15600000, 15600000, Homeostatic functions such as body temperature regulation, eating, drinkig, and reproduction are controlled by the central nervous system including the hypothalamus. There is almost no knowledge concerning thermoregulatory "network" , which makes it difficult to link electrophysiological and pharmachological data directly with responses observed in whole animals. Present study was planed to develop a system which analyzes the network by simultaneously recording activities of many neurons from hypothalamic culture preparation. Neurons taken from the preoptic area of new-born rats (three days old) were dissociated and cultrured. Neurons survived for 7-10 days and at around day 7 long processes were observed. In ordere to make optical recordings from single cultured neurons, we tried to find out conditions for making the neurons generate action potentials. No spontaneous activity was observed not only at 37ﾟCbut also in a wide temperature range of 34-42ﾟC.Application of glutamate (1 mM-0.1 M) or K+ (10-100 mM) also failed to generate action potentials. Signal to noise ratio of the plesently-available optical recording system requires voltage change of several tens mV.So without action potentials optical recordings can not be used for analyzing neuronal networks of the hypothalamus., kaken
- Grant-in-Aid for General Scientific Research (B), 1992 - 1994, 04454143, Analysis of hypothalamic network for thermoregulation., KANOSUE Kazuyuki; FUJIWARA Motoko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Osaka University, 6700000, 6700000, The body temperature is controlled by the central nervous system including the hypothalamus. There is almost no knowledge of thermoregulatory "network" , which makes it difficult to link electrophysiological and pharmachological data directly with thermoregulatory responses observed in whole animals. Present study was pland to answer this question. First, to examine how the control of shivering is shared between the brain's right and left sides, ketamine anesthetized rats had been implanted thermodes on both sides of the preoptic area and received unilateral transection of the hypothalamus just caudal to the anterior hypothalamus, which severed fibers running rosto-caudal diretion. Unilateral preoptic warming on the intact side produced bilateral suppression of cold-induced shivering without predominance of either side of the body but warming on the transected side had no effect on shivering. Therefore, no information seems to be exchanged between the left and right preoptic aera for control of shivering. When a partial transection covered the lateral part of the hypothalamus (the medial forebrain bundle), the transection had the same effect as did unilateral transections of the whole hyporhalamus. Efferent signals for shivering, thus, descend through the medial forebrain bundle. In the second experiment, skin vasodilation occurs bilaterally during unilateral thermal or electrical stimulation of the preoptic area (Kanosue et al., 1991). In rats which had received similar unilateral transection of the hypothalamus as in the shivering experiment, unilateral preoptic warming not only on the intact side but also on the transected side produced bilateral vasodilation on the hind paw. Therefore, information coutrolling thermoregulatory vasomotion--unlike that controlling shivering--crosses the midline within the preoptic area. Efferent fibers for vasomotor control seem to decend through the medial forebrain bundle., kaken
- 奨励研究(A), 1993 - 1993, 05770048, 高齢ラットの異常皮膚血管連動と脳内ゴナドトロピン放出ホルモンの関係, 藤原 素子, 日本学術振興会, 科学研究費助成事業, 大阪大学, 900000, 900000, 閉経期の婦人を悩ませているのぼせが、脳内に放出されるLHRHの体温調節系への作用により誘発される、という仮説を検証する目的で動物を用いて実験を行なった。まず、老齢および若年雄ラットの尾血管運動反応の差を検討した。実験はラットによって,血管運動が体温調節の主たる方法となる温熱的中性温域環境温(26℃)で行なった。この条件下では血管拡張の起こる深部温の閾値に老齢群,若年群間に有意な差はなかった。さらに24℃の環境温下でも実験を行なったが,老齢群,若年群とも尾血管は収縮したままであった。以上の結果より,雌ラットの尾血管運動調節には老齢,若年群間で本質的な違いは無いと結論される。Simpkins(1984)は老齢雌ラットは,若齢ラットでは尾血管が収縮しているような環境温下でも不規則な拡張を示すと報告している。彼らはLong‐Evans系,本実験はWistar 系を用いており、系統の違いによる影響は今後検討すべき課題である。次に無麻酔無拘束の自由行動ラットで、LHRHの受容体が密に存在する中隔野にLHRHを投与し、尾血管反応を調べた。その結果、尾血管が収縮している環境温下で、LHRHの投与により一過性の尾血管拡張が観察された。本研究では老齢雌ラビットをのぼせのモデルとして確立することはできなかったが、無麻酔の動物においても脳内LHEH投与により尾血管拡張反応が誘発されるという、当初の仮説を検証する重要な結果を得ることができた。今後更に、脳内におけるLHRHの作用機序および神経回路に関する研究を進めていく予定である。, kaken
- Grant-in-Aid for General Scientific Research (C), 1990 - 1991, 02670066, Functional conections between right & left hypothalamus in thermcregulation., KANOSUE Kazuyuki; FUJISAWAR Motoko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Osaka Univerisity, 2300000, 2300000, The present study explored the laterality of central nervous thermoregulatory control in anesthetized rats by measuring paw skin vasomotor activity and cold-induced shivering in hind leg muscles during unilateral POAH warming and electrical stimulation or during unilateral thermal stimulation of abdominal skin. Unilateral POAH warming produced vasodilation on both sides of the body, but vasodilation on the ipsilateral side always either occurred at a lower threshold hypothalamic temperature or was stronger than on the contralateral side. In a cold environment(5ﾟC), shivering was suppressed simultaneously in both hind legs when one side of the POAH was warmed, and shivering reappeared simultaneously on both sides when POAH warming stopped. These results suggest that different thermoregtilarory effectors are regulated in a different way by each side of the POAH. In the next series of experiments, the possibility of direct exchange of thermoregulatory control information between the left and right sides of the preoptic area and anterior hypothalamus(POAH)was tested by extracellularly recording single unit activity in the POAH of urethane-anaesthetized rats during local temperature changes and electrical stimulation of the contralateral POAH. Twenty-four of 123 neurons were facilitated and 20 inhibited by contralateral stimulation ; none were antidromically activated. Twenty-seven of the 82 of these neurons tested for thermosensitivity were warm-sensitive, and 20 were cold-sensitive : a neuron's thermosensitivity was not significantly correlated with its response to contralateral stimulation. The highest incidence of response to contralateral stimulation(60%)was found when stimulation and recording sites were both in the anterior half of the POAH. These responses were absent after midsagittal transection of the anterior commissure and its rostral area. These results indicate plentiful and predominantly polysynaptic connections between the right and left sides of the anterior POAH., kaken
- 動作の熟練過程における中枢の制御機構の変容, 0, 0, 0, Competitive research funding
- 基盤研究（C）, 2023 - 2025, 23K10713, Principal investigator, 左右の体肢間で異なる筋出力発揮時の協応メカニズムの解析
■Ⅲ．社会連携活動実績
