研究者総覧

中田 理恵子 (ナカタ リエコ)

  • 研究院生活環境科学系食物栄養学領域 准教授
メールアドレス:
r-nakatacc.nara-wu.ac.jp
Last Updated :2021/06/02

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学位

  • 家政学修士, 奈良女子大学
  • 学術博士, 奈良女子大学

研究キーワード

  • 食品機能成分 ビタミン 葉酸 栄養 

研究分野

  • ライフサイエンス, 栄養学、健康科学
  • 人文・社会, 家政学、生活科学

経歴

  • 1994年 -:奈良女子大学生活環境学部講師

委員歴

  • 2006年 日本栄養改善学会 評議員 日本栄養改善学会 society

    学協会

  • 2006年 日本ビタミン学会 評議員 日本ビタミン学会 society

    学協会

  • 日本家政学会 関西地区幹事(2006-2012, 2018-2021)、 評議員、編集委員(2020-) 日本家政学会 society

    学協会

  • 日本ポリフェノール学会 評議員 society

    学協会

  • 日本栄養・食糧学会 近畿支部参与、JNSV編集委員 society

    学協会

論文

  • A phytol-enriched diet activates PPAR-α in the liver and brown adipose tissue to ameliorate obesity-induced metabolic abnormalities

    An JY; Jheng HF; Nagai H; Sanada K; Takahashi H; Iwase M; Watanabe N; Kim YI; Teraminami A; Takahashi N; Nakata R; Inoue H; Seno S; Matsuda H; Kawada T; Goto T

    Scope: Peroxisome proliferator-activated receptor alpha (PPAR-α) is a ligand-activated transcription factor that regulates lipid and carbohydrate metabolism. We investigate the effects of naturally occurring PPAR-α agonists, phytol, and its metabolite phytanic acid, on obesity-induced metabolic disorders using a mouse model. Methods and results: A luciferase reporter assay shows that phytanic acid potently activates PPAR-α among PPAR subtypes. In high-fat-diet-induced, severely obese mice, a phytol-enriched diet increases phytanic acid levels in the liver and adipose tissue, where PPAR-α is abundantly expressed. A phytol-enriched diet ameliorates severe obesity and the related metabolic abnormalities of white adipose tissue. Moreover, the expression of PPAR-α target genes in the liver and brown adipose tissue is enhanced by a phytol-enriched diet, suggesting that phytol and phytanic acid activate PPAR-α in these organs. We confirm that phytanic acid treatment induced PPAR-α target gene expression in both primary hepatocytes and brown adipocytes from wild-type mice, but not in these cells from PPAR-α-deficient mice. Conclusion: A phytol-enriched diet may increase phytanic acid levels in the liver and brown adipocytes, thereby activating PPAR-α in these organs and ameliorating obesity-induced metabolic diseases., 2018年03月01日, Mol. Nutr. Food Res., 62 (6), e1700688, doi

    研究論文(学術雑誌)

  • レスベラトロール研究の進展

    中田理恵子; 井上裕康

    2018年, 生化学, 90 (4), 529 - 532

  • Rice Koji extract enhances lipid metabolism through prolifeator-activated receptor alpha (PPARα) activation in mouse liver.

    Takahashi H; Chi H-Y; Mohri S; Kamakari K; Nakata K; Ochijo N; Nakata R; Inoue H; Goto T; Kawada T

    Koji is made from grains fermented with Aspergillus oiyzae and is essential for the production of many traditional Japanese foods. Many previous studies have shown that koji contributes to the improvement of dyslipidemia. However, little is known regarding the underlying mechanism of this effect. Furthermore, the compound contributing to the activation of lipid metabolism is unknown. We demonstrated that rice koji extract (RKE) induces the mRNA expression of peroxisome proliferator-activated receptor alpha (PPAR alpha) target genes, which promotes lipid metabolism in murine hepatocytes. This effect was not observed in PPAR alpha-KO hepatocytes. We also demonstrated that RKE contained linolenic acid (LIA), oleic acid (OA), and hydroxyoctadecadienoic acids (HODEs), which activate PPAR alpha, using LC-MS analysis. Our findings suggest that RKE, containing LIA, OA, and HODEs, could be valuable in improving dyslipidemia via PPAR alpha activation., 2016年11月, J. Agric. Food Chem., 64 (46), 8848 - 8856, doi;web_of_science

    研究論文(学術雑誌)

  • Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects

    Hashizume T; Kato A; Tanaka T; Miyoshi S; Itoh N; Nakata R; Inoue H; Oikawa A; Nakai Y; Shimizu M; Inoue J; Sato R

    Soy protein beta-conglycinin has serum lipid-lowering and anti-obesity effects. We showed that singleingestion of beta-conglycinin after fasting alters gene expression in mouse liver. A sharp increase in fibroblast growth factor 21 (FGF21) gene expression, which is depressed by normal feeding, resulted in increased postprandial circulating FGF21 levels along with a significant decrease in adipose tissue weights. Most increases in gene expressions, including FGF21, were targets for the activating transcription factor 4 (ATF4), but not for peroxisome proliferator-activated receptor a. Overexpression of a dominant-negative form of ATF4 significantly reduced beta-conglycinin-induced increases in hepatic FGF21 gene expression. In FGF21-deficient mice, beta-conglycinin effects were partially abolished. Methionine supplementation to the diet or primary hepatocyte culture medium demonstrated its importance for activating liver or hepatocyte ATF4-FGF21 signaling. Thus, dietary beta-conglycinin intake can impact hepatic and systemic metabolism by increasing the postprandial circulating FGF21 levels., 2016年06月, Sci. Rep., 6, 28183, doi;web_of_science

    研究論文(学術雑誌)

  • Smartphone usage during meals is a potential risk for weight gain in post-addescent female students

    Fujiwara T; Nakata R

    2016年, Integrative Food, Nutr. Metab., 3 (5), 424 - 426

  • Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator- activated receptor α

    Takahashi H; Goto T; Yamazaki Y; Kamakari K; Hirata M; Suzuki H; Shibata D; Nakata R; Inoue H; Takahashi N; Kawada T

    PPAR is well known as a master regulator of lipid metabolism. PPAR activation enhances fatty acid oxidation and decreases the levels of circulating and cellular lipids in obese diabetic patients. Although PPAR target genes are widely known, little is known about the alteration of plasma and liver metabolites during PPAR activation. Here, we report that metabolome analysis-implicated upregulation of many plasma lysoGP species during bezafibrate (PPAR agonist) treatment. In particular, 1-palmitoyl lysophosphatidylcholine [LPC(16:0)] is increased by bezafibrate treatment in both plasma and liver. In mouse primary hepatocytes, the secretion of LPC(16:0) increased on PPAR activation, and this effect was attenuated by PPAR antagonist treatment. We demonstrated that Pla(2)g7 gene expression levels in the murine hepatocytes were increased by PPAR activation, and the secretion of LPC(16:0) was suppressed by Pla(2)g7 siRNA treatment. Interestingly, LPC(16:0) activates PPAR and induces the expression of PPAR target genes in hepatocytes. Furthermore, we showed that LPC(16:0) has the ability to recover glucose uptake in adipocytes induced insulin resistance. These results reveal that LPC(16:0) is induced by PPAR activation in hepatocytes; LPC(16:0) contributes to the upregulation of PPAR target genes in hepatocytes and the recovery of glucose uptake in insulin-resistant adipocytes., 2015年02月, J. Lipid Res., 56 (2), 254 - 265, doi;web_of_science

    研究論文(学術雑誌)

  • The 4’-hydroxy group of resveratrol is functionally important for direct activation of PPARα

    Takizawa Y; Nakata R; Fukuhara K; Yamashita H; Kubodera H; Inoue H

    Long-term moderate consumption of red wine is associated with a reduced risk of developing lifestyle-related diseases such as cardiovascular disease and cancer. Therefore, resveratrol, a constituent of grapes and various other plants, has attracted substantial interest. This study focused on one molecular target of resveratrol, the peroxisome proliferator activated receptor α (PPARα). Our previous study in mice showed that resveratrol-mediated protection of the brain against stroke requires activation of PPARα; however, the molecular mechanisms involved in this process remain unknown. Here, we evaluated the chemical basis of the resveratrol-mediated activation of PPARα by performing a docking mode simulation and examining the structure-activity relationships of various polyphenols. The results of experiments using the crystal structure of the PPARα ligand-binding domain and an analysis of the activation of PPARα by a resveratrol analog 4-phenylazophenol (4-PAP) in vivo indicate that the 4'-hydroxyl group of resveratrol is critical for the direct activation of PPARα. Activation of PPARα by 5 μM resveratrol was enhanced by rolipram, an inhibitor of phosphodiesterase (PDE) and forskolin, an activator of adenylate cyclase. We also found that resveratrol has a higher PDE inhibitory activity (IC50 = 19 μM) than resveratrol analogs trans-4-hydroxystilbene and 4-PAP (IC50 = 27-28 μM), both of which has only 4'-hydroxyl group, indicating that this 4'-hydroxyl group of resveratrol is not sufficient for the inhibition of PDE. This result is consistent with that 10 μM resveratrol has a higher agonistic activity of PPARα than these analogs, suggesting that there is a feedforward activation loop of PPARα by resveratrol, which may be involved in the long-term effects of resveratrol in vivo., 2015年, PLoS ONE, 10 (3), e0120865, 国際誌, doi;pubmed;pmc

  • 鉄吸収促進作用のあるDFAIIIは非貧血者では鉄過剰を引き起こさない

    奥原康英; 蜂谷幸子; 重松典宏; 森本恵子; 原博; 中田理恵子

    2015年, 予防医学Aggressive, 2 (3), 18 - 23

  • Resveratrol Targets in Inflammation

    Hiroyasu Inoue; Rieko Nakata

    Resveratrol, a constituent of grapes and various other plants, has been an attractive compound for biomedical studies because moderate long-term drinking of red wine is associated with a reduced risk of lifestyle-related diseases, such as cardiovascular diseases and cancer. Resveratrol is as a phytoalexin, cyclooxygenase (COX) suppressor, and an activator of peroxisome proliferator-activated receptor (PPAR) and SIRT1. As a major phytoalexin, resveratrol is produced by plants in response to various environmental stresses, such as pathogens and ultraviolet (UV) radiation, and promotes resistance to these stresses. A similar active ingredient, salicylic acid (SA), is also produced by plants. Aspirin, acetylated SA, is a major nonsteroidal anti-inflammatory drug (NSAID) because it inhibits COX activity in humans. The jasmonic acid (JA) pathway in plants and the COX pathway in humans are both defense systems against environmental stresses and involve lipid mediators derived from phospholipids. We can hypothesize that there is a molecular basis for the mutually beneficial relationship between plants and humans, which is important for understanding the mode of action of resveratrol in inflammation. Here we provide a review of the studies on resveratrol, especially with respect to the role of COX and PPAR in inflammation., 2015年, ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, 15 (3), 186 - 195, doi;web_of_science

    研究論文(学術雑誌)

  • Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse

    Feng Xu; Yusuke Sudo; Sho Sanechika; Junpei Yamashita; Sho Shimaguchi; Shun-ichiro Honda; Chiho Sumi-Ichinose; Masayo Mori-Kojima; Rieko Nakata; Tadaomi Furuta; Minoru Sakurai; Masahiro Sugimoto; Tomoyoshi Soga; Kazunao Kondo; Hiroshi Ichinose

    Quinonoid dihydropteridine reductase (QDPR) catalyzes the regeneration of tetrahydrobiopterin (BH4), a cofactor for monoamine synthesis, phenylalanine hydroxylation and nitric oxide production. Here, we produced and analyzed a transgenic Qdpr (/) mouse model. Unexpectedly, the BH4 contents in the Qdpr (/) mice were not decreased and even increased in some tissues, whereas those of the oxidized form dihydrobiopterin (BH2) were significantly increased. We demonstrated that unlike the wild-type mice, dihydrofolate reductase regenerated BH4 from BH2 in the mutants. Furthermore, we revealed wide alterations in folate-associated metabolism in the Qdpr (/) mice, which suggests an interconnection between folate and biopterin metabolism in the transgenic mouse model. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved., 2014年11月, FEBS LETTERS, 588 (21), 3924 - 3931, doi;web_of_science

    研究論文(学術雑誌)

  • Possible Involvement of a Tetrahydrobiopterin in Photoreception for UV-B-induced Anthocyanin Synthesis in Carrot

    Junko Takeda; Rieko Nakata; Hiroshi Ueno; Akio Murakami; Mineo Iseki; Masakatsu Watanabe

    Our previous studies of action spectra for UV-B-induced anthocyanin accumulation in cultured carrot cells indicated that a reduced form of pterin, possibly tetrahydrobiopterin, contributes to UV-B photoreception. In this report, we provide additional evidence for the involvement of pterin in UV-B light sensing. UV-B-induced phenylalanine ammonia-lyase (PAL) activity was considerably suppressed by N-acetylserotonin (an inhibitor of tetrahydrobiopterin biosynthesis), and this suppression was partially recovered by adding biopterin or tetrahydrobiobiopterin. In addition, protein(s) specifically bound to biopterin were detected by radiolabeling experiments in N-acetylserotonin-treated cells. Furthermore, diphenyleneiodonium, a potent inhibitor of electron transfer, completely suppressed UV-B-induced PAL activity. These results suggest the occurrence of an unidentified UV-B photoreceptor (other than UVR8, the tryptophan-based UV-B sensor originally identified in Arabidopsis) with reduced pterin in carrot cells. After reexamining published action spectra, we suggest that anthocyanin synthesis is coordinately regulated by these two UV-B sensors., 2014年09月, PHOTOCHEMISTRY AND PHOTOBIOLOGY, 90 (5), 1043 - 1049, doi;web_of_science

    研究論文(学術雑誌)

  • Plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate treatment in pediatric patients with acute lymphoblastic leukemia or Burkitt lymphoma: association with hepatotoxicity

    Masaru Kubota; Rieko Nakata; Souichi Adachi; Ken-Ichiro Watanabe; Toshio Heike; Yasufumi Takeshita; Midori Shima

    This study aimed to investigate: (i) changes of plasma homocysteine, methionine and S-adenosylhomocysteine levels following high-dose methotrexate (HD-MTX) treatment and (ii) the correlation of these sulfur-containing amino acids with MTX-induced hepatotoxicity. Fifteen pediatric patients with acute lymphoblastic leukemia and one patient with Burkitt lymphoma, with a total of 26 treatment courses of HD-MTX, were enrolled. Homocysteine levels increased at 24 h after HD-MTX treatment, and showed marginal decreases at 48 and 72 h. Methionine levels showed a biphasic pattern, i. e. an initial decrease at 24 h followed by increases at 48 and 72 h. S-adenosylhomocysteine exhibited a marginal decrease at 24 h. Changes of homocysteine exhibited significant correlation only with a maximum increase of alanine aminotransferase or total bilirubin from baseline. This study has demonstrated, for the first time, simultaneous changes of plasma homocysteine, methionine and S-adenosylhomocysteine following HD-MTX. The potential of homocysteine as a marker of hepatotoxicity is also presented., 2014年07月, LEUKEMIA & LYMPHOMA, 55 (7), 1591 - 1595, doi;web_of_science

    研究論文(学術雑誌)

  • Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle

    中田 理恵子; Sasaki T; Nakata R; Inoue H; Shimizu M; Inoue J; Sato R

    Exercise can effectively ameliorate type 2 diabetes and insulin resistance. Here we show that the mRNA levels of one of peroxisome proliferator-activated receptor (PPAR) family members, PPAR gamma 1, and genes related to energy metabolism, including PPAR gamma coactivator-1 protein-1 alpha (PGC-1 alpha) and lipoprotein lipase (LPL), increased in the gastrocnemius muscle of habitual exercise-trained mice. When mice were intraperitoneally administered an AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), the mRNA levels of the aforementioned three genes increased in gastrocnemius muscle. AICAR treatment to C2C12 differentiated myotubes also increased PPAR gamma 1 mRNA levels, but not PPAR alpha and -delta mRNA levels, concomitant with increased PGC-1 alpha mRNA levels. An AMPK inhibitor, compound C, blocked these AICAR effects. AICAR treatment increased the half-life of PPAR gamma 1 mRNA nearly threefold (4-12 h) by activating AMPK. When C2C12 myoblast cells infected with a PPAR gamma 1 expression lentivirus were differentiated into myotubes, PPAR gamma 1 overexpression dramatically increased LPL mRNA levels more than 40-fold. In contrast, when PPAR gamma 1 expression was suppressed in C2C12 myotubes, LPL mRNA levels were significantly reduced, and the effect of AICAR on increased LPL gene expression was almost completely blocked. These results indicated that PPAR gamma was intimately involved in LPL gene expression in skeletal muscle and the AMPK-PPAR gamma 1 pathway may play a role in exercise-induced LPL expression. Thus, we identified a novel critical role for PPAR gamma 1 in response to AMPK activation for controlling the expression of a subset of genes associated with metabolic regulation in skeletal muscle., 2014年05月, Am J Physiol Endocrinol Metab, 306 (9), E1085 - E1092, doi;web_of_science

    研究論文(学術雑誌)

  • Resveratrol and Cardiovascular Disease

    中田 理恵子; Nakata R; Inoue H

    2014年, Curr Nutr Rep, 3, 163 - 169

  • Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells

    Yoshie Takizawa; Yukiko Kosuge; Hiroyo Awaji; Emi Tamura; Ayako Takai; Takaaki Yanai; Reiko Yamamoto; Koichi Kokame; Toshiyuki Miyata; Rieko Nakata; Hiroyasu Inoue

    Resveratrol, a polyphenolic phytoalexin found in red wine and various plants, has been reported to up-regulate the expression of endothelial NO synthase (eNOS) in human umbilical vein endothelial cells (HUVEC). However, this effect was neither long term in nature nor physiologically relevant at the concentration of resveratrol studied. In the present study, we investigated the effects of repeated treatments with a lower concentration of resveratrol on the expression of genes in HUVEC. The expression levels of eNOS and silent mating type information regulation 2 homologue 1 (SIRT1) were up-regulated in HUVEC by repeated treatments with 1 μm-resveratrol for 6 d, but not with fenofibrate. Moreover, resveratrol treatment increased the expression of autophagy-regulated genes such as γ-aminobutyric acid A receptor-associated protein (GABARAP), microtubule-associated protein 1 light chain 3B (LC3B) and autophagy-related protein 3 (ATG3), the radical scavenger activity-related metallothionein-1X (MT1X) gene and the anti-inflammatory activity-related annexin A2 (ANXA) gene. In addition, resveratrol treatment down-regulated the expression of the cell-cycle checkpoint control RAD9 homologue B (RAD9B) gene. These results indicate the beneficial effects of resveratrol on the cardiovascular system. © The Authors 2013., 2013年12月28日, British Journal of Nutrition, 110 (12), 2150 - 2155, doi;pubmed

    研究論文(学術雑誌)

  • DHA atttenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells

    中田 理恵子; Kimura R; Takahashi N; Lin S; Goto T; Murota K; Nakata R; Inoue H; Kawada T

    It is known that peroxisome proliferator-activated receptor (PPAR)alpha, whose activation reduces hyperlipidemia, is highly expressed in intestinal epithelial cells. Docosahexaenoic acid (DHA) could improve postprandial hyperlipidemia, however, its relationship with intestinal PPAR alpha activation is not revealed. In this study, we investigated whether DHA can affect postprandial hyperlipidemia by activating intestinal PPAR alpha using Caco-2 cells and C57BL/6 mice. The genes involved in fatty acid (FA) oxidation and oxygen consumption rate were increased, and the secretion of triacylglyceride (TG) and apolipoprotein B (apoB) was decreased in DHA-treated Caco-2 cells. Additionally, intestinal FA oxidation was induced, and TG and apoB secretion from intestinal epithelial cells was reduced, resulting in the attenuation of plasma TG and apoB levels after oral administration of olive oil in DHA-rich oil-fed mice compared with controls. However, no increase in genes involved in FA oxidation was observed in the liver. Furthermore, the effects of DHA on intestinal lipid secretion and postprandial hyperlipidemia were abolished in PPAR alpha knockout mice. In conclusion, the present work suggests that DHA can inhibit the secretion of TG from intestinal epithelial cells via PPAR alpha activation, which attenuates postprandial hyperlipidemia., 2013年12月, J Lipid Res, 54 (12), 3258 - 3268, doi;web_of_science

    研究論文(学術雑誌)

  • Secretion of miraculin through the function of a signal peptide conserved in the Kunitz-type soybean trypsin inhibitor family

    Ayako Takai; Makiko Satoh; Tomomi Matsuyama; Akane Ito; Rieko Nakata; Takashi Aoyama; Hiroyasu Inoue

    Miraculin, a glycoprotein that modifies sour tastes into sweet ones, belongs to the Kunitz-type soybean trypsin inhibitor (STI) family. To clarify the functional relation of miraculin with Kunitz-type STIs, we investigated its subcellular localization and trypsin inhibitory activity. In transgenic Arabidopsis thaliana, miraculin, fused to yellow fluorescent protein, localized to and outside the plasma membrane depending on the putative secretion signal peptide. When transgenic seedlings were cultured in liquid medium, miraculin was present in the supernatant only after cellulase treatment. No trypsin inhibitory activity was detected in native or recombinant miraculin. In conclusion, miraculin is secreted outside the plasma membrane through the function of a signal peptide, conserved in Kunitz-type STIs, whereas its trypsin inhibitory activity may be lost during its evolution. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved., 2013年06月, FEBS LETTERS, 587 (12), 1767 - 1772, doi;web_of_science

    研究論文(学術雑誌)

  • Evaluation of food-derived functional ingredients according to activation of PPAR and suppression of COX-2 expression

    Rieko Nakata; Yoshie Takizawa; Ayako Takai; Hiroyasu Inoue

    The peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors belonging to the nuclear receptor family. They are considered molecular targets for the prevention of lifestyle-related diseases and are involved in the control of cyclooxygenase (COX)-2 expression. COX-2, the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis, and its expression is partly controlled by PPAR. We have identified several natural chemicals, such as resveratrol, that activate PPARs and suppress COX-2 expression. In this review, we provide an evaluation of food-derived functional ingredients that target PPARs and COX-2., 2013年, Food Science and Technology Research, 19 (3), 339 - 345, doi

  • レスベラトロール研究の現状

    中田 理恵子; 中田理恵子; 井上裕康

    2013年, 日本栄養士会雑誌, 56, 544 - 546

  • The Beneficial Effect of Folate-Enriched Egg on the Folate and Homocysteine Levels in Rats Fed a Folate- and Choline-Deficient Diet

    Ayami Sugiyama; Hiroyo Awaji; Kenji Horie; Mujo Kim; Rieko Nakata

    We investigated the effects of folate-enriched egg yolk powder on folate and homocysteine levels in plasma and liver of rats fed the folate- and choline-deficient diet to determine bioavailability in vivo. Three-wk-old Wistar rats were fed (1) the pteroylglutamate (PteGlu), (2) the choline, (3) the PteGlu and choline, (4) the folate-enriched egg yolk powder diet for 4 wk after having been fed the folate-and choline-deficient diet. The hepatic folate level in the folate-enriched egg yolk powder group was significantly higher than that in the folate-and choline-deficient or the control groups. The homocysteine concentration in plasma and liver of the folate-enriched egg yolk powder group was significantly lower than that of the folate-and choline-deficient or the PteGlu groups. The S-adenosyl-methionine (SAM)/S-adenosyl-homocysteine (SAH) ratio in the folate-enriched egg yolk powder group was significantly higher than that in the folate-and choline-deficient group. These effects were similar in the PteGlu and choline, but not the PteGlu or the choline groups. These data suggest that the intake of folate-enriched eggs, as well as of both folate and choline, induced the beneficial effects on folate and homocysteine metabolism. Thus, folate-enriched eggs could be used as beneficial source of folate with a high bioavailability., 2012年12月, JOURNAL OF FOOD SCIENCE, 77 (12), H268 - H272, doi;web_of_science

    研究論文(学術雑誌)

  • Recent Advances in the Study on Resveratrol

    Rieko Nakata; Satoru Takahashi; Hiroyasu Inoue

    Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog I (SIRT1) activator, and more. Despite scepticism concerning the biological availability of resveratrol, a growing body of in viva evidence indicates that resveratrol has protective effects in several stress and disease models. Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health., 2012年03月, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35 (3), 273 - 279, doi;web_of_science

  • Franesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.

    中田 理恵子; Goto T; Kim YI; Funakoshi K; Teraminami A; Uemura T; Hirai S; Lee JY; Makishima M; Nakata R; Inoue H; Senju H; Matsunaga M; Horio F; Takahashi N; Kawada T

    Goto T, Kim YI, Funakoshi K, Teraminami A, Uemura T, Hirai S, Lee JY, Makishima M, Nakata R, Inoue H, Senju H, Matsunaga M, Horio F, Takahashi N, Kawada T. Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPAR alpha-dependent and -independent pathways. Am J Physiol Endocrinol Metab 301: E1022-E1032, 2011. First published August 23, 2011; doi:10.1152/ajpendo.00061.2011.-Peroxisome proliferator-activated receptors (PPARs) control energy homeostasis. In this study, we showed that farnesol, a naturally occurring ligand of PPARs, could ameliorate metabolic diseases. Obese KK-Ay mice fed a high-fat diet (HFD) containing 0.5% farnesol showed significantly decreased serum glucose level, glucosuria incidence, and hepatic triglyceride contents. Farnesol-containing HFD upregulated the mRNA expressions of PPAR alpha target genes involved in fatty acid oxidation in the liver. On the other hand, farnesol was not effective in upregulating the mRNA expressions of PPAR gamma target genes in white adipose tissues. Experiments using PPAR alpha-deficient [(-/-)] mice revealed that the upregulation of fatty acid oxidation-related genes required PPAR alpha function, but the suppression of hepatic triglyceride accumulation was partially PPAR alpha dependent. In hepatocytes isolated from the wild-type and PPAR alpha (-/-) mice, farnesol suppressed triglyceride synthesis. In luciferase assay, farnesol activated both PPAR alpha and the farnesoid X receptor (FXR) at similar concentrations. Moreover, farnesol increased the mRNA expression level of a small heterodimer partner known as one of the FXR target genes and decreased those of sterol regulatory element-binding protein-1c and fatty acid synthase in both the wildtype and PPAR alpha (-/-) hepatocytes. These findings suggest that farnesol could improve metabolic abnormalities in mice via both PPAR alpha-dependent and -independent pathways and that the activation of FXR by farnesol might contribute partially to the PPAR alpha-independent hepatic triglyceride content-lowering effect. To our knowledge, this is the first study on the effect of the dual activators of PPAR alpha and FXR on obesity-induced metabolic disorders., 2011年11月, Am. J. Physiol. Endocrinol. Metab., 301 (5), E1022 - E1032, doi;web_of_science

    研究論文(学術雑誌)

  • Citronellol and Geraniol, Components of Rose Oil, Activate PPAR α and γ and Suppress Cyclooxygenase-2 Expression

    中田 理恵子; Katsukawa M; Nakata R; Koeji K; Hori K; Takahashi S; Inoue H

    We evaluated the effects of rose oil on the peroxisome proliferator-activated receptor (PPAR) and cyclooxygenase-2 (COX-2). Citronellol and geraniol, the major components of rose oil, activated PPAR alpha and gamma, and suppressed LPS-induced COX-2 expression in cell culture assays, although the PPAR gamma-dependent suppression of COX-2 promoter activity was evident only with citronellol, indicating that citronellol and geraniol were the active components of rose oil., 2011年05月, Biosci. Biotechnol. Biochem., 75 (5), 1010 - 1012, doi;web_of_science

    研究論文(学術雑誌)

  • Skipping breakfast is associated with reproductive dysfunction in post-adolescent female college students

    Tomoko Fujiwara; Rieko Nakata

    Although increasing attention has been paid to the adverse effects of skipping breakfast on quality of life, there are very few reports concerning the relationship between skipping breakfast and reproductive function. Therefore, we examined this issue by conducting a questionnaire survey of female college students aged from 18 to 20 years old. The 5 annual surveys of questionnaire demonstrated that the severity of dysmenorrhea was significantly higher in the population that skipped breakfast. The incidence of irregular menses was also higher in the population that skipped breakfast, although there was no difference in the incidence of premenstrual symptoms. The group that skipped breakfast showed a tendency to suffer from constipation. In addition, despite no difference in body mass index, there was a significantly higher incidence of a self-perception of poor general health among the group that skipped breakfast. These findings suggest that skipping breakfast is associated with menstrual disorders, and affects the physical condition of female college students who are undergoing post-adolescent maturation. Since these menstrual disorders may influence the quality of life of young women not only in the present but also in the future, skipping breakfast should be re-evaluated from the perspective of future reproductive function. (C) 2010 Elsevier Ltd. All rights reserved., 2010年12月, APPETITE, 55 (3), 714 - 717, doi;web_of_science

    研究論文(学術雑誌)

  • Citral, a component of lemongrass oil, activates PPAR alpha and gamma and suppresses COX-2 expression

    Michiko Katsukawa; Rieko Nakata; Yoshie Takizawa; Kazuyuki Hori; Saori Takahashi; Hiroyasu Inoue

    Lemongrass is a widely used herb as a food flavoring, as a perfume, and for its analgesic and anti-inflammatory purposes; however, the molecular mechanisms of these effects have not been elucidated. Previously, we identified carvacrol from the essential oil of thyme as a suppressor of cyclooxygenase (COX)-2, a key enzyme for prostaglandin synthesis, and also an activator of peroxisome proliferator-activated receptor (PPAR), a molecular target for "lifestyle-related" diseases. In this study, we evaluated the essential oil of lemongrass using our established assays for COX-2 and PPARs. We found that COX-2 promoter activity was suppressed by lemongrass oil in cell-based transfection assays, and we identified citral as a major component in the suppression of COX-2 expression and as an activator of PPAR alpha and gamma. PPAR gamma-dependent suppression of COX-2 promoter activity was observed in response to citral treatment In human macrophage-like U937 cells, citral suppressed both U'S-induced COX-2 mRNA and protein expression, dose-dependently. Moreover, citral induced the mRNA expression of the PPAR alpha-responsive carnitine palmitoyltransferase 1 gene and the PPAR gamma-responsive fatty acid binding protein 4 gene, suggesting that citral activates PPAR alpha and gamma, and regulates COX-2 expression. These results are important for understanding the anti-inflammatory and anti-lifestyle-related disease properties of lemongrass. (C) 2010 Elsevier B.V. All rights reserved., 2010年11月, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1801 (11), 1214 - 1220, doi;web_of_science

    研究論文(学術雑誌)

  • Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo

    中田 理恵子; Tsukamoto T; Nakata R; Tamura E; Kosuge Y; Kariya A; Katsukawa M; Inoue H

    Background: Appropriate long-term drinking of red wine is associated with a reduced risk of cardiovascular disease. Resveratrol, a well-known SIRT1 activator is considered to be one of the beneficial components contained in red wine, and also developed as a drug candidate. We previously demonstrated that resveratrol protects brain against ischemic stroke in mice through a PPAR alpha-dependent mechanism. Here we report the different effects of the oligomers of resveratrol. Methods: We evaluated the activation of PPARs by epsilon-viniferin, a resveratrol dimer, and vaticanol C, a resveratrol tetramer, in cell-based reporter assays using bovine arterial endothelial cells, as well as the activation of SIRT1. Moreover, we tested the metabolic action by administering vaticanol C with the high fat diet to wild-type and PPAR alpha-knockout male mice for eight weeks. Results: We show that vaticanol C activates PPAR alpha and PPAR beta/delta in cell-based reporter assays, but does not activate SIRT1. epsilon-Viniferin shows a similar radical scavenging activity as resveratrol, but neither effects on PPARs and SIRT-1. Eight-week intake of vaticanol C with a high fat diet upregulates hepatic expression of PPAR alpha-responsive genes such as cyp4a10, cyp4a14 and FABP1, and skeletal muscle expression of PPAR beta/delta-responsive genes, such as UCP3 and PDK4 ( pyruvate dehydrogenase kinase, isoform 4), in wild-type, but not PPAR alpha-knockout mice. Conclusion: Vaticanol C, a resveratrol tetramer, activated PPAR alpha and PPAR beta/delta in vitro and in vivo. These findings indicate that activation of PPAR alpha and PPAR beta/delta by vaticanol C may be a novel mechanism, affording beneficial effects against lifestyle-related diseases., 2010年05月, Nutrition & Metabolism, 7, 46, doi;web_of_science

    研究論文(学術雑誌)

  • Carvacrol, a component of thyme oil, activates PPARα and γ, and suppresses COX-2expression.

    中田 理恵子; Hotta M; Nakata R; Katsukawa M; Hori K; Takahashi S; Inoue H

    Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis. Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors belonging to the nuclear receptor superfamily and are involved in the control of COX-2 expression, and vice versa. Here, we show that COX-2 promoter activity was suppressed by essential oils derived from thyme, clove, rose, eucalyptus, fennel, and bergamot in cell-based transfection assays using bovine arterial endothelial cells. Moreover, from thyme oil, we identified carvacrol as a major component of the suppressor of COX-2 expression and an activator of PPAR alpha and gamma. PPAR gamma-dependent suppression of COX-2 promoter activity was observed in response to carvacrol treatment. In human macrophage-like U937 cells, carvacrol suppressed lipopolysaccharide-induced COX-2 mRNA and protein expression, suggesting that carvacrol regulates COX-2 expression through its agonistic effect on PPAR alpha. These results may be important in understanding the antiinflammatory and antilifestyle-related disease properties of carvacrol.-Hotta, M., R. Nakata, M. Katsukawa, K. Hori, S. Takahashi, and H. Inoue. Carvacrol, a component of thyme oil, activates PPAR alpha and gamma and suppresses COX-2 expression. J. Lipid Res. 2010. 51: 132-139., 2010年01月, J. Lipid Res., 51 (1), 132 - 139, doi;web_of_science

    研究論文(学術雑誌)

  • 特殊なPPAR活性化能を示す香辛料シナモンバーグ精油

    中田 理恵子; 勝川路子; 中田理恵子; 滝澤祥恵; 井上裕康

    2010年, 日本味と匂学会誌, 17, 203 - 206

  • Functional Expression of Miraculin, a Taste-Modifying Protein in Escherichia Coli

    Tomomi Matsuyama; Makiko Satoh; Rieko Nakata; Takashi Aoyama; Hiroyasu Inoue

    Miraculin isolated from red berries of Richadella dulcifica, a native shrub of West Africa, has the unusual property of modifying a sour taste into a sweet one. This homodimer protein consists of two glycosylated polypeptides that are cross-linked by a disulfide bond. Recently, functional expression of miraculin was reported in host cells with the ability to glycosylate proteins, such as lettuce, tomato and the microbe Aspergillus oryzae, but not Escherichia coli. Thus, a question remains as to whether glycosylation of miraculin is essential for its taste-modifying properties. Here we show that recombinant miraculin expressed in E. coli has taste-modifying properties as a homodimer, not as a monomer, indicating that glycosylation is not essential for the taste-modifying property., 2009年04月, JOURNAL OF BIOCHEMISTRY, 145 (4), 445 - 450, doi;web_of_science

    研究論文(学術雑誌)

  • Skipping breakfast adversely affects menstrual disorders in young college students

    Tomoko Fujiwara; Natsuyo Sato; Hiroyo Awaji; Hiroko Sakamoto; Rieko Nakata

    In the present study we conducted a questionnaire survey to examine the relationship between dietary habits and menstrual disorders in young women. Subjects were recruited from 315 college students and were classified as: Group I, eating breakfast; Group II, skipping breakfast; Group III, not eating fast foods; Group IV, eating fast foods; Group V, not eating processed foods; and Group VI, eating processed foods. The intensity of dysmenorrhea was scored using three grades. All participants were further divided into groups based on having regular or irregular menstruation, having premenstrual symptoms or not, and self-perception of good or poor general health. General health was poor in Groups II and VI, and dysmenorrhea scores were high in Groups II, IV and VI. The incidence of irregular menses was also high in Group II. However, there was no apparent relation between premenstrual symptoms and dietary habits. These findings suggest that skipping breakfast adversely affects menstrual disorders in young college students., 2009年, INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 60 (S6), 23 - 31, doi;web_of_science

    研究論文(学術雑誌)

  • シロイヌナズナにおけるミラクリンーYFP融合タンパク質の発現系

    中田 理恵子; 佐藤麻紀子; 中田理恵子; 青山卓史; 井上裕康

    2009年, 日本味と匂学会誌, 16, 293 - 294

  • COX-2発現抑制とPPAR活性化を指標とした香辛料成分の機能性評価

    中田 理恵子; 勝川路子; 中田理恵子; 井上裕康

    2009年, 日本味と匂学会誌, 16, 683 - 686

  • 誘導型シクロオキシゲナーゼ発現抑制を指標とした植物油の機能性評価

    中田 理恵子; 堀田真理子; 中田理恵子; 井上裕康

    2008年, 日本家政学学会誌, 59 (6), 373 - 378, doi

  • シロイヌナズナを用いた組換えミラクリンの発現と大腸菌を用いた組換え体との比較

    中田 理恵子; 佐藤麻紀子; 松山友美; 中田理恵子; 青山卓史; 井上裕康

    2008年, 日本味と匂学会誌, 15 (3), 517 - 520

  • Young Japanese college students with dysmenorrheal have high frequency of irregular menstruation and premenstryal symptoms.

    中田 理恵子; Fujiwara T; Nakata R

    2007年, The Open Medical Informatics Journal, 1, 8 - 11

  • Adverse effects of dietary habits on menstrual disorders in young women.

    中田 理恵子; Fujiwara T; Sato N; Awaji H; Nakata R

    2007年, The Open Food Science Journal, 1, 24 - 30

  • Betaine supplementation suppresses plasma homocysteine level elevation induced by folate deficiency in rats

    Masako Yagisawa; Yuko Doi; Terumi Uenohara; Maiko Toda; Norihiro Shigematsu; Rieko Nakata

    The effects of betaine on the plasma homocysteine concentration were investigated in partially folate deficient rats. The rats were fed a test diet containing folic acid at a dose of 8 (control) or 0.5 (low folate) mg/kg. After a 4-week feeding, the plasma homocysteine concentration in the low-folate group increased to 1.6-fold that in the control group. Betaine supplementation (30 g/kg diet) significantly suppressed the plasma homocysteine level elevation and led to an upward trend in liver betaine-homocysteine methyltransferase (BHMT) activity, whereas no change was observed with supplementation with choline (10 g/kg diet), a precursor of betaine. The results of this study suggest that betaine suppresses the plasma homocysteine level elevation induced by low folate intake, and the suppression is associated with the metabolic pathway driven by BHMT. (c) 2006 Elsevier Inc. All rights reserved., 2006年06月, NUTRITION RESEARCH, 26 (6), 266 - 270, doi;web_of_science

    研究論文(学術雑誌)

  • Effects of chronic betaine ingestion on methionine-loading induced plasma homocysteine elevation in rats

    Masako Yagisawa; Norihiro Shigematsu; Rieko Nakata

    The effects of chronic betaine ingestion were investigated in rats. Rats were fed an experimental diet containing 5% bctaine for 4wk and methionine was intravenously administered. The elevations of plasma homocysteine were assessed by comparing the increments to the initial measured value and the positive incremental area under the plasma homocysteine concentration curve over the 240-min post-methionine-loading period (Delta AUC(0-240)). In the betaine-ingesting rats, Delta AUC(0-240) was significantly lower than in the control group (48% of the control), and the increments of plasma homocysteine were also lower compared with the control, especially 15-30 min after methionine loading. Choline, a precursor of betaine, did not alter the plasma homocysteme elevation. In a definite period immediately after methionine loading, carnitine, a methyl-group-rich amino acid, induced a significant increase of plasma homocysteme, compared to the control. Moreover, plasma homocysteine concentration was significantly decreased by 4 wk of betaine ingestion. Betaine enhanced liver BHMT activity whereas choline and carnitine did not show any effects on BHMT activity. These results suggest that betaine contributes to both the decrease in the plasma homocysteine concentration and the suppression of plasma homocysteine elevation through the activation of liver BHMT., 2006年06月, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 52 (3), 194 - 199, doi;web_of_science

    研究論文(学術雑誌)

  • Assessment of human regular menstrual cycle.

    中田 理恵子; Fujiwara T; Nakata R

    2006年, Current Trends in Endocrinology, 2, 59 - 64

  • The influence of food intake on female reproductive function in young women.

    中田 理恵子; Fujiwara T; Nakata R; Fujiwara H

    2005年, Current Trends in Endocrinology, 1, 137 - 143

  • Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats

    M Yagisawa; N Okawa; N Shigematsu; R Nakata

    An intravenous methionine-loading model was characterized, and the suppressive effect of betaine on plasma homocysteine elevation induced by methionine loading was examined in rats. The plasma homocysteine concentrations significantly increased 5-120 minutes after 0.34 mmol/kg of methionine loading and then returned to the baseline within 240 minutes. Betaine was then intravenously administered at the same time as the methionine loading. The total increment of plasma homocysteine was assessed using the positive incremental area under the plasma homocysteine concentration curve over the 240-minute post-methionine-loading period (DeltaAUC(0-240)). Betaine reduced DeltaAUC(0-240) dose-dependently: 81% of the control by 1.7 mmol/kg of betaine and 33% by 3.4 mmol/kg. The effects of glycine and methylglycine, analogues of betaine, were also investigated. As observed for betaine, methylglycine decreased DeltaAUC(0-240) to 44% of the control, whereas glycine showed no significant effect on DeltaAUC(0-240), indicating that methyl groups of betaine and dimethylglycine were necessary to suppress plasma homocysteine elevation. These results suggest that betaine contributes to the suppression of plasma homocysteine elevation by promoting homocysteine metabolism, and seems to work as a methyl donor. (C) 2004 Elsevier Inc. All rights reserved., 2004年11月, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 15 (11), 666 - 671, doi;web_of_science

    研究論文(学術雑誌)

  • Current problems of food intake in young women in Japan: Their influence on female reproductive function

    Tomoko Fujiwara; Rieko Nakata

    Accumulating evidence suggests that food customs are associated with quality of life in women of the reproductive age. In Japan, dietary limitation for cosmetic purposes, skipping food intake, intake of processed foods and the shift from Japanese to Westernized style food have increased among young women. These changes in food habits can cause inadequate intake of calories, micronutrients, unsaturated fat, phytestrogens and fiber as well as increasing environmental toxins. Furthermore, these food habits increase risk as a result of intake of food additives, anti-oxidants, processing agents and sweeteners, which have been demonstrated to be harmful to human health. These factors are speculated to not only influence the present lifestyle, but also to induce gynecologic disorders such as dysmenorrhea and irregular menstruation. The adverse effects of these dietary habits on pregnancy outcome and carcinogenesis of breast and ovarian cancers have also been demonstrated. In addition, latent development of organic diseases such as endometriosis, which are accompanied by dysmenorrhea, is a concern under the current nutritional environment in young women. Thus, it is an urgent issue to evaluate the present situation of eating habits in young Japanese women and estimate the influence of these habits on the quality of life including reproductive functions., 2004年, Reproductive Medicine and Biology, 3 (3), 107 - 114, doi

  • Regulation on reproductive functions by membrane-bound cell surface peptidases.

    中田 理恵子; Fujiwara H; Nakata R; Fujiwara T; Ueda M; Maeda M

    2004年, Current Topics in Biochemical Research, 6, 1 - 13

  • 「中国・新彊ウイグル自治区の女性と生活-その3 平成12(2002)年度 少数民族に関する生活調査-」

    中田 理恵子; 岩崎雅美他

    2002年, 家政学研究, 48 (1), 57 - 76

  • Change in caspase-3-like protease in the liver and plasma during rat liver regeneration following partial hepatectomy

    S Hayami; M Yaita; Y Ogiri; F Sun; R Nakata; S Kojo

    Recent studies have shown that many factors orchestrate liver regeneration after a two-thirds partial hepatectomy (PH). However, the termination mechanism in liver regeneration has not been thoroughly studied. In this paper, we report that the activity of liver caspase-3-like protease, which is specifically activated in apoptosis, increases 18, 36, and 48 hr after PH during maximal hepatocyte proliferative activity. This is the first study that shows the activation of an apoptosis-executing enzyme during physiological liver regeneration. These results suggest that apoptosis is induced in each surge of DNA synthesis as the termination mechanism. When phenoxybenzamine, an alpha -blocker that has been reported to inhibit DNA synthesis during liver regeneration, was injected 8 hr after PH, the caspase-3-like activity in the liver peaked at 15 hr after PH and the enzyme activity also increased in plasma at 18 and 24 hr after PH in sharp contrast to the case of normal regeneration. These results indicate that extensive apoptosis is caused by phenoxybenzamine and that the secondary necrosis of apoptotic cells results in the increase of caspase-3-like protease activity in the plasma. BIOCHEM PHARMACOL 60;12:1883-1886, 2000. (C) 2000 Elsevier Science Inc., 2000年12月, BIOCHEMICAL PHARMACOLOGY, 60 (12), 1883 - 1886, doi;web_of_science

    研究論文(学術雑誌)

  • Determination of folate derivatives in rat tissues during folate deficiency

    R Nakata

    A method for the sensitive and specific determination of folate derivatives was developed. The method involves hydrolysis by gamma -glutamyl hydrolase and high-performance liquid chromatography with electrochemical detection. The method was applied to measure the change in the level of folate derivatives in the liver, kidney, spleen and brain of rats during folate deficiency. 5,6,7,8-Tetrahydrofolic acid was the major folate derivative in the liver, kidney, spleen and brain. Total concentration of folate derivatives decreased from the second week of folate deficiency in the liver, kidney spleen and brain followed by anemia, which appeared at the fifth week. The level of 5,6,7,8-tetrahydrofolic acid in the brain did not change during folate deficiency, but it significantly decreased in the liver, kidney and spleen., 2000年10月, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 46 (5), 215 - 221, doi;web_of_science

    研究論文(学術雑誌)

  • Facile degradation of apolipoprotein B by radical reactions and the presence of cleaved proteins in serum

    K Tanaka; H Iguchi; S Taketani; R Nakata; S Tokumaru; T Sugimoto; S Kojo

    A facile cleavage of peptide bonds of apolipoprotein B (apoB) by radical reaction is reported, When human LDL was subjected to oxidative damage using Cu2+, extensive degradation of apoB was observed based on immunoblotting, The degradation of apoB was inhibited by radical scavengers (beta-mercaptoethanol, butylated hydroxytoluene, and probucol) and promoted by a radical initiator [2,2'-azobis(2-amidinopropane)dihydrochloride], When human serum was treated with Cu2+, a similar cleavage pattern of apoB was observed. The cleaved apoB proteins were also detected in normal serum on the basis of immunoblots, These results suggest that apoB is highly reactive toward radicals in vitro and in vivo, with reaction resulting in the cleavage of peptide bonds., 1999年01月, JOURNAL OF BIOCHEMISTRY, 125 (1), 173 - 176, web_of_science

    研究論文(学術雑誌)

  • Change ire the level of vitamin C and lipid peroxidation in tissues of the inherently scorbutic rat during ascorbate deficiency

    S Tokumaru; S Takeshita; R Nakata; Tsukamoto, I; S Kojo

    To investigate an accurate profile of vitamin C deficiency, ascorbate deficiency was caused in the inherently scorbutic rat [Osteogenic Disorder Shionogi (ODS)], and changes in the level of the vitamin in 12 tissues of the animals (plasma, liver, stomach, small and large intestines, lung, heart, kidney, adrenal gland, spleen, muscle, and brain) were followed based on the specific method (Kishida et al. Anal. Chem. 1992, 64, 1505-1507). The level of ascorbate in plasma decreased most rapidly, and the rate of decline of the vitamin was the slowest in the brain among the 12 tissues. Based on the kinetic profile of ascorbate decay, these tissues were classified into four groups. After 25 days of ascorbate deficiency, indicators of oxidative stress changed significantly compared with the control group. The indices included increased lipid hydroperoxide level determined by the specific method (Tokumaru et al. Anal. Chim. Acta 1995, 307, 97-102) in the brain, elevated thiobarbituric acid-reactive substances (TBARS) and glutathione peroxidase activity in the heart, and the fall of glutathione in plasma and the liver., 1996年09月, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 44 (9), 2748 - 2753, doi;web_of_science

    研究論文(学術雑誌)

  • 80%エネルギー制限食下での不規則な摂食がラットの身体および1日のエネルギー代謝に及ぼす影響(共著)

    中田 理恵子

    1995年, 日本家政学会誌, 46 (9), 833 - 840, doi

  • REGULATION OF THYMIDYLATE SYNTHASE IN REGENERATING RAT-LIVER AFTER PARTIAL-HEPATECTOMY

    M WAKABAYASHI; R NAKATA; TSUKAMOTO, I

    1994年09月, BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 34 (2), 345 - 350, web_of_science

    研究論文(学術雑誌)

  • ラット肝再生に及ぼす葉酸の影響

    中田 理恵子

    1994年, ビタミン, 68 (8), 445 - 449, doi

  • EFFECT OF AGING ON RAT-LIVER REGENERATION AFTER PARTIAL-HEPATECTOMY

    TSUKAMOTO, I; R NAKATA; S KOJO

    1993年07月, BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 30 (4), 773 - 778, web_of_science

    研究論文(学術雑誌)

  • 1日の運動時刻による運動機能・生理機能の相違

    中田 理恵子

    1993年, 日本栄養・食糧学会誌, 46 (1), 33 - 38, doi

  • EFFECT OF ENDOTOXIN ON RAT-LIVER REGENERATION AFTER PARTIAL-HEPATECTOMY

    TSUKAMOTO, I; R NAKATA; S KOJO

    1992年09月, BIOCHEMISTRY INTERNATIONAL, 27 (6), 1047 - 1050, web_of_science

    研究論文(学術雑誌)

  • A NEW IMMUNOBLOTTING ASSAY FOR THYMIDYLATE SYNTHETASE AND ITS APPLICATION TO THE REGULATION OF ENZYME-ACTIVITY IN REGENERATING RAT-LIVER

    TSUKAMOTO, I; R NAKATA; M MIYOSHI; S TAKETANI; S KOJO

    1988年02月, BIOCHIMICA ET BIOPHYSICA ACTA, 964 (2), 254 - 259, web_of_science

    研究論文(学術雑誌)

  • PURIFICATION AND CHARACTERIZATION OF THYMIDYLATE SYNTHETASE FROM RAT REGENERATING LIVER

    R NAKATA; TSUKAMOTO, I; M MIYOSHI; S KOJO

    1987年05月, BIOCHIMICA ET BIOPHYSICA ACTA, 924 (2), 297 - 302, web_of_science

    研究論文(学術雑誌)

  • EFFECT OF THYROPARATHYROIDECTOMY ON THE ACTIVITIES OF THYMIDYLATE SYNTHETASE AND THYMIDINE KINASE DURING LIVER-REGENERATION AFTER PARTIAL-HEPATECTOMY

    R NAKATA; TSUKAMOTO, I; M MIYOSHI; S KOJO

    1987年04月, CLINICAL SCIENCE, 72 (4), 455 - 461, web_of_science

    研究論文(学術雑誌)

  • LIVER-REGENERATION IN STREPTOZOTOCIN-DIABETIC RATS

    R NAKATA; TSUKAMOTO, I; M MIYOSHI; S KOJO

    1986年03月, BIOCHEMICAL PHARMACOLOGY, 35 (5), 865 - 867, doi;web_of_science

  • α-adrenergic regulation in the activities of thymidylate synthetase and thymidine kinase during liver regeneration after partial hepatectomy

    中田 理恵子

    1985年, European Journal of Pharmacology, 114 (3), 355 - 360, doi;web_of_science

    研究論文(学術雑誌)

  • LIVER-REGENERATION AFTER CARBON-TETRACHLORIDE INTOXICATION IN THE RAT

    R NAKATA; TSUKAMOTO, I; M MIYOSHI; S KOJO

    1985年, BIOCHEMICAL PHARMACOLOGY, 34 (4), 586 - 588, doi;web_of_science

  • Adolescent Dietary Habit-induced Obstetric and Gynecologic Disease (ADHOGD) as a New Hypothesis-Possible Involvement of Clock System.

    Tomoko Fujiwara; Masanori Ono; Michihiro Mieda; Hiroaki Yoshikawa; Rieko Nakata; Takiko Daikoku; Naomi Sekizuka-Kagami; Yoshiko Maida; Hitoshi Ando; Hiroshi Fujiwara

    There are growing concerns that poor dietary behaviors at young ages will increase the future risk of chronic diseases in adulthood. We found that female college students who skipped breakfast had higher incidences of dysmenorrhea and irregular menstruation, suggesting that meal skipping affects ovarian and uterine functions. Since dysmenorrhea is more prevalent in those with a past history of dieting, we proposed a novel concept that inadequate dietary habits in adolescence become a trigger for the subsequent development of organic gynecologic diseases. Since inadequate feeding that was limited during the non-active phase impaired reproductive functions in post-adolescent female rats, we hypothesize that circadian rhythm disorders due to breakfast skipping disrupts the hypothalamic-pituitary-ovarian axis, impairs the reproductive rhythm, and leads to ovarian and uterine dysfunction. To explain how reproductive dysfunction is memorized from adolescence to adulthood, we hypothesize that the peripheral clock system also plays a critical role in the latent progression of reproductive diseases together with the central system, and propose naming this concept "adolescent dietary habit-induced obstetric and gynecologic disease (ADHOGD)". This theory will contribute to analyzing the etiologies of and developing prophylaxes for female reproductive diseases from novel aspects. In this article, we describe the precise outline of the above hypotheses with the supporting evidence in the literature., 2020年05月02日, Nutrients, 12 (5), 国際誌, doi;pubmed

  • Time Restriction of Food Intake During the Circadian Cycle Is a Possible Regulator of Reproductive Function in Postadolescent Female Rats.

    Fujiwara T; Nakata R; Ono M; Mieda M; Ando H; Daikoku T; Fujiwara H

    2019年04月, Current developments in nutrition, 3 (4), nzy093, doi;pubmed

  • Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice

    Kiriyama K; Goto T; Yamamoto H; Ara T; Takahashi H; Jheng HF; Nomura W; Inoue H; Nakata R; Kawada T

    2019年03月, Journal of Functional Foods, 54, 529 - 535

  • 9-Oxo-10(E),12(Z),15(Z)-Octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor α in Hepatocytes.

    Takahashi H; Kamakari K; Goto T; Hara H; Mohri S; Suzuki H; Shibata D; Nakata R; Inoue H; Takahashi N; Kawada T

    2015年09月, Lipids, doi;pubmed

MISC

  • レスベラトロールの心血管系に対する効果とその作用機構

    山上小百合; 中田理恵子; 有沢玲; 本郷翔子; 滝澤祥恵; 井上裕康

    2017年, 脂質生化学研究, 59, 54 - 56

  • 長鎖不飽和脂肪酸とその腸内細菌代謝物によるGPR120活性化の検討

    本郷翔子; 森本育美; 山上小百合; 古田美咲; 滝澤祥恵; 中田理恵子; 井上裕康

    2016年, 脂質生化学研究, 58, 53 - 54

  • レスベラトロールによるPPARα活性化のcAMPを介するフィードードフォワード制御

    滝澤祥恵; 中田理恵子; 本郷翔子; 森本育美; 川西彩代; 山上小百合; 古田美咲; 井上裕康

    2015年, 脂質生化学研究, 57, 153 - 155

  • 大豆由来成分による脂質代謝改善効果とPPARα活性化

    中田理恵子; 松下佳奈恵; 本郷翔子; 伊藤有里加; 森本育美; 滝澤祥恵; 井上裕康

    2014年, 脂質生化学研究, 56

  • 低濃度レスベラトロールによるHUVEC での遺伝子発現変動

    滝澤祥恵; 小菅由希子; 淡路比呂代; 田村恵美; 高井綾子; 矢内隆章; 小亀浩市; 宮田敏行; 中田理恵子; 井上裕康

    2013年, 脂質生化学研究, 55, 94 - 96

  • 健康保持増進への寄与が期待できる精油成分の機能性評価

    中田 理恵子; 井上裕康; 中田理恵子

    2013年, 日本食品化学研究振興財団第19回研究成果報告書

  • COX-2およびPPARを標的とした精油成分の機能性評価

    中田 理恵子; 中田理恵子; 滝澤祥恵; 岩佐千絢; 高井綾子; 勝川路子; 井上裕康

    2012年, 脂質生化学研究, 54, 252 - 255

  • COX-2およびPPARを標的とした食品成分の機能性評価

    中田 理恵子; 滝澤祥恵; 中田理恵子; 高井綾子; 井上裕康

    2012年, New Food Industry, 54 (12), 1 - 6

  • COX-2およびPPARを標的としたレスベラトロールの機能性評価

    中田 理恵子; 井上裕康; 中田理恵子

    2012年, 日本ポリフェノール学会誌, 1, 33 - 37

  • 生活習慣病予防が期待される精油成分の新たな機能

    中田 理恵子; 井上裕康; 中田理恵子

    2011年, バイオインダストリー, 69, 41 - 43

  • レスベラトロール4量体バチカノールCは、培養細胞および個体レベルでPPARαとPPARβ/δを活性化する

    中田 理恵子; 塚本朋子; 中田理恵子; 田村恵美; 小菅由希子; 刈谷斐; 勝川路子; 井上裕康

    2011年, ビタミン, 85, 70 - 72, doi

  • レスベラトロール4’位水酸基はPPAR活性化に関与する

    中田 理恵子; 滝澤祥恵; 越地聡美; 勝川路子; 中田理恵子; 井上裕康

    2011年, 脂質生化学研究, 53

  • PPARαを介したレスベラトロールの効果と脂質代謝の異なる系統差の相違

    中田 理恵子; 中田理恵子; 小菅由希子; 滝澤祥恵; 田村恵美; 井上裕康

    2011年, 脂質生化学研究, 53, 144 - 146

  • 生活習慣病予防が期待されるスパイス精油の有効性

    中田 理恵子; 井上裕康; 中田理恵子

    2011年, Aromatopia, 20, 6 - 9

  • PPARαを介したレスベラトロールの作用機構-個体レベルでの検討-

    中田 理恵子; 中田理恵子; 田村恵美; 小菅由希子; 刈谷斐; 勝川路子; 井上裕康

    2010年, 脂質生化学研究, 52, 199 - 201

  • タイム油成分カルバクロールはPPARαとPPARγを活性化しCOX-2の発現を抑制する

    中田 理恵子; 堀田真理子; 中田理恵子; 勝川路子; 堀一之; 高橋沙織; 井上裕康

    2010年, ビタミン, 84, 255 - 256

  • たまごに含まれる葉酸の有用性について

    中田 理恵子; 中田理恵子

    2008年, Food Style, 12 (4)

  • レスベラトロール4量体バチカノールCによる核内受容体PPARα及びβ/δの活性化

    中田 理恵子; 塚本朋子; 中田理恵子; 勝川路子; 赤尾幸博; 野澤義則; 三島敏; 井上裕康

    2008年, 脂質生化学研究, 50, 304 - 307

  • 葉酸欠乏が脂質代謝関連酵素の遺伝子発現に及ぼす影響

    中田 理恵子; 中田理恵子; 淡路比呂代; 渡邊志保; 井上裕康

    2008年, 脂質生化学研究, 50, 300 - 303

  • 植物性ポリフェノールにおける核内受容体PPARの活性化

    中田 理恵子; 井上裕康; 中田理恵子

    2006年, 脂質生化学研究, 48, 141 - 143

  • 葉酸の生体内機能の評価に関する研究

    中田 理恵子

    2004年, 食生活学・文化及び地球環境科学に関する研究助成研究紀要(アサヒビール学術振興財団), 17, 35 - 47

  • チミジル酸合成酵素を標的にした新規抗がん剤の開発

    中田 理恵子; 中田理恵子

    2003年, 化学と工業, 56 (11), 1260

  • Effects of Irregular Feeding under an 80% Energy Restricted Condition on the Growth and the Daily Energy Metabolism in Rats

    NAKATA Rieko

    1995年, Journal of Home Economics of Japan, 46 (9), 833 - 840, doi

  • Effects of Folic Acid on Rat Liver Regeneration After Partial Hepatectomy

    NAKATA Rieko

    1994年, Vitamins, 68 (8), 445 - 449, doi

  • 体力・健康づくりにおける運動と栄養の相互作用‐特に運動のみの効果と1日の運動時刻による生理生化学的相違と季節的な変化について

    中田 理恵子

    1990年, 広島医学, 43 (12), 2076 - 2083

  • 野菜による変異原抑制効果

    中田 理恵子

    1990年, 広島女子大学家政学部紀要, 26, 101 - 107

  • Circadian changes in the development of physical strength by exercise

    NAKATA Rieko

    1990年, Journal of Hiroshima Medical Association, 43 (12), 2076 - 2083

  • 尿中3メチルヒスチジンの比色定量法の確立とその応用(共著)

    中田 理恵子

    1989年, 広島女子大学家政学部紀要, 25, 1 - 7

  • 米麹抽出物が脂質代謝に与える効果に関する研究

    高橋春弥; CHI Hsin‐Yi; 毛利晋輔; 鎌苅浩介; 中田啓司; 一條範好; 中田理恵子; 井上裕康; 後藤剛; 後藤剛; 河田照雄; 河田照雄

    2018年04月27日, 日本栄養・食糧学会大会講演要旨集, 72nd, 224, j_global;url

  • 麹抽出物の脂質代謝改善作用に関する研究

    高橋春弥; CHI Hsin‐Yi; 毛利晋輔; 鎌苅浩介; 中田啓司; 一條範好; 中田理恵子; 井上裕康; 後藤剛; 後藤剛; 河田照雄; 河田照雄

    2017年03月05日, 日本農芸化学会大会講演要旨集(Web), 2017, ROMBUNNO.2A08p08 (WEB ONLY), j_global;url

  • Rice Koji Extract Enhances Lipid Metabolism through Peroxisome Proliferator-Activated Receptor Alpha (PPAR alpha) Activation in Mouse Liver (vol 64, pg 8848, 2016)

    Haruya Takahashi; Hsin-Yi Chi; Shinsuke Mohri; Kosuke Kamakari; Keiji Nakata; Noriyoshi Ichijo; Rieko Nakata; Hiroyasu Inoue; Tsuyoshi Goto; Teruo Kawada

    AMER CHEMICAL SOC, 2017年01月, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65 (1), 251 - 251, doi;web_of_science

    その他

  • 脂質代謝亢進時における代謝変動の網羅的解析及び変動代謝物の機能解析

    高橋春弥; 後藤剛; 山崎陽太; 鎌苅浩介; 平田茉莉子; 柴田大輔; 中田理恵子; 井上裕康; 高橋信之; 高橋信之; 河田照雄

    2016年09月14日, 日本栄養・食糧学会近畿支部大会および公開シンポジウム講演抄録集, 55th, 44, j_global;url

  • 腸内細菌の長鎖不飽和脂肪酸代謝物によるGPR120活性化の検討

    本郷 翔子; 森本 育美; 山上 小百合; 古田 美咲; 滝澤 祥恵; 井上 飛鳥; 青木 淳賢; 東山 繁樹; 吉田 守克; 宮里 幹也; 岸野 重信; 小川 順; 中田 理恵子; 井上 裕康

    (公社)日本生化学会, 2016年09月, 日本生化学会大会プログラム・講演要旨集, 89回, [2P - 106]

  • フィトールおよびその代謝産物のPPARα活性化能が肝臓および脂肪組織における脂質代謝に及ぼす影響

    眞田康平; 安芝英; 後藤剛; 高橋春弥; 永井宏幸; 金英一; 中田理恵子; 井上裕康; 高橋信之; 高橋信之; 河田照雄

    2016年04月25日, 日本栄養・食糧学会大会講演要旨集, 70th, 232, j_global;url

  • 活動期に対応したラットの摂食行動はカロリー制限による卵巣機能抑制の新たな制御因子か?

    藤原 智子; 山岸 郁乃; 井上 裕康; 中田 理恵子; 藤原 浩

    (公社)日本栄養・食糧学会, 2016年04月, 日本栄養・食糧学会大会講演要旨集, 70回, 274 - 274

  • GPR120活性化を指標とする新規食品機能評価系の検討

    森本 育美; 滝澤 祥恵; 本郷 翔子; 井上 飛鳥; 青木 淳賢; 東山 繁樹; 吉田 守克; 宮里 幹也; 中田 理恵子; 井上 裕康

    (公社)日本生化学会, 2015年12月, 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2P1232] - [2P1232]

  • メタボロミクスを用いたPPARα活性化時の変動代謝物に関する研究

    高橋春弥; 後藤剛; 山崎陽太; 鎌苅浩介; 平田茉莉子; 鈴木秀幸; 柴田大輔; 中田理恵子; 井上裕康; 高橋信之; 河田照雄

    2015年09月08日, 肥満研究, 21 (Supplement), 208, j_global;url

  • TGFα切断アッセイを用いたω-3系脂肪酸によるGPR120活性化

    森本 育美; 滝澤 祥恵; 本郷 翔子; 井上 飛鳥; 青木 淳賢; 東山 繁樹; 吉田 守克; 宮里 幹也; 中田 理恵子; 井上 裕康

    (公社)日本ビタミン学会, 2015年04月, ビタミン, 89 (4), 223 - 223

  • A possible function of resveratrol and essential oil-derived chemicals for prevention of life-style related diseases targeted to COX-2 and PPAR

    Hiroyasu Inoue; Yoshie Takizawa; Ayako Takai; Chisako Takashiba; Satomi Koeji; Chiharu Iwasa; Rieko Nakata

    ELSEVIER IRELAND LTD, 2011年08月, CHEMISTRY AND PHYSICS OF LIPIDS, 164, S29 - S29, doi;web_of_science

    研究発表ペーパー・要旨(国際会議)

  • Functional Expression of Miraculin, a Taste-Modifying Protein in Arabidopsis thaliana and Escherichia coli

    Makiko Satoh; Tomomi Matsuyama; Rieko Nakata; Takashi Aoyama; Hiroyasu Inoue

    OXFORD UNIV PRESS, 2009年02月, CHEMICAL SENSES, 34 (2), J14 - J14, web_of_science

    研究発表ペーパー・要旨(国際会議)

  • RESVERATROL ACTIVATES NUCLEAR RECEPTOR PPARS IN VITRO AND IN VIVO

    Rieko Nakata; Emi Tamura; Yukiko Kosuge; Aya Kariya; Michiko Katsukawa; Hiroyasu Inoue

    KARGER, 2009年, ANNALS OF NUTRITION AND METABOLISM, 55, 160 - 160, web_of_science

    研究発表ペーパー・要旨(国際会議)

書籍等出版物

  • 分子栄養学

    中田 理恵子 (, 範囲: エピゲノム)

    講談社, 2018年

  • 非栄養素の分子栄養学

    中田理恵子; 井上裕康 (, 範囲: ポリフェノールによるPPAR機能制御と骨格筋代謝改善効果)

    建帛社, 2017年

  • 食品因子による栄養機能制御

    井上裕康; 中田理恵子; 滝澤祥恵 (, 範囲: 北海道で命名されたレスベラトロールのPPAR活性化を介した機能性)

    建帛社, 2015年

  • 食物科学概論(改訂版)

    中田理恵子 (, 範囲: 栄養素の代謝)

    朝倉書店, 2014年

  • 食品学Ⅱ-食品の分類と利用法-(改訂第2版)

    中田理恵子; 井上裕康 (, 範囲: 「油糧食品」「微生物利用食品」)

    南江堂, 2011年

  • 食品学Ⅰ-食品の化学・物性と機能性―(改訂第2版)

    中田理恵子; 井上裕康 (, 範囲: 「食品の機能」)

    南江堂, 2011年

  • Methods and Protocols, Methods in Molecular Biology Vol.644

    Inoue H; Nakakta R (, 範囲: Techniques Used to Study Regulation of Cyclooxygenase-2 Promoter sites)

    Springer, 2010年

  • 「ビタミン総合事典」

    中田理恵子 (, 範囲: 葉酸 -欠乏症-)

    朝倉書店, 2010年

  • 食品学Ⅱ 食品の分類と利用法

    中田理恵子; 井上裕康 (, 範囲: 油糧食品、微生物利用食品)

    南江堂, 2007年

  • 食品学Ⅰ 食品の化学・物性と機能性

    中田理恵子; 井上裕康 (, 範囲: 食品の機能性)

    南江堂, 2007年

  • 中国・シルクロード

    中田理恵子 (, 範囲: ウイグル族の食生活と栄養)

    東方出版, 2006年

  • 血栓症ナビゲーター

    中田理恵子; 宮田敏行 (, 範囲: 高ホモシステイン血症)

    メディカルレビュー社, 2006年

  • 中国・シルクロードの女性と生活

    中田理恵子 (, 範囲: ウイグル族の食生活)

    東方出版, 2004年

  • 食物科学概論

    中田理恵子 (, 範囲: 栄養素の代謝)

    朝倉書店, 2003年

講演・口頭発表等

  • 葉酸代謝酵素γ―グルタミルヒドロラーゼの臓器局在の検討

    第64回日本家政学会大会, 2012年

  • COX-2発現抑制、PPAR活性化を指標としたニンニク油の機能性評価

    第64回日本家政学会大会, 2012年

  • PPARαを介したレスベラトロールの作用と系統差による効果の相違

    第66回日本栄養食糧学会大会, 2012年

  • COX-2およびPPARを標的としたニンニク油の機能性評価

    第66回日本栄養食糧学会大会, 2012年

  • 運動負荷とレスベラトロールによる組織選択的PPARα活性化

    第63回日本ビタミン学会, 2012年

  • 葉酸欠乏における脂質代謝の変化-高脂肪負荷の影響-

    第63回日本ビタミン学会, 2012年

  • COX-2およびPPARを標的とした精油成分の機能性評価

    第54回日本脂質生化学会, 2012年

  • レスベラトロール摂取と習慣的運動による筋肉PPARα活性化と持久力向上

    第6回日本ポリフェノール学会年次大会, 2012年

  • ミラクリンの分子進化に関する考察:細胞内局在の視点から

    日本栄養食糧学会近畿支部大会, 2012年

  • Cellular localization of Miraculin-YFP fusion protein

    第46回日本味と匂学会, 2012年

  • 習慣的運動とレスベラトロールによる筋肉PPARα活性化

    第33回日本肥満学会, 2012年

  • PPAR活性化を介するレスベラトロールの機能性

    第33回日本肥満学会シンポジウム「食品の機能と肥満症」, 2012年

  • 4'hydroxy group of resveratrol plays a key role in PPARα activation

    Keystone symposium -Aging and Diseases of Aging-, 2012年

  • Resveratrol improves lipid metabolism and life span via PPARα.

    Keystone symposium -Aging and Diseases of Aging-, 2012年

  • 4'hydroxy group of resveratrol plays a key role in PPARα activation

    Keystone symposium -Aging and Diseases of Aging-, 2012年

  • Resveratrol improves lipid metabolism and life span via PPARα.

    Keystone symposium -Aging and Diseases of Aging-, 2012年

  • レスベラトロール4'水酸基はPPAR活性化に関与する

    第53回日本脂質生化学会, 2011年

  • PPARαを介したレスベラトロールの効果と系統差による脂質代謝の影響

    第53回日本脂質生化学会, 2011年

  • 葉酸欠乏における高脂肪摂取の影響

    第65回日本栄養食糧学会大会, 2011年

  • 若年女性の生殖機能に対する朝食欠食の抑制作用の実験的検証

    第65回日本栄養食糧学会大会, 2011年

  • 味覚修飾タンパク質ミラクリンは細胞外シグナル配列を持つ

    第65回日本栄養食糧学会大会, 2011年

  • COX-2およびPPARを標的としたシナモンバーグ油の機能性評価

    第65回日本栄養食糧学会大会, 2011年

  • レスベラトロールによる運動持久力改善効果の検討

    第65回日本栄養食糧学会大会, 2011年

  • レスベラトロールによるPPARα活性化における4'水酸基の関与

    第65回日本栄養食糧学会大会, 2011年

  • ワイン凍結乾燥物の長期摂取における心臓エネルギー代謝遺伝子への影響について

    第65回日本栄養食糧学会大会, 2011年

  • レスベラトロール摂取と適度な運動の相乗効果

    第63回日本家政学会大会, 2011年

  • PPARαを介したレスベラトロールの作用機構と系統差の相違

    第63回日本家政学会大会, 2011年

  • 食事リズムが若年女性の生殖機能に及ぼす影響について

    第63回日本家政学会大会, 2011年

  • ふなずしの呈味成分の生成

    第63回日本家政学会大会, 2011年

  • PPARαを介したレスベラトロールの作用機構-系統差の相違-

    日本ビタミン学会第63回大会, 2011年

  • 大腸菌によるγ―グルタミルヒドロラーゼの発現とラット臓器での局在

    日本ビタミン学会第63回大会, 2011年

  • Resveratrol and its tetramer activate PPARs in vitro and in vivo.

    XI Asian Congress of Nutrition, 2011年

  • A possible novel function of Asian herbs for prevention of lifestyle-related diseases targeted to COX-2 and PPARs.

    XI Asian Congress of Nutrition, 2011年

  • Skipping breakfast adversely affects reproductive function in post-adolescent female college students.

    XI Asian Congress of Nutrition, 2011年

  • A possible function of resveratrol and essential oil-derived chemicals for prevention of lifestyle-related diseases targeted to COX-2 and PPAR.

    52nd International Conference on the Bioscience of Lipids, 2011年

  • COX-2-PPAR-Resveratrol

    第84回日本生化学会シンポジウム「核内受容体と代謝」, 2011年

  • 運動負荷による筋肉でのレスベラトロールPPARα活性化

    第84回日本生化学会大会, 2011年

  • レスベラトロール類似体によるPPARα活性化

    第84回日本生化学会大会, 2011年

  • 組換えγ―グルタミルヒドロラーゼの発現と臓器局在

    第84回日本生化学会大会, 2011年

  • 味覚修飾タンパク質ミラクリンの細胞内局在検討

    第84回日本生化学会大会, 2011年

  • PPARとCOX-2を指標にした香辛料成分の機能評価

    第84回日本生化学会大会, 2011年

  • ミラクリンの酸味受容体候補PKD1L3/PKD2L1に対する影響の検討

    日本味と匂学会第45回大会, 2011年

  • COX-2とPPARを指標にしたレスベラトロールの機能性評価

    第5回日本ポリフェノール学会年次大会シンポジウム「ポリフェノール研究の最前線」, 2011年

  • Activation of PPARs by resveratrol in vitro and in vivo.

    2011 International Conference on Food Factors, 2011年

  • A possible function of resveratrol and essential oil-derived chemicals for prevention of lifestyle-related diseases targeted COX-2 and PPAR.

    2011 International Conference on Food Factors, 2011年

  • Resveratrol and its tetramer activate PPARs in vitro and in vivo.

    XI Asian Congress of Nutrition, 2011年

  • A possible novel function of Asian herbs for prevention of lifestyle-related diseases targeted to COX-2 and PPARs.

    XI Asian Congress of Nutrition, 2011年

  • Skipping breakfast adversely affects reproductive function in post-adolescent female college students.

    XI Asian Congress of Nutrition, 2011年

  • A possible function of resveratrol and essential oil-derived chemicals for prevention of lifestyle-related diseases targeted to COX-2 and PPAR.

    52nd International Conference on the Bioscience of Lipids, 2011年

  • Activation of PPARs by resveratrol in vitro and in vivo.

    2011 International Conference on Food Factors, 2011年

  • A possible function of resveratrol and essential oil-derived chemicals for prevention of lifestyle-related diseases targeted COX-2 and PPAR.

    2011 International Conference on Food Factors, 2011年

  • 大腸菌による組換えγ―グルタミルヒドロラーゼの発現と精製

    第64回日本栄養食糧学会大会, 2010年

  • COX-2およびPPARを標的にした食品機能成分の探索

    第64回日本栄養・食糧学会大会, 2010年

  • in vivoにおけるPPARαを介したレスベラトロールの作用機構

    第64回日本栄養食糧学会大会, 2010年

  • レスベラトロール摂取が運動持久力に及ぼす影響

    第64回日本栄養食糧学会大会, 2010年

  • 大腸菌を宿主とした組換えγ―グルタミルヒドロラーゼの発現系の構築

    第64回日本家政学会大会, 2010年

  • 食生活習慣が若年女性の生殖機能に及ぼす影響について

    第64回日本家政学会大会, 2010年

  • COX-2発現抑制、PPAR活性化を指標にしたレモングラス精油の機能性評価

    第64回日本家政学会大会, 2010年

  • PPAR活性化を指標にした食品機能成分の探索

    第64回日本栄養食糧学会大会シンポジウム「脂質・エネルギー代謝制御の分子栄養学」, 2010年

  • 大腸菌を用いた組換えγ―グルタミルヒドロラーゼの発現系構築と精製

    第62回日本ビタミン学会大会, 2010年

  • PPARおよびCOX-2への作用を指標にしたレモングラス精油成分の機能性評価

    第62回日本ビタミン学会大会, 2010年

  • PPARαを介したレスベラトロールの作用機構-個体レベルでの検討-

    第52回日本脂質生化学会, 2010年

  • Resveratrol activates PPARs in vitro and in vivo.

    Keystone symposium (Bioactive Lipids: Biochemistry and Diseases), 2010年

  • Evaluation of essential oils by activation of PPARs and suppression of COX-2 expression

    Keystone symposium (Bioactive Lipids: Biochemistry and Diseases), 2010年

  • 思春期直後の性成熟完成期にあたる女性を対象とした食事調査結果について

    日本調理科学会大会, 2010年

  • 特殊なPPAR活性化能を示す香辛料シナモンバーグ精油

    日本味と匂学会第44回大会, 2010年

  • レスベラトロール四量体バチカノールCによるPPARα,β/δ活性化-培養細胞および個体レベルでの検討-

    第33回日本分子生物学会年会・第83回日本生化学会大会合同大会, 2010年

  • Resveratrol activates PPARs in vitro and in vivo.

    Keystone symposium (Bioactive Lipids: Biochemistry and Diseases), 2010年

  • Evaluation of essential oils by activation of PPARs and suppression of COX-2 expression

    Keystone symposium (Bioactive Lipids: Biochemistry and Diseases), 2010年

  • 葉酸欠乏による肝臓及び脂肪組織での脂質代謝関連酵素の発現変動

    第63回日本栄養食糧学会大会, 2009年

  • PPARα欠損マウスを用いたレスベラトロール摂取の影響

    第63回日本栄養食糧学会大会, 2009年

  • レスベラトロール摂取による運動持久力改善効果の検討

    第63回日本栄養食糧学会大会, 2009年

  • レスベラトロールがヒト臍帯静脈血管内皮細胞の遺伝子発現に及ぼす影響

    第63回日本栄養食糧学会大会, 2009年

  • Change in gene expression of lipid metabolic enzyme in liver and adipose tissue of the folate-deficient rats.

    4th International Conference on Phospholipase A2 and Lipid mediators, 2009年

  • Evaluation of essential oils by activation of PPARs and suppression of COX-2 expression.

    4th International Conference on Phospholipase A2 and Lipid mediators, 2009年

  • 葉酸欠乏が肝臓及び脂肪組織における脂質代謝関連酵素の発現に及ぼす影響

    日本ビタミン学会第61回大会, 2009年

  • PPARおよびCOX-2への作用を指標としたバラ油成分の機能性評価

    日本ビタミン学会第61回大会, 2009年

  • レスベラトロール摂取によるPPARαを介した作用機構

    日本家政学会第61回大会, 2009年

  • COX-2発現抑制、PPAR活性化を指標とした精油の機能性評価

    日本家政学会第61回大会, 2009年

  • 朝食の欠食が若年女性の生殖機能に及ぼす影響について

    日本家政学会第61回大会, 2009年

  • COX-2発現抑制とPPAR活性化を指標とした香辛料成分の機能性評価

    日本味と匂学会第43回大会, 2009年

  • Resveratrol activates nuclear receptor PPARs in vitro and in vivo.

    19th International Congress of Nutrition, 2009年

  • 大腸菌を用いたγ―グルタミルヒドロラーゼの発現と精製

    第82回日本生化学会大会, 2009年

  • レスベラトロール連続処理による血管内皮細胞の遺伝子発現

    第82回日本生化学会大会, 2009年

  • in vivoにおけるレスベラトロールによるPPARα活性化

    第82回日本生化学会大会, 2009年

  • レスベラトロールによるPPARαを介した運動持久力改善効果の検討

    第82回日本生化学会大会, 2009年

  • PPAR活性化およびCOX-2発現抑制を指標にしたバラ油の機能性評価

    第82回日本生化学会大会, 2009年

  • PPARを介したレスベラトロールの作用機構

    第82回日本生化学会大会シンポジウム「レスベラトロールに関する最近の知見」, 2009年

  • Carvacrol and other components of essential oils activate PPARs and suppress COX-2 expression.

    Bioactive Lipid Conference, 2009年

  • COX-2およびPPARを指標とした精油成分の機能性評価-第2報-

    日本栄養食糧学会近畿支部第48回研究発表会, 2009年

  • Change in gene expression of lipid metabolic enzyme in liver and adipose tissue of the folate-deficient rats.

    4th International Conference on Phospholipase A2 and Lipid mediators, 2009年

  • Evaluation of essential oils by activation of PPARs and suppression of COX-2 expression.

    4th International Conference on Phospholipase A2 and Lipid mediators, 2009年

  • Resveratrol activates nuclear receptor PPARs in vitro and in vivo.

    19th International Congress of Nutrition, 2009年

  • Carvacrol and other components of essential oils activate PPARs and suppress COX-2 expression.

    Bioactive Lipid Conference, 2009年

  • 葉酸欠乏における遺伝子発現の変化

    第62回日本栄養食糧学会大会, 2008年

  • 葉酸高含有卵(葉酸たまご)の有用性の評価(第2報)

    第62回日本栄養食糧学会大会, 2008年

  • 核内受容体PPARαを介するブドウ新芽エキスによる運動持久力改善効果の検討

    第62回日本栄養食糧学会大会, 2008年

  • ブドウ新芽エキス摂取による運動持久力改善効果の検討

    日本家政学会第60回大会, 2008年

  • 遺伝子組換え技術による味覚修飾タンパク質ミラクリンの発現

    日本家政学会第60回大会, 2008年

  • 味覚修飾タンパク質ミラクリンの発現とその機能評価

    第55回日本生化学会近畿支部例会, 2008年

  • 葉酸欠乏が脂質代謝関連酵素の遺伝子発現に及ぼす影響

    第50回日本脂質生化学会, 2008年

  • レスベラトロール4量体バチカノールCによる核内受容体PPARα及びβ/δの活性化

    第50回脂質生化学会, 2008年

  • 葉酸欠乏による遺伝子発現の変動

    日本ビタミン学会第60回大会, 2008年

  • レスベラトロール4量体バチカノールCによる核内受容体PPARの活性化

    日本ビタミン学会第60回大会, 2008年

  • 大腸菌とシロイヌナズナを用いた組換えミラクリンの発現とその機能評価

    日本味と匂学会第42回大会, 2008年

  • 葉酸高含有卵(葉酸たまご)の生体内での有用性の評価

    日本家政学会関西支部第30回研究発表会, 2008年

  • COX-2およびPPARを標的とした精油成分の機能性評価

    日本栄養食糧学会近畿支部第47回研究発表会, 2008年

  • HUVECにおけるレスベラトロール連続処理による遺伝子発現変動の検討

    日本栄養食糧学会近畿支部第47回研究発表会, 2008年

  • 葉酸欠乏による遺伝子発現変動-肝臓と脂肪組織における脂質代謝関連酵素の変化-

    第31回日本分子生物学会年会・第81回日本生化学会大会合同大会, 2008年

  • レスベラトロール摂取によるPPARα依存的遺伝子群の誘導

    第31回日本分子生物学会年会・第81回日本生化学会大会合同大会, 2008年

  • 大腸菌を用いた味覚修飾活性を有する組換えミラクリンの発現

    第31回日本分子生物学会年会・第81回日本生化学会大会合同大会, 2008年

  • レスベラトロール配糖体ピセイドによるPPARαを介した脂質代謝改善効果の検討

    第74回日本栄養・食糧学会大会, 2020年05月

  • 妊娠および授乳期の葉酸欠乏が出生仔の脂質代謝に及ぼす影響

    日本家政学会第72回大会, 2020年05月

  • The direct activation of PPARalpha by 4’-hydroxyl group of resveratrol and a feedforward regulation via cAMP

    The 9th International Conference on Polyphenols and Health - ICPH2019(, 2019年11月

  • 妊娠・授乳期の葉酸欠乏が仔の脂質代謝に及ぼす影響

    第92回日本生化学会大会, 2019年09月

  • レスベラトロールによるPPARα活性化とcAMPを介した制御

    第92回日本生化学会大会, 2019年09月

  • cAMPを介したレスベラトロールによるPPARα活性化の制御

    第61回日本脂質生化学会, 2019年07月

  • 妊娠・授乳期の葉酸欠乏が出生仔の脂質代謝に及ぼす影響

    日本ビタミン学会第72回大会, 2019年06月

  • 加熱調理したサトイモレクチンが免疫細胞に与える影響

    日本家政学会第71回大会, 2019年05月

  • 心血管系機能に対するレスベラトロール摂取の効果

    日本家政学会第71回大会, 2019年05月

  • cAMPを介したレスベラトロールによるPPARα活性化

    第73回日本栄養・食糧学会大会, 2019年05月

  • モリンガ種子抽出物の抗疲労効果の検証

    日本農芸化学会2019年度大会, 2019年03月

  • 運動とレスベラトロールによる骨格筋代謝改善効果

    第91回日本生化学会大会, 2018年09月

  • マウス由来初代培養心筋細胞に対するレスベラトロールの効果とPPARα活性化の関与

    第91回日本生化学会大会, 2018年09月

  • マウス由来初代培養心筋細胞に対するレスベラトロールの効果

    Food Congress 2018, 2018年09月

  • レスベラトロールと運動による骨格筋代謝改善効果

    Food Congress 2018, 2018年09月

  • 雌性ラットにおける日内リズムと摂食リズムの乖離が食餌制限後の生殖機能回復へ及ぼす影響

    日本家政学会第70回大会, 2018年05月

  • 母ラットの葉酸摂取量が出生仔の代謝に及ぼす影響

    日本家政学会第70回大会, 2018年05月

  • 加熱調理したキントキマメレクチンがマウスガンおよび免疫細胞へ与える影響

    第72回日本栄養・食糧学会大会, 2018年05月

  • マウス由来培養心筋細胞に対するレスベラトロールの効果

    第72回日本栄養・食糧学会大会, 2018年05月

  • ホモシステインの上昇が骨強度に及ぼす影響

    第72回日本栄養・食糧学会大会, 2018年05月

所属学協会

  • 日本肥満学会

  • 日本栄養改善学会

  • 日本脂質生化学会

  • 日本ビタミン学会

  • 日本家政学会

  • 日本栄養・食糧学会

  • 日本生化学会

Works(作品等)

  • 食品素材の機能性評価

    2008年 - 2009年

  • 食品素材の機能性評価

    2007年 - 2008年

  • 葉酸高含有機能性卵の有用性評価に関する研究

    2006年 - 2007年

  • α‐グリコシルグリセロールの機能性評価

    2005年 - 2006年

  • ツイントースの鉄吸収促進作用

    2005年 - 2006年



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