研究者総覧

松田 覚 (マツダ サトル)

  • 研究院生活環境科学系食物栄養学領域 教授
Last Updated :2021/04/15

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学位

  • 医学博士, 東京大学

研究分野

  • ライフサイエンス, 医化学

経歴

  • 2003年10月 奈良女子大学生活環境学部教授
  • 2000年04月 - 2003年09月 名古屋大学医学部助教授
  • 1997年07月 - 2000年03月 名古屋大学医学部講師
  • 1992年04月 - 1997年06月 東京大学医科学研究所助手
  • 1990年04月 - 1992年03月 学術振興会特別研究員

学歴

  • - 1988年 東京大学大学院 医学系研究科 第一臨床医学

論文

  • Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses.

    辻愛; 松田覚

    Psychiatric illnesses may be qualified to the cellular impairments of the function for survival or death in neurons, which may consequently appear as abnormalities in the neuroplasticity. The molecular mechanism has not been well understood, however, it seems that PI3K, AKT, GSK3, and their downstream molecules have crucial roles in the pathogenesis. Through transducing cell surviving signal, the PI3K/AKT/GSK3 pathway may organize an intracellular central network for the action of the synaptic neuroplasticity. In addition, the pathways may also regulate cell proliferation, cell migration, and apoptosis. Several lines of evidence have supported a role for this signaling network underlying the development and treatment for psychiatric illnesses. Indeed, the discovery of molecular biochemical phenotypes would represent a breakthrough in the research for effective treatment. In this review, we summarize advances on the involvement of the PI3K/AKT/GSK3 pathways in cell signaling of neuronal cells. This study may provide novel insights on the mechanism of mental disorder involved in psychiatric illnesses and would open future opportunity for contributions suggesting new targets for diagnostic and/or therapeutic procedures., 2019年02月13日, Diseases (Basel, Switzerland), 7 (1), 国際誌, doi;pubmed;pmc

  • By using either endogenous or transplanted stem cells, which could you prefer for neural regeneration?

    辻愛; 松田覚

    2018年10月, Neural regeneration research, 13 (10), 1731 - 1732, 国際誌, doi;pubmed;pmc

  • Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer's Disease.

    辻愛, 松田覚

    Alzheimer’s disease is a neurodegenerative sickness, where the speed of personal disease progression differs prominently due to genetic and environmental factors such as life style. Alzheimer’s disease is described by the construction of neuronal plaques and neurofibrillary tangles composed of phosphorylated tau protein. Mitochondrial dysfunction may be a noticeable feature of Alzheimer’s disease and increased production of reactive oxygen species has long been described. Superoxide dismutases (SODs) protect from excess reactive oxygen species to form less reactive hydrogen peroxide. It is suggested that SODs can play a protective role in neurodegeneration. In addition, PI3K/AKT pathway has been shown to play a critical role on the neuroprotection and inhibiting apoptosis via the enhancing expression of the SODs. This pathway appears to be crucial in Alzheimer’s disease because it is related to the tau protein hyper-phosphorylation. Dietary supplementation of several ordinary compounds may provide a novel therapeutic approach to brain disorders by modulating the function of the PI3K/AKT pathway. Understanding these systems may offer a better efficacy of new therapeutic approaches. In this review, we summarize recent progresses on the involvement of the SODs and PI3K/AKT pathway in neuroprotective signaling against Alzheimer’s disease., 2018年04月20日, Diseases (Basel, Switzerland), 6 (2), 国際誌, doi;pubmed;pmc

  • PI3K/AKT signaling mediated by G protein-coupled receptors is involved in neurodegenerative Parkinson's disease

    Noriko Nakano; Satoru Matsuda; Mayuko Ichimura; Akari Minami; Mako Ogino; Toshiyuki Murai; Yasuko Kitagishi

    Parkinson's disease (PD) is a common progressive and multifactorial neurodegenerative disease, characterized by the loss of midbrain dopaminergic neurons. Numerous pathological processes including, inflammation, oxidative stress, mitochondrial dysfunction, neurotransmitter imbalance, and apoptosis as well as genetic factors may lead to neuronal degeneration. Motor deficits in PD are due mostly to the progressive loss of nigrostriatal dopaminergic neurons. Neuroprotection of functional neurons is of significance in the treatment of PD. G protein-coupled receptors (GPCRs) have been implicated in the neuroprotection against PD through the survival of dopaminergic neurons. In addition, phosphatidyl-inositol-3-kinase (PI3K)/AKT signaling has also been demonstrated to be neuroprotective. Knowledge of the mechanisms involved in this cellular protection could be critical for developing treatments to prevent this neurodegenerative disorder. In this review, we highlight the protective roles of the PI3K/AKT signaling pathway in the function of representative serotonin GPCRs. Particular attention is given to the molecular mechanisms of this pathway proposed to explain the favorable effects of food ingredients against neurodegenerative disease., 2017年02月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 39 (2), 253 - 260, doi;web_of_science

  • Roles of oncogenes and tumor-suppressor genes in osteoclastogenesis

    Akari Minami; Mako Ogino; Noriko Nakano; Mayuko Ichimura; Atsuko Nakanishi; Toshiyuki Murai; Yasuko Kitagishi; Satoru Matsuda

    Osteoporosis is a bone disease that poses a tremendous burden to health care. The receptor activator of nuclear factor-KB (RANK) and its ligand (RANKL) have been a major focus of this research field. RANKL signaling not only activates a variety of downstream signaling pathways required for osteoclast development, but crosstalk with other signaling pathways also adjusts bone homeostasis both in normal physiology and in bone disease. Consequently, novel drugs specifically targeting RANK-RANKL and their signaling pathways in osteoclasts are expected to revolutionize the treatment of various bone diseases such as osteoporosis. Osteoclasts are the exclusive cells involved in bone resorption. Abnormal activation of osteoclasts can lead to reduced bone density, resulting in osteopenia, osteoporosis and other bone disorders. To date, the mechanism of how osteoclast precursors differentiate into mature osteoclasts remains elusive. Cell proliferation and cell death may be key processes in the progression as well as other cell types. Oncogene products and tumor-suppressor molecules play a pivotal role in regulating the processes, which are important in regulating the configuration of bone disorders. Based on the understanding of these processes, promising alternatives to the use of medications against osteoporosis include specific diets with plant-derived supplements to modulate the expression and/or activity of these molecules. In this review, we summarize the progress of research with a focus on the modulatory roles of oncogene products and tumor-suppressor molecules and suggest the scope of further research concerning the prevention of osteoporosis in this field., 2017年02月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 39 (2), 261 - 267, doi;web_of_science

  • PINK1 signaling in mitochondrial homeostasis and in aging (Review)

    Yasuko Kitagishi; Noriko Nakano; Mako Ogino; Mayuko Ichimura; Akari Minami; Satoru Matsuda

    Mitochondrial dysfunction is involved in the pathology of Parkinson's disease, an age-associated neurodegenerative disorder. Phosphatase and tensin homolog (PTEN)-induced putative kinase protein 1 (PINK1) is responsible for the most common form of recessive Parkinson's disease. PINK1 is a mitochondrial kinase that is involved in mitrochondrial quality control and promotes cell survival. PINK1 has been shown to protect against neuronal cell death induced by oxidative stress. Accordingly, PINK1 deficiency is associated with mitochondrial dysfunction as well as increased oxidative cellular stress and subsequent neuronal cell death. In addition, several mitochondrial chaperone proteins have been shown to be substrates of the PINK1 kinase. In this review, we discuss recent studies concerning the signaling cascades and molecular mechanisms involved in the process of mitophagy, which is implicated in neurodegeneration and in related aging associated with oxidative stress. Particular attention will be given to the molecular mechanisms proposed to explain the effects of natural compounds and/or food ingredients against oxidative stress. Knowledge of the molecular mechanisms involved in this cellular protection could be critical for developing treatments to prevent and control excessive progression of neurodegenerative disorders., 2017年01月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 39 (1), 3 - 8, doi;web_of_science

  • Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review)

    Satoru Matsuda; Mayuko Ichimura; Mako Ogino; Noriko Nakano; Akari Minami; Toshiyuki Murai; Yasuko Kitagishi

    Due to the key role in various cellular processes including cell proliferation and cell survival on many cell types, dysregulation of the PI3K/AKT pathway represents a crucial step of the pathogenesis in many diseases. Furthermore, the tumor suppressor PTEN negatively regulates the PI3K/AKT pathway through its lipid phosphatase activity, which is recognized as one of the most frequently deleted and/or mutated genes in human cancer. Given the pervasive involvement of this pathway, the development of the molecules that modulate this PI3K/AKT signaling has been initiated in studies which focus on the extensive effective drug discovery. Consequently, the PI3K/AKT pathway appears to be an attractive pharmacological target both for cancer therapy and for neurological protection necessary after the therapy. A better understanding of the molecular relations could reveal new targets for treatment development. We review recent studies on the features of PI3K/AKT and PTEN, and their pleiotropic functions relevant to the signaling pathways involved in cancer progress and in neuronal damage by the therapy., 2016年11月, INTERNATIONAL JOURNAL OF ONCOLOGY, 49 (5), 1785 - 1790, doi;web_of_science

  • Roles of PTEN with DNA Repair in Parkinson's Disease

    Mako Ogino; Mayuko Ichimura; Noriko Nakano; Akari Minami; Yasuko Kitagishi; Satoru Matsuda

    Oxidative stress is considered to play key roles in aging and pathogenesis of many neurodegenerative diseases such as Parkinson's disease, which could bring DNA damage by cells. The DNA damage may lead to the cell apoptosis, which could contribute to the degeneration of neuronal tissues. Recent evidence suggests that PTEN (phosphatase and tensin homolog on chromosome 10) may be involved in the pathophysiology of the neurodegenerative disorders. Since PTEN expression appears to be one dominant determinant of the neuronal cell death, PTEN should be a potential molecular target of novel therapeutic strategies against Parkinson's disease. In addition, defects in DNA damage response and DNA repair are often associated with modulation of hormone signaling pathways. Especially, many observations imply a role for estrogen in a regulation of the DNA repair action. In the present review, we have attempted to summarize the function of DNA repair molecules at a viewpoint of the PTEN signaling pathway and the hormone related functional modulation of cells, providing a broad interpretation on the molecular mechanisms for treatment of Parkinson's disease. Particular attention will be paid to the mechanisms proposed to explain the health effects of food ingredients against Parkinson's disease related to reduce oxidative stress for an efficient therapeutic intervention., 2016年06月, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17 (6), E954, doi;web_of_science

  • BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer's Disease

    Atsuko Nakanishi; Akari Minami; Yasuko Kitagishi; Yasunori Ogura; Satoru Matsuda

    Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer's disease. Alzheimer's disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer's disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer's disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer's disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field., 2015年02月, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 16 (2), 2879 - 2892, doi;web_of_science

  • Functions and characteristics of PINK1 and Parkin in cancer

    Satoru Matsuda; Atsuko Nakanishi; Akari Minami; Yoko Wada; Yasuko Kitagishi

    Most of the Parkinson disease (PD) linked genes are also associated with cancers. In particular, phosphatase and tensin homologue-induced kinase 1 (PINK1) and Parkin, both of which are involved in recessively inherited familial forms of PD linked to mitochondrial dysfunction, appear to be abnormally expressed in cancers. Functional studies have revealed that PINK1 recruits Parkin to mitochondria to initiate mitophagy, an important autophagic quality control mechanism that rids the cell of damaged mitochondria. Although PD and cancer are obviously disparate human disorders, there is an evidence for low cancer rates in patients with PD. The relationship between cancer rates and PD might be related to the involvement of common pathways in both diseases. This paper provides a concise overview on the cellular functions of the PINK1 and Parkin., 2015年01月, FRONTIERS IN BIOSCIENCE-LANDMARK, 20, 491 - 501, doi;web_of_science

    研究論文(学術雑誌)

  • Function of α-synuclein and PINK1 in Lewy body dementia

    松田覚

    alpha-synuclein (-syn) is the major protein component of Lewy bodies, a key pathological characteristic of the degenerating brain. The misfolding and aggregation of -syn is associated with both the idiopathic and familial forms of Parkinson's disease (PD) and Lewy body dementia (LBD). However, the function of -syn is poorly understood, as it shows both neurotoxic and neuroprotective activities. Mutations in phosphatase and tensin homologue-induced putative kinase 1 (PINK1) also cause recessively inherited PD. Studies support the notion of neuroprotective roles for PINK1, as it protects cells from damage-induced mitochondrial dysfunction, oxidative stress and cell apoptosis. PINK1 plays an essential role in mitochondrial quality control and its homeostasis is maintained through mitochondrial stabilization. The -syn aggregation is linked to various aspects of mitochondrial dysfunction and PINK1-related mitophagy. Determination of the molecular pathways that lead to -syn oligomerization and further aggregation may be the basis for the successful design and development of treatments for these neurodegenerative diseases. The present review summarizes the function of PINK1 underlying -syn aggregation and the mechanisms through which mitochondrial dysfunction plays a role in this process., 2015年01月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 35 (1), 3 - 9, doi;web_of_science

    研究論文(学術雑誌)

  • Certain Diet and Lifestyle May Contribute to Islet β-cells Protection in Type-2 Diabetes via the Modulation of Cellular PI3K/AKT Pathway.

    松田覚

    2014年11月, Open Biochem J, 8, 74-82, doi

  • Atherosclerosis and tumor suppressor molecules (Review)

    Miho Suzuki; Aicari Minami; Atsuko Nakanishi; Keiko Kobayashi; Satoru Matsuda; Yasunori Ogura; Yasuko Kitagishi

    Atherosclerosis, the major cause of heart attack and stroke, is a chronic inflammatory disease characterized by the formation of atherosclerotic plaque. Oxidized low-density lipoprotein through increased oxidative stress has been identified as one of the primary factors responsible for atherogenesis. Cell proliferation and death are key processes in the progression of atherosclerosis. The oxidative environment in areas of lipid accumulation is mainly created by the production of reactive oxygen species, which are assumed to mediate vascular tissue injury. Oxidative DNA damage and levels of DNA repair are reduced during dietary lipid lowering. The tumor suppressor molecules play a pivotal role in regulating cell proliferation, DNA repair and cell death, which are important processes in regulating the composition of atherosclerotic plaque. Accordingly, in this review, we discuss the fundamental role of tumor suppressor molecules in regulating atherogenesis. In particular, we discuss how tumor suppressor molecules are activated in the complex environment of atherosclerotic plaque, and regulate growth arrest, cell senescence and the apoptosis of vascular smooth muscle cells, which may protect against the progression of atherosclerosis. In addition, we discuss promising alternatives to the use of medications (such as statin) against atherosclerosis, namely diet, with the use of plant-derived supplements to modulate the expression and/or activity of tumor suppressor molecules. We also summarize the progress of research made on herbs with a focus on the modulatory roles of tumor suppressors, and on the molecular mechanisms underlying the prevention if atherosclerosis, supporting designs for further research in this field., 2014年10月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 34 (4), 934 - 940, doi;web_of_science

    研究論文(学術雑誌)

  • The tumor suppressor PTEN interacts with p53 in hereditary cancer (Review)

    Atsuko Nakanishi; Yasuko Kitagishi; Yasunori Ogura; Satoru Matsuda

    Numerous hereditary syndromes caused by mutations in multiple tumor suppressor genes can cause cancers. Germ line mutations in PTEN and p53 tumor suppressor cause Cowden syndrome and Li-Fraumeni syndrome, respectively. There exists some phenotypic overlap in these syndromes, and they are associated with high risks of breast cancer. The tumor suppressor protein PTEN is a dual-specificity phosphatase which has protein phosphatase activity and lipid phosphatase activity that antagonizes PI3K activity. Cells that lack PTEN have constitutively higher levels of PIP3 and activated downstream targets. PTEN gene is recognized as one of the most frequently mutated or mutated in many human cancers. Li-Fraumeni syndrome results from germline mutations of the tumor suppressor p53 gene encoding a transcriptional factor able to regulate cell cycle and apoptosis when DNA damage occurs. The p53 protein cooperates with PTEN and might be an essential blockage in development of mammary tumors. Many findings have demonstrated that PTEN as well as p53 plays a critical role in DNA damage response. This review summarizes the function of PTEN and p53 in carcinogenic cell signaling. In addition, we will discuss the role of PTEN signaling through its interaction with p53 and MDM2 pathways for the potential implications in hereditary cancer prevention and therapeutic intervention., 2014年06月, INTERNATIONAL JOURNAL OF ONCOLOGY, 44 (6), 1813 - 1819, doi;web_of_science

  • Link between PI3K/AKT/PTEN Pathway and NOX Protein in Diseases

    Atsuko Nakanishi; Yoko Wada; Yasuko Kitagishi; Satoru Matsuda

    Accumulating evidence has revealed that the PI3K/AKT/PTEN pathway acts as a pivotal determinant of cell fate regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ROS) generation. NADPH oxidase (NOX) family of enzymes generates the ROS. The regulation of NOX enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. Cells are continuously exposed to the ROS, which represent mutagens and are thought to be a major contributor to several diseases including cancer and aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated by a variety of proteins involved in the redox mechanism. In this review, the roles of oxidative stress in PI3K/AKT/PTEN signaling are summarized with a focus on the links between the pathways and NOX protein in several diseases including cancer and aging., 2014年06月, AGING AND DISEASE, 5 (3), 203 - 211, doi;web_of_science

  • Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease.

    松田覚

    Alzheimer's disease (AD) is characterized by the formation of senile plaques and neurofibrillary tangles composed of phosphorylated Tau. Several findings suggest that correcting signal dysregulation for Tau phosphorylation in AD may offer a potential therapeutic approach. The PI3K/AKT/GSK-3 beta pathway has been shown to play a pivotal role in neuroprotection, enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis. This pathway appears to be crucial in AD because it promotes protein hyper-phosphorylation in Tau. Understanding those regulations may provide a better efficacy of new therapeutic approaches. In this review, we summarize advances in the involvement of the PI3K/AKT/GSK-3 beta pathways in cell signaling of neuronal cells. We also review recent studies on the features of several diets and the signaling pathway involved in AD., 2014年, ALZHEIMERS RESEARCH & THERAPY, 6 (3), 35, doi;web_of_science

  • Connection between tumor suppressor BRCA1 and PTEN in damaged DNA repair

    Akari Minami; Atsuko Nakanishi; Yasunori Ogura; Yasuko Kitagishi; Satoru Matsuda

    Genomic instability finally induces cell death or apoptosis. The tumor suppressor, phosphatase and tensin homolog on chromosome 10 (PTEN), is a dual-specificity phosphatase, which has protein phosphatase activity and lipid phosphatase activity that antagonizes PI3K activity. Cells that lack PTEN have constitutively higher levels of PIP3 and activated downstream PI3K/AKT targets. BRCA1, a well-known breast cancer tumor suppressor, is to associate with breast cancer risk and genetic susceptibility. Many studies have demonstrated that PTEN, as well as BRCA1, plays a critical role in DNA damage responses. The BRCA1 functionally cooperates with PTEN and might be an essential blockage in the development of several tumors. Actually, the PTEN and BRCA1 genes are recognized as one of the most frequently deleted and/or mutated in many human cancers. The PI3K/AKT pathway is constitutively active in BRCA1-defective human cancer cells. Loss or decrease of these PTEN or BRCA1 function, by either mutation or reduced expression, has a role in various tumor developments. This review summarizes recent findings of the function of BRCA1 and PTEN involved in genomic stability and cancer cell signaling., 2014年, Frontiers in Oncology, 4, 318, doi

  • RUFY, rab and rap family proteins involved in a regulation of cell polarity and membrane trafficking

    Yasuko Kitagishi; Satoru Matsuda

    Cell survival, homeostasis and cell polarity rely on the control of membrane trafficking pathways. The RUN domain (comprised of the RPIP8, UNC-14, and NESCA proteins) has been suggested to be implicated in small GTPase-mediated membrane trafficking and cell polarity. Accumulating evidence supports the hypothesis that the RUN domain-containing proteins might be responsible for an interaction with a filamentous network linked to actin cytoskeleton and/or microtubules. In addition, several downstream molecules of PI3K are involved in regulation of the membrane trafficking by interacting with vesicle-associated RUN proteins such as RUFY family proteins. In this review, we summarize the background of RUN domain research with an emphasis on the interaction between RUN domain proteins including RUFY proteins (designated as RUN and FYVE domain-containing proteins) and several small GTPases with respect to the regulation of cell polarity and membrane trafficking on filamentous network. © 2013 by the authors licensee MDPI, Basel, Switzerland., 2013年03月, International Journal of Molecular Sciences, 14 (3), 6487 - 6498, doi

  • Redox regulation of tumor suppressor PTEN in cancer and aging

    松田覚

    2013年01月, Int J Mol Med, 31 (3), 511

  • Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver Disease.

    松田覚

    2013年01月, ISRN Endocrinol, 3013, 472432

  • Expression and function of PPARs in placenta

    Satoru Matsuda; Mayumi Kobayashi; Yasuko Kitagishi

    Peroxisome proliferator-activated receptors (PPAR) are members of the superfamily of nuclear hormone receptors involved in embryonic development and differentiation of several tissues including placenta, which respond to specific ligands such as polyunsaturated fatty acids by altering gene expression. Three subtypes of this receptor have been discovered, each evolving to achieve different biological functions. The PPARs also control a variety of target genes involved in lipid homeostasis. Similar to other nuclear receptors, the transcriptional activity of PPARs is affected not only by ligand-stimulation but also by crosstalk with other molecules. For example, both PPARs and the RXRs are ligand-activated transcription factors that coordinately regulate gene expression. In addition, several mechanisms underlying negative regulation of gene expression by PPARs have been shown. It is suggested that PPARs are key messengers responsible for the translation of nutritional stimuli into changes in gene expression pathways for placental development. © 2013 Satoru Matsuda et al., 2013年, PPAR Research, 2013, 256508, doi

  • Function and Characteristics of PINK1 in Mitochondria

    Satoru Matsuda; Yasuko Kitagishi; Mayumi Kobayashi

    Mutations in phosphatase and tensin homologue-induced kinase 1 (PINK1) cause recessively inherited Parkinson's disease, a neurodegenerative disorder linked to mitochondrial dysfunction. Studies support the notion of neuroprotective roles for the PINK1, as it protects cells from damage-mediated mitochondrial dysfunction, oxidative stress, and cell apoptosis. PARL is a mitochondrial resident rhomboid serine protease, and it has been reported to mediate the cleavage of the PINK1. Interestingly, impaired mitophagy, an important autophagic quality control mechanism that clears the cells of damaged mitochondria, may also be an underlying mechanism of disease pathogenesis in patients for Parkinson's disease with the PARL mutations. Functional studies have revealed that PINK1 recruits Parkin to mitochondria to initiate the mitophagy. PINK1 is posttranslationally processed, whose level is definitely regulated in healthy steady state of mitochondria. As a consequence, PINK1 plays a pivotal role in mitochondrial healthy homeostasis., 2013年, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013, 601587, doi;web_of_science

  • Diets involved in PPAR and PI3K/AKT/PTEN pathway may contribute to neuroprotection in a traumatic brain injury

    Yasuko Kitagishi; Satoru Matsuda

    Traumatic encephalopathy has emerged as a significant public health problem. It is believed that traumatic encephalopathy is caused by exposure to repetitive brain trauma prior to the initial symptoms of neurodegenerative disease. Therefore, prevention is important for the disease. The PI3K/AKT/PTEN (phosphoinositide-3 kinase/AKT/phosphatase and tensin homologue deleted on chromosome 10) pathway has been shown to play a pivotal role in neuroprotection, enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis. PTEN negatively regulates the PI3K/AKT pathways through its lipid phosphatase activity. Although PTEN has been discovered as a tumor suppressor, PTEN is also involved in several other diseases, including diabetes and Alzheimer's disease. Dietary fish oil rich in polyunsaturated fatty acids may induce the PTEN expression by activation of peroxisome proliferator-activated receptor. Supplementation of these natural compounds may provide a new therapeutic approach to the brain disorder. We review recent studies on the features of several diets and the signaling pathways involved in traumatic encephalopathy., 2013年, ALZHEIMERS RESEARCH & THERAPY, 5 (5), 42, doi;web_of_science

  • Peroxisome proliferator-activated receptor and vitamin D receptor signaling pathways in cancer cells

    Satoru Matsuda; Yasuko Kitagishi

    Peroxisome proliferator-activated receptors (PPARs) are members of the superfamily of nuclear hormone receptors, which respond to specific ligands such as polyunsaturated fatty acids by altering gene expression. Three subtypes of this receptor have been discovered, each evolving to achieve different biological functions. Like other nuclear receptors, the transcriptional activity of PPARs is affected not only by ligand-stimulation, but also by cross-talk with other molecules. For example, both PPARs and the RXRs are ligand-activated transcription factors that coordinately regulate gene expression. In addition, PPARs and vitamin D receptor (VDR) signaling pathways regulate a multitude of genes that are of importance for cellular functions including cell proliferation and cell differentiation. Interaction of the PPARs and VDR signaling pathways has been shown at the level of molecular cross-regulation of their transcription factor. A variety of ligands influencing the PPARs and VDR signaling pathways have been shown to reveal chemopreventive potential by mediating tumor suppressive activities in human cancers. Use of these compounds may represent a potential novel strategy to prevent cancers. This review summarizes the roles of the PPARs and the VDR in pathogenesis and progression of cancer., 2013年, Cancers, 5 (4), 1261 - 1270, doi

  • Roles of PI3K/AKT/PTEN pathway as a target for Pharmaceutical therapy

    Satoru Matsuda; Atsuko Nakanishi; Yoko Wada; Yasuko Kitagishi

    Multiple enzymes participate in the phosphorylation of a group of phosphoinositide lipids. Because of their important role in signal transduction, the dysregulated metabolism of phosphoinositides represents a key step in many disease settings. Loss of their function has been demonstrated to occur as an early event a wide variety of carcinogenesis and has therefore been suggested as a biomarker for the premalignant disease. In addition, genetic alterations at multiple nodes in the pathway have been implicated in several other diseases. Accordingly, given this pervasive involvement in many diseases, the development of molecules that modulates this pathway has been initiated in studies. They have been the focus of extensive research and drug discovery activities. A better understanding of the molecular connections could uncover new targets for drug development. © Matsuda et al., 2013年, Open Medicinal Chemistry Journal, 7 (1), 23 - 29, doi

    研究論文(学術雑誌)

  • Elucidating the regulation of T cell subsets (Review)

    Yasuko Kitagishi; Mayumi Kobayashi; Yurie Yamashina; Satoru Matsuda

    CD4-positive T lymphocytes mainly direct immune as well as autoimmune responses against a variety of pathogens or allergens. This is achieved through the acquisition of specialized functions followed by differentiation into various T cell subsets. The differentiation process of naive T cells into effector subsets is regulated by dendritic cells and secreted cytokines. Signal transducer and activator of transcription proteins play critical roles in transmitting cytokine-mediated signals and specifying T cell differentiation. Epigenetic changes such as historic acetylation and methylation along with DNA methylation also regulate expression of differentiation-specific genes. Defining, exactly how extrinsic signals control the specification of T cells will provide important insights and therapeutic opportunities., 2012年12月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 30 (6), 1255 - 1260, doi;web_of_science

    研究論文(学術雑誌)

  • Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells

    Naoko Okumura; Hitomi Yoshida; Yuri Nishimura; Yasuko Kitagishi; Satoru Matsuda

    Protein kinase AKT mediates cell proliferation and survival signals, and also contributes to cancer progression. Increased expression and/or activation of AKT is involved in a variety of human cancers. In cells treated with sage or rosemary extract, mRNA and protein expression levels of AKT1 were reduced compared with those of the control cells 48 h after the herbal treatments. We found that terpinolene, a common component of sage and rosemary, markedly reduced the protein expression of AKT1 in K562 cells and inhibited cell proliferation., 2012年02月, ONCOLOGY LETTERS, 3 (2), 321 - 324, doi;web_of_science

    研究論文(学術雑誌)

  • Clobetasol synergistically diminishes Ciz1 expression with genistein in U937 cells

    Naoko Okumura; Hitomi Yoshida; Yuri Nishimura; Yasuko Kitagishi; Satoru Matsuda

    Cip-interacting zinc finger protein 1 (Ciz1) stimulates DNA replication and has been implicated in the tumorigenesis of breast cancer cells. In order to investigate the possibility of using medicinal glucocorticoids against breast cancer, we studied whether certain glucocorticoids affect the expression of Ciz1. The in vitro effect of clobetasol treatment on the reduction of Ciz1 expression was detected by reverse transcriptase-polymerase chain reaction. Western blotting also confirmed the down-regulation of the protein in a dose-dependent manner upon clobetasol treatment in U937 monocytoid cells. Furthermore, we found that Ciz1 protein expression was decreased after pre-treatment of the cells with clobetasol and genistein. An extract of Lens culinaris also had a synergistic effect on the repression of Ciz1 protein expression., 2012年02月, MOLECULAR MEDICINE REPORTS, 5 (2), 567 - 569, doi;web_of_science

    研究論文(学術雑誌)

  • Genistein downregulates presenilin 1 and ubiquilin 1 expression

    Naoko Okumura; Hitomi Yoshida; Yuri Nishimura; Mutsumi Murakami; Yasuko Kitagishi; Satoru Matsuda

    The aim of this study was to determine the effects of several food ingredients and chemical inhibitors on the expression of presenilin, a molecule involved in gamma-secretase activity and the generation of amyloid-beta peptide in Alzheimer's disease. Western blotting revealed the downregulation of presenilin 1 protein expression by stimulation with genistein in vitro, while the effects on presenilin 1 gene expression examined by reverse transcriptase-polymerase chain reaction (RT-PCR) were unaltered in Daudi cells. Genistein likely downregulates presenilin via the inhibition of ubiquilin 1 expression in lymphoid cells. Our findings provide new insights that may help to establish preventive strategies against Alzheimer's disease., 2012年02月, MOLECULAR MEDICINE REPORTS, 5 (2), 559 - 561, doi;web_of_science

    研究論文(学術雑誌)

  • Clobetasol down-regulates SLPI expression in U937 monocytoid cells

    Naoko Okumura; Hitomi Yoshida; Yasuko Kitagishi; Yuri Nishimura; Satoru Matsuda

    In order to investigate how glucocorticoids affect the expression of secretory leukocyte peptidase inhibitor (SLPI), which is overexpressed in a variety of cancers, clobetasol was added to cell culture medium of U937 cells and the SLPI mRNA levels were examined. The in vitro effect of the treatment on SLPI expression was detected by reverse transcriptase-polymerase chain reaction. Clobetasol treatment of U937 cells induced an up- and down-regulation of SLPI expression in a dose-dependent manner. Western blotting confirmed the down-regulation of SLPI protein expression. We hypothesized a loop formation in the SLPI genome domain, in which the glucocorticoid receptor regulates bi-directional transcriptional activity., 2012年02月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 29 (2), 324 - 326, web_of_science

    研究論文(学術雑誌)

  • PI3K/AKT/PTEN signaling as a molecular target in leukemia angiogenesis

    Naoko Okumura; Hitomi Yoshida; Yasuko Kitagishi; Mutsumi Murakami; Yuri Nishimura; Satoru Matsuda

    PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The mechanism by which the signaling pathway regulates angiogenesis remains to be further elucidated. However, it has become an attractive target for drug therapy against leukemia, because angiogenesis is a key process in malignant cell growth. In this paper, we will focus on the roles and mechanisms of PI3K/AKT/PTEN pathway in regulating angiogenesis. © 2012 Naoko Okumura et al., 2012年, Advances in Hematology, 2012, 843085, doi

  • Alternative splicings on p53, BRCA1 and PTEN genes involved in breast cancer

    Naoko Okumura; Hitomi Yoshida; Yasuko Kitagishi; Yuri Nishimura; Satoru Matsuda

    Alternative splicing is a major contributor to transcriptome and proteome diversity, which can lead to the deregulation of crucial cellular processes and have been associated with a variety of human diseases including cancer. As p53, BRCA1, and PTEN proteins have a key role in preventing breast cancer formation, cancer-associated splicing variants of these tumor suppressor genes are potential molecular markers and may contribute to the development of diagnostic and prognostic methods. In the present review, we summarize these tumor suppressor genes at a viewpoint of alternative splicing involved in breast cancer. (C) 2011 Elsevier Inc. All rights reserved., 2011年09月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 413 (3), 395 - 399, doi;web_of_science

  • Long-term cultivation of in vitro Apis mellifera cells by gene transfer of human c-myc proto-oncogene

    Yasuko Kitagishi; Naoko Okumura; Hitomi Yoshida; Yuri Nishimura; Jun-ichi Takahashi; Satoru Matsuda

    Establishment of cell lines representative of honeybee character would greatly assist in their analysis. Here, we show that immortalized cell line, designated as MYN9, has been generated from honeybee embryo by the gene transfer of human c-myc proto-oncogene. The morphology of the cell is characteristic of embryonic stem cell, although the cell is stable and does not spontaneously differentiate. Polymerase chain reaction analyses show that the cell is originated from authentic honeybee cell. It is proposed that the integration of human c-myc gene into honeybee precursor populations results in the establishment of stable cell line suitable for cellular and molecular studies., 2011年08月, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 47 (7), 451 - 453, doi;web_of_science

    研究論文(学術雑誌)

  • Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells

    Yuri Nishimura; Yasuko Kitagishi; Hitomi Yoshida; Naoko Okumura; Satoru Matsuda

    SIRT1 is a mammalian candidate molecule involved in longevity and diverse metabolic processes. The present study aimed to determine the effects of certain herbs and spices on SIRT1 expression. Human cell lines Daudi, Jurkat, U937 and K562 were cultured in RPMI-1640. Herb and spice powders were prepared and the supernatants were collected. RT-PCR was used to quantify the expression level of the gene. Protein samples were then analyzed by Western blotting. Western blotting revealed the down-regulation of SIRT1 protein expression in Daudi cells treated with extracts of black pepper or turmeric. On the other hand, the effect on the SIRT1 gene expression examined by reverse transcription polymerase chain reaction was unaltered. In conclusion, component(s) of certain herbs and spices may induce the down-regulation of SIRT1 protein., 2011年07月, MOLECULAR MEDICINE REPORTS, 4 (4), 727 - 730, doi;web_of_science

    研究論文(学術雑誌)

  • Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells

    Hitomi Yoshida; Naoko Okumura; Yuri Nishimura; Yasuko Kitagishi; Satoru Matsuda

    In the present study, we aimed to determine the effects of herbs or spices on the expression of presenilin 1, a molecule involved in gamma-secretase activity and the generation of amyloid-beta peptide in Alzheimer's disease. Western blot analysis revealed that presenilin 1 protein expression was down-regulated by stimulation with turmeric or cinnamon extracts in vitro, while the effects on presenilin 1 gene expression examined by reverse transcriptase-polymerase chain reaction were unaltered. Our results showed that curcumin, a component of turmeric, induced the down-regulation of presenilin 1 protein in Jurkat and K562 cell lines., 2011年07月, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2 (4), 629 - 632, doi;web_of_science

    研究論文(学術雑誌)

  • How do you RUN on?

    Hitomi Yoshida; Yasuko Kitagishi; Naoko Okumura; Mutsumi Murakami; Yuri Nishimura; Satoru Matsuda

    RUN domain is present in several proteins related to the functions of Rap and Rab family GTPases. Accumulating evidence supports the hypothesis that RUN domain-containing proteins act as a component of vesicle traffic and might be responsible for an interaction with a filamentous network linked to actin cytoskeleton or microtubules. That is to say, on one hand, RUN domains associate with Rab or Rap family proteins, on the other hand, they also might interact with motor proteins such as kinesin or myosin via intervention molecules. In this review, we summarize the background and current status of RUN domain research with an emphasis on the interaction between RUN domain and motor proteins with respect to the vesicle traffic on filamentous network. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved., 2011年06月, FEBS LETTERS, 585 (12), 1707 - 1710, doi;web_of_science

  • Ethanol extract of Rosemary repressed PTEN expression in K562 culture cells.

    松田覚

    2011年, Int J appl Biol pharm Technol, 2, 316-322

  • Dicer functions in aquatic species.

    松田覚

    2011年, J amino acids, 2011, 782187

  • 奈良近郊で販売された野菜などに含まれる硝酸態窒素量測定および簡便で効果的な除去法の検討

    松田覚; 井関詩緒他

    2010年12月, 日本家政学会誌, 61, 813-817

  • Rab5(Q79L) interacts with the carboxyl terminus of RUFY3

    Hitomi Yoshida; Naoko Okumura; Yasuko Kitagishi; Naoki Shirafuji; Satoru Matsuda

    2010年, INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 6 (2), 187 - 189, web_of_science

  • Ubiquitin and proteasomes are involved in the degradation of cytosolic Doppel protein.

    松田覚

    2010年, Int J Curr Res, 5, 38-40

  • Insulin receptor substrate protein 53 (IRSp53) as a binding partner of antimetastasis molecule NESH, a member of Abelson interactor protein family

    S. Matsuda; S. Yokozaki; H. Yoshida; Y. Kitagishi; N. Shirafuji; N. Okumura

    2008年07月, ANNALS OF ONCOLOGY, 19 (7), 1356 - U2, doi;web_of_science

  • NESH protein expression switches to the adverse effect of imatinib mesylate

    Satoru Matsuda; Yasukatu Ichigotani; Naoko Okumura; Hitomi Yoshida; Yuka Kajiya; Yasuko Kitagishi; Naoki Shirafuji

    2008年06月, MOLECULAR ONCOLOGY, 2 (1), 16 - 19, doi;web_of_science

  • NESH (Abi-3) is pre-sent in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation

    Noriko Hirao; Seiichi Sato; Tetsuya Gotoh; Masahiro Maruoka; Jun Suzuki; Satoru Matsuda; Tornoyuki Shishido; Katsuko Tani

    Abl interactor (Abi) was identified as an Abl tyrosine kinase-binding protein and subsequently shown to be a component of the macromolecular Abi/WAVE complex, which is a key regulator of Rae-dependent actin polymerization. Previous studies showed that Abi-1 promotes c-Ab1-mediated phosphorylation of Mammalian Enabled (Mena) and WAVE2. In addition to Abi-1, mammals possess Abi-2 and NESH (Abi-3). In this study, we compared the three Abi proteins in terms of the promotion of c-Abl-mediated phosphorylation and the formation of Abi/WAVE complex. Although Abi-2, like Abi-1, promoted the c-Abl-mediated phosphorylation of Mena and WAVE2, NESH (Abi-3) had no such effect. This difference was likely due to their binding abilities as to c-Abl. Immunoprecipitation revealed that NESH (Abi-3) is present in the Abi/WAVE complex. Our results suggest that NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved., 2006年11月, FEBS LETTERS, 580 (27), 6464 - 6470, doi;web_of_science

    研究論文(学術雑誌)

  • Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control

    K Okochi; T Suzuki; J Inoue; S Matsuda; T Yamamoto

    Tob is a member of an emerging family of anti-proliferative proteins that suppress cell growth when over-expressed. tob mRNA is highly expressed in anergic T cells and over-expression of Tob suppresses transcription of interleukin-2 (IL-2) through its interaction with Smads. Here, we identified two types of cDNA clones coding for poly(A)-binding protein (PABP) and inducible PABP (iPABP) by screening an expression cDNA library with the GST-Tob probe. Co-immunoprecipitation and GST-pull down experiments showed that Tob associated with the carboxyl-terminal region of iPABP. We then found that iPABP, like PABP, was involved in regulation of translation: iPABP enhanced translation of IL-2 mRNA in vitro. The enhanced translation of IL-2 mRNA required the 3'UTR and poly(A) sequences. Tob abrogated the enhancement of translation through its interaction with carboxyl-terminal region of iPABP in vitro. Consistently, over-expression of Tob in NIH3T3 cells, in which exogenous iPABP was stably expressed, resulted in suppression of IL-2 production from the simultaneously transfected IL-2 expression plasmid. Finally, Tob, whose expression was induced by anergic stimulation, was co-immunoprecipitated with iPABP in human T cells. These findings suggest that Tob is involved in the translational suppression of IL-2 mRNA in anergic T cells through its interaction with iPABP., 2005年02月, GENES TO CELLS, 10 (2), 151 - 163, doi;web_of_science

    研究論文(学術雑誌)

  • Intercept-PCR, an improvement for elevating performance to find a new member of a certain gene family

    S. Matsuda; Y. Ichigotani; T. Okuda; K. Miyazaki; T. Yamamoto; Y. Nimura; T. Irimura; S. Nakatsugawa; M. Hamaguchi

    We have established a method by which the performance of reverse transcriptase coupled polymerase chain reaction (RT-PCR) for seeking a new gene is improved. The actual procedure is quite easy: it is only to add several specific oligonucleotides into the reaction mixture of the usual RT-PCR. To verify the effectiveness of this method is also easy: it is only to detect the PCR products in the preliminary experiment. The finding in the present study provides valuable information for gene cloning tactics., 2000年, Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology, 16 (1), 1 - 4, pubmed

    研究論文(学術雑誌)

  • Prevention in Daily Life against Progression of COVID-19.

    Murakami M; Ikeda Y; Tsuji A; Matsuda S

    2020年07月

  • Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review)

    Satoru Matsuda; Mutsumi Murakami; Yuka Ikeda; Yukie Nakagawa; Ai Tsuji; Yasuko χ Yasuko kitagishi

    2020年06月17日, Biomedical Reports, doi

    研究論文(学術雑誌)

  • Special bioactive compounds and functional foods may exhibit neuroprotective effects in patients with dementia (Review)

    Mutsumi Murakami; Yuka Ikeda; Yukie Nakagawa; Ai Tsuji; Yasuko Kitagishi; Satoru Matsuda

    2020年06月02日, Biomedical Reports, doi

    研究論文(学術雑誌)

  • Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling (Review)

    Yuka Ikeda; Mutsumi Murakami; Yukie Nakagawa; Ai Tsuji; Yasuko Kitagishi; Satoru Matsuda

    2020年04月22日, Biomedical Reports, doi

    研究論文(学術雑誌)

  • Is Lockdown Effective Against Fatality of COVID-19?

    Satoru Matsuda

    2020年07月17日, Biomedical Journal of Scientific & Technical Research, 28 (5), doi

    研究論文(学術雑誌)

  • Save Children from Mortal Shock of COVID-19

    Satoru Matsuda; Yuka Ikeda; Mutsumi Murakami; Ai Tsuji

    Letter to the Editor, 2020年06月05日, Journal of Advances in Medicine and Medical Research, 23 - 25, doi;url;url

    研究論文(学術雑誌)

  • COVID-19, an infertility risk?

    Ai Tsuji; Yuka Ikeda; Mutsumi Murakami; Satoru Matsuda

    2020年, Clinical Obstetrics, Gynecology and Reproductive Medicine, 6 (3), doi

    研究論文(学術雑誌)

  • Cigarette smoke may be an exacerbation factor in nonalcoholic fatty liver disease via modulation of the PI3K/AKT pathway

    Mayuko Ichimura; Akari Minami; Noriko Nakano; Yasuko Kitagishi; Toshiyuki Murai; Satoru Matsuda

    2015年, AIMS Molecular Science, 2 (4), 427 - 439, doi;url

    研究論文(学術雑誌)

  • A role for SHPS-1/SIRPα1 in IL-1β- and TNFα-dependent signaling

    Ali Reja Mohammad Ruhul Amin; Kazuya Machida; Kumi Oshima; Myat Lin Oo; Aye Aye Thant; Takeshi Senga; Satoru Matsuda; Anwarul Azim Akhand; Akito Maeda; Tomohiro Kurosaki; Michinari Hamaguchi

    2002年12月, Oncogene, 21 (57), 8871 - 8878, doi;url;url

    研究論文(学術雑誌)

  • Expression of p73 gene, cell proliferation and apoptosis in breast cancer: Immunohistochemical and clinicopathological study

    Tatsuyoshi Yamamoto; Koji Oda; Tomoyuki Kubota; Kou Miyazaki; Yasushi Takenouti; Yuji Nimura; Michinari Hamaguchi; Satoru Matsuda

    2002年08月, Oncol Rep ., 9 (4), 729 - 735

  • SHPS-1: a budding molecule against cancer dissemination.

    Oshima K; Machida K; Ichigotani Y; Nimura Y; Shirafuji N; Hamaguchi M; Matsuda S

    2002年07月, Cancer Res., 62 (14), 3929 - 3933

  • Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90

    Zhang Y; Thant AA; Machida K; Ichigotani Y; Naito Y; Hiraiwa Y; Senga T; Sohara Y; Matsuda S; Hamaguchi M

    2002年07月, Cancer Res., 62 (14), 3962 - 3965

  • In search of a function for the E3B1/Abi2/Argbp1/NESH family

    Ichigotani Y; Fujii K; Hamaguchi M; Matsuda S

    2002年06月, 9 (6), 591 - 595

  • SHPS-1, a multifunctional transmembrane glycoprotein

    Kumi Oshima; A.R.M Ruhul Amin; Atsushi Suzuki; Michinari Hamaguchi; Satoru Matsuda

    2002年05月22日, FEBS Letters, 519 (1-3), 1 - 7, doi;url

    研究論文(学術雑誌)

  • Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells

    Ichigotani Y; Yokozaki S; Fukuda Y; Hamaguchi M; Matsuda S

    2002年04月, Cancer Res., 62 (8), 2215 - 2219

  • A Role for Focal Adhesion Kinase in Hyluronan-Dependent MMP-2 Secretion in a Human Small-Cell Lung Carcinoma Cell Line, QG90

    Yanying Zhang; Aye Aye Thant; Yukiko Hiraiwa; Yuko Naito; Thet Thet Sein; Yasuyoshi Sohara; Satoru Matsuda; Michinari Hamaguchi

    2002年01月, Biochemical and Biophysical Research Communications, 290 (3), 1123 - 1127, doi

    研究論文(学術雑誌)

  • STAT and SMAD signaling in cancer.

    Iwamoto T; Oshima K; Seng T; Feng X; Oo ML; Hamaguchi M; Matsuda S

    2002年, Histol Histopathol., 17 (3), 887 - 895

  • Suppression of cell spreading by v-Crk requires Ras-MEK-MAP kinase signaling

    Yuzhen Liu; Yukiko Hiraiwa; Enbo Liu; Hisashi Kurata; Aye Aye Thant; Satoru Matsuda; Michinari Hamaguchi

    2001年09月, Oncogene, 20 (41), 5908 - 5912, doi;url;url

    研究論文(学術雑誌)

  • p73 is highly expressed in myoepithelial cells and in carcinomas with metaplasia

    Tatsuyoshi Yamamoto; Koji Oda; Kou Miyazaki; Yasukatu Ichigotani; Yasushi Takenouchi; Tomotaka Kamei; Naoki Shirafuji; Yuji Nimura; Michinari Hamaguchi; Satoru Matsuda

    2001年08月01日, International Journal of Oncology, doi;url

    研究論文(学術雑誌)

  • Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3

    S. Matsuda; C. Iriyama; S. Yokozaki; Y. Ichigotani; N. Shirafuji; K. Yamaki; T. Hayakawa; M. Hamaguchi

    2001年08月, Journal of Human Genetics, 46 (8), 483 - 486, doi;url;url

    研究論文(学術雑誌)

  • Hyaluronan Activates Cell Motility of v-Src-transformed Cells via Ras-Mitogen–activated Protein Kinase and Phosphoinositide 3-Kinase-Akt in a Tumor-specific Manner

    Yasuyoshi Sohara; Naoki Ishiguro; Kazuya Machida; Hisashi Kurata; Aye Aye Thant; Takeshi Senga; Satoru Matsuda; Koji Kimata; Hisashi Iwata; Michinari Hamaguchi

    We investigated the production of hyaluronan (HA) and its effect on cell motility in cells expressing the v-src mutants. Transformation of 3Y1 by v-src virtually activated HA secretion, whereas G2A v-src, a nonmyristoylated form of v-src defective in cell transformation, had no effect. In cells expressing the temperature-sensitive mutant of v-Src, HA secretion was temperature dependent. In addition, HA as small as 1 nM, on the other side, activated cell motility in a tumor-specific manner. HA treatment strongly activated the motility of v-Src–transformed 3Y1, whereas it showed no effect on 3Y1- and 3Y1-expressing G2A v-src. HA-dependent cell locomotion was strongly blocked by either expression of dominant-negative Ras or treatment with a Ras farnesyltransferase inhibitor. Similarly, both the MEK1 inhibitor and the kinase inhibitor clearly inhibited HA-dependent cell locomotion. In contrast, cells transformed with an active MEK1 did not respond to the HA. Finally, an anti-CD44–neutralizing antibody could block the activation of cell motility by HA as well as the HA-dependent phosphorylation of mitogen-activated protein kinase and Akt. Taken together, these results suggest that simultaneous activation of the Ras-mitogen-activated protein kinase pathway and the phosphoinositide 3-kinase pathway by the HA-CD44 interaction is required for the activation of HA-dependent cell locomotion in v-Src–transformed cells., 2001年06月, Molecular Biology of the Cell, 12 (6), 1859 - 1868, doi

    研究論文(学術雑誌)

  • Cloning and sequencing of a novel human gene which encodes a putative hydroxylase

    C. Iriyama; S. Matsuda; R. Katsumata; M. Hamaguchi

    2001年04月, Journal of Human Genetics, 46 (5), 289 - 292, doi;url;url

    研究論文(学術雑誌)

  • A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob

    Toru Suzuki; Satoru Matsuda; Junko K. Tsuzuku; Yutaka Yoshida; Tadashi Yamamoto

    2001年02月, Genes to Cells, 6 (2), 131 - 138, doi;url

    研究論文(学術雑誌)

  • A role for FAK in the Concanavalin A-dependent secretion of matrix metalloproteinase-2 and -9

    Thet Thet Sein; Aye Aye Thant; Yukiko Hiraiwa; ARM Ruhul Amin; Yasuyoshi Sohara; Yuzhen Liu; Satoru Matsuda; Tadashi Yamamoto; Michinari Hamaguchi

    2000年11月, Oncogene, 19 (48), 5539 - 5542, doi;url;url

    研究論文(学術雑誌)

  • Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family

    Y. Ichigotani; S. Matsuda; K. Machida; K. Oshima; T. Iwamoto; K. Yamaki; T. Hayakawa; M. Hamaguchi

    2000年11月, Journal of Human Genetics, 45 (6), 378 - 382, doi;url;url

    研究論文(学術雑誌)

  • Constitutive Tyrosine Phosphorylation of ErbB-2 via Jak2 by Autocrine Secretion of Prolactin in Human Breast Cancer

    Toshimasa Yamauchi; Naoko Yamauchi; Kohjiro Ueki; Takuya Sugiyama; Hironori Waki; Hiroshi Miki; Kazuyuki Tobe; Satoru Matsuda; Toshio Tsushima; Tadashi Yamamoto; Toshiro Fujita; Yuji Taketani; Masashi Fukayama; Satoshi Kimura; Yoshio Yazaki; Ryozo Nagai; Takashi Kadowaki

    2000年10月, Journal of Biological Chemistry, 275 (43), 33937 - 33944, doi;url

    研究論文(学術雑誌)

  • The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK–STAT activation

    Takashi Iwamoto; Takeshi Senga; Yuko Naito; Satoru Matsuda; Yozo Miyake; Akihiko Yoshimura; Michinari Hamaguchi

    2000年09月, Oncogene, 19 (41), 4795 - 4801, doi;url;url

    研究論文(学術雑誌)

  • C-Cbl protein in human cancer tissues is frequently tyrosine phosphorylated in a tumor-specific manner.

    T Kamei; K Machida; Y Nimura; T Senga; I Yamada; S Yoshii; S Matsuda; M Hamaguchi

    2000年08月01日, International Journal of Oncology, doi;url

    研究論文(学術雑誌)

  • The Ras-mitogen-activated protein kinase pathway is critical for the activation of matrix metalloproteinase secretion and the invasiveness in v-crk-transformed 3Y1.

    Liu E; Thant AA; Kikkawa F; Kurata H; Tanaka S; Nawa A; Mizutani S; Matsuda S; Hanafusa H; Hamaguchi M

    2000年05月, Cancer Res., 60 (9), 2361 - 2364

  • Clustered cysteine residues in the kinase domain of v-Src: critical role for protein stability, cell transformation and sensitivity to herbimycin A

    Takeshi Senga; Kou Miyazaki; Kazuya Machida; Hiroyuki Iwata; Satoru Matsuda; Izumi Nakashima; Michinari Hamaguchi

    2000年01月, Oncogene, 19 (2), 273 - 279, doi;url;url

    研究論文(学術雑誌)

  • Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1

    Aye Aye Thant; Thet Thet Sein; Enbo Liu; Kazuya Machida; Fumitaka Kikkawa; Teruhiko Koike; Motoharu Seiki; Satoru Matsuda; Michinari Hamaguchi

    1999年11月, Oncogene, 18 (47), 6555 - 6563, doi;url;url

    研究論文(学術雑誌)

  • Critical Amino Acid Substitutions in the Src SH3 Domain That Convert c-Src to Be Oncogenic

    Kou Miyazaki; Takeshi Senga; Satoru Matsuda; Miho Tanaka; Kazuya Machida; Yasushi Takenouchi; Yuji Nimura; Michinari Hamaguchi

    1999年10月, Biochemical and Biophysical Research Communications, 263 (3), 759 - 764, doi

    研究論文(学術雑誌)

  • Molecular Cloning of Macrophin, a Human Homologue of Drosophila Kakapo with a Close Structural Similarity to Plectin and Dystrophin

    Takahito Okuda; Satoru Matsuda; Shigekazu Nakatsugawa; Yasukatu Ichigotani; Naoko Iwahashi; Masahide Takahashi; Takeo Ishigaki; Michinari Hamaguchi

    1999年10月, Biochemical and Biophysical Research Communications, 264 (2), 568 - 574, doi

    研究論文(学術雑誌)

  • ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system

    Yutaka Yoshida; Satoru Matsuda; Naoko Ikematsu; Junko Kawamura-Tsuzuku; Johji Inazawa; Hisashi Umemori; Tadashi Yamamoto

    1998年05月, Oncogene, 16 (20), 2687 - 2693, doi;url;url

    研究論文(学術雑誌)

  • Suppression of cell growth by ectopic expression of N-cadherin.

    X Wang; A A Thant; K Machida; Y Hiraiwa; H Iwata; S Matsuda; M Hamaguchi

    1998年05月01日, International Journal of Oncology, doi;url

    研究論文(学術雑誌)

  • Homozygous deletion and frequent allelic loss of the 21q11.1-q21.1 region including theANA gene in human lung carcinoma

    Takashi Kohno; Masashi Kawanishi; Satoru Matsuda; Hitoshi Ichikawa; Minoru Takada; Misao Ohki; Tadashi Yamamoto; Jun Yokota

    1998年03月, Genes, Chromosomes and Cancer, 21 (3), 236 - 243, doi;url

    研究論文(学術雑誌)

  • Inhibition of Human Pancreatic Cancer Growth by the Adenovirus-Mediated Introduction of a Novel Growth Suppressing Gene, tob, In Vitro

    Hironobu Yanagie; H. Sumimoto; Y. Nonaka; S. Matsuda; I. Hirose; S. Hanada; H. Sugiyama; S. Mikamo; Y. Takeda; I. Yoshizaki; K. Nakazawa; K. Tani; T. Yamamoto; S. Asano; M. Eriguchi; T. Muto

    1998年, Advances in Experimental Medicine and Biology, 91 - 96, doi;url

    論文集(書籍)内論文

  • Molecular Cloning and Characterization of a Novel Cytoplasmic Protein-tyrosine Phosphatase That Is Specifically Expressed in Spermatocytes

    Miho Ohsugi; Satomi Kuramochi; Satoru Matsuda; Tadashi Yamamoto

    1997年12月, Journal of Biological Chemistry, 272 (52), 33092 - 33099, doi;url

    研究論文(学術雑誌)

  • Mitochondrial antisense RNA for cytochrome C oxidase (MARCO) can induce morphologic changes and cell death in human hematopoietic cell lines

    Shirafuji N; Takahashi S; Matsuda S; Asano S

    1997年12月, 90 (11), 4567 - 4577

  • A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies

    Akiko Fujimoto-Nishiyama; Shunsuke Ishii; Satoru Matsuda; Jun-ichiro Inoue; Tadashi Yamamoto

    1997年08月, Gene, 195 (2), 267 - 275, doi

    研究論文(学術雑誌)

  • Cloning and characterization of the mouse tob gene

    Yutaka Yoshida; Satoru Matsuda; Tadashi Yamamoto

    1997年05月, Gene, 191 (1), 109 - 113, doi

    研究論文(学術雑誌)

  • Molecular cloning and characterization of Byp, a murine receptor-type tyrosine phosphatase similar to human DEP-1

    Satomi Kuramochi; Satoru Matsuda; Yoichi Matsuda; Toshiyuki Saitoh; Miho Ohsugi; Tadashi Yamamoto

    1996年01月02日, FEBS Letters, 378 (1), 7 - 14, doi;url

    研究論文(学術雑誌)

  • Characterization of p59fyn-mediated signal transduction on T cell activation

    Noemi Fusaki; Kentaro Semba; Takuya Katagiri; Gen Suzuki; Satoru Matsuda; Tadashi Yamamoto

    1994年, International Immunology, 6 (8), 1245 - 1255, doi;url

    研究論文(学術雑誌)

  • 17 beta-estradiol mimics ligand activity of the c-erbB2 protooncogene product.

    S. Matsuda; Y. Kadowaki; M. Ichino; T. Akiyama; K. Toyoshima; T. Yamamoto

    1993年11月15日, Proceedings of the National Academy of Sciences, 90 (22), 10803 - 10807, doi;url

    研究論文(学術雑誌)

  • Detection of the Ligand Activity of thec-erbB-2Protein in Calf Serum

    RuJiao Shan; Satoru Matsuda; Motohide Ichino; Tadashi Yamamoto

    1992年01月, Japanese Journal of Cancer Research, 83 (1), 15 - 19, doi;url

    研究論文(学術雑誌)

  • Active c-erbB-2 induces short-term growth of FDC-P2 cells after IL-3 depletion

    Budsaba Wongsasant; Satoru Matsuda; Tadashi Yamamoto

    1991年12月, Biochemical and Biophysical Research Communications, 181 (3), 981 - 988, doi

    研究論文(学術雑誌)

  • Granulocyte colony-stimulating factor stimulates human mature neutrophilic granulocytes to produce interferon-alpha

    Shirafuji N; Matsuda S; Ogura H; Tani K; Kodo H; Ozawa K; Nagata S; Asano S; Takaku F

    1990年01月, 75 (1), 17 - 19

  • Human granulocyte colony-stimulating factor specifically binds to murine myeloblastic NFS-60 cells and activates their guanosine triphosphate binding proteins/adenylate cyclase system

    Matsuda S; Shirafuji N; Asano S

    1989年11月, 74 (7), 2343 - 2348

  • A new bioassay for human granulocyte colony-stimulating factor (hG-CSF) using murine myeloblastic NFS-60 cells as targets and estimation of its levels in sera from normal healthy persons and patients with infectious and hematological disorders.

    Shirafuji N; Asano S; Matsuda S; Watari K; Takaku F; Nagata S

    1989年02月, Journal of Biological Chemistry, 17 (2), 116 - 119, doi;url

    研究論文(学術雑誌)

  • Production of granulocyte colony-stimulating factor by acute myelomonocytic leukemia cells

    Naoki Shirafuji; Shigetaka Asano; Koji Kozai; Satoshi Takahashi; Satoru Matsuda; Fumimaro Takaku; Shigekazu Nagata

    1988年01月, Leukemia Research, 12 (9), 745 - 750, doi

    研究論文(学術雑誌)

MISC

  • Neuron membrane trafficking and protein kinases involved in autism and ADHD

    Yasuko Kitagishi; Akari Minami; Atsuko Nakanishi; Yasunori Ogura; Satoru Matsuda

    A brain-enriched multi-domain scaffolding protein, neurobeachin has been identified as a candidate gene for autism patients. Mutations in the synaptic adhesion protein cell adhesion molecule 1 (CADM1) are also associated with autism spectrum disorder, a neurodevelopmental disorder of uncertain molecular origin. Potential roles of neurobeachin and CADM1 have been suggested to a function of vesicle transport in endosomal trafficking. It seems that protein kinase B (AKT) and cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) have key roles in the neuron membrane trafficking involved in the pathogenesis of autism. Attention deficit hyperactivity disorder (ADHD) is documented to dopaminergic insufficiencies, which is attributed to synaptic dysfunction of dopamine transporter (DAT). AKT is also essential for the DAT cell-surface redistribution. In the present paper, we summarize and discuss the importance of several protein kinases that regulate the membrane trafficking involved in autism and ADHD, suggesting new targets for therapeutic intervention., MDPI AG, 2015年01月30日, International Journal of Molecular Sciences, 16 (2), 3095 - 3115, doi;pubmed

    書評論文,書評,文献紹介等

  • PI3K/AKT/PTEN pathway as a target for Crohn's disease therapy (Review)

    Nana Tokuhira; Yasuko Kitagishi; Miho Suzuki; Akari Minami; Atsuko Nakanishi; Yuna Ono; Keiko Kobayashi; Satoru Matsuda; Yasunori Ogura

    The pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease, is a subject of increasing interest. Loss-of-function mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) are strong genetic factors linked to Crohn's disease, which eventually leads to an excessive mucosal inflammatory response directed against components of normal gut microbiota. Reactive oxygen species (ROS) play an important role in inflammation processes, as well as in transduction of signals from receptors for several cytokines, such as tumor necrosis factor α (TNFα). ROS activate nuclear factor-κB (NF-κB) via IκB kinase (IKK) through the PI3K/AKT/PTEN pathway. Therefore, this pathway is recognized to play a key role in Crohn's disease. Loss of function has been demonstrated to occur as an early event in a wide variety of diseases. Given this prevalent involvement in a number of diseases, the molecular development that modulates this pathway has been the subject of several studies. In addition, it has been the focus of extensive research and drug discovery activities. A better understanding of the molecular assemblies may reveal novel targets for the therapeutic development against Crohn's disease., Spandidos Publications, 2015年01月01日, International Journal of Molecular Medicine, 35 (1), 10 - 16, doi;pubmed

    書評論文,書評,文献紹介等

  • Defective DNA repair systems and the development of breast and prostate cancer (Review)

    Yasuko Kitagishi; Mayumi Kobayashi; Satoru Matsuda

    Genetic defects in DNA repair and DNA damage response genes often lead to an increase in cancer incidence. The role of defects is also associated with the modulation of hormone signaling pathways. A number of studies have suggested a role for estrogen in the regulation of DNA repair activity. Furthermore, mutations or epigenetic silencing in DNA repair genes have been associated with the sensitivity of cancers to hormonal therapy. The molecular basis for the progression of cancers from hormone-dependent to hormone-independent remains a critical issue in the management of these types of cancer. In the present review, we aimed to summarize the function of DNA repair molecules from the viewpoint of carcinogenesis and hormone-related cell modulation, providing a comprehensive view of the molecular mechanisms by which hormones may exert their effects on the regulation of tumor progression., 2013年01月, International Journal of Oncology, 42 (1), 29 - 34, doi;pubmed

    書評論文,書評,文献紹介等

  • ヒト白血球培養細胞におけるグルタミン酸デカルボキシラーゼの発現様式の解析

    植野 洋志; 菊田 香苗; 通山 由美; 松川 聡子; 松田 覚; 赤桐 里美

    2013年, ビタミン, 87, 147 - 151, doi

  • Protection against cancer with medicinal herbs via activation of tumor suppressor

    Yasuko Kitagishi; Mayumi Kobayashi; Satoru Matsuda

    Cancer remains a major cause of death, although research is ongoing for the development of more effective drugs. Some herbs have shown potential in preventing the occurrence and/or progression of cancer and other chronic diseases. They are being screened comprehensively to explore the possibility of development of feasible anticancer drugs. However, more information is required about the response to and the molecular target for specific herbs. It seems that there is a relationship between some medicinal herbs and tumor suppressor molecules which protect a cell from cancer. In this paper, we summarize the progress of recent research on herbs, with a particular focus on its anticancer role and molecular mechanisms underlying the cancer prevention property, supporting design for further research in this field. © 2012 Yasuko Kitagishi et al., 2012年, Journal of Oncology, doi

    書評論文,書評,文献紹介等

  • In search of a function for the TIS21/PC3/BTG1/TOB family

    S Matsuda; JP Rouault; JP Magaud; C Berthet

    The Btg family of anti-proliferative gene products includes Pc3/Tis21/Btg2, Btg1, Tob, Tob2, Ana/Btg3, Pc3k and others. These proteins are characterized by similarities in their amino-terminal region: the Btg1 homology domain. However, the pleiotropic nature of these family proteins has been observed and no common physiological function among family members was suggested from the history of their identification. Recent progress in the search for Btg family functions has come from the analysis of cell regulation and of cell differentiation. It is now emerging that every member of this family has a potential to regulate cell growth. We would like to propose here to use a nomenclature APRO as a new term for the family. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B,V, All rights reserved., ELSEVIER SCIENCE BV, 2001年05月, FEBS LETTERS, 497 (2-3), 67 - 72, web_of_science

    書評論文,書評,文献紹介等

  • Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3

    S Matsuda; K Miyazaki; Y Ichigotani; H Kurata; Y Takenouchi; T Yamamoto; Y Nimura; T Irimura; S Nakatsugawa; M Hamaguchi

    A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1990 bp and has a predicted open reading frame encoding 433 amino acids. It possesses an Src homology 3 (SH3) motif, a leucine zipper motif and no catalytic domain, suggesting that it seems to be an adapter protein. PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 1q21-22. (C) 2000 Elsevier Science B.V. All rights reserved., ELSEVIER SCIENCE BV, 2000年04月, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1491 (1-3), 321 - 326, web_of_science

  • Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer

    S Matsuda; R Katsumata; T Okuda; T Yamamoto; K Miyazaki; T Senga; K Machida; AA Thant; S Nakatsugawa; M Hamaguchi

    A full-length cDNA clone encoding a novel protein containing WD-40 repeats, which were frequently involved in protein-protein interactions, was isolated and-sequenced. This clone had a predicted open reading frame (ORF) encoding 350 amino acids possessing six repeats of WD-40 motif, It was most closely homologous to TRIP-1, a phosphorylation substrate of the transforming growth factor-beta type II receptor. In the process of characterizing the function of the new gene product, we found that overexpression of the gene seemed to activate mitogen-activated protein kinase and to promote anchorage-independent growth of the cells, Moreover, the gene product was frequently overexpressed in human tumor breast tissues compared with their normal breast tissues, suggesting that the gene might be involved in the tumor progression, Radiation hybrid mapping placed the gene into human chromosome 12q11-12 near the marker D12S1593., AMER ASSOC CANCER RESEARCH, 2000年01月, CANCER RESEARCH, 60 (1), 13 - 17, web_of_science

  • Molecular cloning and characterization of a novel human gene (HERNA) which encodes a putative RNA-helicase

    S Matsuda; Y Ichigotani; T Okuda; T Irimura; S Nakatsugawa; M Hamaguchi

    A full-length cDNA encoding a novel protein was isolated and sequenced from a human hepatocellular cDNA library. This cDNA consists of 7037 base pairs and has a predicted open reading frame encoding 1924 amino acids. It possesses an RNA-helicase motif containing a DEXH-box in its amino-terminus and an RNase motif in the carboxy-terminus. From a striking homology to Caenorhabditis elegans K12H4.8, it might be a human homolog of the K12H4.8. PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 14q31 near the marker D14S605. (C) 2000 Elsevier Science B.V. All rights reserved., ELSEVIER SCIENCE BV, 2000年01月, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1490 (1-2), 163 - 169, web_of_science

  • c‐Src及びv‐SrcのSH3ドメイン 癌化能・基質特異性の比較

    宮崎耕; 松田覚; 二村雄次; 浜口道成

    1999年08月30日, 日本癌学会総会記事, 58th, 521 - 521, j_global

  • 遺伝子診断 Srcチロシンキナーゼ

    松田覚; 宮崎耕; 浜口道成

    1999年01月, 臨床検査, 43 (1), 75 - 80, doi;j_global

  • 紫外線・重金属等の環境変動の細胞内情報伝達に重要な役割を担っているチロシンキナーゼの環境科学的意義

    松田覚; 浜口道成

    1997年, 環境科学会年会一般講演・シンポジウム・プログラム, 1997, 224 - 225, j_global

  • Tob, a novel protein that interacts with p185(erbB2), is associated with antiproliferative activity

    S Matsuda; J KawamuraTsuzuku; M Ohsugi; M Yoshida; M Emi; Y Nakamura; M Onda; Y Yoshida; A Nishiyama; T Yamamoto

    We have molecularly cloned a cDNA for a novel protein termed Tob (Transducer of ErbB-2) that interacts with the c-erbB-2 gene product p185(erbB2). Nucleotide sequencing reveals that the Tob protein is a 45 kDa protein that does not contain either SH2 (Src Homology 2) or SH3 domain but is homologous to the previously characterized anti-proliferative gene product BTG-1 at its amino-terminal half. The carboxyl-terminal half of Tob is characterized by the presence of a sequence rich in proline and glutamine and shows no homology to known proteins. Like BTG-1, exogenously expressed Tob is able to suppress growth of NIH3T3 cells, but the growth suppression is hampered by the presence of kinase-active p185(erbB2). By using the GST-Tob protein that contains either full length or amino-terminal half of Tob, we show that the carboxyl-terminal half of Tob is relevant to its interaction with p185(erbB2). Furthermore, we could co-immunoprecipitate the Tob protein with anti-ErbB-2 antibody, and reciprocally the p185(erbB2). With anti-Tob antibodies. These data suggest that p185(erbB2) negatively regulates the Tob-mediated anti-proliferative pathway through its interaction with Tob, resulting possibly in growth stimulation by p185(erbB2). Finally, expression of the Tob mRNA is observed in various cell types and is not correlated with expression of c-erbB-2, suggesting that other receptor-type protein-tyrosine kinases are also involved in the Tob-mediated regulation of cell growth., STOCKTON PRESS, 1996年02月, ONCOGENE, 12 (4), 705 - 713, web_of_science

書籍等出版物

  • 食物科学概論

    松田覚 他 (, 範囲: 分担)

    朝倉書店, 2014年03月

  • 高校生物基礎

    松田覚 (, 範囲: 監修)

    実教出版, 2012年01月

  • 未来を拓く理数教育への挑戦―奈良女子大学附属中等教育学校

    松田覚; 吉田 信也 (, 範囲: 編集)

    文理閣, 2010年07月

  • 恋愛食ー賢い女子中高生のための食育

    松田覚他 (, 範囲: 編集)

    久美, 2006年02月

  • 食 up to date

    松田覚

    金芳堂, 2005年01月

担当経験のある科目(授業)

  • 分子食医化学演習 (奈良女子大学)

  • 食品貯蔵学 (奈良女子大学)

  • 病態内科学 (奈良女子大学)

  • キャリアデザイン・ゼミナールA(33) (奈良女子大学)

  • キャリアデザイン・ゼミナールA(13) (奈良女子大学)

  • キャリアデザイン・ゼミナールA(12) (奈良女子大学)

  • 分子食医化学 (奈良女子大学)

  • 臨床栄養学総論 (奈良女子大学)

  • キャリアデザイン・ゼミナールA(32) (奈良女子大学)

  • キャリアデザイン・ゼミナールA(23) (奈良女子大学)

  • キャリアデザイン・ゼミナールA(11) (奈良女子大学)

  • 病態生理・生化学実験 (奈良女子大学)

  • 分子生活習慣病論演習 (奈良女子大学)

  • 食医化学演習 (奈良女子大学)

  • 食品生物工学 (奈良女子大学)

  • 分子生活習慣病論 (奈良女子大学)

  • 食医化学 (奈良女子大学)

  • 基礎栄養学実験 (奈良女子大学)

  • 生化学Ⅰ (奈良女子大学)

所属学協会

  • 日本分子生物学会

  • 日本生化学会

  • 日本癌学会

  • 日本家政学会



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