髙地　リベカTakachi Ribekaタカチ　リベカ

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プロフィール情報

• 姓

  髙地, タカチ

• 名

  リベカ, リベカ

学位

• 修士（食品栄養学）, 東京農業大学
• 博士（医学）, 東北大学

研究キーワード

• 介入研究
• 減塩
• 食事評価システム開発
• 栄養疫学
• intervention study
• dietary salt intake reduction
• Development of automated self-administered dietary assessment system
• Nutritional Epidemiology

研究分野

• 人文・社会, 家政学、生活科学
• ライフサイエンス, 衛生学、公衆衛生学分野：実験系を含まない

学歴

• 2009年, 東北大学, 大学院医学系研究科, 医科学専攻, 日本国
• 2005年, 東京農業大学大学院, 農学研究科, 食品栄養学専攻, 日本国
• 1994年, 東京農業大学, 農学部, 栄養学科, 日本国

Ⅱ．研究活動実績

論文

• 査読あり, 英語, Kidney Blood Press Res, Associations of Urinary and Dietary Sodium-To-Potassium Ratios with Albuminuria in Community-Dwelling Japanese Adults: A Cross-Sectional Study., 2022年08月05日, 47, 9, 576, 585, 10.1159/000526277
• 査読あり, 英語, Preventive Medicine, Association of sugary drink consumption with all-cause and cause-specific mortality: the Japan Public Health Center-based Prospective Study, Hsi-Lan Huang; Sarah Krull Abe; Norie Sawada; Ribeka Takachi; Junko Ishihara; Motoki Iwasaki; Taiki Yamaji; Hiroyasu Iso; Tetsuya Mizoue; Mitsuhiko Noda; Masahiro Hashizume; Manami Inoue; Shoichiro Tsugane, BACKGROUND: Few epidemiologic studies have assessed the associations of sugary drink consumption with mortality outcomes among Asian populations. METHODS: This study included 70,486 participants in the Japan Public Health Center-based Prospective Study at the age of 45-74 years in 1995-1999. A validated food frequency questionnaire was used to assess the consumption of sugary drinks. We estimated the risk of total and cause-specific mortality associated with sugary drink consumption using Cox proportional hazards regression model. RESULTS: Mean follow-up was 17.1 years, during which 11,811 deaths were documented. Sugary drink consumption was associated with higher total mortality, with multivariate HR of 1.06 (95% CI 1.00-1.13) for quintile 3, 1.07 (95% CI 1.01-1.13) for quintile 4, and 1.15 (95% CI 1.09-1.22) for quintile 5, compared with quintile 1 (P < 0.001 for trend). Additionally, positive associations with cause-specific mortality were observed, including death from circulatory system diseases (quintile 5 vs quintile 1; HR, 1.23; 95% CI 1.09-1.38) and heart disease (quintile 5 vs quintile 1; HR, 1.35; 95% CI 1.14-1.60). CONCLUSION: In this large Japanese prospective study, sugary drink consumption was associated with all-cause and cause-specific mortality., 2021年07月, 148, 106561, 106561, 研究論文（学術雑誌）, 国際誌, 10.1016/j.ypmed.2021.106561

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• 査読あり, 英語, Cancer Epidemiol Biomarkers Prev., Sugary drink consumption and subsequent colorectal cancer risk: the Japan Public Health Center-based Prospective Cohort Study, Leung CY; Abe SK; Sawada N; Ishihara J; Takachi R; Yamaji T; Iwasaki M; Hashizume M; Inoue M; Tsugane S, BACKGROUND: Most studies examining the associations of sugary drink consumption on colorectal cancer risk have been conducted in Western populations. METHODS: This study consisted of 74,070 participants in the Japan Public Health Center-based Prospective Study who completed a food frequency questionnaire (1995-1999). The participants were followed until December 2013 to investigate the associations between sugary drink consumption and colorectal cancer risk using Cox proportional hazards regression models. RESULTS: Among the 74,070 participants, mean age was 56.5 years at baseline, with a mean body mass index (BMI) of 23.5 and a mean daily consumption of 286 mL/day for men and 145 mL/day for women. During a follow-up of 15 years, 1,648 colorectal cancer cases were identified. No overall greater risk of colorectal cancer was observed among men [multivariable HR = 0.84; 95% confidence of interval (CI), 0.70-1.02; ≥254 mL/day vs. nonconsumers] and women (HR = 1.20; 95% CI, 0.96-1.50, ≥134 mL/day vs. nonconsumers). Sugary drink consumption was associated with colon cancer among women (HR = 1.36; 95% CI, 1.03-1.78, ≥134 mL/day vs. nonconsumers). HRs for proximal colon cancer among women who consumed sugary drinks, as compared with nonconsumers, were 1.47 (95% CI, 1.03-2.10) for sugary drink consumption less than 134 mL/day, and 1.45 (95% CI, 1.01-2.09) for at least 134 mL/day. CONCLUSIONS: In this large prospective cohort of Japanese with a moderate sugary drink consumption level and low prevalence of obesity, we observed a 36% increased risk of colon cancer in women. IMPACT: Our findings highlight the importance of subsite- and sex-specific investigation., 2021年04月, 30, 4, 782, 8, 研究論文（学術雑誌）, 国際誌, 10.1158/1055-9965.EPI-20-1364

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• 査読あり, 日本語, 家政学研究, 奈良女子大学家政学会, 食事調査に用いる料理データベース開発を目的とした男女・年代別の主食の飯および副菜の野菜類のポーションサイズの検討, 高地リベカ; 本多泉美; 石井有里; 丸谷幸子; 石原淳子; 髙田和子, 2021年03月, 67, 2, 43, 9

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• 査読あり, 英語, Geriatrics & Gerontology International, Body mass index and risk of recurrent falls in community‐dwelling Japanese aged 40–74 years: The Murakami cohort study, Kazutoshi Nakamura; Kaori Kitamura; Yumi Watanabe; Keiko Kabasawa; Akemi Takahashi; Aya Hinata; Toshiko Saito; Ryosaku Kobayashi; Rieko Oshiki; Ribeka Takachi; Shoichiro Tsugane; Masayuki Iki; Ayako Sasaki; Osamu Yamazaki; Kei Watanabe, 2021年06月, 21, 6, 498, 505, 研究論文（学術雑誌）, 10.1111/ggi.14167

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• 査読あり, 英語, Nutrition Journal, Variations in the estimated intake of acrylamide from food in the Japanese population, Kumiko Kito; Junko Ishihara; Junpei Yamamoto; Takayuki Hosoda; Ayaka Kotemori; Ribeka Takachi; Kazutoshi Nakamura; Junta Tanaka; Taiki Yamaji; Taichi Shimazu; Yuri Ishii; Norie Sawada; Motoki Iwasaki; Hiroyasu Iso; Tomotaka Sobue; Shoichiro Tsugane, 2020年12月, 19, 1, 研究論文（学術雑誌）, 10.1186/s12937-020-00534-y

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• 査読あり, 英語, Nutrition Journal, Development and validation of nutrient estimates based on a food-photographic record in Japan, Keigo Saeki; Naoto Otaki; Maiko Kitagawa; Nobuhiro Tone; Ribeka Takachi; Rika Ishizuka; Norio Kurumatani; Kenji Obayashi, Abstract Background Previous studies have reported that estimates of portion size, energy, and macronutrients such as carbohydrates, proteins, and fat based on the food-photographic record closely correlate with directly weighed values. However, the correlation based on a large sample of the test meal with the evidence of many nutrients is yet to be determined. We conducted this study to assess the correlation and difference between the food-photographic record and weighed results for 44 nutrients based on a larger number of test meals than those in previous studies. Methods We assessed the nutrients of test meals using a food-photographic record and direct weighing and compared the results of the two methods. Twenty participants prepared a total of 1163 test meals. Each participant cooked 28–29 different kinds of dishes. Five participants cooked the same dish with their own recipes. For the most commonly consumed 41 dishes, 20 participants served a meal with their usual portion size. For the remaining 73 dishes, five participants served a meal with their usual portion size. An independent researcher weighed each ingredient and calculated the nutrients of the test meals. The participants took photographs of the test meals using a digital camera. Two independent, trained analysts measured the longitudinal and transverse diameters of the food area on the photographs of the test meals, compared the portion size with the reference photographs, and calculated the nutrients based on a database that contained reference photographs. Results Rank correlation coefficients between estimates from the food-photographic record of each test meal and weighed results were high for portion size (r = 0.93), energy (r = 0.93), protein (r = 0.90), fat (r = 0.92), and carbohydrate (r = 0.94), and those for the 44 nutrients ranged from 0.78 to 0.94. We found high reproducibility between the two analysts for all the nutrients (r > 0.90). Conclusions We found a high correlation and small difference between the food-photographic record method and weighed results of a large number of nutrients in many test meals., 2020年12月, 19, 1, 104, 研究論文（学術雑誌）, 10.1186/s12937-020-00615-y

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• 査読あり, 英語, PLOS ONE, Association between meat intake and mortality due to all-cause and major causes of death in a Japanese population, Eiko Saito; Xiaohe Tang; Sarah Krull Abe; Norie Sawada; Junko Ishihara; Ribeka Takachi; Hiroyasu Iso; Taichi Shimazu; Taiki Yamaji; Motoki Iwasaki; Manami Inoue; Shoichiro Tsugane, We examined the association between meat intake and mortality due to all-cause and major causes of death using a population-based cohort study in Japan. 87,507 Japanese aged between 45 and 74 years old at 5-year follow-up study were followed for 14.0 years on average. Associations between meat intake and mortality risk were assessed using a Cox proportional hazards model. A heavy intake of total meat was associated with a higher risk of all-cause mortality relative to the lowest quartile intake in men (Q4: HR,1.18; 95%CIs, 1.06–1.31). A higher intake of total meat was associated with a lower risk of stroke mortality in women (Q2: HR, 0.70; 95%CIs, 0.51–0.94, Q3: HR, 0.68; 95%CIs, 0.50–0.95, Q4: HR, 0.66; 95%CIs, 0.44–0.99). A heavy intake of red meat was also associated with all-cause mortality (Q4: HR, 1.13; 95%CIs, 1.02–1.26) and heart disease mortality (Q4: HR, 1.51; 95%CIs, 1.11–2.06) in men but not in women. Heavy intake of chicken was inversely associated with cancer mortality in men. Heavy intakes of total and red meat were associated with an increase in all-cause and heart disease mortality in men, while total meat intake was associated with a lower risk of stroke mortality in women. , 2020年12月, 15, 12, e0244007, e0244007, 研究論文（学術雑誌）, 10.1371/journal.pone.0244007

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• 査読あり, 英語, Cancer Medicine, Fermented and nonfermented soy foods and the risk of breast cancer in a Japanese population‐based cohort study, Ritsuko Shirabe; Eiko Saito; Norie Sawada; Junko Ishihara; Ribeka Takachi; Sarah Krull Abe; Taichi Shimazu; Taiki Yamaji; Atsushi Goto; Motoki Iwasaki; Manami Inoue; Shoichiro Tsugane, BACKGROUND: Although preclinical studies suggest that fermented soy foods may have a protective effect against breast cancer, no prospective cohort studies have examined this association. OBJECTIVE: Our study examined the association between fermented and nonfermented soy food intake and breast cancer risk using a population-based prospective cohort study in Japan. METHODS: We included a total of 47,614 women aged 45-74 years in an analysis of the Japan Public Health Center-based Prospective Study (JPHC Study). A validated food frequency questionnaire (FFQ) was used for the assessment of dietary intake. Breast cancer incidence was analyzed by multivariate Cox proportional hazards regression models. RESULTS: During an average of 15.5 years of follow-up, 825 breast cancer cases were newly identified. We found no association of intake of soy foods with breast cancer risk, regardless of fermentation, with multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) for the highest quartiles of fermented and nonfermented soy food intake of 0.94 (0.67, 1.32) and 1.15 (0.85, 1.57) compared with the lowest quartile (p for trend = 0.305 and 0.393). Unlike nonfermented soy, higher intake of fermented soy foods was associated with a significant decrease in the risk of nonlocalized breast cancer. The HR and 95% CI in the highest compared to lowest intake category of fermented soy foods was 0.53 (0.28, 0.99) versus nonfermented soy foods 0.85 (0.51, 1.42) (p for trend = 0.026 and 0.797). CONCLUSIONS: Our analyses showed that fermented soy foods had no association with overall breast cancer but may be associated with decreased risk of nonlocalized breast cancer., 2020年12月, 10, 2, 757, 771, 研究論文（学術雑誌）, 国際誌, 10.1002/cam4.3677

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• 査読あり, 英語, British Journal of Nutrition, Predictors of decline in vitamin D status in middle-aged and elderly individuals: a 5-year follow-up study, Kazutoshi Nakamura; Kaori Kitamura; Yumi Watanabe; Toshiko Saito; Akemi Takahashi; Ryosaku Kobayashi; Rieko Oshiki; Keiko Kabasawa; Ribeka Takachi; Shoichiro Tsugane; Masayuki Iki; Ayako Sasaki; Kei Watanabe, Little is known about predictors of decline in vitamin D status (vitamin D decline) over time. We aimed to determine demographic and lifestyle variables associated with vitamin D decline by sufficiently controlling for seasonal effects of vitamin D uptake in a middle-aged to elderly population. Using a longitudinal study design within the larger framework of the Murakami Cohort Study, we examined 1044 individuals aged between 40 and 74 years, who provided blood samples at baseline and at 5-year follow-up, the latter of which were taken on a date near the baseline examination (±14 d). Blood 25-hydroxyvitamin D (25(OH)D) concentrations were determined with the Liaison^® 25OH Vitamin D Total Assay. A self-administered questionnaire collected demographic, body size and lifestyle information. Vitamin D decline was defined as the lowest tertile of 5-year changes in blood 25(OH)D (Δ25(OH)D) concentration (<6·7 nmol/l). Proportions of those with vitamin D decline were 182/438 (41·6 %) in men and 166/606 (27·4 %) in women (P < 0·0001). In men, risk of vitamin D decline was significantly lower in those with an outdoor occupation (P = 0·0099) and those with the highest quartile of metabolic equivalent score (OR 0·34; 95 % CI 0·14, 0·83), and higher in those with ‘university or higher’ levels of education (OR 2·92; 95 % CI 1·04, 8·19). In women, risk of vitamin D decline tended to be lower with higher levels of vitamin D intake (P_{for trend} = 0·0651) and green tea consumption (P_{for trend} = 0·0025). Predictors of vitamin D decline differ by sex, suggesting that a sex-dependent intervention may help to maintain long-term vitamin D levels., 2020年10月14日, 124, 7, 729, 735, 研究論文（学術雑誌）, 国際誌, 10.1017/s0007114520001580

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• 査読あり, 英語, Nutrients, Short-Term Effects of Salt Restriction via Home Dishes Do Not Persist in the Long Term: A Randomized Control Study, Sachiko Maruya; Ribeka Takachi; Maki Kanda; Misako Nakadate; Junko Ishihara, Salt intake reduction is crucial to prevent non-communicable diseases (NCDs) globally. This study aimed to investigate the short- and long-term effects of monitoring salt concentration in homemade dishes on reducing salt intake in a Japanese population. A double-blind randomized controlled trial using a 2 × 2 factorial design with two interventions was conducted in 195 participants; they were assigned to both interventions for a group monitoring salt concentration in soups (control: no monitoring) and a group using low-sodium seasoning (control: regular seasoning). We evaluated 24-hour urinary sodium excretions at baseline and after a three-month intervention for the changes as major outcomes, at six- and twelve-months after baseline as long-term follow-up surveys. Urinary sodium excretion decreased in both intervention and control groups after the intervention. However, differences in the change for both monitoring and low-sodium seasoning interventions were statistically non-significant (p = 0.29 and 0.52, respectively). Urinary sodium excretion returned to the baseline level after twelve-months for all groups. Monitoring of salt concentration is ineffective in reducing salt intake for short- and long-term among the people studied in this cohort., 2020年10月, 12, 10, 3034, 3034, 研究論文（学術雑誌）, 10.3390/nu12103034

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• 査読あり, 英語, European Journal of Nutrition, Comparison between the impact of fermented and unfermented soy intake on the risk of liver cancer: the JPHC Study, Sarah Krull Abe; Norie Sawada; Junko Ishihara; Ribeka Takachi; Nagisa Mori; Taiki Yamaji; Taichi Shimazu; Atsushi Goto; Motoki Iwasaki; Manami Inoue; Shoichiro Tsugane, PURPOSE: The aim of this study was to compare the impact of fermented and unfermented soy intake, based on the following soy-derived products: tofu, soymilk, natto, and miso, on the risk of liver cancer among Japanese adults. METHODS: 75,089 Participants of the Japan Public Health Center-based Prospective Study (JPHC Study) were followed from the time of the 5-year follow-up questionnaire until the end of 2012-2013. Subjects with available data on hepatitis B virus (HBV) and hepatitis C virus (HCV) infection status from blood samples (n = 14,016) and those who were anti-HCV antibody (anti-HCV) or hepatitis B virus antigen (HBsAg) positive (n = 1033) were also analyzed separately. Cox proportional hazard models were employed to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs). RESULTS: During 1,145,453 person-years, 534 newly diagnosed cases of liver cancer were identified in the JPHC Study. For miso intake among men, the multivariate-adjusted highest versus lowest quartile HR was 0.65 (95% CI, 0.48-0.89); p for trend = 0.006. Results were similar in those who were anti-HCV or HBsAg positive, 0.24 (0.08-0.70); p for trend = 0.004 highest versus lowest tertile. For the sub-analysis among only participants with known hepatitis infection status and HCV and HBsAg adjustment, a similar association was observed. In the multivariate complete cohort analysis, among women, the highest intake of fried tofu was inversely associated with the risk of liver cancer, HR = 0.45 (0.26-0.80); p for trend = 0.014. CONCLUSIONS: We observed no association between total soy intake, fermented and unfermented, and risk of liver cancer, and only an inverse association between miso intake and liver cancer among men., 2020年07月27日, 60, 3, 1389, 1401, 研究論文（学術雑誌）, 国際誌, 10.1007/s00394-020-02335-9

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• 査読あり, 英語, Cancer Epidemiology Biomarkers & Prevention, Soy Food Intake and Pancreatic Cancer Risk: The Japan Public Health Center–based Prospective Study, Yoko Yamagiwa; Norie Sawada; Taichi Shimazu; Taiki Yamaji; Atsushi Goto; Ribeka Takachi; Junko Ishihara; Motoki Iwasaki; Manami Inoue; Shoichiro Tsugane, BACKGROUND: Although the poor prognosis and increasing incidence of pancreatic cancer highlight the need for prevention strategies, few lifestyle risk factors for pancreatic cancer have yet been identified. Soybeans contain various bioactive compounds. However, the association between soy food intake and pancreatic cancer risk remains unknown. METHODS: The Japan Public Health Center-based Prospective Study is a cohort study conducted in a general Japanese population. To determine the association of soy food intake and pancreatic cancer incidence, we analyzed 90,185 participants who responded to a questionnaire on medical history and lifestyle factors, including dietary factors based on a food frequency questionnaire in 1995-1998, using Cox proportional hazards models. RESULTS: During a median follow-up of 16.9 years, 577 cases of pancreatic cancer were identified. In the multivariate-adjusted model, total soy food intake was statistically significantly associated with an increased risk of pancreatic cancer [HR for the highest vs. lowest intake quartile: 1.48; 95% confidence interval (CI), 1.15-1.92; Ptrend = 0.007]. Among soy foods, nonfermented soy food intake showed a statistically significant positive association with pancreatic cancer (HR, 1.41; 95% CI, 1.09-1.81; Ptrend = 0.008), whereas fermented soy food intake showed no association (HR, 0.96; 95% CI, 0.73-1.26; Ptrend = 0.982). CONCLUSIONS: Higher intake of soy foods, particularly nonfermented soy foods, might increase pancreatic cancer risk. IMPACT: This study is the first to report an association between the intake of various soy foods and pancreatic cancer risk. Further studies are required to confirm our findings., 2020年06月, 29, 6, 1214, 1221, 研究論文（学術雑誌）, 国際誌, 10.1158/1055-9965.epi-19-1254

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• 査読あり, 英語, British Journal of Nutrition, Dietary calcium and vitamin K are associated with osteoporotic fracture risk in middle-aged and elderly Japanese women, but not men: the Murakami Cohort Study, Kseniia Platonova; Kaori Kitamura; Yumi Watanabe; Ribeka Takachi; Toshiko Saito; Keiko Kabasawa; Akemi Takahashi; Ryosaku Kobayashi; Rieko Oshiki; Aleksandr Solovev; Masayuki Iki; Shoichiro Tsugane; Ayako Sasaki; Osamu Yamazaki; Kei Watanabe; Kazutoshi Nakamura, Although dietary Ca, vitamin D and vitamin K are nutritional factors associated with osteoporosis, little is known about their effects on incident osteoporotic fractures in East Asian populations. This study aimed to determine whether intakes of these nutrients predict incident osteoporotic fractures. We adopted a cohort study design with a 5-year follow-up. Subjects were 12 794 community-dwelling individuals (6301 men and 6493 women) aged 40–74 years. Dietary intakes of Ca, vitamin D and vitamin K were assessed with a validated FFQ. Covariates were demographic and lifestyle factors. All incident cases of major osteoporotic limb fractures, including those of the distal forearm, neck of humerus, neck or trochanter of femur and lumbar or thoracic spine were collected. Hazard ratios (HR) for energy-adjusted Ca, vitamin D and vitamin K were calculated with the residual method. Mean age was 58·8 (sd 9·3) years. Lower energy-adjusted intakes of Ca and vitamin K in women were associated with higher adjusted HR of total fractures (P_{for trend} = 0·005 and 0·08, respectively). When vertebral fracture was the outcome, P_{for trend} values for Ca and vitamin K were 0·03 and 0·006, respectively, and HR of the lowest and highest (reference) intake groups were 2·03 (95 % CI 1·08, 3·82) and 2·26 (95 % CI 1·19, 4·26), respectively. In men, there were null associations between incident fractures and each of the three nutrient intakes. Lower intakes of dietary Ca and vitamin K were independent lifestyle-related risk factors for osteoporotic fracture in women but not men. These associations were robust for vertebral fractures, but not for limb fractures., 2020年05月07日, 1, 10, 研究論文（学術雑誌）, 10.1017/s0007114520001567

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• 査読あり, 英語, European Journal of Nutrition, Associations between changes in fruit and vegetable consumption and weight change in Japanese adults, Calistus Wilunda; Norie Sawada; Atsushi Goto; Taiki Yamaji; Ribeka Takachi; Junko Ishihara; Nagisa Mori; Ayaka Kotemori; Motoki Iwasaki; Shoichiro Tsugane, BACKGROUND: Fruits and vegetables may induce greater satiety, reduce hunger, decrease energy intake, and modulate energy metabolism, thereby playing a role in weight loss. OBJECTIVE: To determine the associations between changes in fruit and vegetable consumption and weight change over a 5-year interval in Japanese adults. METHODS: This cohort study included 54,015 subjects (54.6% female, mean age 56.5 years) of the Japan Public Health Center-based Prospective Cohort Study who had no known history of major chronic diseases at baseline. Data on fruit and vegetable consumption were collected using a validated food frequency questionnaire. Body weight was self-reported. We used multivariable linear mixed-effects regression models to examine the associations between changes in fruit and vegetable consumption and change in body weight. RESULTS: On average, body weight decreased by 25 g [95% confidence interval (CI), 3, 47] for every 100 g/d increase in total vegetable consumption. Change in fruit consumption was nonlinearly associated with weight change. Fruit consumption was directly associated with weight change among subjects who increased consumption (70 g; 95% CI, 39, 101) but was not associated with weight change among subjects who reduced or did not change fruit consumption. These associations did not vary by sex, age, and body mass index (BMI) at baseline. The association with vegetables was restricted to yellow/red vegetables (- 74 g; 95% CI, - 129, - 18) and allium vegetables (- 129 g; 95% CI, - 231, - 28). Lower-fiber vegetables were inversely associated with weight change, whereas lower-fiber fruits or higher-energy fruits were directly associated with weight change beyond 0 g/d change in consumption. CONCLUSIONS: Change in vegetable consumption was inversely associated with weight change while fruit consumption was positively associated with weight change among subjects who increased consumption. The influence of fruits and vegetables on weight change may depend on the characteristics of the fruits and vegetables., 2020年04月06日, 60, 1, 217, 227, 研究論文（学術雑誌）, 国際誌, 10.1007/s00394-020-02236-x

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• 査読あり, 英語, Journal of Epidemiology, Study Design and Baseline Profiles of Participants in the Uonuma CKD Cohort Study in Niigata, Japan, Keiko Kabasawa; Junta Tanaka; Kazutoshi Nakamura; Yumi Ito; Kinya Yoshida; Ribeka Takachi; Norie Sawada; Shoichiro Tsugane; Ichiei Narita, BACKGROUND: Evidence for primary prevention of chronic kidney disease (CKD) is insufficient. The population-based prospective Uonuma CKD cohort study aims to explore associations of lifestyle and other risk factors with CKD. We report here the study design and baseline profiles. METHODS: All 67,322 residents aged ≥40 years in Minamiuonuma City, Uonuma City, and Yuzawa Town, Niigata Prefecture, Japan and 11,406 participants who attended local health-check examinations were targeted for baseline questionnaire and biochemical sampling, respectively. Information was gathered from 43,217 (64.2%) questionnaires and 8,052 (70.6%) biochemical samples; 6,945 participants consented to both questionnaire and biochemical sampling at baseline, conducted between fiscal years 2012 and 2015. Participants provided information regarding sociodemographic, lifestyle, and self-reported outcomes. Urine albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were measured. The primary outcome is CKD based on self-report and biochemical/clinical diagnosis. RESULTS: Mean age of questionnaire respondents was 63.3 (standard deviation [SD], 12.5) years for men and 64.3 (SD, 13.3) years for women. Among participants who submitted urine samples, median ACR was 10.0 (interquartile range [IQR], 5.0-24.0) mg/g for men and 13.0 (IQR, 7.7-27.0) mg/g for women, and median eGFR was 73.6 mL/min/1.73 m2 (IQR, 63.5-84.5) for men and 73.5 mL/min/1.73 m2 (IQR, 64.4-83.5) for women. ACR 30 mg/g or more was found in 1,741 participants (21.7%) and eGFR <60 mL/min/1.73 m2 in 1,361 participants (16.9%). CONCLUSION: The Uonuma CKD cohort study was established to investigate the impact of lifestyle on CKD development and to provide data for preventing the onset and progression of CKD., 2020年04月05日, 30, 4, 170, 176, 研究論文（学術雑誌）, 国内誌, 10.2188/jea.je20180220

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• 査読あり, 英語, European Journal of Pain, Total physical activity and risk of chronic low back and knee pain in middle‐aged and elderly Japanese people: The Murakami cohort study, Aleksandr Solovev; Yumi Watanabe; Kaori Kitamura; Akemi Takahashi; Ryosaku Kobayashi; Toshiko Saito; Ribeka Takachi; Keiko Kabasawa; Rieko Oshiki; Kseniia Platonova; Shoichiro Tsugane; Masayuki Iki; Ayako Sasaki; Osamu Yamazaki; Kei Watanabe; Kazutoshi Nakamura, BACKGROUND: Specific components of physical activity, such as vigorous exercise and heavy occupational work, are known to increase the risk of chronic low back pain (CLBP) and chronic knee pain (CKP), but impacts of other components are less known. This study aimed to assess the relationship between total physical activity and risk of CLBP and CKP from a public health perspective. METHODS: Participants were 7,565 individuals, aged 40-74 years, who did not have CLBP or CKP, and who participated in the 5-year follow-up survey. A self-administered questionnaire was used to obtain information on demographics, body size and lifestyle (including physical activity) in the baseline survey in 2011-2013, and on CLBP and CKP using Short Form 36 (SF-36) in the follow-up survey. Sitting, standing, walking and strenuous work for occupational activity were assessed for total physical activity, and walking slowly, walking quickly, light to moderate exercise and strenuous exercise were assessed for leisure-time physical activity using metabolic equivalent hours/day (METs score). RESULTS: Mean age of participants was 60.1 years (SD, 8.8). Participants with higher METs scores had a significantly higher risk of CKP (p for trend = 0.0089, OR of 4th quartile = 1.29, 95% CI: 1.04-1.59 vs. 1st quartile), but not CLBP. An intermediate leisure-time METs score was associated with a lower risk of CLBP (OR = 0.75, 95%CI: 0.61-0.92 vs. 0 METs-group). CONCLUSIONS: A high level of total physical activity may increase the risk of CKP, whereas an intermediate level of leisure-time physical activity may decrease the risk of CLBP, in middle-aged and elderly individuals. SIGNIFICANCE: Evidence on the longitudinal association between total physical activity and CLBP and CKP in middle-aged and elderly people is lacking. We conducted a cohort study to assess this association, and found that high levels of total physical activity increased risk of CKP, and intermediate levels of leisure-time physical activity decreased risk of CLBP. This suggests that the effect of physical activity on chronic pain differed by pain site., 2020年04月, 24, 4, 863, 872, 研究論文（学術雑誌）, 国際誌, 10.1002/ejp.1535

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• 査読あり, 英語, European Journal of Cancer Prevention, Doneness preferences, meat and meat-derived heterocyclic amines intake, and N-acetyltransferase 2 polymorphisms: Association with Colorectal Adenoma in Japanese Brazilians., Sanjeev Budhathoki; Motoki Iwasaki; Taiki Yamaji; Gerson S. Hamada; Nelson T. Miyajima; Jose C. Zampieri; Sangita Sharma; Mohammadreza Pakseresht; Fariba Kolahdooz; Junko Ishihara; Ribeka Takachi; Hadrien Charvat; Loïic Le Marchand; Shoichiro Tsugane, Intake of heterocyclic amines (HCAs) and other mutagenic compounds formed during cooking has been hypothesized to be responsible for the positive association observed between red meat and colorectal cancer. We evaluated whether well-done/very well-done preferences for various meat and fish items, higher intakes of meat and fish, and meat-derived and fish-derived HCA are associated with the risk of colorectal adenoma (CRA) in a Japanese-Brazilian population. We selected 302 patients with adenoma and 403 control individuals who underwent total colonoscopy between 2007 and 2013, and collected information on aspects of meat intake using a detailed questionnaire. We also estimated HCA intake of the study participants using an HCA database that matched the cooking methods of this population. Latent class analysis on the basis of response to doneness preferences for different cooking methods of commonly consumed meat and fish items identified four distinct subgroups. Compared with the subgroup characterized by a preference for rare/medium well-done cooking for most meat and fish items, the odds ratio of CRA for the well-done/very well-done preference subgroup was 1.19 (95% confidence interval: 0.51-2.75). High intake of mixed-meat dishes was suggestively associated inversely with CRA, whereas a high intake of poultry was associated positively with CRA. No clear association with intake of total or specific HCAs and no effect modification by N-acetyltransferase 2 acetylation genotype were observed. We found no statistically significant associations between meat and HCA intake and CRA. These findings do not support a positive association between meat and meat-derived HCA intake and the risk of CRA., 2020年01月, 29, 1, 7, 14, 研究論文（学術雑誌）, 国際誌, 10.1097/cej.0000000000000506

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• 査読あり, 英語, BMC Nephrology, Association of estimated dietary acid load with albuminuria in Japanese adults: a cross-sectional study, Keiko Kabasawa; Michihiro Hosojima; Ribeka Takachi; Kazutoshi Nakamura; Yumi Ito; Akihiko Saito; Norie Sawada; Shoichiro Tsugane; Junta Tanaka; Ichiei Narita, BACKGROUND: Acid-base imbalance might promote the progression of chronic kidney disease (CKD), but whether nutrient-derived dietary acid load increases the risk of albuminuria or even high normoalbuminuria is unclear. METHODS: A Japanese cohort comprising 3250 men and 3434 women aged 40-97 years with urine albumin-to-creatinine ratio (ACR) < 33.9 mg/mmol or estimated glomerular filtration rate ≥ 15 ml/min/1.73 m2 were assessed. We performed a cross-sectional evaluation of the association between net endogenous acid production (NEAP), estimated as dietary protein to potassium content ratio, and the presence of high normoalbuminuria (ACR: 1.13-3.38 mg/mmol) or microalbuminuria. RESULTS: Median NEAP was 43.4 (interquartile range (IQR): 34.2-53.4) mEq/day in men and 35.0 (IQR: 27.7-43.6) mEq/day in women. Median ACR was 1.11 (IQR: 0.57-2.49) mg/mmol in men and 1.47 (IQR: 0.82-2.83) mg/mmol in women. In multivariate analysis, the adjusted odds ratio of the highest versus lowest NEAP quartile for microalbuminuria was 1.47 (95% confidence interval (CI): 1.08-1.99) in men and 1.54 (95% CI: 1.11-2.14) in women. For high normoalbuminuria or microalbuminuria, the adjusted odds ratio was 1.28 (95% CI: 1.02-1.59) in men and 1.39 (95% CI: 1.11-1.74) in women. From nutrient composition analysis, subjects with the highest potassium intake, but not protein intake, had lower adjusted odds ratios for the presence of microalbuminuria than those in the lowest quartile for potassium intake. CONCLUSIONS: Higher NEAP was associated with albuminuria and its association might negatively relate to potassium intake in an adult Japanese population., 2019年12月, 20, 1, 194, 194, 研究論文（学術雑誌）, 国際誌, 10.1186/s12882-019-1352-8

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• 査読あり, 英語, JAMA Internal Medicine, Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality in a Japanese Cohort, Sanjeev Budhathoki; Norie Sawada; Motoki Iwasaki; Taiki Yamaji; Atsushi Goto; Ayaka Kotemori; Junko Ishihara; Ribeka Takachi; Hadrien Charvat; Tetsuya Mizoue; Hiroyasu Iso; Shoichiro Tsugane, IMPORTANCE Epidemiological evidence regarding the long-term effects of higher dietary protein intake on mortality outcomes in the general population is not clear.OBJECTIVE To evaluate the associations between animal and plant protein intake and all-cause and cause-specific mortality.DESIGN, SETTING, AND PARTICIPANTS This prospective cohort study included 70 696 participants in the Japan Public Health Center-based Prospective Cohort who were aged 45 to 74 years and had no history of cancer, cerebrovascular disease, or ischemic heart disease at study baseline. Data were collected from January 1, 1995, through December 31, 1999, with follow-up completed December 31, 2016, during which 12 381 total deaths were documented. Dietary intake information was collected through a validated food frequency questionnaire and used to estimate protein intake in all participants. Participants were grouped into quintile categories based on their protein intake, expressed as a percentage of total energy. Data were analyzed from July 18, 2017, through April 10, 2019.MAIN OUTCOMES AND MEASURES Hazard ratios (HRs) and 95% CIs for all-cause and cause-specific mortality were estimated using Cox proportional hazards regression models with adjustment for potential confounding factors.RESULTS Among the 70 696 participants, 32 201 (45.5%) were men (mean [SD] age, 55.6 [7.6] years) and 38 495 (54.5%) were women (mean [SD] age, 55.8 [7.7] years). Intake of animal protein showed no clear association with total or cause-specific mortality. In contrast, intake of plant protein was associated with lower total mortality, with multivariable-adjusted HRs of 0.89 (95% CI, 0.83-0.95) for quintile 2; 0.88 (95% CI, 0.82-0.95) for quintile 3; 0.84 (95% CI, 0.77-0.92) for quintile 4; and 0.87 (95% CI, 0.78-0.96) for quintile 5, with quintile 1 as the reference category (P = .01 for trend). For cause-specific mortality, this association with plant protein intake was evident for cardiovascular disease (CVD)-related mortality (HRs, 0.84 [95% CI, 0.73-0.96] to 0.70 [95% CI, 0.59-0.83]; P = .002 for trend). Isocaloric substitution of 3% energy from plant protein for red meat protein was associated with lower total (HR, 0.66; 95% CI, 0.55-0.80), cancer-related (HR, 0.61; 95% CI, 0.45-0.82), and CVD-related (HR, 0.58; 95% CI, 0.39-0.86) mortality; substitution for processed meat protein was associated with lower total (HR, 0.54; 95% CI, 0.38-0.75) and cancer-related (HR, 0.50; 95% CI, 0.30-0.85) mortality.CONCLUSIONS AND RELEVANCE In this large prospective study, higher plant protein intake was associated with lower total and CVD-related mortality. Although animal protein intake was not associated with mortality outcomes, replacement of red meat protein or processed meat protein with plant protein was associated with lower total, cancer-related, and CVD-related mortality., 2019年11月01日, 179, 11, 1509, 1509, 研究論文（学術雑誌）, 10.1001/jamainternmed.2019.2806

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• 査読あり, 英語, Maturitas, Modifiable factors associated with symptomatic knee osteoarthritis: The Murakami cohort study, Ryoya Takiguchi; Rintaro Komatsu; Kaori Kitamura; Yumi Watanabe; Akemi Takahashi; Ryosaku Kobayashi; Rieko Oshiki; Toshiko Saito; Keiko Kabasawa; Ribeka Takachi; Shoichiro Tsugane; Masayuki Iki; Ayako Sasaki; Osamu Yamazaki; Kazutoshi Nakamura, 2019年10月, 128, 53, 59, 研究論文（学術雑誌）, 10.1016/j.maturitas.2019.06.013

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• 査読あり, 英語, European Journal of Cancer Prevention, Cruciferous vegetable intake and colorectal cancer risk, Nagisa Mori; Norie Sawada; Taichi Shimazu; Taiki Yamaji; Atsushi Goto; Ribeka Takachi; Junko Ishihara; Motoki Iwasaki; Manami Inoue; Shoichiro Tsugane, We aimed to assess the association between cruciferous vegetable intake and colorectal cancer (CRC) development among Japanese adults aged between 45 and 74 years in the Japan Public Health Center-based Prospective Study. During 1 325 853 person-years of follow-up, 2612 CRC cases were identified. The association of cruciferous vegetable intake with CRC risk was assessed using a Cox proportional hazard regression model to compute hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. No significant association was observed between the highest cruciferous vegetable intake quartile (compared with the lowest) and CRC risk in men (multivariate HRs: 1.08; 95% CI: 0.91, 1.29) and women (multivariate HRs: 0.99; 95% CI: 0.80, 1.22) and its subsites. Women showed a marginal negative association between cruciferous vegetable intake and the risk of colon cancer (CC) after excluding participants who developed CC in the first 3 years of follow-up (P for trend = 0.08); a positive association was found with proximal CC in men. Cruciferous vegetable intake does not have a significant association with CRC risk in the Japanese general population., 2019年09月, 28, 5, 420, 427, 研究論文（学術雑誌）, 国際誌, 10.1097/cej.0000000000000491

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• 査読あり, 英語, Open Access J Public Health., The effect of educational background music on reducing salt intake at a university canteen., Maruya S; Sato Y; Nakai H; Takachi R, 2019年08月, 2, 4, 028, 研究論文（学術雑誌）

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• 査読あり, 英語, International Journal of Cancer, Fruit and vegetable intake and pancreatic cancer risk in a population‐based cohort study in Japan, Yoko Yamagiwa; Norie Sawada; Taichi Shimazu; Taiki Yamaji; Atsushi Goto; Ribeka Takachi; Junko Ishihara; Motoki Iwasaki; Manami Inoue; Shoichiro Tsugane, Oxidative stress and chronic inflammation are potential pathogenic factors of pancreatic cancer. Although fruits and vegetables are abundant in antioxidants and anti-inflammatory constituents, the reported associations between fruit and vegetable intake and pancreatic cancer risk have been inconsistent. Here, we investigated the association between fruit and vegetable intake and pancreatic cancer risk as part of the Japan Public Health Center-based Prospective Study. The analysis included 90,185 participants who responded to a medical and lifestyle questionnaire during 1995-1998. Associations between fruit and vegetable intake and pancreatic cancer risk were evaluated with Cox proportional hazards models. Additional analyses were stratified by smoking status and body mass index. During follow-up (median duration, 16.9 years), 577 participants were diagnosed with pancreatic cancer. In multivariate-adjusted models, pancreatic cancer risk was inversely associated with total fruit intake (highest vs. lowest intake quartile; hazard ratio [HR]: 0.74, 95% confidence interval [CI]: 0.57-0.95, p-trend: 0.116) and positively associated with total vegetable intake (HR: 1.30, 95% CI: 1.01-1.66, p-trend: 0.151). For total fruit intake, the inverse association with pancreatic cancer risk was more apparent in never smokers (HR: 0.67, 95% CI: 0.47-0.97, p-trend: 0.034). For total vegetable intake, the positive association was statistically significant in ever smokers (HR: 1.49, 95% CI: 1.01-2.19, p-trend: 0.043) and statistically nonsignificant in never smokers. In summary, total fruit intake and total vegetable intake had inverse and positive associations, respectively, with pancreatic cancer risk. Vegetable intake may correlate with increased risk partly because of the influence of smoking on vegetable intake., 2019年04月15日, 144, 8, 1858, 1866, 研究論文（学術雑誌）, 国際誌, 10.1002/ijc.31894

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• 査読あり, 英語, Clinical Nutrition, Cruciferous vegetable intake and mortality in middle-aged adults: A prospective cohort study, Nagisa Mori; Taichi Shimazu; Hadrien Charvat; Michihiro Mutoh; Norie Sawada; Motoki Iwasaki; Taiki Yamaji; Manami Inoue; Atsushi Goto; Ribeka Takachi; Junko Ishihara; Mitsuhiko Noda; Hiroyasu Iso; Shoichiro Tsugane, BACKGROUND & AIMS: Cruciferous vegetables contain isothiocyanates, which effectively reduce inflammation and oxidative stress related to chronic diseases, inhibit the bioactivation of procarcinogens, and enhance the excretion of carcinogens. However, at present, no large cohort studies have investigated the effect of cruciferous vegetable on mortality. We aimed to examine the association between cruciferous vegetable intake and all-cause mortality, namely cancer, heart disease, cerebrovascular disease, and injuries, in a large cohort study conducted between 1990 and 1993, in Japan. METHODS: The analysis included 88,184 participants (age: 45-74 years) with no history of cancer, myocardial infarction, and stroke. Participants were tracked for a median of 16.9 years, during which 15,349 deaths were occurred. The association between cruciferous vegetable intake and risk of all-cause and cause-specific mortality was determined by Cox proportional hazard regression analysis to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs), after adjustment for potential confounding factors. RESULTS: An inverse association was found between cruciferous vegetable intake and total mortality in both gender. HRs (95% CI) for all-cause mortality in the highest compared to the lowest quintile were 0.86 (0.80, 0.93) for men (P = 0.0002 for trend) and 0.89 (0.81, 0.98) for women (P = 0.03 for trend). Cruciferous vegetable intake was associated with lower cancer mortality in men, as well as with heart disease-, cerebrovascular disease-, and injury-related mortality in women. CONCLUSIONS: This prospective study suggests that a higher cruciferous vegetables intake is associated with reduced risk of all-cause mortality., 2019年04月, 38, 2, 631, 643, 研究論文（学術雑誌）, 国際誌, 10.1016/j.clnu.2018.04.012

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• 査読あり, 英語, Nutrients, Validity and Reproducibility of a Self-Administered Food Frequency Questionnaire for the Assessment of Sugar Intake in Middle-Aged Japanese Adults, Rieko Kanehara; Atsushi Goto; Ayaka Kotemori; Nagisa Mori; Ari Nakamura; Norie Sawada; Junko Ishihara; Ribeka Takachi; Yukari Kawano; Motoki Iwasaki; Shoichiro Tsugane, We evaluated the validity and reproducibility of estimated sugar intakes using a food frequency questionnaire (FFQ) among middle-aged Japanese adults in the Japan Public Health Centre-Based Prospective (JPHC) study. In subsamples of the JPHC study (Cohorts I and II in multiple areas), we computed Spearman’s correlations of FFQ results with urine sugar concentrations and dietary records (DR) for validity; we evaluated correlations between two FFQs for reproducibility. During 1994–1998, participants (Cohort I: n = 27 [men], n = 45 [women]) provided two (spring and fall) 24-h urine samples and completed 7-consecutive-day DR per season (I: n = 99, n = 113; II: n = 168, n = 171) and two FFQs (147 food items) at yearly intervals (I: n = 101, n = 108; II: n = 143, n = 146). Sugar intakes from FFQ were correlated with urinary sugar (de-attenuated correlations: 0.40; 95%CI: 0.19, 0.58). After adjustment for sociodemographic and lifestyle variables, correlations between FFQ and DR for men and women were 0.57 (0.42, 0.69) and 0.41 (0.24, 0.55) (I) and 0.56 (0.44, 0.65) and 0.34 (0.20, 0.47) (II), respectively. Correlations between FFQs for men and women were 0.63 (0.49, 0.73) and 0.55 (0.41, 0.67) (I) and 0.66 (0.55, 0.74) and 0.63 (0.52, 0.72) (II). In conclusion, our study showed moderate FFQ validity and reproducibility for sugar intake evaluation., 2019年03月05日, 11, 3, 554, 554, 研究論文（学術雑誌）, 10.3390/nu11030554

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• 査読あり, 英語, Asia Pacific journal of clinical nutrition, Food frequency questionnaire reproducibility for middle-aged and elderly Japanese., Koutatsu Maruyama; Ai Ikeda; Junko Ishihara; Ribeka Takachi; Norie Sawada; Taichi Shimazu; Kazutoshi Nakamura; Junta Tanaka; Taiki Yamaji; Motoki Iwasaki; Hiroyasu Iso; Shoichiro Tsugane, BACKGROUND AND OBJECTIVES: The aim of this study was to examine the reproducibility of a self-administered food frequency questionnaire (FFQ) originally developed for the Japan Public Health Center-Based Prospective Study (JPHC study) and modified for use in the Next Generation (JPHC-NEXT) study. METHODS AND STUDY DESIGN: Participants included 98 men and 142 women aged 40-74 years from the five areas included in the JPHCNEXT protocol. In November 2012, participants were recruited and asked to complete the first nutrition survey. The second nutrition survey was completed after 1 year. RESULTS: We estimated daily energy as well as 53 nutrient and 29 food group intakes using the FFQ. To assess reproducibility, we calculated Spearman correlation coefficients between both FFQs, which showed mostly intermediate-to-high values. Median (range) correlation coefficients and quartile distribution in the same and adjacent categories for energy-adjusted nutrient intakes were 0.55 (0.42-0.84) and 84.7% (76.5%-98.0%) in men and 0.54 (0.35-0.80) and 84.5% (76.1%-94.4%) in women. The respective values for energy-adjusted food group intakes in men and women were also mostly intermediate to high: 0.54 (0.39-0.79) and 83.7% (75.5%-90.8%) in men and 0.57 (0.40-0.83) and 84.5% (77.5%-93.7%) in women. CONCLUSIONS: The FFQ developed for the JPHC-NEXT study has reasonable reproducibility. Because this FFQ has also been validated in a previous study, it can be considered a useful dietary assessment tool to examine associations between dietary consumption and lifestyle-related diseases., 2019年, 28, 2, 362, 370, 研究論文（学術雑誌）, 国際誌, 10.6133/apjcn.201906_28(2).0019

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• 査読あり, 英語, Journal of Pain Research, Epidemiological profiles of chronic low back and knee pain in middle-aged and elderly Japanese from the Murakami cohort, Akemi Takahashi; Kaori Kitamura; Yumi Watanabe; Ryosaku Kobayashi; Toshiko Saito; Ribeka Takachi; Keiko Kabasawa; Rieko Oshiki; Shoichiro Tsugane; Masayuki Iki; Ayako Sasaki; Osamu Yamazaki; Kazutoshi Nakamura, Purpose: Epidemiological profiles of chronic low back and knee pain have not been studied extensively. This study aimed to determine the prevalence of and potential risk factors associated with chronic low back and knee pain in middle-aged and elderly Japanese. Methods: This cross-sectional study involved 14,217 community-dwelling individuals aged 40-74 years living in the Murakami area of Japan. A self-administered questionnaire was used to obtain information regarding marital status, education level, occupation, household income, and body size. Participants also reported current chronic pain, if any, by site and degree of severity, using the verbal rating scale of the Short Form 36. Results: The prevalence of moderate-very severe chronic pain was 9.7% in the low back, 6.7% in the knee, 13.9% in either the low back or knee, and 2.6% in both the low back and knee. Multivariate analysis revealed that lower education level, lower income, and manual occupation in men and older age and higher body mass index in women were significantly associated with a higher prevalence of chronic low back pain. In both sexes, older age, lower education level, and higher body mass index were significantly associated with a higher prevalence of knee pain. Regarding sex differences, adjusted ORs of chronic pain of the low back and knee for women were 0.85 (95% CI 0.75-0.97) and 1.27 (95% CI 1.09-1.49), respectively. Conclusion: Nearly 14% of middle-aged and elderly individuals had moderate-very severe chronic pain of the low back or knee, and this pain was associated with many demographic factors, including sex, age, education level, household income, occupation, and body size., 2018年12月, 11, 3161, 3169, 研究論文（学術雑誌）, 国際誌, 10.2147/jpr.s184746

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• 査読あり, 英語, Environmental Health and Preventive Medicine, The Murakami Cohort Study of vitamin D for the prevention of musculoskeletal and other age-related diseases: a study protocol, Kazutoshi Nakamura; Ribeka Takachi; Kaori Kitamura; Toshiko Saito; Ryosaku Kobayashi; Rieko Oshiki; Yumi Watanabe; Keiko Kabasawa; Akemi Takahashi; Shoichiro Tsugane; Masayuki Iki; Ayako Sasaki; Osamu Yamazaki, BACKGROUND: Age-related musculoskeletal diseases are becoming increasingly burdensome in terms of both individual quality of life and medical cost. We intended to establish a large population-based cohort study to determine environmental, lifestyle, and genetic risk factors of musculoskeletal and other age-related diseases, and to clarify the association between vitamin D status and such diseases. METHODS: We targeted 34,802 residents aged 40-74 years living in areas of northern Niigata Prefecture, including Sekikawa Village, Awashimaura Village, and Murakami City (Murakami region). The baseline questionnaire survey, conducted between 2011 and 2013, queried respondents on their lifestyle and environmental factors (predictors), and self-reported outcomes. Plasma 25-hydroxyvitamin D (25[OH]D) concentration, an indicator of vitamin D status, was determined with the Liaison® 25OH Vitamin D Total Assay. The primary outcome of this study was osteoporotic fracture; other outcomes included age-related diseases including knee osteoarthritis, perception of chronic pain, dementia, and long-term care insurance use. Mean ages of men and women were 59.2 (SD = 9.3, N = 6907) and 59.0 (SD = 9.3, N = 7457) years, respectively. From the blood samples provided by 3710 men and 4787 women, mean 25(OH)D concentrations were 56.5 (SD = 18.4) nmol/L (22.6 ng/mL) and 45.4 (SD = 16.5) nmol/L (18.2 ng/mL), respectively. DISCUSSION: Follow-up surveys are planned every 5 years for 15 years, and incident cases of our targeted diseases will be followed at hospitals and clinics in and nearby the cohort area. We anticipate that we will be able to clarify the association between vitamin D status and multiple disease outcomes in a Japanese population., 2018年12月, 23, 1, 28, 28, 研究論文（学術雑誌）, 国際誌, 10.1186/s12199-018-0715-2

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• 査読あり, 英語, European Journal of Clinical Nutrition, Effect of monitoring salt concentration of home-prepared dishes and using low-sodium seasonings on sodium intake reduction, Misako Nakadate; Junko Ishihara; Motoki Iwasaki; Kaori Kitamura; Erika Kato; Junta Tanaka; Kazutoshi Nakamura; Takuma Ishihara; Ayumi Shintani; Ribeka Takachi, BACKGROUND/OBJECTIVES: Objective methods such as the monitoring of salt concentrations in home-prepared dishes may be effective in reducing salt intake. We investigated the effect of monitoring the salt concentration of home-prepared dishes (Monitoring) on salt reduction and change in taste threshold, and the effect of the simultaneous use of low-sodium seasonings (Seasoning) to compare the effect of Monitoring with the conventional method. SUBJECTS/METHODS: We conducted a double-blind randomized controlled study using a 2 × 2 factorial design with two interventions. A total of 50 participants (40-75 years-old) were recruited among residents of Niigata Prefecture, a high sodium-consuming population in Japan, then randomly allocated to four groups. After excluding participants with incomplete urine collection, change in salt intake was evaluated using 24-hour urinary excretion as a surrogate of intake for 43 participants. Change in taste threshold was evaluated in 48 participants after excluding those with incomplete threshold measurement. RESULTS: The Monitoring intervention group showed a significant decrease in sodium intake (-777 mg/24 h), whereas the decrease in the Seasoning intervention group was not significant (-413 mg/24 h). Sodium intake did not statistically differ between the intervention and control groups (-1011 mg/24 h and -283 mg/24 h for Monitoring and Seasoning, respectively). The changes in taste threshold measurement were very small and did not markedly differ between groups. CONCLUSIONS: Monitoring the salt concentration of dishes had a potentially stronger salt-reducing effect than the use of low-sodium seasonings, a conventional method. Confirmation requires additional study with a larger sample size., 2018年10月, 72, 10, 1413, 1420, 研究論文（学術雑誌）, 国際誌, 10.1038/s41430-017-0053-2

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• 査読あり, 英語, International Journal of Cancer, Dietary consumption of antioxidant vitamins and subsequent lung cancer risk: The Japan Public Health Center-based prospective study, Saki Narita; Eiko Saito; Norie Sawada; Taichi Shimazu; Taiki Yamaji; Motoki Iwasaki; Junko Ishihara; Ribeka Takachi; Kenji Shibuya; Manami Inoue; Shoichiro Tsugane, While many epidemiological studies have studied the association between lung cancer risk and fruits and vegetable consumption (the major sources of antioxidant vitamins), only a few have investigated the direct association with antioxidants in consideration of cancer subtypes and smoking status. Here, we examined the association between consumption of antioxidant vitamins and lung cancer risk in one of the largest prospective cohort studies in Japan. We investigated the association of dietary antioxidant vitamins intake, namely retinol, vitamin C, vitamin E, α-carotene, and β-carotene and subsequent incidence of lung cancer among 38,207 men and 41,498 women in the Japan Public Health Center-based prospective study. Cox proportional hazard regression was performed with adjustment for potential confounders and by strata of cancer subtypes and smoking status. Antioxidant and other dietary intakes were assessed using a food frequency questionnaire (FFQ). During 1,233,096 person-years of follow-up between 1995 and 2013, a total of 1,690 lung cancer cases were newly diagnosed. In a multivariate regression model, while higher retinol intake was positively associated with overall lung cancer risk in men (HR 1.26; 95% CI 1.05-1.51; ptrend  = 0.003), the estimates were more evident with small cell carcinoma (HR 1.92; 95% CI 1.13-3.24; ptrend  < 0.001). Null associations were observed for other antioxidant vitamins. Our prospective study suggests that higher consumption of retinol may be associated with an increased risk of lung cancer in men, especially with small cell carcinoma, although confirmation is required., 2018年06月15日, 142, 12, 2441, 2460, 研究論文（学術雑誌）, 国際誌, 10.1002/ijc.31268

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• 査読あり, 英語, Cancer Causes & Control, Dietary patterns and prostate cancer risk in Japanese: the Japan Public Health Center-based Prospective Study (JPHC Study), Sangah Shin; Eiko Saito; Norie Sawada; Junko Ishihara; Ribeka Takachi; Akiko Nanri; Taichi Shimazu; Taiki Yamaji; Motoki Iwasaki; Shizuka Sasazuki; Manami Inoue; Shoichiro Tsugane, PURPOSE: The development of prostate cancer may be impacted by environmental factors, including diet. The aim of this study was to evaluate the association between dietary patterns and risk of prostate cancer in a large prospective cohort study among Japanese men. METHODS: A total of 43,469 men who participated in the Japan Public Health Center-based Prospective Study were followed from 1995 to 1998 to the end of 2012, during which 1,156 cases of prostate cancer were newly identified. Dietary intake was assessed using a validated food frequency questionnaire in the 5-year follow-up survey. RESULTS: Three major dietary patterns were derived using exploratory factors analysis: prudent, westernized, and traditional dietary patterns. The westernized dietary pattern was associated with a higher risk of total prostate cancer (HR: 1.22; 95% CI 1.00-1.49; p trend = 0.021), localized cancer (HR: 1.24; 95% CI 0.97-1.57; p trend = 0.045), and advanced cancer (HR: 1.23; 95% CI 0.82-1.84; p trend = 0.233). The prudent dietary pattern was associated with a lower risk of total and localized prostate cancer, with respective multivariable HRs for the highest and lowest quintiles of 0.71 (95% CI 0.50-1.02; p trend = 0.037) and 0.63 (95% CI 0.38-1.03; p trend = 0.048) among subjects detected by subjective symptoms. No association was found between the traditional dietary pattern and prostate cancer risk among our subjects. CONCLUSION: Our results suggest that a western-style diet may lead to a higher risk of prostate cancer in the total population, whereas the prudent diet contributes to a lower risk among subjects detected by subjective symptoms., 2018年06月, 29, 6, 589, 600, 研究論文（学術雑誌）, 国際誌, 10.1007/s10552-018-1030-3

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• 査読あり, 英語, Clinical Nutrition, Dietary patterns and colorectal cancer risk in middle-aged adults: A large population-based prospective cohort study, Sangah Shin; Eiko Saito; Norie Sawada; Junko Ishihara; Ribeka Takachi; Akiko Nanri; Taichi Shimazu; Taiki Yamaji; Motoki Iwasaki; Shizuka Sasazuki; Manami Inoue; Shoichiro Tsugane; S. Tsugane; JPHC Study group., BACKGROUND & AIMS: A finding between dietary pattern and cancer may provide visions beyond the assessment of individual foods or nutrients. We examined the influence of dietary pattern with colorectal cancer (CRC) among a Japanese population. METHODS: A total of 93,062 subjects (43,591 men, 49,471 women) who participated in the Japan Public Health Center-based Prospective Study were followed from 1995-1998 to the end of 2012, during which 2482 cases of CRC (1514 men, 968 women) were newly identified. Dietary data was obtained from a validated food-frequency questionnaire between 1995 and 1998. RESULTS: Three dietary pattern was derived from principal components factor: prudent, westernized, and traditional pattern. After controlled for potential confounders, the prudent pattern showed a decreased association of CRC risk in men (HR for highest quintile vs lowest: 0.85; 95% CI: 0.72-1.00; P trend <0.05), slightly more strongly with distal colon cancer (P trend <0.05); but an increased risk of rectal cancer in women (P trend <0.05). The westernized pattern showed a significant positive linear trend for colon (P trend <0.05) and distal cancer (P trend <0.05) in women. There was no apparent association of traditional Japanese dietary pattern on the overall or any specific sites risk of CRC. CONCLUSIONS: A prudent dietary pattern showed an inverse association with CRC risk in men, and a westernized pattern was related with a higher risk of colon and distal cancer in women., 2018年06月, 37, 3, 1019, 1026, 研究論文（学術雑誌）, 国際誌, 10.1016/j.clnu.2017.04.015

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• 査読あり, 英語, European Journal of Clinical Nutrition, Dietary intake of antioxidant vitamins and risk of stroke: the Japan Public Health Center–based Prospective Study, S Uesugi; J Ishihara; H Iso; N Sawada; R Takachi; M Inoue; S Tsugane, 2017年10月, 71, 10, 1179, 1185, 研究論文（学術雑誌）, 10.1038/ejcn.2017.71

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• 査読あり, 英語, PLOS ONE, Weight loss from 20 years of age is associated with cognitive impairment in middle-aged and elderly individuals, Kaori Kitamura; Yumi Watanabe; Kazutoshi Nakamura; Akemi Takahashi; Ribeka Takachi; Rieko Oshiki; Ryosaku Kobayashi; Toshiko Saito; Shoichiro Tsugane; Ayako Sasaki, 2017年10月, 12, 10, e0185960, e0185960, 研究論文（学術雑誌）, 10.1371/journal.pone.0185960

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• 査読あり, 英語, Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ, 日本疫学会, Online version of the self-administered food frequency questionnaire for the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT) protocol: Relative validity, usability, and comparison with a printed questionnaire, Kato Erika; Takachi Ribeka; Ishihara Junko; Ishii Yuri; Sasazuki Shizuka; Sawada Norie; Iwasaki Motoki; Shinozawa Yurie; Umezawa Jun; Tanaka Junta; Yokoyama Yuta; Kitamura Kaori; Nakamura Kazutoshi; Tsugane Shoichiro,

  Background: Online dietary assessment tools offer advantages over printed questionnaires, such as the automatic and direct data storage of answers, and have the potential to become valuable research methods. We developed an online survey system (web-FFQ) for the existing printed FFQ used in the JPHC-NEXT protocol, the platform of a large-scale genetic cohort study. Here, we examined the validity of ranking individuals according to dietary intake using this web-FFQ and its usability compared with the printed questionnaire (print-FFQ) for combined usage.

  Methods: We included 237 men and women aged 40–74 years from five areas specified in the JPHC-NEXT protocol. From 2012 to 2013, participants were asked to provide 12-day weighed food records (12d-WFR) as the reference intake and to respond to the print- and web-FFQs. Spearman's correlation coefficients (CCs) between estimates using the web-FFQ and 12d-WFR were calculated. Cross-classification of intakes was compared with those using the print-FFQ.

  Results: Most participants (83%) answered that completing the web-FFQ was comparable to or easier than completing the printed questionnaire. The median value of CCs across energy and 53 nutrients for men and women was 0.47 (range, 0.10–0.86) and 0.46 (range, 0.16–0.69), respectively. CCs for individual nutrient intakes were closely similar to those based on the print-FFQ, irrespective of response location. Cross-classification by quintile of intake based on two FFQs was reasonably accurate for many nutrients and food groups.

  Conclusion: This online survey system is a reasonably valid measure for ranking individuals by intake for many nutrients, like the printed FFQ. Mixing of two FFQs for exposure assessments in epidemiological studies appears acceptable.

  , 2017年09月, 27, 9, 435, 446, 研究論文（学術雑誌）, 10.1016/j.je.2016.08.021

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• 査読あり, 英語, Journal of Epidemiology, Comparison of weighed food record procedures for the reference methods in two validation studies of food frequency questionnaires, Yuri Ishii; Junko Ishihara; Ribeka Takachi; Yurie Shinozawa; Nahomi Imaeda; Chiho Goto; Kenji Wakai; Toshiaki Takahashi; Hiroyasu Iso; Kazutoshi Nakamura; Junta Tanaka; Taichi Shimazu; Taiki Yamaji; Shizuka Sasazuki; Norie Sawada; Motoki Iwasaki; Haruo Mikami; Kiyonori Kuriki; Mariko Naito; Naoko Okamoto; Fumi Kondo; Satoyo Hosono; Naoko Miyagawa; Etsuko Ozaki; Sakurako Katsuura-Kamano; Keizo Ohnaka; Hinako Nanri; Noriko Tsunematsu-Nakahata; Takamasa Kayama; Ayako Kurihara; Shiomi Kojima; Hideo Tanaka; Shoichiro Tsugane, 2017年07月, 27, 7, 331, 337, 研究論文（学術雑誌）, 10.1016/j.je.2016.08.008

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• 査読あり, 英語, The Journal of Nutrition, Cruciferous Vegetable Intake Is Inversely Associated with Lung Cancer Risk among Current Nonsmoking Men in the Japan Public Health Center (JPHC) Study, Nagisa Mori; Taichi Shimazu; Shizuka Sasazuki; Miho Nozue; Michihiro Mutoh; Norie Sawada; Motoki Iwasaki; Taiki Yamaji; Manami Inoue; Ribeka Takachi; Ayaka Sunami; Junko Ishihara; Tomotaka Sobue; Shoichiro Tsugane, 2017年05月, 147, 5, 841, 849, 研究論文（学術雑誌）, 10.3945/jn.117.247494

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• 査読あり, 英語, Journal of Epidemiology, Fruit and vegetable intake and the risk of overall cancer in Japanese: A pooled analysis of population-based cohort studies, Ribeka Takachi; Manami Inoue; Yumi Sugawara; Ichiro Tsuji; Shoichiro Tsugane; Hidemi Ito; Keitaro Matsuo; Keitaro Tanaka; Akiko Tamakoshi; Tetsuya Mizoue; Kenji Wakai; Chisato Nagata; Shizuka Sasazuki, 2017年04月, 27, 4, 152, 162, 研究論文（学術雑誌）, 10.1016/j.je.2016.05.004

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• 査読あり, 英語, PLOS ONE, Dietary patterns and all-cause, cancer, and cardiovascular disease mortality in Japanese men and women: The Japan public health center-based prospective study, Akiko Nanri; Tetsuya Mizoue; Taichi Shimazu; Junko Ishihara; Ribeka Takachi; Mitsuhiko Noda; Hiroyasu Iso; Shizuka Sasazuki; Norie Sawada; Shoichiro Tsugane, 2017年04月, 12, 4, e0174848, e0174848, 研究論文（学術雑誌）, 10.1371/journal.pone.0174848

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• 査読あり, 日本語, 家政学研究 = Research journal of living science, 奈良女子大学家政学会, 食生活評価システムの開発と実用化へ向けたパイロット研究 : 料理ベース食事調査ウェブシステム, 大内 詩野; 髙地 リベカ; 小田 瑞希; 林 えりこ; 山岸 万里菜; 斉藤 裕美; 中舘 美佐子; 石原 淳子, 2017年03月, 63, 2, 54, 64

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• 査読あり, 英語, British Journal of Nutrition, Dietary pattern and breast cancer risk in Japanese women: the Japan Public Health Center-based Prospective Study (JPHC Study), Sangah Shin; Eiko Saito; Manami Inoue; Norie Sawada; Junko Ishihara; Ribeka Takachi; Akiko Nanri; Taichi Shimazu; Taiki Yamaji; Motoki Iwasaki; Shizuka Sasazuki; Shoichiro Tsugane, Evidence that diet is associated with breast cancer risk is inconsistent. Most of the studies have focused on risks associated with specific foods and nutrients, rather than overall diet. In this study, we aimed to evaluate the association between dietary patterns and breast cancer risk in Japanese women. A total of 49 552 Japanese women were followed-up from 1995 to 1998 (5-year follow-up survey) until the end of 2012 for an average of 14·6 years. During 725 534 person-years of follow-up, 718 cases of breast cancer were identified. We identified three dietary patterns (prudent, westernised and traditional Japanese). The westernised dietary pattern was associated with a 32 % increase in breast cancer risk (hazard ratios (HR) 1·32; 95 % CI 1·03, 1·70; P_trend=0·04). In particular, subjects with extreme intake of the westernised diet (quintile (Q) Q5_5th) had an 83 % increase in risk of breast cancer in contrast to those in the lowest Q1 (HR 1·83; 95 % CI 1·25, 2·68; P_trend=0·01). In analyses stratified by menopausal status, postmenopausal subjects in the highest quintile of the westernised dietary pattern had a 29 % increased risk of breast cancer (HR 1·29; 95 % CI 0·99, 1·76; P_trend=0·04). With regard to hormone receptor status, the westernised dietary pattern was associated with an increased risk of oestrogen receptor-positive/progesterone receptor-positivetumours (HR 2·49; 95 % CI 1·40, 4·43; P_trend<0·01). The other dietary patterns were not associated with the risk of breast cancer in Japanese women. A westernised dietary pattern is associated with an increased risk of breast cancer in Japanese women., 2016年05月, 115, 10, 1769, 1779, 研究論文（学術雑誌）, 10.1017/s0007114516000684

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• 査読あり, 英語, Journal of Epidemiology, Validity of a Self-Administered Food-Frequency Questionnaire for Assessing Amino Acid Intake in Japan: Comparison With Intake From 4-Day Weighed Dietary Records and Plasma Levels, Motoki Iwasaki; Junko Ishihara; Ribeka Takachi; Hidemi Todoriki; Hiroshi Yamamoto; Hiroshi Miyano; Taiki Yamaji; Shoichiro Tsugane, 2016年, 26, 1, 36, 44, 研究論文（学術雑誌）, 10.2188/jea.je20150044

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• 査読あり, 英語, Journal of Epidemiology, 日本疫学会, Validity of Short and Long Self-Administered Food Frequency Questionnaires in Ranking Dietary Intake in Middle-Aged and Elderly Japanese in the Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area, Yokoyama Yuta; Takachi Ribeka; Ishihara Junko; Ishii Yuri; Sasazuki Shizuka; Sawada Norie; Shinozawa Yurie; Tanaka Junta; Kato Erika; Kitamura Kaori; Nakamura Kazutoshi; Tsugane Shoichiro, Background: Longitudinal epidemiological studies require both the periodic update of intake information via repeated dietary survey and the minimization of subject burden in responding to questionnaires. We developed a 66-item Food Frequency Questionnaire (short-FFQ) for the Japan Public Health Center-based prospective Study for the Next Generation (JPHC-NEXT) follow-up survey using major foods from the FFQ developed for the original JPHC Study. For the JPHC-NEXT baseline survey, we used a larger 172-item FFQ (long-FFQ), which was also derived from the JPHC-FFQ. We compared the validity of ranking individuals by levels of dietary consumption by these FFQs among residents of selected JPHC-NEXT study areas.
  Methods: From 2012 to 2013, 240 men and women aged 40–74 years from five areas in the JPHC-NEXT protocol were asked to respond to the long-FFQ and provide 12-day weighed food records (WFR) as reference; 228 also completed the short-FFQ. Spearman's correlation coefficients (CCs) between estimates from the FFQs and WFR were calculated and corrected for intra-individual variation of the WFR.
  Results: Median CC values for energy and 53 nutrients for the short-FFQ for men and women were 0.46 and 0.44, respectively. Respective values for the long-FFQ were 0.50 and 0.43. Compared with the long-FFQ, cross-classification into exact plus adjacent quintiles with the short-FFQ ranged from 68% to 91% in men and 58% to 85% in women.
  Conclusions: Similar to the long-FFQ, the short-FFQ provided reasonably valid measures for ranking middle-aged and elderly Japanese for many nutrients and food groups. The short-FFQ can be used in follow-up surveys in prospective cohort studies aimed at updating diet rank information., 2016年, 26, 8, 420, 432, 研究論文（学術雑誌）, 10.2188/jea.je20150064

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• 査読あり, 英語, Bone, Impact of demographic, environmental, and lifestyle factors on vitamin D sufficiency in 9084 Japanese adults, K. Nakamura; K. Kitamura; R. Takachi; T. Saito; R. Kobayashi; R. Oshiki; Y. Watanabe; S. Tsugane; A. Sasaki; O. Yamazaki, 2015年05月, 74, 10, 17, 研究論文（学術雑誌）, 10.1016/j.bone.2014.12.064

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• 査読あり, 英語, European Journal of Cancer Prevention, Comparison of plasma levels of nutrient-related biomarkers among Japanese populations in Tokyo, Japan, São Paulo, Brazil, and Hawaii, USA, Motoki Iwasaki; Adrian A. Franke; Gerson S. Hamada; Nelson T. Miyajima; Sangita Sharma; Junko Ishihara; Ribeka Takachi; Shoichiro Tsugane; Loïc Le Marchand, 2015年03月, 24, 2, 155, 161, 研究論文（学術雑誌）, 10.1097/cej.0000000000000136

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• 査読あり, 英語, Cancer Epidemiology Biomarkers & Prevention, Dietary Heterocyclic Amine Intake, NAT2 Genetic Polymorphism, and Colorectal Adenoma Risk: The Colorectal Adenoma Study in Tokyo, Sanjeev Budhathoki; Motoki Iwasaki; Taiki Yamaji; Shizuka Sasazuki; Ribeka Takachi; Hiromi Sakamoto; Teruhiko Yoshida; Shoichiro Tsugane, 2015年03月, 24, 3, 613, 620, 研究論文（学術雑誌）, 10.1158/1055-9965.epi-14-1051

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• 査読あり, 英語, Cancer Causes & Control, Validity of a self-administered food frequency questionnaire in the estimation of heterocyclic aromatic amines, Motoki Iwasaki; Tomomi Mukai; Ribeka Takachi; Junko Ishihara; Yukari Totsuka; Shoichiro Tsugane, 2014年08月, 25, 8, 1015, 1028, 研究論文（学術雑誌）, 10.1007/s10552-014-0401-7

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• 査読あり, 英語, Journal of the Academy of Nutrition and Dietetics, Self-Reported Taste Preference Can Be a Proxy for Daily Sodium Intake in Middle-Aged Japanese Adults, Ribeka Takachi; Junko Ishihara; Motoki Iwasaki; Yuri Ishii; Shoichiro Tsugane, 2014年05月, 114, 5, 781, 787, 研究論文（学術雑誌）, 10.1016/j.jand.2013.07.043

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• 査読あり, 英語, International Journal of Hygiene and Environmental Health, Dietary cadmium intake and breast cancer risk in Japanese women: A case–control study, Hiroaki Itoh; Motoki Iwasaki; Norie Sawada; Ribeka Takachi; Yoshio Kasuga; Shiro Yokoyama; Hiroshi Onuma; Hideki Nishimura; Ritsu Kusama; Kazuhito Yokoyama; Shoichiro Tsugane, 2014年01月, 217, 1, 70, 77, 研究論文（学術雑誌）, 10.1016/j.ijheh.2013.03.010

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• 査読あり, 英語, Cancer Causes & Control, Dietary arsenic intake and subsequent risk of cancer: the Japan Public Health Center-based (JPHC) Prospective Study, Norie Sawada; Motoki Iwasaki; Manami Inoue; Ribeka Takachi; Shizuka Sasazuki; Taiki Yamaji; Taichi Shimazu; Shoichiro Tsugane, 2013年07月, 24, 7, 1403, 1415, 研究論文（学術雑誌）, 10.1007/s10552-013-0220-2

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• 査読あり, 英語, European Journal of Clinical Nutrition, Dietary patterns and type 2 diabetes in Japanese men and women: the Japan Public Health Center-based Prospective Study, A Nanri; T Shimazu; R Takachi; J Ishihara; T Mizoue; M Noda; M Inoue; S Tsugane, 2013年01月, 67, 1, 18, 24, 研究論文（学術雑誌）, 10.1038/ejcn.2012.171

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• 査読あり, 日本語, 新潟医学会雑誌, 新潟医学会, 日本人における脳血管疾患死亡率、食塩摂取量及び食品群別寄与率の推移, 坂口裕太; 宜保智樹; 高地リベカ, わが国における死因別死亡率では1980年代まで脳血管疾患が第一位を占め, 現在も欧米と比べ死亡率が高い. また, 部位別の悪性新生物年齢調整死亡率では胃がんが欧米と比して著名に高い. 食塩の過剰摂取はこれらの疾患に共通するリスク要因である. 日本人の食塩摂取量は年々減少していると言われているものの, 今なお一人1日当たり平均10.5g摂取しており, 推奨値6g/日とは大きく隔たりがある. 本研究の目的は, 脳血管疾患と食塩摂取量の推移により両者の動向と関連性を観察すること, 及び食塩摂取量の性・年齢階級別推移及び食塩摂取量に寄与する食品の推移を記述することにより食塩摂取量低減のターゲットを明らかにすることである. 記述疫学的研究デザインにより, 政府統計による脳血管疾患年齢調整死亡率の年次推移及び厚生労働省国民健康・栄養調査結果による年次推移を観察した. その結果, 脳血管疾患の年齢調整死亡率は男女ともに最近の40年間減少し続けていた..食塩摂取量も長期的には減少傾向にあり,各年齢階級においても同様に推移していた. エネルギー1,000keal当たりの調整食塩摂取量は一定で稚移し,調味料の食塩摂取量への寄与は1980年から増加傾向にあり,2001年以降約70%とほぼ一定で推移していることが明らかになった.今後さらなる食塩の摂取量の低減のためには調味料によりもたらされる食塩,及び中高年世代の食塩摂取量の低減が重要なタ-ゲットであることが示唆された., 2013年, 127, 1, 48, 54

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• 査読あり, 日本語, 新潟医学会雑誌, 新潟医学会, 日本人における虚血性心疾患死亡率、脂質摂取量及び食品群別寄与率の推移, 宜保智樹; 坂口裕太; 高地リベカ, 本邦における心疾患死亡率は2010年死因別死亡率の中で2番目に多く, その中で最も多いのは虚血性心疾患である. 虚血性心疾患と体重過多, 脂質摂取量と体重増加についてはそれぞれ関連が明らかにされているが, 脂質摂取量と虚血性心疾患を直接結びつける研究は日本において十分に行われていない. そこで, 日本人の脂質摂取量, 及び虚血性心疾患のリスク要因と考えられる脂肪酸等を多く含む食品群の脂質寄与率の経年変化を観察し, それぞれ虚血性心疾患死亡率の推移との関連性を記述疫学的に検討することとした. 1960年～2008年の政府統計による虚血性心疾患年齢調整死亡率の年次推移, 及び1946年～2008年の厚生労働省国民栄養調査（2003年より国民健康・栄養調査）結果より, 脂質摂取量及び食品群別脂質摂取寄与率の年次推移を観察した. その結果, 1960年から1970年にかけて脂質摂取量の増加に伴い虚血性心疾患が増加したものの, 以降は脂質摂取量が増加の後ほぼ横ばいとなる一方, 虚血性心疾患は減少し続けた. したがって, 脂質摂取量の推移によって虚血性心疾患の減少を説明することはできなかった. 一方, 油脂類の脂質摂取に対する寄与率減少に伴って虚血性心疾患も減少しており, 油脂類と虚血性心疾患は関連性があることが示唆された. 油脂類はトランス脂肪酸摂取に大きく寄与している可能性があり, 油脂類の摂取量と虚血性心疾患の直接的な因果関係をコホート研究などで検証する必要がある., 2013年, 127, 2, 103, 7

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• 査読あり, 英語, Journal of Bone and Mineral Research, Effect of low-dose calcium supplements on bone loss in perimenopausal and postmenopausal Asian women: A randomized controlled trial, Kazutoshi Nakamura; Toshiko Saito; Ryosaku Kobayashi; Rieko Oshiki; Kaori Kitamura; Mari Oyama; Sachiko Narisawa; Mitsue Nashimoto; Shunsuke Takahashi; Ribeka Takachi, 2012年11月, 27, 11, 2264, 2270, 研究論文（学術雑誌）, 10.1002/jbmr.1676

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• 査読あり, 英語, The American Journal of Clinical Nutrition, Zinc and heme iron intakes and risk of colorectal cancer: a population-based prospective cohort study in Japan, Azusa Hara; Shizuka Sasazuki; Manami Inoue; Motoki Iwasaki; Taichi Shimazu; Norie Sawada; Taiki Yamaji; Ribeka Takachi; Shoichiro Tsugane, 2012年10月01日, 96, 4, 864, 873, 研究論文（学術雑誌）, 10.3945/ajcn.112.041202

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• 査読あり, 日本語, 日本公衆衛生雑誌, 日本公衆衛生学会, 食事摂取量推定のための料理単位法の開発地域とは異なる集団への適用可能性, 鬼頭 久美子; 石原 淳子; 君羅 満; 高地 リベカ; 細井 聖子; 石井 有里; 岩崎 基, 目的 料理単位法は，料理とその構成食品から成るデータベースによって，料理単位の成分表により対象者の食品群•栄養素等の摂取量を計算する食事調査方法である。料理データベースの開発地域内においては食品群•栄養素等の妥当性が確認されている。しかし，開発地域とは異なる集団への適用については検討されていない。そこで，本研究では，首都圏の集団への適用可能性について検討した。
  方法 国立がん研究センターがん予防•検診研究センターの2004年～2006年の検診受診者のうち，首都圏在住の40から69歳の受診者から，性•年齢階級別に無作為に抽出し，参加依頼を行った。最終的に，参加希望者187人（参加受諾率20.7%）のうち，144人を解析対象とした。比較基準の方法として用いた週末を含む 4 日間の秤量法食事記録調査（秤量法）は，栄養士が対象者の記録を確認後，5 訂増補日本食品標準成分表に準じて，食品コードを付与し，重量換算を行った。また，料理単位法は別の栄養士によって，対象者が記入した料理名から料理データベースの料理コードを充当し，料理単位の成分表（東北地方の住民224人，1 日間の秤量法食事記録から作成）により食品群•栄養素等摂取量を推定した。4 日間の秤量法から算出された食品群•栄養素等推定摂取量との差，Pearson の相関係数および先行研究との比較により，適用可能性を検討した。
  結果 料理名の88%が料理データベースの料理名などから充当可能であった。相関係数が0.6以上のものは，食品群では男性で12，女性で10食品群，栄養素等では男性で34，女性では27栄養素であった。食品群の一部で顕著な過大評価がみられ，栄養素等推定摂取量の多くで過小評価されやすい傾向が確認された。先行研究との妥当性の比較では，全体的に低くなる傾向が確認された。
  結論 摂取量が推定された食品群•栄養素等の多くについて，相関係数が0.6以上であり，料理データベース開発地域とは異なる地域集団への適用可能性を示唆するものと考えられた。しかしながら，栄養素によっては，絶対値の摂取量推定に地域ごとのデータが必要であることが示唆された。, 2012年09月15日, 59, 9, 700, 711, 10.11236/jph.59.9_700

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• 査読あり, 英語, Gastroenterology, Consumption of n-3 Fatty Acids and Fish Reduces Risk of Hepatocellular Carcinoma, Norie Sawada; Manami Inoue; Motoki Iwasaki; Shizuka Sasazuki; Taichi Shimazu; Taiki Yamaji; Ribeka Takachi; Yasuhito Tanaka; Masashi Mizokami; Shoichiro Tsugane, 2012年06月, 142, 7, 1468, 1475, 研究論文（学術雑誌）, 10.1053/j.gastro.2012.02.018

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• 査読あり, 英語, Epidemiology, Long-term Dietary Cadmium Intake and Cancer Incidence, Norie Sawada; Motoki Iwasaki; Manami Inoue; Ribeka Takachi; Shizuka Sasazuki; Taiki Yamaji; Taichi Shimazu; Yoko Endo; Shoichiro Tsugane, 2012年05月, 23, 3, 368, 376, 研究論文（学術雑誌）, 10.1097/ede.0b013e31824d063c

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• 査読あり, 英語, Journal of epidemiology, Japan Epidemiological Association, Reproducibility and Validity of Dietary Patterns Assessed by a Food Frequency Questionnaire Used in the 5-Year Follow-Up Survey of the Japan Public Health Center-Based Prospective Study, NANRI Akiko; SHIMAZU Taichi; ISHIHARA Junko; TAKACHI Ribeka; MIZOUE Tetsuya; INOUE Manami; TSUGANE Shoichiro, Background: Analysis of dietary pattern is increasingly popular in nutritional epidemiology. However, few studies have examined the validity and reproducibility of dietary patterns. We assessed the reproducibility and validity of dietary patterns identified by a food frequency questionnaire (FFQ) used in the 5-year follow-up survey of the Japan Public Health Center-Based Prospective Study (JPHC Study).
  Methods: The participants were a subsample (244 men and 254 women) from the JPHC Study. Principal component analysis was used to identify dietary patterns from 28- or 14-day dietary records and 2 FFQs. To assess reproducibility and validity, we calculated Spearman correlation coefficients between dietary pattern scores derived from FFQs separated by a 1-year interval, and between dietary pattern scores derived from dietary records and those derived from a FFQ completed after the dietary records, respectively.
  Results: We identified 3 Japanese dietary patterns from the dietary records and 2 FFQs: prudent, westernized, and traditional. Regarding reproducibility, Spearman correlation coefficients between the 2 FFQs ranged from 0.55 for the westernized Japanese pattern in men and the prudent Japanese pattern in women to 0.77 for the traditional Japanese pattern in men. Regarding validity, the corresponding values between dietary records and the FFQ ranged from 0.32 for the westernized Japanese pattern in men to 0.63 for the traditional Japanese pattern in women.
  Conclusions: Acceptable reproducibility and validity was shown by the 3 dietary patterns identified by principal component analysis based on the FFQ used in the 5-year follow-up survey of the JPHC Study., 2012年, 22, 3, 205, 215, 研究論文（学術雑誌）, 10.2188/jea.je20110087

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• 査読あり, 英語, International Journal of Cancer, Intake of n-3 and n-6 polyunsaturated fatty acids and development of colorectal cancer by subsite: Japan Public Health Center-based prospective study, Shizuka Sasazuki; Manami Inoue; Motoki Iwasaki; Norie Sawada; Taichi Shimazu; Taiki Yamaji; Ribeka Takachi; Shoichiro Tsugane, 2011年10月, 129, 7, 1718, 1729, 研究論文（学術雑誌）, 10.1002/ijc.25802

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• 査読あり, 英語, Asia Pac J Clin Nutr, Red meat intake may increase the risk of colon cancer in Japanese, a population with relatively low red meat consumption, Ribeka Takachi; Yoshitaka Tsubono; Keisuke Baba; Manami Inoue; Shizuka Sasazuki; Motoki Iwasaki; Shoichiro Tsugane, Asian populations have changed from traditional to Westernized diets, with increased red meat intake. They are suggested to be particularly susceptible to the adverse effects of red meat on the development of colorectal cancers, however, few prospective studies of this putative link have been conducted. We examined associations between the consumption of red and processed meat and the risk of subsite-specific colorectal cancer by gender in a large Japanese cohort. During 1995-1998, a validated food frequency questionnaire was administered to 80,658 men and women aged 45-74 years. During 758,116 person-years of follow-up until the end of 2006, 1,145 cases of colorectal cancer were identified. Higher consumption of red meat was significantly associated with a higher risk of colon cancer among women [multivariate hazard ratios (95%CIs) for the highest versus lowest quintiles (HR): 1.48 (1.01, 2.17; trend p=0.03)], as was higher consumption of total meat among men [HR=1.44 (1.06, 1.98; trend p=0.07)]. By site, these positive associations were found for the risk of proximal colon cancer among women and for distal colon cancer among men. No association was found between the consumption of processed meat and risk of either colon or rectal cancer. In conclusion, red meat intake may modestly increase the risk of colon cancer in middle-aged Japanese, although the highest quintile of red meat consumption could be considered moderate by Western standards., 2011年, 20, 4, 603, 612, 研究論文（学術雑誌）

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• 査読あり, 英語, Journal of Epidemiology, Japan Epidemiological Association, Validity of a Self-Administered Food Frequency Questionnaire for Middle-Aged Urban Cancer Screenees: Comparison With 4-Day Weighed Dietary Records, Takachi Ribeka; Ishihara Junko; Iwasaki Motoki; Hosoi Satoko; Ishii Yuri; Sasazuki Shizuka; Sawada Norie; Yamaji Taiki; Shimazu Taichi; Inoue Manami; Tsugane Shoichiro, Background: The validity of estimates of dietary intake calculated using a food frequency questionnaire (FFQ) depends on the specific population. The 138-item FFQ used in the 5-year follow-up survey for the Japan Public Health Center-based Prospective Study was initially developed for and validated in rural residents. However, the validity of estimates based on this FFQ for urban residents, whose diet and lifestyle differ from those of rural residents, has not been clarified. We examined the validity of ranking individuals according to level of dietary consumption, as estimated by this FFQ, among an urban population in Japan.
  Methods: Among 896 candidates randomly selected from examinees of cancer screening provided by the National Cancer Center, Japan, 144 participated in the study. In 2007–2008, at an average 2.7 years after cancer screening, participants were asked to respond to the questionnaire and to provide 4-day weighed diet records (4d-DRs) for use as the reference intake. Spearman correlation coefficients (CCs) between the FFQ and 4d-DR estimates were calculated, after correction for intraindividual variation of 4d-DRs.
  Results: The median (range) deattenuated CC for men and women was 0.57 (0.23 to 0.89) and 0.47 (0.08 to 0.94), respectively, across 45 nutrients and 0.51 (0.10 to 0.98) and 0.51 (−0.36 to 0.88) for 43 food groups.
  Conclusions: Although the FFQ was developed for a rural population, it provided reasonably valid measures of consumption for many nutrients and food groups in middle-aged screenees living in urban areas in Japan., 2011年, 21, 6, 447, 458, 研究論文（学術雑誌）, 10.2188/jea.je20100173

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• 査読あり, 英語, Gastric Cancer, Socioeconomic status and gastric cancer survival in Japan, Aya Kuwahara; Ribeka Takachi; Yoshitaka Tsubono; Shizuka Sasazuki; Manami Inoue; Shoichiro Tsugane, 2010年11月, 13, 4, 222, 230, 研究論文（学術雑誌）, 10.1007/s10120-010-0561-4

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• 査読あり, 英語, AMERICAN JOURNAL OF CLINICAL NUTRITION, Sodium intake adjustment in the evaluation of the association between salted foods and risk of cancer and cardiovascular disease Reply, Ribeka Takachi; Yoshitaka Tsubono; Manami Inoue; Shoichiro Tsugane, 2010年09月, 92, 3, 668, 669, 10.3945/ajcn.2010.29884

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• 査読あり, 英語, The American Journal of Clinical Nutrition, Confounders in Asian studies Reply, Ribeka Takachi; Yoshitaka Tsubono; Manami Inoue; Shoichiro Tsugane, 2010年06月, 91, 6, 1805, 1806, 研究論文（学術雑誌）, 10.3945/ajcn.2010.29621

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• 査読あり, 英語, Journal of Nutrition, High Dietary Intake of Magnesium May Decrease Risk of Colorectal Cancer in Japanese Men, E. Ma; S. Sasazuki; M. Inoue; M. Iwasaki; N. Sawada; R. Takachi; S. Tsugane, 2010年04月, 140, 4, 779, 785, 研究論文（学術雑誌）, 10.3945/jn.109.117747

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• 査読あり, 英語, Journal of Food Composition and Analysis, Heterocyclic amines content of meat and fish cooked by Brazilian methods, Motoki Iwasaki; Hiroyuki Kataoka; Junko Ishihara; Ribeka Takachi; Gerson Shigeaki Hamada; Sangita Sharma; Loïc Le Marchand; Shoichiro Tsugane, 2010年02月, 23, 1, 61, 69, 研究論文（学術雑誌）, 10.1016/j.jfca.2009.07.004

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• 査読あり, 英語, The American Journal of Clinical Nutrition, Consumption of sodium and salted foods in relation to cancer and cardiovascular disease: the Japan Public Health Center–based Prospective Study, Ribeka Takachi; Manami Inoue; Taichi Shimazu; Shizuka Sasazuki; Junko Ishihara; Norie Sawada; Taiki Yamaji; Motoki Iwasaki; Hiroyasu Iso; Yoshitaka Tsubono; Shoichiro Tsugane, 2010年02月, 91, 2, 456, 464, 研究論文（学術雑誌）, 10.3945/ajcn.2009.28587

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• 査読あり, 英語, Nutrition and Cancer, Fruits and Vegetables in Relation to Prostate Cancer in Japanese Men: The Japan Public Health Center-Based Prospective Study, Ribeka Takachi; Manami Inoue; Norie Sawada; Motoki Iwasaki; Shizuka Sasazuki; Junko Ishihara; Yoshitaka Tsubono; Shoichiro Tsugane; for the Japan Public Health Center-, 2009年12月, 62, 1, 30, 39, 研究論文（学術雑誌）, 10.1080/01635580903191502

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• 査読あり, 日本語, 榮養學雑誌, 特定非営利活動法人 日本栄養改善学会, 料理画像を用いた食事評価の疫学研究への応用に関する基礎的検討, 石原 淳子; 高地 リベカ; 細井 聖子; 岩崎 基, We compiled 4-day dietary records with digital photographic images of meals to investigate the variation of frequently consumed foods which could enable the development of a dish-based database for dietary assessment in epidemiological studies. We also evaluated the validity of using a digital photographic image as a tool to assess the dietary intake of a food group. Participants in the study were 144 men and women living in urban areas of Japan who were asked to take pictures with a digital camera of all foods and beverages they consumed during 4 consecutive days. Simultaneous dietary records were used as the reference. The dietary intake was independently calculated from the two methods. We found that the variation in intake was high for such seasoning as salt which indicated that the degree of measurement error may be high when a representative portion size for such seasoning was used in a dish-based database. The estimated intake level by two methods was similar for green-yellow vegetables, fruit, fish, meat, eggs, milk and other dairy products, whereas the over/under-estimation for other food groups was too great to be used for accurate assessment. In contrast, the validity for ranking individuals by the estimated multiple-day intake was relatively high, with the exception of beverages, seasonings and spices., 2009年10月01日, 67, 5, 252, 259, 10.5264/eiyogakuzashi.67.252

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• 査読あり, 日本語, 日本給食経営管理学会誌, 日本給食経営管理学会, 女子大生を対象とした給食の脂肪酸給与量計画に及ぼす献立要因に関する研究．, 上杉宰世; 彦坂令子; 大川正美; 高地リベカ; 君羅満, 2009年09月, 3, 2, 13, 24

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• その他, 東北大学博士論文, A population- based prospective study of fruit and vegetable intake, and the risk of total cancers, prostate cancer, and cardiovascular disease, Ribeka Takachi, 2009年09月
• 査読あり, 英語, The European Journal of Public Health, Education in relation to incidence of and mortality from cancer and cardiovascular disease in Japan, S. Ito; R. Takachi; M. Inoue; N. Kurahashi; M. Iwasaki; S. Sasazuki; H. Iso; Y. Tsubono; S. Tsugane, 2008年10月, 18, 5, 466, 472, 研究論文（学術雑誌）, 10.1093/eurpub/ckn052

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• 査読あり, 英語, American Journal of Epidemiology, Fruit and Vegetable Intake and Risk of Total Cancer and Cardiovascular Disease: Japan Public Health Center-based Prospective Study, R. Takachi; M. Inoue; J. Ishihara; N. Kurahashi; M. Iwasaki; S. Sasazuki; H. Iso; Y. Tsubono; S. Tsugane, 2007年11月, 167, 1, 59, 70, 研究論文（学術雑誌）, 10.1093/aje/kwm263

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• 査読あり, 日本語, 栄養学雑誌, 日本栄養改善学会, 実践的な料理データベース作成のための標本サイズと妥当性．, 高地リベカ; 工藤陽子; 渡邊昌; 君羅満, 2006年06月, 64, 2, 97, 105, 10.5264/eiyogakuzashi.64.97

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• 査読あり, その他, 健康･体力･栄養, 尿中ナトリウム、カリウム、リン排泄量による自記式簡易食事調査法「料理単位法」の検討．, 工藤陽子; 高地リベカ; 君羅満, 2005年03月, 10, 2, 108, 17
• その他, 東京農業大学修士論文, 若年及び高齢女性の脂肪酸摂取と血小板凝集能に関する研究, 高地リベカ, 2005年03月
• 査読あり, その他, 健康･体力･栄養, 料理単位による食事調査．, 君羅満; 高地リベカ; 工藤陽子; 羽場亮太; 上杉宰世; 伊澤正利; 高橋東生; 飯樋洋二; 渡邊昌, 2004年12月, 10, 1, 3, 13
• 査読あり, 日本語, 日本衛生学雑誌, 日本衛生学会, 主要ミネラルの1日摂取量と24時間尿中排泄量との関連．, 君羅満; 工藤陽子; 高地リベカ; 羽場亮太; 渡邊昌, Objectives and Methods: The associations between dietary intake and urinary excretion of sodium (Na), potassium (K), calcium (Ca), magnesium (Mg), and phosphorus (P), and the major dietary sources derived from the urinary minerals were studied in a nutritional survey of 219 Japanese females aged 27-84 years, who completed anthropometric measurements, a one-day dietary record, and a 24hr urine collection.
  Results: The minerals excreted in the urine were significantly and positively correlated with each other, in which Na excretion was correlated with K and Ca excretion (r=0.490 and r=0.482, respectively, p<0.01) and Ca excretion was correlated with Mg excretion (r=0.526, p<0.01). The ratios of urinary exertion to dietary intake of Na, K, Ca, Mg, and P were 81.5%, 62.7%, 24.5%, 21.7%, and 56.1%, respectively. The dietary intake and the urinary excretion of the minerals expressed per body weight (kg) were significantly and positively correlated (Na, r=0.267; K, r=0.460; Ca, r=0.181; Mg, r=0.245; P, r=0.351, p<0.01). Further examinations using chief component analysis for food intake showed several significant positive correlations, including between Na intake and the intake of vegetables, noodles, and seasonings (r=0.332-0.381, p<0.01); between K, Mg and P intake and the intake of vegetables, fruits, and potatoes (r=0.332-0.533, p<0.01); and between Ca intake and the intake of bread and dairy foods (r=0.428, p<0.01). In addition, significant positive associations were found between Na excretion and the intake of confectionaries, nuts, and seeds (r=0.223, p<0.01). Weak correlations were also found between K excretion and the intake of vegetables (r=0.296, p<0.01); between Ca and P excretion and the intake of meat, oil, and fats (r=0.135, P<0.05; r=0.193, P<0.01, respectively), and between Mg excretion and the intake of bread and dairy foods (r=0.137, P<0.05).
  Conclusions: Findings from this study indicate that, while urinary excretion of Ca and Mg is unlikely to be a reliable biochemical marker of dietary intake, the levels of urinary excretion of Na, K, and P can be reflective of the intake of salt, vegetables, and meats, respectively. The urinary excretion of the minerals, particularly Na, K, and Ca, may be highly linked to salt intake in Japanese females., 2004年01月, 59, 1, 23, 30, 10.1265/jjh.59.23

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• 査読あり, 英語, BioFactors, The effect of dietary and plasma fatty acids on platelet aggregation in senior generation of Japanese women, Ribeka Takachi; Mitsuru Kimira; Sayo Uesugi; Yoko Kudo; Kazuyuki Ouchi; Shaw Watanabe, 2004年, 22, 1-4, 205, 210, 研究論文（学術雑誌）, 10.1002/biof.5520220143

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• 査読あり, 英語, British Journal of Nutrition, Non-alcoholic beverages intake and risk of CVD among Japanese men and women: the Japan Public Health Center study, Renzhe Cui; Hiroyasu Iso; Ehab Salah Eshak; Koutatsu Maruyama; Junko Ishihara; Ribeka Takachi; Norie Sawada; Shoichiro Tsugane, Abstract The association between the intake of non-alcoholic beverages and CVD in Asians is uncertain. The intake of non-alcoholic beverages was estimated in 77 407 participants of the Japan Public Health Centre-based cohort study aged 45–74 years. The Cox regression calculated the hazard ratios (HR) and 95 % CI for incident CVD according to sex-specific quintiles of intake of non-alcoholic beverages. A total of 4578 incident CVD (3751 strokes and 827 CHD) were diagnosed during a 13·6-year median follow-up. The risks of stroke and total CVD were lower for the highest v. lowest intake quintiles of non-alcoholic beverages in men and women: the multivariable HRs (95 % CIs) were 0·82 (0·71, 0·93, P_trend = 0·005) and 0·86 (0·76, 0·97, P_trend = 0·02), respectively, in men and were 0·73 (0·63, 0·86, P_trend = 0·003) and 0·75 (0·65, 0·87, P_trend = 0·005), respectively, in women. The reduced risk was evident for both ischaemic and haemorrhagic strokes and was mainly attributable to green tea consumption. The intake of non-alcoholic beverages from coffee and other beverages was not associated with the risk of CVD in both men and women. Also, there was no association between the intake of non-alcoholic beverages and the risk of CHD in either sex. In conclusion, the risks of stroke and total CVD were lower with a higher intake of non-alcoholic beverages in Japanese men and women., 2021年07月21日, 1, 8, 研究論文（学術雑誌）, 10.1017/s0007114521002737

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• 査読あり, 英語, European Journal of Clinical Nutrition, Validity of dietary isothiocyanate intake estimates from a food frequency questionnaire using 24 h urinary isothiocyanate excretion as an objective biomarker: the JPHC-NEXT protocol area, Nagisa Mori; Norie Sawada; Junpei Yamamoto; Junko Ishihara; Taichi Shimazu; Ribeka Takachi; Utako Murai; Kazutoshi Nakamura; Junta Tanaka; Taiki Yamaji; Motoki Iwasaki; Hiroyasu Iso; Masuko Kobori; Shoichiro Tsugane, BACKGROUND/OBJECTIVES: Isothiocyanate (ITC) is formed via the hydrolysis of glucosinolates by myrosinase, found in cruciferous vegetables. Although myrosinase is inactivated by the cooking process, no studies have incorporated the effect of cooking into the estimation of dietary ITC intake or evaluated the validity. We evaluated the validity of dietary ITC intake estimated from a food frequency questionnaire (FFQ), and urinary ITC levels using 24 h urine samples or a WFR (weighed food record), and evaluated the reproducibility of dietary ITC in two FFQs administered at an interval of 1-year. SUBJECTS/METHODS: The JPHC-NEXT Protocol Area included a total of 255 middle-aged participants across Japan. We calculated dietary ITC intake from WFR and two FFQs by assuming that cooked cruciferous vegetables contain zero ITC. Urinary ITC excretion was measured at two points during summer and winter. The validity and reproducibility of dietary ITC intake estimated by FFQ were assessed using Spearman's correlation coefficients. RESULTS: Although we observed a moderate correlation between dietary ITC intake derived from a 12-day WFR and urinary ITC excretion, notwithstanding the cooking process, the correlation between dietary ITC intake estimated by FFQ and mean urinary ITC excretion was low. However, the correlation was improved when we compared urinary ITC excretion and a 3-day WFR or FFQ collected during winter. Our FFQ showed good reproducibility. CONCLUSION: Although seasonality is a critical factor, dietary ITC intake estimated using an FFQ showed moderate validity and reproducibility and can be used in future epidemiological studies., 2022年03月, 76, 3, 462, 468, 研究論文（学術雑誌）, 国際誌, 10.1038/s41430-021-00970-x

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• 査読あり, 英語, European Journal of Nutrition, Dietary glycemic index, glycemic load and mortality: Japan Public Health Center-based prospective study, Hsi-Lan Huang; Sarah Krull Abe; Norie Sawada; Ribeka Takachi; Junko Ishihara; Motoki Iwasaki; Taiki Yamaji; Hiroyasu Iso; Tetsuya Mizoue; Mitsuhiko Noda; Masahiro Hashizume; Manami Inoue; Shoichiro Tsugane, PURPOSE: Long-term associations of dietary glycemic index (GI) and glycemic load (GL) with mortality outcomes remain unclear. METHODS: The present analysis included 72,783 participants of the Japan Public Health Center-based Prospective Study. Participants who responded to the 5-year follow-up questionnaire in 1995-1999 were followed-up until December 2015. We estimated the risk of total and cause-specific mortality associated with GI and GL using Cox proportional hazards regression models. RESULTS: During 1,244,553 person years of follow-up, 7535 men and 4913 women died. GI was positively associated with all-cause mortality. As compared with the lowest quartile, the multivariable HR for those who had the highest quartile of GI was 1.14 (95% CI 1.08-1.20). The HRs for death comparing the highest with the lowest quartile were 1.28 (95% CI 1.14-1.42) for circulatory system diseases, 1.33 (95% CI 1.14-1.55) for heart disease, 1.32 (95% CI 1.11-1.57) for cerebrovascular disease, and 1.45 (95% CI 1.18-1.78) for respiratory diseases. GI was not associated with mortality risks of cancer and digestive diseases. GL showed a null association with all-cause mortality (highest vs lowest quartile; HR 1.04; 95% CI 0.96-1.12). However, among those who had the highest quartile of GL, the HRs for death from circulatory system diseases was 1.24 (95% CI 1.05-1.46), cerebrovascular disease was 1.34 (95% CI 1.03-1.74), and respiratory diseases was 1.35 (95% CI 1.00-1.82), as compared with the lowest quartile. CONCLUSION: In this large prospective cohort study, dietary GI and GL were associated with mortality risks., 2021年12月, 60, 8, 4607, 4620, 研究論文（学術雑誌）, 国際誌, 10.1007/s00394-021-02621-0

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• 査読あり, 英語, Journal of nutritional science, Validity of a food frequency questionnaire for the estimation of total polyphenol intake estimates and its major food sources in the Japanese population: the JPHC FFQ Validation Study., Nagisa Mori; Norie Sawada; Junko Ishihara; Ayaka Kotemori; Ribeka Takachi; Utako Murai; Masuko Kobori; Shoichiro Tsugane, We examine the validity and reproducibility of a food frequency questionnaire (FFQ) in a subsample of participants in the Japan Public Health Center-based Prospective Cohort Study using a database of polyphenol-containing foods commonly consumed in the Japanese population. Participants of the validation study were recruited from two different cohorts. In Cohort I, 215 participants completed a 28-d dietary record (DR) and the FFQ, and in Cohort II, 350 participants completed DRs and the FFQ. The total polyphenol intake estimated from the 28-d DR and FFQ were log-transformed and adjusted for energy intake by the residual method. Spearman correlation coefficients (CCs) between estimates from the FFQ and 28-d DR as well as two FFQs administered at a 1-year interval were computed. Median intakes of dietary polyphenols calculated from the DRs were 1172 mg/d for men and 1024 mg/d for women in Cohort I, and 1061 mg/d for men and 942 mg/d for women in Cohort II. The de-attenuated CCs for polyphenol intake between the DR and FFQ were 0⋅47 for men and 0⋅37 for women in Cohort I and 0⋅44 for men and 0⋅50 for women in Cohort II. Non-alcoholic beverages were the main contributor to total polyphenol intake in both men and women, accounting for 50 % of total polyphenol intake regardless of cohort and gender, followed by alcoholic beverages and seasoning and spices in men, and seasoning and spices, fruits and other vegetables in women. The present study showed that this FFQ had moderate validity and reproducibility and is suitable for use in future epidemiological studies., 2021年, 10, e35, 研究論文（学術雑誌）, 国際誌, 10.1017/jns.2021.25

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• 査読あり, 英語, Journal of the American Geriatrics Society, Association of coffee, green tea, and caffeine with the risk of dementia in older Japanese people, Nana Matsushita; Yuta Nakanishi; Yumi Watanabe; Kaori Kitamura; Keiko Kabasawa; Akemi Takahashi; Toshiko Saito; Ryosaku Kobayashi; Ribeka Takachi; Rieko Oshiki; Shoichiro Tsugane; Masayuki Iki; Ayako Sasaki; Osamu Yamazaki; Kei Watanabe; Kazutoshi Nakamura, 2021年12月, 69, 12, 3529, 3544, 研究論文（学術雑誌）, 10.1111/jgs.17407

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• 査読あり, 英語, Global Health & Medicine, Burden of cancer attributable to modifiable factors in Japan in 2015, Manami Inoue; Mayo Hirabayashi; Sarah Krull Abe; Kota Katanoda; Norie Sawada; Yingsong Lin; Junko Ishihara; Ribeka Takachi; Chisato Nagata; Eiko Saito; Atsushi Goto; Kayo Ueda; Junko Tanaka; Megumi Hori; Tomohiro Matsuda, The This study estimated the cancer burden attributable to modifiable factors in Japan in 2015 using the best available epidemiological evidence and a standard methodology. We selected the following factors for inclusion in the estimates, namely tobacco smoking (active smoking and secondhand smoking), alcohol drinking, excess bodyweight, physical inactivity, infectious agents (Helicobacter pylori, hepatitis C virus, hepatitis B virus, human papilloma virus, Epstein-Barr virus, and human T-cell leukemia virus type 1), dietary intake (highly salted food, fruit, vegetables, dietary fiber, red meat, processed meat), exogenous hormone use, never breastfeeding and air pollution, given that these were considered modifiable, in theory at least. We first estimated the population attributable fraction (PAF) of each cancer attributable to these factors using representative relative risks of Japanese and the prevalence of exposures in Japanese around 2005, in consideration of the 10-year interval between exposure and cancer outcomes. Using nationwide cancer incidence and mortality statistics, we then estimated the attributable cancer incidence and mortality in 2015. We finally obtained the PAF for site-specific and total cancers attributable to all modifiable risk factors using this formula, with statistical consideration of the effect of overlap between risk factors. The results showed that 35.9% of all cancer incidence (43.4% in men and 25.3% in women) and 41.0% of all cancer mortality (49.7% in men and 26.8% in women) would be considered preventable by avoidance of these exposures. Infections and active smoking followed by alcohol drinking were the greatest contributing factors to cancer in Japan in 2015., 2022年02月28日, 4, 1, 26, 36, 研究論文（学術雑誌）, 国内誌, 10.35772/ghm.2021.01037

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• 査読あり, その他, Journal of Epidemiology, Applicability of a web-based 24-hour dietary recall tool for Japanese populations in large-scale epidemiological studies, Yoshie Hose; Junko Ishihara; Ayaka Kotemori; Misako Nakadate; Sachiko Maruya; Junta Tanaka; Hiroshi Yatsuya; Atsuko Aoyama; Chifa Chiang; Tsuneo Konta; Takamasa Kayama; Yoshiyuki Ueno; Manami Inoue; Norie Sawada; Shoichiro Tsugane; Ribeka Takachi, 2023年, 33, 8, 419, 427, 研究論文（学術雑誌）, 10.2188/jea.je20220071

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• 査読あり, 英語, GHM Open, Burden of cancer attributable to insufficient vegetable, fruit and dietary fiber consumption in Japan in 2015, Junko Ishihara; Ribeka Takachi; Sarah Krull Abe; Mayo Hirabayashi; Eiko Saito; Megumi Hori; Kota Katanoda; Tomohiro Matsuda; Manami Inoue, 2021年12月31日, 1, 2, 70, 75, 研究論文（学術雑誌）, 10.35772/ghmo.2021.01018

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• 査読あり, 英語, GHM Open, Burden of cancer attributable to excess red and processed meat consumption in Japan in 2015, Sarah Krull Abe; Ribeka Takachi; Junko Ishihara; Mayo Hirabayashi; Eiko Saito; Megumi Hori; Kota Katanoda; Tomohiro Matsuda; Manami Inoue, 2021年12月31日, 1, 2, 91, 96, 研究論文（学術雑誌）, 10.35772/ghmo.2021.01019

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• 査読あり, 英語, GHM Open, Burden of cancer attributable to consumption of highly salted food in Japan in 2015, Ribeka Takachi; Junko Ishihara; Sarah Krull Abe; Mayo Hirabayashi; Eiko Saito; Megumi Hori; Kota Katanoda; Tomohiro Matsuda; Manami Inoue, 2021年12月31日, 1, 2, 85, 90, 研究論文（学術雑誌）, 10.35772/ghmo.2021.01017

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• 査読無し, 日本語, 家政学研究, 奈良女子大学家政学会, 「栄養疫学」：減塩と脳血管疾患・胃がんの研究, 高地リベカ, 2015年, 62, 1, 52, 6

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• 査読あり, 英語, Scientific reports, Sugary drink consumption and risk of kidney and bladder cancer in Japanese adults., Chi Yan Leung; Sarah Krull Abe; Norie Sawada; Junko Ishihara; Ribeka Takachi; Taiki Yamaji; Motoki Iwasaki; Masahiro Hashizume; Manami Inoue; Shoichiro Tsugane, Globally, sugary drinks are widely consumed, however, few epidemiologic studies have investigated the association between sugary drink consumption and risk of kidney and bladder cancer. We examined the association of sugary drinks with risk of kidney and bladder cancer in 73,024 participants from the Japan Public Health Center-based Prospective Study who reported no history of cancer. Sugary drink consumption was assessed using a validated food frequency questionnaire at study baseline (1995-1999). Individuals were followed to December 31, 2013. Multivariable Cox proportional hazards regression models were used to calculate hazard ratios (HR) and 95% confidence intervals (CIs). During 1,069,815 person years of follow-up, 169 kidney cancer and 297 bladder cancer cases were documented. After adjusting for potential confounders, no greater risk of kidney and bladder cancer was observed. However, sugary drink consumption was positively associated with the risk of kidney cancer (HR for 100 ml/day increase in consumption was 1.11 [95% CI 1.01-1.22]) and bladder cancer (HR for 100 ml/d increase in consumption was 1.11 [95% CI 1.01-1.22]) among women after exclusion of cases diagnosed in the first three years of follow-up. In this large prospective cohort, consumption of sugary drinks was significantly associated with a small increase in hazard ratio for kidney and bladder cancer among women after exclusion of cases diagnosed within the first three years., 2021年11月04日, 11, 1, 21701, 21701, 研究論文（学術雑誌）, 国際誌, 10.1038/s41598-021-01103-x

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• 査読あり, 英語, BMC public health, Education, household income, and depressive symptoms in middle-aged and older Japanese adults., Aya Hinata; Keiko Kabasawa; Yumi Watanabe; Kaori Kitamura; Yumi Ito; Ribeka Takachi; Shoichiro Tsugane; Junta Tanaka; Ayako Sasaki; Ichiei Narita; Kazutoshi Nakamura, BACKGROUND: Income inequality has dramatically increased worldwide, and there is a need to re-evaluate the association between socio-economic status (SES) and depression. Relative contributions of household income and education to depression, as well as their interactions, have not been fully evaluated. This study aimed to examine the association between SES and depressive symptoms in Japanese adults, focusing on interactions between education and household income levels. METHODS: This cross-sectional study used data from baseline surveys of two cohort studies. Participants were 38,499 community-dwelling people aged 40-74 years who participated in baseline surveys of the Murakami cohort study (2011-2012) and Uonuma cohort study (2012-2015) conducted in Niigata Prefecture, Japan. Information regarding marital status, education level, household income, occupation, activities of daily living (ADL), and history of cancer, myocardial infarction, stroke, and diabetes was obtained using a self-administered questionnaire. Depressive symptoms were examined using the Center for Epidemiologic Studies Depression Scale (CES-D). Logistic regression analysis was used to obtain odds ratios (ORs). Covariates included age, sex, marital status, education, household income, occupation, ADL, and disease history. RESULTS: Individuals with higher education levels had lower ORs (adjusted P for trend = 0.0007) for depressive symptoms, independently of household income level. The OR of the university-or-higher group was significantly lower than that of the junior high school group (adjusted OR = 0.79). Individuals with lower household income levels had higher ORs (adjusted P for trend< 0.0001) for depressive symptoms, independently of education level. The type of occupation was not associated with depressive symptoms. In subgroup analyses according to household income level, individuals with higher education levels had significantly lower ORs in the lowest- and lower-income groups (adjusted P for trend = 0.0275 and 0.0123, respectively), but not in higher- and highest-income groups (0.5214 and 0.0915, respectively). CONCLUSIONS: Both education and household income levels are independently associated with the prevalence of depressive symptoms, with household income levels showing a more robust association with depressive symptoms than education levels. This suggests that a high household income level may offset the risk of depressive symptoms from having a low education level., 2021年11月18日, 21, 1, 2120, 2120, 研究論文（学術雑誌）, 国際誌, 10.1186/s12889-021-12168-8

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• 査読あり, 英語, ANNALS OF NUTRITION AND METABOLISM, CRUCIFEROUS VEGETABLE INTAKE AND LUNG CANCER RISK: A PROSPECTIVE STUDY AND A META-ANALYSIS, Nagisa Mori; Taichi Shimazu; Miho Nozue; Norie Sawada; Motoki Iwasaki; Ribeka Takachi; Ayaka Sunami; Junko Ishihara; Tomotaka Sobue; Shoichiro Tsugane, 2017年, 71, 667, 667
• 査読あり, 英語, The Journal of nutrition, Inverse Association between Fruit and Vegetable Intake and All-Cause Mortality: Japan Public Health Center-Based Prospective Study., Yuki Sahashi; Atsushi Goto; Ribeka Takachi; Junko Ishihara; Kumiko Kito; Rieko Kanehara; Taiki Yamaji; Motoki Iwasaki; Manami Inoue; Tsugane Shoichiro; Norie Sawada, BACKGROUND: A dose-response and nonlinear association between fruit and vegetable intake and mortality has been reported in Europe and the United States, but little is known about this association in Asia. OBJECTIVES: This study aimed to evaluate the association of fruit and vegetable intake with all-cause, cancer, cardiovascular, and respiratory disease mortality in a Japanese cohort. METHODS: In the Japan Public Health Center-based prospective study, we included 94,658 participants (mean age; 56.4 ± 7.8 years, male; 46.0%) without cancer and cardiovascular disease at baseline. Information on fruit and vegetable intake was collected using a validated food frequency questionnaire. The Cox proportional-hazards model was used to estimate hazard ratios (HR) and 95% confidence intervals (CIs) of each quintile of fruit and vegetable intake, separately, in relation to all-cause and cause-specific mortality using the first quintile as a reference. Nonlinear associations were evaluated using a likelihood ratio test, comparing a linear model with a restricted cubic spline model. RESULTS: During a median of 20.9 follow-up years (interquartile range: 19.6-23.8), 23,687 all-cause deaths were documented. After adjusting for age, sex, and potential confounding factors, fruit and vegetable intake was nonlinearly and significantly associated with lower all-cause mortality, with the fourth and fifth quintiles having comparable HRs (fruit: fourth quintile, HR: 0.91; 95%CI: 0.87, 0.95, fifth quintile, HR: 0.92; 95%CI: 0.88, 0.96; P for nonlinearity < 0.001; vegetable: fourth quintile, HR: 0.92; 95%CI: 0.88, 0.97, fifth quintile, HR: 0.93; 95%CI: 0.89, 0.98; P for nonlinearity = 0.002). Fruit intake was significantly associated with lower cardiovascular mortality (HR in the fifth quintile: 0.91; 95%CI: 0.83, 0.99; P for nonlinearity = 0.01). CONCLUSIONS: In the Japanese population, higher intake of fruits and vegetables was nonlinearly associated with decreased all-cause mortality. These findings may contribute to the establishment of dietary recommendations for enhancing life expectancy in Asia., 2022年06月28日, 152, 10, 2245, 2254, 研究論文（学術雑誌）, 国際誌, 10.1093/jn/nxac136

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• 査読あり, 英語, Journal of the American Medical Directors Association, Leisure-Time and Non-Leisure-Time Physical Activities are Dose-Dependently Associated With a Reduced Risk of Dementia in Community-Dwelling People Aged 40-74 Years: The Murakami Cohort Study., Kaori Kitamura; Yumi Watanabe; Keiko Kabasawa; Akemi Takahashi; Toshiko Saito; Ryosaku Kobayashi; Ribeka Takachi; Rieko Oshiki; Shoichiro Tsugane; Masayuki Iki; Ayako Sasaki; Osamu Yamazaki; Kei Watanabe; Kazutoshi Nakamura, OBJECTIVE: Although physical activity (PA) in late life is considered a preventive factor for dementia, effects of different types of PAs on the development of dementia in early old age are unclear. This study aimed to determine the effect of leisure-time and non-leisure-time PAs on dementia risk in middle-aged and older adults during an 8-year follow-up. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: Participants were 13,773 community-dwelling individuals aged 40-74 years who completed the baseline self-administered questionnaire survey of the Murakami cohort study in 2011-2013. METHODS: Main predictors were leisure-time and non-leisure-time (commute, occupational work, and housework) PAs as assessed by MET score (MET-hour/d). The outcome was newly developed dementia determined using a long-term care insurance database. Covariates included demographics, lifestyle, body size, disease history, and PA level. Hazard ratios (HRs) were calculated using Cox proportional hazards models. RESULTS: Mean age of participants was 59.0 (SD 9.3) years. Higher levels of leisure-time PA were associated with lower HRs (adjusted P for trend <.001), with all tertiles having significantly lower HRs (low: 0.71, 95% CI 0.51-0.99; medium: 0.59, 95% CI 0.43-0.81; high: 0.55, 95% CI 0.41-0.75) relative to the reference (zero). Higher quartiles of non-leisure-time PA were associated with lower adjusted HRs for dementia (adjusted P for trend < .001), with the second-fourth quartiles having significantly lower HRs (second: 0.73, 95% CI 0.54-0.98; third: 0.59, 95% CI 0.43-0.81; fourth: 0.55, 95% CI 0.41-0.75) relative to the lowest quartile. These associations were robust regardless of sex and age group. CONCLUSIONS AND IMPLICATIONS: Both leisure-time and non-leisure-time PAs are independently and robustly associated with a reduced risk of dementia., 2022年07月, 23, 7, 1197, 1204, 研究論文（学術雑誌）, 国際誌, 10.1016/j.jamda.2022.01.053

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• 英語, European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity, Correction: Physical activity and recurrent fall risk in community-dwelling Japanese people aged 40-74 years: the Murakami cohort study., Shoto Kamimura; Takashi Iida; Yumi Watanabe; Kaori Kitamura; Keiko Kabasawa; Akemi Takahashi; Toshiko Saito; Ryosaku Kobayashi; Rieko Oshiki; Ribeka Takachi; Shoichiro Tsugane; Masayuki Iki; Ayako Sasaki; Osamu Yamazaki; Kei Watanabe; Kazutoshi Nakamura, 2022年10月24日, 19, 1, 25, 25, 国際誌, 10.1186/s11556-022-00306-z

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• 査読あり, 英語, European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity, Physical activity and recurrent fall risk in community-dwelling Japanese people aged 40-74 years: the Murakami cohort study., Shoto Kamimura; Takashi Iida; Yumi Watanabe; Kaori Kitamura; Keiko Kabasawa; Akemi Takahashi; Toshiko Saito; Ryosaku Kobayashi; Rieko Oshiki; Ribeka Takachi; Shoichiro Tsugane; Masayuki Iki; Ayako Sasaki; Osamu Yamazaki; Kei Watanabe; Kazutoshi Nakamura, BACKGROUND: Falls are important causes of injury and mortality in older people, and associated medical costs can be enormous. Physical activity (PA) is a potential preventive factor for falls. However, few studies have examined the effect of different types of PA on fall prevention. This study aimed to evaluate the association between PA levels and the incidence of recurrent falls by type of PA in middle-aged and older people. METHODS: This cohort study targeted 7,561 community-dwelling individuals aged 40-74 years who did not experience recurrent falls in the year before baseline. Information on PA levels, demographics, body size, lifestyle, and fall/disease history was obtained using a self-administered questionnaire in the baseline survey. Levels of total PA, leisure-time PA, and non-leisure-time PA (occupation, commuting, and housework) were estimated using metabolic equivalent (MET) scores (MET-h/day; hours spent on a given activity per day multiplied by its MET intensity). PA levels were categorized into four groups. Falls were recorded as none, once, or twice or more (recurrent falls). The outcome of the study was the incidence of recurrent falls in the past year before a survey conducted 5 years after the baseline survey. Logistic regression analyses were performed to calculate odds ratios for recurrent falls. RESULTS: Higher total PA and non-leisure-time PA levels were associated with a higher risk of recurrent falls (P for trend = 0.0002 and 0.0001, respectively), with the highest total PA and non-leisure-time PA groups having a significantly higher adjusted OR (1.96 [95%CI:1.33-2.88] and 2.15 [95%CI:1.48-3.14], respectively) relative to the lowest group (reference). As for leisure-time PA, the medium group had a significantly lower adjusted OR (0.70 [95%CI:0.49-0.99]) relative to the reference group. By sex, the adjusted OR in the medium leisure-time PA group was significantly lower relative to the reference group in women (0.50 [95%CI: 0.29-0.85]) but not in men. CONCLUSIONS: Medium level leisure-time PA reduces the risk of recurrent falls in middle-aged and older people, whereas higher level non-leisure-time PA is associated with a higher risk of recurrent falls., 2022年09月02日, 19, 1, 20, 20, 研究論文（学術雑誌）, 国際誌, 10.1186/s11556-022-00300-5

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• 日本語, 日本公衆衛生学会総会抄録集, 日本公衆衛生学会, 加齢性運動器疾患の分子疫学コホート研究(村上鮭で元気プロジェクト), 中村 和利; 高地 リベカ; 北村 香織; 斎藤 トシ子; 小林 量作; 押木 利英子; 佐々木 綾子; 山崎 理; 伊木 雅之, 2013年10月, 72回, 272, 272
• 日本語, Osteoporosis Japan, ライフサイエンス出版(株), 地域住民における血中25-hydroxyvitamin Dレベル 村上コホート研究, 中村 和利; 北村 香織; 斎藤 トシ子; 小林 量作; 押木 利英子; 高地 リベカ; 佐々木 綾子; 山崎 理, 2013年09月, 21, Suppl.1, 219, 219
• 査読あり, 英語, The British journal of nutrition, Dietary sodium sources according to four 3-day weighed food records and their association with multiple 24-hour urinary excretions among middle-aged and elderly Japanese participants in rural areas., Fuyuka Ogawa; Ribeka Takachi; Junko Ishihara; Marina Yamagishi; Sachiko Maruya; Yuri Ishii; Kumiko Kito; Kazutoshi Nakamura; Junta Tanaka; Taiki Yamaji; Hiroyasu Iso; Motoki Iwasaki; Shoichiro Tsugane; Norie Sawada, Reducing sodium (Na) intake is an urgent global challenge, especially in East Asia and high-income Asia-Pacific regions. However, the sources of Na and their effects on urinary Na excretion have not been fully studied. We sought to clarify these sources and their association with urinary Na excretion. We examined four 3-day weighed food records and five 24-h urinary collections from each of 253 participants in Japan, aged 35-80 years, between 2012 and 2013. We compared the levels of Na according to four categories: foods contributing to discretionary or nondiscretionary Na intake, the situation in which dishes were cooked and consumed, food groups and types of cuisine. We also conducted regression analysis in which 24-h urinary Na excretion was a dependent variable and the amounts of food intake in the four categories were independent variables. Levels of Na were the highest in discretionary intake (60.6%) and in home-prepared dishes (84.0%). Of the food groups, miso soup showed the highest percentage contribution to Na intake (13.3%) after seasonings such as soy sauce. In the regression analysis, the standardised coefficient for foods of nondiscretionary Na sources was larger than that for discretionary sources, whereas that for home-prepared dishes was consistent with the levels of Na in those foods. Pickled products, followed by fresh fish and shellfish, miso soup and rice, were associated with high urinary Na excretion. Thus, discretionary foods (such as miso soup) contribute the most to Na consumption, although nondiscretionary intake (such as pickled vegetables) may influence urinary Na excretion., 2022年08月18日, 129, 11, 1, 23, 研究論文（学術雑誌）, 国際誌, 10.1017/S0007114522002653

  DOI URL共同研究・競争的資金等URL
• 査読あり, 英語, Nutrients, Validity of the Food Frequency Questionnaire-Estimated Intakes of Sodium, Potassium, and Sodium-to-Potassium Ratio for Screening at a Point of Absolute Intake among Middle-Aged and Older Japanese Adults., Tomoka Matsuno; Ribeka Takachi; Junko Ishihara; Yuri Ishii; Kumiko Kito; Sachiko Maruya; Kazutoshi Nakamura; Junta Tanaka; Kazumasa Yamagishi; Taiki Yamaji; Hiroyasu Iso; Motoki Iwasaki; Shoichiro Tsugane; Norie Sawada, Using Food Frequency Questionnaires (FFQs) to compare dietary references for screening has been in high demand. However, FFQs have been widely used for ranking individuals in a population based on their dietary intake. We determined the validity of sodium (salt equivalent) intake, potassium intake, and sodium-to-potassium (Na/K) ratio obtained using the FFQ for identifying individuals who deviated from the dietary reference intakes (DRIs) measured using multiple 24-h urinary excretion measurements or 12-day weighed food records (WFR). This study included 235 middle-aged subjects. The correlation coefficients (CCs) between the FFQ and WFR estimates were mostly moderate (0.24-0.54); the CCs between the FFQ and 24-h urinary excretion measurements were low or moderate (0.26-0.38). Values of area under the receiver-operating curve (AUC) at the point of DRIs for salt equivalent or potassium were >0.7 with the WFR as the reference standard and 0.60-0.76 with the 24-h urinary excretion as the reference standard. Using both standard measures, the AUC for the Na/K ratio was <0.7. The accuracy of salt equivalent and potassium intake estimation using the FFQ to determine absolute intake point was comparable to that using WFR, allowing for quantified error, but not as good as that of 24-h urinary excretion., 2022年06月23日, 14, 13, 研究論文（学術雑誌）, 国際誌, 10.3390/nu14132594

  DOI URL共同研究・競争的資金等URL
• 査読無し, 英語, Journal of nutritional science and vitaminology, New Environmental-Related Approaches to Improved Eating Behavior and Nutrition across One's Life Course., Ribeka Takachi; Sachiko Maruya; Junko Ishihara, It is worthwhile to discuss new environmental-related approaches to eating behavior that are effective throughout one's life course for better nutrition. Salt-reduction programs for children may benefit from strategies that actively engage families and teachers, according to a school-based cluster randomized controlled trial (School-EduSalt) in China to reduce salt intake in children and their families. Considering young people's lifestyle, a population-based approach for healthy low-risk people is necessary; for example, the use of an educational song consisting of interesting sounds and lyrics as BGM may be effective. Self-monitoring of salt intake or salt concentrations in home seasoning by a versatile salinity meter may be another effective educational approach in reducing salt intake by raising the individual's awareness on their rate of salt intake. Further, shift workers have increased risk of diet-related chronic conditions due to their eating habits. Moreover, mental illnesses among workers require nutritional approaches because they may have effects on subsequent weight changes. Finally, studies for the eldery suggest the importance of a nutritional approach especially for males living alone to prevent or improve frailty. A three-month approach that included nutritional education for the elderly reduced frailty, and the effects persisted post-intervention. These results are quite encouraging for nutritionists in their efforts to create a vibrant society, despite its incredibly age., 2022年, 68, Supplement, S58-S60, 研究論文（学術雑誌）, 国内誌, 10.3177/jnsv.68.S58

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• 査読あり, 英語, Journal of affective disorders, Low plasma 25-hydroxyvitamin D levels are associated with an increased risk of depressive symptoms in community-dwelling Japanese people aged between 40 and 74 years: The Murakami cohort study., Aya Hinata; Kaori Kitamura; Yumi Watanabe; Keiko Kabasawa; Toshiko Saito; Akemi Takahashi; Ribeka Takachi; Ryosaku Kobayashi; Rieko Oshiki; Masayuki Iki; Shoichiro Tsugane; Ayako Sasaki; Kei Watanabe; Kazutoshi Nakamura, BACKGROUND: Association between vitamin D levels and the occurrence of depression are not always consistent. The present cohort study aimed to determine this association in older adults, using a method for measuring vitamin D levels which is more accurate than those used in previous studies. METHODS: Participants were 3447 individuals aged 40-74 years without depressive symptoms at baseline who participated in the 5-year follow-up survey. The baseline investigation, including a self-administered questionnaire survey and blood collection, was conducted in 2011-2013. Plasma 25-hydroxyvitamin D (25[OH]D) levels were measured, and divided into overall quartiles summed up by sub-quartiles and stratified by age, sex, and season. The outcome was depressive symptoms determined by the CES-D (11-item, cut-off score of 6/7) 5 years later. Covariates were demographics, lifestyles, baseline CES-D score, and disease history. RESULTS: Mean plasma 25(OH)D levels were 58.0 nmol/L in men and 45.7 in women (P < 0.0001), and cumulative incidences of depressive symptoms were 249/1577 (15.8 %) in men and 313/1870 (16.7 %) in women (P = 0.4526). The lower 25(OH)D quartile group had higher adjusted ORs in men and women combined (P for trend = 0.0107) and women (P for trend = 0.0003), but not in men. Adjusted ORs of the lowest quartile group were significantly higher than the highest group in men and women combined (OR = 1.39, 95 % CI: 1.06-1.81) and women (OR = 1.89, 95 % CI: 1.31-2.72). LIMITATION: Depressive symptoms were self-reported. CONCLUSIONS: Low vitamin D levels were associated with a high risk of depressive symptoms, especially in women. Women are thus considered a major target for preventing vitamin D deficiency to address depression., 2023年01月03日, 325, 48, 54, 研究論文（学術雑誌）, 国際誌, 10.1016/j.jad.2022.12.104

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• 査読あり, 英語, Scientific reports, Prospective study of dietary changes in cancer survivors for five years including pre- and post- diagnosis compared with those in cancer-free participants., Yuri Ishii; Ribeka Takachi; Junko Ishihara; Taiki Yamaji; Motoki Iwasaki; Manami Inoue; Shoichiro Tsugane; Norie Sawada, The number of long-term survivors after a cancer diagnosis is increasing. Few investigations have compared survivors' diets to their original pre-diagnosis dietary pattern or with the patterns of cancer-free controls. We examined the dietary changes in survivors for five years (i.e. before to after diagnosis) in cancer survivors, comparing them with cancer-free controls in a prospective cohort study in Japan. Using 1995-1998 for the baseline and 2000-2003 for the follow-up survey, a validated food frequency questionnaire was administered to 33,643 men and 39,549 women aged 45-74 years. During the follow-up period, 886 men and 646 women had developed cancer. Participants that had not been diagnosed with cancer served as controls. There was a greater decrease in the calorie intake (median change: - 168 kcal/d [Interquartile range: - 640, 278]) in male cancer survivors compared to controls (- 33 kcal/d [- 453, 380], P < .001). On comparison with cancer-free controls, multiple linear regression analysis revealed a significantly larger reduction in energy-adjusted ethanol intake for male cancer survivors (β =  - 0.36). There was no difference in changes in fruit and vegetable or red meat intake and no other significant differences in dietary changes between survivors and controls for either gender. This suggests that most dietary changes in survivors after cancer diagnosis are not systematically different from those that occur in people without a cancer diagnosis., 2023年01月18日, 13, 1, 982, 982, 研究論文（学術雑誌）, 国際誌, 10.1038/s41598-023-27820-z

  DOI URL共同研究・競争的資金等URL
• 査読あり, 英語, Journal of Alzheimer's disease : JAD, Sex Differences in the Association Between Body Mass Index and Dementia Risk in Community-Dwelling Japanese People Aged 40-74 Years., Alena Zakharova; Kaori Kitamura; Yumi Watanabe; Keiko Kabasawa; Akemi Takahashi; Toshiko Saito; Ryosaku Kobayashi; Rieko Oshiki; Ribeka Takachi; Shoichiro Tsugane; Osamu Yamazaki; Kei Watanabe; Kazutoshi Nakamura, BACKGROUND: The association between body mass index (BMI) and dementia risk is heterogeneous across age groups and might be influenced by sex. OBJECTIVE: This study aimed to clarify sex differences in the association between BMI and dementia risk in community-dwelling people. METHODS: This cohort study with an 8-year follow-up targeted 13,802 participants aged 40-74 years at baseline in 2011-2013. A self-administered questionnaire requested information on body size, including height, weight, and waist circumference (the values of which were validated by direct measurement), socio-demographics, lifestyle, and disease history. BMI was calculated and categorized as < 18.5 (underweight), 18.5-20.6 (low-normal), 20.7-22.7 (mid-normal), 22.8-24.9 (high-normal), 25.0-24.9 (overweight), and≥30.0 kg/m2 (obese). Incident cases of dementia were obtained from the long-term care insurance database. A Cox proportional hazards model was used to calculate multivariable-adjusted hazard ratios (HRs). RESULTS: The mean age of participants was 59.0 years. In men, higher BMI was associated with lower dementia risk (fully-adjusted p for trend = 0.0086). In women, the association between BMI and dementia risk was U-shaped; the "underweight," "low-normal," and "overweight" groups had a significantly higher risk (fully-adjusted HR = 2.12, 2.08, and 1.78, respectively) than the reference ("high-normal" group). These findings did not change after excluding dementia cases which occurred within the first four years of the follow-up period. CONCLUSION: Overweight/obese women, but not men, had an increased risk of dementia, suggesting that sex differences in adiposity might be involved in the development of dementia., 2023年06月19日, 94, 3, 949, 959, 研究論文（学術雑誌）, 国際誌, 10.3233/JAD-230294

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• 査読あり, 英語, Global health & medicine, Economic burden of cancer attributable to modifiable risk factors in Japan., Eiko Saito; Shiori Tanaka; Sarah Krull Abe; Mayo Hirayabashi; Junko Ishihara; Kota Katanoda; Yingsong Lin; Chisato Nagata; Norie Sawada; Ribeka Takachi; Atsushi Goto; Junko Tanaka; Kayo Ueda; Megumi Hori; Tomohiro Matsuda; Manami Inoue, Controlling avoidable causes of cancer may save cancer-related healthcare costs and indirect costs of premature deaths and productivity loss. This study aimed to estimate the economic burden of cancer attributable to major lifestyle and environmental risk factors in Japan in 2015. We evaluated the economic cost of cancer attributable to modifiable risk factors from a societal perspective. We obtained the direct medical costs for 2015 from the National Database of Health Insurance Claims and Specific Health Checkups of Japan, and estimated the indirect costs of premature mortality and of morbidity due to cancer using the relevant national surveys in Japan. Finally, we estimated the economic cost of cancer associated with lifestyle and environmental risk factors. The estimated cost of cancer attributable to lifestyle and environmental factors was 1,024,006 million Japanese yen (\) (8,460 million US dollars [$]) for both sexes, and \673,780 million ($5,566 million) in men and \350,226 million ($2,893 million) in women, using the average exchange rate in 2015 ($1 = \121.044). A total of \285,150 million ($2,356 million) was lost due to premature death in Japan in 2015. Indirect morbidity costs that could have been prevented were estimated to be \200,602 million ($1,657 million). Productivity loss was highest for stomach cancer in men (\28,735 million/$237 million) and cervical cancer in women (\24,448 million/$202 million). Preventing and controlling cancers caused by infections including Helicobacter pylori, human papillomavirus and tobacco smoking will not only be life-saving but may also be cost-saving in the long run., 2023年08月31日, 5, 4, 238, 245, 研究論文（学術雑誌）, 国内誌, 10.35772/ghm.2023.01001

  DOI URL共同研究・競争的資金等URL
• 査読あり, 英語, Maturitas, Alcohol consumption, smoking, and risk of dementia in community-dwelling Japanese people aged 40-74 years: The Murakami cohort study., Shugo Kawakami; Ren Yamato; Kaori Kitamura; Yumi Watanabe; Keiko Kabasawa; Akemi Takahashi; Toshiko Saito; Ryosaku Kobayashi; Rieko Oshiki; Ribeka Takachi; Shoichiro Tsugane; Osamu Yamazaki; Kei Watanabe; Kazutoshi Nakamura, OBJECTIVE: Alcohol drinking and tobacco smoking have impacts on lifestyle-related diseases, but their association with dementia remains a debated topic. This study aimed to examine longitudinal associations between alcohol consumption, smoking, and dementia risk in middle-aged and older Japanese people. METHODS: This study used a cohort design with an 8-year follow-up. Participants were community-dwelling Japanese people (N = 13,802) aged 40-74 years. The baseline survey, including a self-administered questionnaire, was conducted in 2011-2013. Predictors were alcohol consumption and tobacco smoking. The outcome was incident dementia obtained from a long-term care insurance database. Covariates were demographics, lifestyle factors, body mass index, general health status, and history of stroke, diabetes, and depression. RESULTS: Participant mean age was 59.0 years. The 1-149, 150-299, and 300-449 g ethanol/week groups had significantly lower adjusted hazard ratios (HRs) (0.62, 0.59, and 0.47, respectively) compared with the reference group, with no significant linear association. HRs increased toward 1 when past-drinkers and those with poor health status and a disease history were excluded (0.80, 0.66, and 0.82, respectively). Higher smoking levels were dose-dependently associated with a higher HR (adjusted P for trend = 0.0105), with the ≥20 cigarettes/day group having a significantly higher adjusted HR (1.80). Heavy drinkers (≥449 g ethanol/week) with smoking habits, but not those without smoking habits, had higher dementia risk (P for interaction = 0.0046). CONCLUSION: Light-to-moderate alcohol consumption is associated with decreased dementia risk, and smoking is dose-dependently associated with increased dementia risk, with an interaction between high alcohol consumption and smoking on dementia risk., 2023年10月, 176, 107788, 107788, 研究論文（学術雑誌）, 国際誌, 10.1016/j.maturitas.2023.107788

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• 査読あり, 英語, European journal of clinical nutrition, Reproducibility and dietary correlates of plasma polyphenols in the JPHC-NEXT Protocol Area study., Nagisa Mori; Neil Murphy; Norie Sawada; David Achaintre; Taiki Yamaji; Augustin Scalbert; Junko Ishihara; Ribeka Takachi; Kazutoshi Nakamura; Junta Tanaka; Motoki Iwasaki; Hiroyasu Iso; Manami Inoue; Marc J Gunter; Shoichiro Tsugane, BACKGROUND: In recent years, an increasing number of epidemiological studies have suggested a role of polyphenols in the prevention of chronic diseases. Prospective cohort studies have typically measured polyphenol concentrations in a single blood sample and the reproducibility of plasma polyphenol measurements is largely unknown. OBJECTIVE: We evaluated the reproducibility of 35 plasma polyphenols collected at an interval of 1-year. We also examined correlations of these polyphenols with food group intakes calculated from weighed food records (WFR) and food frequency questionnaire (FFQ). METHODS: The study included 227 middle-aged participants from the JPHC-NEXT Protocol Area in Japan. We measured 35 polyphenols in plasma collected at two points 1-year apart. Food group intakes were calculated from 12-day WFR and FFQ. For the reproducibility analysis, the intraclass correlation coefficient (ICC) of 35 polyphenol concentrations were examined between the two points. Pearson's partial correlations was used to assess the correlation between polyphenols and food groups. RESULTS: Moderate- to high ICCs were observed for tea-originated polyphenols such as gallic acid, quercetin, epigallocatechin, and kaempferol - and coffee-derived polyphenols, such as caffeic acid, and ferulic acid. For the dietary analyses, moderate correlations were observed for non-alcoholic beverages intake and epigallocatechin, epicatechin, catechin, and gallic acid. For green tea, higher correlations were observed with these polyphenols. CONCLUSION: Plasma concentrations of tea and coffee-related polyphenols, except for catechin, had good reproducibility over a 1-year period. The correlations between intake of non-alcoholic beverages, particularly green tea, and tea polyphenols, indicated moderate- to high correlations., 2024年01月, 78, 1, 34, 42, 研究論文（学術雑誌）, 国際誌, 10.1038/s41430-023-01349-w

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• 査読あり, 英語, Journal of Bone and Mineral Metabolism, Body mass index, height, and osteoporotic fracture risk in community-dwelling Japanese people aged 40–74 years, Toshi Nishikura; Kaori Kitamura; Yumi Watanabe; Keiko Kabasawa; Akemi Takahashi; Toshiko Saito; Ryosaku Kobayashi; Rieko Oshiki; Ribeka Takachi; Shoichiro Tsugane; Osamu Yamazaki; Kei Watanabe; Kazutoshi Nakamura, 2024年01月, 42, 1, 47, 59, 研究論文（学術雑誌）, 10.1007/s00774-023-01478-z

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• 査読あり, 英語, Journal of epidemiology, Validity of the intake of sugars, amino acids, and fatty acids estimated using a self-administered food frequency questionnaire in middle-aged and elderly Japanese: the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area., Utako Murai; Junko Ishihara; Ribeka Takachi; Ayaka Kotemori; Yuri Ishii; Kazutoshi Nakamura; Junta Tanaka; Hiroyasu Iso; Shoichiro Tsugane; Norie Sawada, BACKGROUND: The Japanese database of food composition was revised in 2020, during which both the number of food items and the number of food items measured for sugars, amino acids, and fatty acids were increased. We evaluated the validity of estimated intakes of sugars, amino acids and fatty acids using a long-food frequency questionnaire (FFQ) among middle-aged and elderly Japanese. METHODS: From 2012 to 2013, 240 men and women aged 40-74 years from five areas in the JPHC-NEXT protocol were asked to respond to the long-FFQ and provide a 12-day weighed food record (WFR) as reference. The long-FFQ, which included 172 food and beverage items and 11 seasonings, was compared with a 3-day WFR, completed during each distinct season, and validity was assessed using Spearman's correlation coefficients. RESULTS: Percentage differences based on the long-FFQ with the 12-day WFR in men and women varied from -83.9% to 419.6%, and from -75.8% to 623.1% for sugars, -17.5% to 2.8% and -5.8% to 19.6% for amino acids, and -58.5% to 78.8% and -43.4% to 129.3% for fatty acids, respectively. Median values of correlation coefficients for the long-FFQ in men and women were 0.52 and 0.42 for sugars, 0.38 and 0.37 for amino acids, and 0.42 and 0.42 for fatty acids, respectively. CONCLUSIONS: The long-FFQ provided reasonable validity in estimating the intakes of sugars, amino acids, and fatty acids in middle-aged and elderly Japanese. Although caution is warranted for some nutrients, these results may be used in future epidemiological studies., 2024年01月06日, 研究論文（学術雑誌）, 国内誌, 10.2188/jea.JE20230132

  DOI URL共同研究・競争的資金等URL
• 査読あり, 英語, Nutrients, Urinary Biomarkers in Screening for the Usual Intake of Fruit and Vegetables, and Sodium, Potassium, and the Sodium-to-Potassium Ratio: Required Number and Accuracy of Measurements, Aoi Suzuki; Ribeka Takachi; Junko Ishihara; Sachiko Maruya; Yuri Ishii; Kumiko Kito; Kazutoshi Nakamura; Junta Tanaka; Taiki Yamaji; Hiroyasu Iso; Motoki Iwasaki; Shoichiro Tsugane; Norie Sawada, 2024年02月, 16, 3, 442, 研究論文（学術雑誌）, 10.3390/nu16030442

  PermalinkDOI URL共同研究・競争的資金等URL
• 査読あり, 英語, Archives of physical medicine and rehabilitation, Chronic Pain in the Lower Extremities and Low Back is Associated With Recurrent Falls in Community-Dwelling Japanese People Aged 40-74 Years., Yuko Nagashima; Kaori Kitamura; Yumi Watanabe; Keiko Kabasawa; Akemi Takahashi; Toshiko Saito; Ryosaku Kobayashi; Rieko Oshiki; Ribeka Takachi; Shoichiro Tsugane; Osamu Yamazaki; Kei Watanabe; Kazutoshi Nakamura, OBJECTIVE: To determine the longitudinal association between chronic pain in the lower extremities and low back and the odds of recurrent falls in middle-aged and older people. DESIGN: A cohort study. SETTING: Communities in Japan. PARTICIPANTS: Participants were 7540 community-dwelling volunteers aged 40-74 years (N=7540). The baseline survey was a self-administered questionnaire conducted between 2011-2013. Predictors were presence of chronic pain in the knee, foot or ankle, and low back, with the degree of pain categorized as none, very mild/mild, moderate, or severe/very severe. Covariates in the multivariate model of chronic pain in a site were demographics, body mass index, physical activity level, disease history, and chronic pain in the other 2 sites. Logistic regression analysis was used to calculate odds ratios (ORs). INTERVENTIONS: None. MAIN OUTCOME MEASURE(S): Recurrent falls in the year before the 5-year follow-up survey. RESULTS: Mean participant age was 60.2 years. Higher degrees of chronic pain were associated with higher odds of recurrent falls for the knee (P=.0002) with a higher OR of 1.48 (95% CI: 1.11-1.97), for the foot or ankle (P=.0001) with a higher OR of 1.97 (95% CI: 1.36-2.86), and for the low back (P=.0470) with a higher OR of 1.45 (95% CI: 1.09-1.91) in those with any degree of pain relative to those without pain. Higher degrees of chronic knee pain were associated with higher odds of recurrent falls in women (P=.0005), but not in men (P=.0813). Meanwhile, higher degrees of chronic low back pain were associated with the odds of recurrent falls in men (P=.0065), but not in women (P=.8735). CONCLUSIONS: Chronic pain in the knee, foot or ankle, and lower back was independently and dose-dependently associated with a higher risk of recurrent falls. A marked sex-dependent difference was also noted in the association., 2024年03月, 105, 3, 498, 505, 研究論文（学術雑誌）, 国際誌, 10.1016/j.apmr.2023.09.021

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• 査読あり, 英語, Archives of Osteoporosis, Low plasma 25-hydroxyvitamin D levels are not associated with a high risk of recurrent falls in community-dwelling Japanese adults: the Murakami cohort study, Toshi Nishikura; Kaori Kitamura; Yumi Watanabe; Keiko Kabasawa; Toshiko Saito; Akemi Takahashi; Ribeka Takachi; Ryosaku Kobayashi; Rieko Oshiki; Shoichiro Tsugane; Kei Watanabe; Kazutoshi Nakamura, 2024年04月03日, 19, 1, 研究論文（学術雑誌）, 10.1007/s11657-024-01381-8

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• 査読あり, 英語, Journal of Alzheimer’s Disease, Self-reported sleep duration and bedtime are associated with dementia risk in community-dwelling people aged 40–74 years: the Murakami cohort study., B Irina; Watanabe Y; Kitamura K; Kabasawa K; Saito T; Takahashi A; Kobayashi R; Oshiki R; Takachi R; Tsugane S; Yamazaki O; Watanabe K; Nakamura K, 2024年03月, in press, 研究論文（学術雑誌）

MISC

• 査読無し, 日本語, 栄養学雑誌, 栄養疫学における食事評価の現状と課題~集団の疾病予防エビデンスづくりの視点から~(日本疫学会から), 石原淳子; 高地リベカ, 2018年09月03日, 76, 5 Supplement, 82

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• 査読無し, 日本語, New Diet Therapy, (一社)日本臨床栄養協会, 日本人の食生活と生活習慣病 日本人の食生活に適した減塩のポピュレーション戦略の模索, 石原 淳子; 高地 リベカ, 2018年09月, 34, 2, 144, 144

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• 査読無し, 日本語, 食に関する助成研究調査報告書, すかいらーくフードサイエンス研究所, 疫学研究における新たな食事の曝露評価法開発に関する研究, 石原 淳子; 高地 リベカ; 井上 真奈美, 2015年, 28, 95, 102

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• 査読無し, 日本語, 国立がん研究センターがん研究開発費総括研究報告書(Web), 多目的コホートに基づくがん予防など健康の維持・増進に役立つエビデンスの構築に関する研究, 津金昌一郎; 澤田典絵; 笹月静; 岩崎基; 島津太一; 山地太樹; 井上真奈美; 佐藤日出夫; 六本木義光; 伊藤善信; 小松真吾; 小林一司; 塚田昌大; 塚田昌大; 崎山八郎; 伊禮壬紀夫; 大和慎一; 松井一光; 片桐幹雄; 田上豊資; 後藤尚; 仲宗根正; 一居誠; 小久保喜弘; 磯博康; 山岸良匡; 斉藤功; 溝上哲也; 国吉秀樹; 栗山進一; 中村和利; 佐々木綾子; 高地リベカ; 石原淳子; 高橋俊明; 小野剛; 小松裕和; 安田誠史; 横井左奈; 山下英俊; 祖父江友孝; 三村將; 青柳潔, 2014年, 2013, 23-A-31, WEB ONLY

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• 査読無し, その他, The Lipid, 脂質とがんの疫学, 髙地 リベカ; 髙地リベカ; 津金昌一郎, 2014年, 25, 4, 344, 51
• 査読無し, その他, 月刊カレントテラピー, 減塩運動の現状と展望～にいがた減塩ルネサンス運動, 髙地 リベカ; 山﨑理; 小島美世; 永瀨吉彦; 髙地リベカ; 中村和利, 2013年, 31, 10, 39, 44
• 査読無し, 日本語, アジア諸国でのがん予防、がん検診、がん治療向上のための調査研究 平成23年度 総括・分担研究報告書, アジア諸国でのがん予防,がん検診,がん治療向上のための調査研究 東アジア地域におけるがん一次予防普及のための検証的研究, 井上真奈美; 石原淳子; 高地リベカ; 入江ふじこ, 2012年, 25, 28

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• 査読無し, 日本語, 総合健康推進財団研究報告書, アジア集団における食事摂取量把握精度向上をめざした食事データベースの構築, 井上真奈美; 石原淳子; 高地リベカ, 2011年07月08日, 2009, 1, 8

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• 査読無し, 日本語, 新潟県医師会報, 新潟県医師会, 村上コホート研究について, 中村和利; 髙地リベカ; 北村香織; 斎藤トシ子; 小林量作; 押木利英子; 佐々木綾子; 山崎理, 2011年, 740, 740, 2, 5
• 査読無し, その他, 臨床栄養, 野菜果物とがん・循環器疾患について, 髙地 リベカ; 髙地リベカ; 坪野吉孝, 2008年, 112, 3, 242, 3
• 査読無し, その他, 栄養日本, 生活習慣病予防における栄養指導効果検証のための簡易食事調査「料理単位法」の妥当性と応用可能性, 髙地 リベカ; 君羅満; 髙地リベカ; 工藤陽子; 渡邊昌; 菅野英子; 佐藤恵子, 2006年, 49, 3, 40, 2
• その他, 日本疫学会学術総会講演集(Web), 家庭調味モニタリングまたは低塩調味料による減塩効果検討のための無作為化比較試験, 神田真希; 丸谷幸子; 中舘美佐子; 松本海保; 島袋夏乃華; 戸谷みのり; 本多泉美; 岩崎基; 高地リベカ; 石原淳子; 石原淳子, 2019年, 29th
• 査読無し, 日本語, 日本衛生学雑誌, 日本衛生学会, カドミウム摂取量と乳がんリスクの関連 ホルモン受容体を考慮した解析, 伊藤 弘明; 岩崎 基; 澤田 典絵; 高地 リベカ; 春日 好雄; 横山 史朗; 小沼 博; 西村 秀紀; 草間 律; 横山 和仁; 津金 昌一郎, (第84回日本衛生学会学術総会若手優秀演題会長賞), 2014年05月, 69, Suppl., S194, S194, 研究発表ペーパー・要旨（全国大会，その他学術会議）
• 査読無し, 日本語, 食と医療, 食塩・塩蔵食品とがん・NCDの予防, 高地リベカ, 2024年01月, 28, 006, 010, 記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）

書籍等出版物

• 疫学の辞典, 朝倉書店, 日本語, 事典, 978-4-254-31097
• 食物摂取頻度調査票　FFQ NEXT, 建帛社, 日本語, 学術書
• コンパクト公衆栄養学第３版, 朝倉書店, 2016年, その他, 査読無し, その他
• 公衆栄養学実習, 建帛社, 2012年, その他, 査読無し, その他, 9784767904689
• 公衆栄養学・栄養疫学実習, 建帛社, 石原淳子; 高地リベカ; 鬼頭久美子; 木村安美; 小手森綾香; 後藤温; 多田由紀; 遠又靖丈; 丸谷幸子; 丸山広達; 村井詩子; 吉﨑貴大, 2024年03月, その他, その他, 9784767907529
• 疫学の事典, 朝倉書店, 三浦克之; 玉腰暁子; 尾島俊之; 高地リベカ 他, 2023年01月, その他, その他, 9784254310979
• 地域公衆栄養学実習, 講談社サイエンティフィク, 市川知美; 松本範子; 金田直子; 高地リベカ 他, 2022年10月, その他, その他, 9784065265802

講演・口頭発表等

• 高地リベカ, 国内, がん予防学術大会2023金沢, シンポジウム「社会環境アプローチによるがんリスク低減の取り組み」食生活分野における取り組みと事例, シンポジウム・ワークショップパネル（指名）
• Keiko Kabasawa, 国際, American Society of Nephrology Kidney Week 2023, Diet and the discrepancy between cystatin C- and creatinine-based eGFR in middle-aged and older community-dwelling Japanese adults, ポスター発表, 英語
• 高地リベカ, 国内, 第22回日本栄養改善学会近畿支部会学術総会, モバイル型Web食事評価システムの開発と概要, 口頭発表（一般）, 日本語
• 村井 詩子, 国内, 第34回日本疫学会学術総会, 食品成分表(八訂)を用いた食物摂取頻度調査票の妥当性ー総食物繊維摂取量に着目して, ポスター発表, 日本語
• 鈴木 碧, 国内, 第34回日本疫学会学術総会, 尿中カリウム排泄量による野菜類・果実類の習慣的摂取量のスクリーニング, ポスター発表, 日本語
• 山岸 万里菜, 国内, 第34回日本疫学会学術総会, 重回帰法を用いたNa排泄量・Na/K比の予測式開発と内的妥当性の検証(JPHC-NEXT妥当性研究), ポスター発表, 日本語
• 石井 有里, 国内, 第34回日本疫学会学術総会, がん診断前後を含む５年間の食事摂取量変化について がん診断なし群との比較 JPHC研究より, ポスター発表, 日本語
• Huang HL, Abe SK, Sawada N, Takachi R, Ishihara J, Iwasaki M, Yamaji T, Iso H, Mizoue T, Noda M, Hashizume M, Inoue M, Tsugane S; JPHC Study Group., 国際, World Congress of Epidemiology, 2021, Association of sugary drink consumption with all-cause and cause-specific mortality: the JPHC study
• 高地リベカ, 国内, 日本栄養・食糧学会関東支部第109回シンポジウム, がんの栄養疫学　～有効な対策立案に役立つエビデンス創出を目指して～, シンポジウム・ワークショップパネル（指名）
• 北村香織, 渡邊裕美, 蒲澤圭子, 髙橋明美, 斎藤トシ子, 小林量作, 髙地リベカ, 押木利恵子, 津金昌一郎, 伊木雅之, 佐々木綾子, 山﨑理, 渡邊慶, 中村和利, 国内, 日本老年社会科学会第64回大会, 余暇および非余暇の身体活動は、40-74歳の地域在住者の認知症のリスク低下と用量依存的に関連している：村上コホート研究
• 山岸万里菜、高地リベカ、石原淳子、小川冬華、丸谷幸子、石井有里、鬼頭久美子、中村和利、田中純太、山地太樹、磯博康、岩崎基、津金昌一郎、澤田典絵, 国内, 第33回日本疫学会学術総会（浜松）, 秤量食事記録によるナトリウム摂取源と24時間尿中ナトリウム排泄量との関連
• 荻野麻子、高地リベカ、石原淳子、菅原詩緒理、保科由智恵、鬼頭久美子、中舘美佐子、丸谷幸子、鈴木碧、小原拓、石黒真美、上野史彦、野田あおい、相澤美里、髙橋一平、米沢祐大、山下貴宏、鈴木重德、村上慶子、栗山進一, 国内, 第33回日本疫学会学術総会（浜松）, 複数回のFFQ による栄養素等摂取量推定の妥当性〜東北メディカル・メガバンク計画コホート調査妥当性研究
• Takachi R, Maruya S., 国際, 22ND IUNS-ICN, International Congress of Nutrition in Tokyo, The effect of educational BGM on reducing salt intake at a university canteen., シンポジウム・ワークショップパネル（指名）, 英語
• 蒲澤佳子、松下邦洋、高地リベカ、中村和利、伊藤由美、田中純太、成田一衛, 国内, 第65回日本腎臓学会総会, 一般地域住民における尿と食事Na/K比とアルブミン尿の関連, 日本語
• Takachi R, Ishihara J, Maruya S, Tanaka J, Yatsuya H, Aoyama A, Hirakawa Y, Chiang C, Konta T, Kayama Y, Inoue M, Sawada N, Tsugane S, 国際, International Conference on Diet and Activity Methods 2020, eICDAM 2021, Automated Web-based Assessment system using Recipe-Data for Japanese (AWARDJP) – a pilot study for the middle and old age population-base cohort studies in Japan.
• 藤原紗音，丸谷幸子，小川冬華，松野友香，高地リベカ, 国内, 第67回日本栄養改善学会学術総会, 藤原紗音，丸谷幸子，小川冬華，松野友香，高地リベカ. 「適塩ソング」BGM 放送の食塩摂取行動への影響―特定給食施設における非無作為化比較試験―
• 鬼頭久美子、石原淳子、山本純平、小手森綾香、草野幹太、小野澤桃子、村岡志桜里、丸山広達、岡田知佳、高地リベカ、中村和利、田中純太、山地太樹、島津太一、石井有里、澤田典絵、岩崎基、磯博康、津金昌一郎, 国内, 第30回日本疫学会学術総会, 食事由来のトランス脂肪酸摂取量～2012-13年の摂取状態及び食物摂取頻度調査票の妥当性検証～
• Kanehara R; Goto A; Kotemori A; Mori N; Nakamura A; Sawada N; Ishihara J; Takachi R; Kawano Y; Iwasaki M; Tsugane S, 国際, Nutrients 2019 – Nutritional Advances in the Prevention and Management of Chronic Disease, Estimation of Sugar Intake and Validation Study for a Self-Administered Food Frequency Questionnaire Using Urinary Sugar in Middle-Aged Japanese Adults., 2019年09月, 英語, 国際会議
• Takeuchi A; Harada S; Shimazu T; Yamaji T; Sawada N; Ishihara J; Takachi R; Nakamura K; Tanaka J; Inoue M; Iwasaki M; Iso H; Sugimoto M; Hirayama A; Soga T; Tomita M; Tsugane S; Takebayashi T, 国際, 2019 Metabolomics Conference, 15th Annual Conference of the Metabolomics Society, Detect and Quantify Sources of Variability in Metabolite Measurement in a Japanese population, 2019年06月, 英語, 国際会議
• 神田真希、丸谷幸子、中舘美佐子、松本海保、島袋夏乃華、戸谷みのり、本多泉美、岩崎基、高地リベカ、石原淳子., 国内, 第29回日本疫学会学術総会, 家庭調味モニタリングまたは低塩調味料による減塩効果の検討のための無作為化比較試験., 2019年02月, 日本語, 国内会議

  共同研究・競争的資金等URL
• 山極洋子, 澤田典絵, 島津太一, 山地太樹, 後藤温, 高地リベカ, 石原淳子, 岩崎基,井上真奈美, 津金昌一郎, 国内, 第29回日本疫学会学術総会, 果物・野菜摂取と膵がん罹患の関連の検討:多目的コホート研究., 2019年02月, 日本語, 国内会議
• 松本麻由佳、丸谷幸子、西本侑加、加藤祐子、中館美佐子、高地リベカ、石原淳子, 国内, 第28回日本疫学会学術総会, 簡易チェックシートによる食塩摂取量スクリーニングの妥当性, 2018年02月01日, 日本語

  共同研究・競争的資金等URL
• 藤田みほ, 石原淳子, 八谷寛, 田中純太, 西本侑加, 丸谷幸子, 平川仁尚, 江啓発, 加藤祐子, 澤田典絵, 井上真奈美, 青山温子, 髙地リベカ, 国内, 第28回日本疫学会学術総会, 料理ベース食事調査Webシステムのコホートでの活用に関するパイロット研究～第1報 実施方法と回答状況～, 2018年02月, その他

  共同研究・競争的資金等URL
• 加藤祐子; 石原淳子; 八谷寛; 田中純太; 藤田みほ; 西本侑加; 丸谷幸子; 青山温子; 平川仁尚; 江啓発; 澤田典絵; 井上真奈美; 髙地リベカ, 国内, 第28回日本疫学会学術総会, 料理データベース食事調査Webシステムのコホートでの活用に関するパイロット研究～第2報 摂取量の推定結果～, 2018年02月, その他

  共同研究・競争的資金等URL
• 金原里恵子; 後藤温; 小手森綾香; 森渚; 中村有里; 澤田典絵; 石原淳子; 髙地リベカ; 川野因; 岩崎基; 津金昌一郎, 国内, 第28回日本疫学会学術総会, 食物摂取頻度調査票による単純糖質摂取量の妥当性および再現性, 2018年02月, その他
• Mori N; Sawada N; Shimazu T; Yamamoto J; Ishihara J; Takachi R; Nakamura K; Tanaka J; Yamaji T; Iwasaki M; Iso H, 国際, European Congress of Epidemiology, IEA, Validity and reproducibility of isothiocyanate intake assessed by food frequency questionnaire in the JPHC-NEXT Validation Study: Comparison with 12-day weighed food records., 2018年07月, その他
• 高地リベカ; 西本侑加; 丸谷幸子; 松本海保; 神田真希, 国内, 第65回 日本栄養改善学会学術総会, 質問票を用いた血中25(OH)D濃度予測式開発と開発集団内における妥当性, 2018年09月, その他
• 石原淳子; 高地リベカ, 国内, 第65回 日本栄養改善学会学術総会＜日本疫学会・日本病態栄養学会・日本栄養改善学会共催シンポジウム＞「栄養改善の効果につながる食事評価法を考える」, 「栄養疫学における食事評価の現状と課題 〜集団の疾病予防エビデンスづくりの視点から〜（日本疫学会から）」, 2018年09月03日, その他
• 森渚; 島津太一; 武藤倫弘; 澤田典絵; 岩崎基; 山路大樹; 井上真奈美; 後藤温; 高地リベカ; 石原淳子; 津金昌一郎, 国内, 第77回 日本癌学会学術総会, アブラナ科野菜摂取と全死亡およびがん死亡リスクとの関連., 2018年09月, その他
• Kabasawa K; Hosojima M; Ito Y; Kabasawa H; Takachi R; Nakamura K; Saito A; Tanaka J; Tsugane S; Narita I, 国際, American Society of Nephrology, Kidney Week 2018., The association with estimated dietary acid load and albuminuria in the Japanese adults., 2018年, その他
• 髙地リベカ; 井上真奈美; 菅原由美; 辻一郎; 津金昌一郎; 伊藤秀美; 松尾恵太郎; 田中恵太郎; 玉腰暁子; 溝上哲也; 若井建志; 永田知里; 笹月静, 第27回日本疫学会学術総会, 野菜・果物摂取と全がん罹患率との関係：日本人における大規模コホートのプール解析．, 2017年01月, その他
• 三浦咲; 中舘美佐子; 石原淳子; 岩崎基; 中村和利; 北村香織; 加藤恵梨香; 横山悠太; 田中純太; 柏木友紀穂; 松木祐実; 髙地リベカ, 第27回日本疫学会学術総会, 家庭調味モニタリングの介入研究ベースラインにおける地域別基本特性の検討(1) ナトリウム・高塩分食品摂取．, 2017年01月, その他

  共同研究・競争的資金等URL
• 中舘美佐子; 石原淳子; 岩崎基; 中村和利; 北村香織; 加藤恵梨香; 横山悠太; 田中純太; 柏木友紀穂; 松木祐美; 三浦咲; 髙地リベカ, 第27回日本疫学会学術総会, 家庭調味モニタリングの介入研究ベースラインにおける地域別基本特性の検討(2)食習慣・食嗜好．, 2017年01月, その他

  共同研究・競争的資金等URL
• 丸谷幸子; 西本侑加; 髙地リベカ, 第63回日本栄養改善学会学術総会, 減塩BGMの効果を検証する食堂介入研究, 2017年09月, その他
• 西本侑加; 髙地リベカ, 第63回日本栄養改善学会学術総会, 乳酸菌飲料及びヨーグルト摂取と大腸がんの関連に関する検討：システマティックレビュー, 2017年09月, その他
• 高地リベカ, 第39回日本臨床栄養学会総会・第38回日本臨床栄養協会総会 第15回大連合大会・日本疫学会共催シンポジウム, 日本人の食生活と生活習慣病「食生活とがん」, 2017年, その他
• 山岸万里奈; 髙地リベカ; 石原淳子; 石井有里; 篠澤友里江; 北村香織; 野田愛; 三代泉; 貢英彦; 澤田典絵; 島津太一; 中村和利; 田中純太; 磯博康; 笹月静; 津金昌一郎; 統合妥当性研究グルー, 第26回 日本疫学会学術総会, 味付けの好み・食行動と24時間尿中ナトリウム排泄量（5回/年）との関連, 2016年01月, その他
• Takachi R; Ishihara J; Ishii Y; Ohuchi S; Saito H; Nakadate M; Yokoyama Y; Yoshida M; Takamoto E; Inoue M, 9th International Conference on Diet and Activity Methods, An innovative methods for dietary assessment in Japan – as a platform for the large-scale cohort consortium –, 2015年09月, 英語, 国際会議
• Ishihara J; Takachi R, The 25th Annual Scientific Meeting of the Japan Epidemiological Association, 2015 (Nagoya, Japan), Need for innovative dietary assessment method in Asia., 2015年01月, その他
• Takachi R; Ishihara J; Nakadate M; Iwasaki M; Kitamura K; Kato E; Yokoyama Y; Tanaka J; Nakamura K, 第25回 日本疫学会学術総会, Randomized controlled crossover trial of salt reduction: (1) effect of low-sodium seasoning use., 2015年01月, その他
• Nakadate M; Ishihara J; Iwasaki M; Kitamura K; Kato E; Yokoyama Y; Tanaka J; Nakamura K; Takachi R, 第25回 日本疫学会学術総会, Randomized controlled crossover trial of salt reduction: (2) effect of monitoring salt concentration.（優秀演題賞受賞）, 2015年01月, その他
• Kato E; Takachi R; Ishihara J; Ishii Y; Sasazuki S; Sawada N; Tanaka J; Yokoyama Y; Kitamura K; Nakamura K; Tsugane S, 第25回 日本疫学会学術総会, Validity and feasibility of Web-based self-administered FFQ developed for the JPHC-NEXT protocol., 2015年01月, その他
• Yokoyama Y; Takachi R; Ishihara J; Ishii Y; Sasazuki S; Sawada N; Tanaka J; Kato E; Kitamura K; Nakamura K; Tsugane S, 第25回 日本疫学会学術総会, Short and long FFQs to rank dietary intakes in middle-aged Japanese: for the JPHC-NEXT protocol., 2015年01月, その他
• Imaeda N; Ishihara J; Takachi R; Goto C; Ishii Y; Kojima S; Nanri H; Nakamura K; Yamaguchi M; Tanaka J; Fukuda N; Iso H; Hosono S; Shimazu T; Miyagawa N; Sawada N; Wakai K; Sasazuki S; Tanaka H; Tsugane S, 第25回 日本疫学会学術総会, Comparison of dietary record procedures in calibration studies for two large cohort studies., 2015年01月, その他
• Nakamura K; Kitamura K; Takachi R; Saito T; Kobayashi R; Oshiki R; Watanabe Y, World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases 2015, The Murakami Cohort Study for the prevention of musculoskeletal diseases with vitamin D in Japan., 2015年03月, その他
• 髙地リベカ; 吉田美佳; 高本栄一郎; 石井有里; 大内詩野; 山岸万里奈; 小田瑞希; 林えりこ; 中舘美佐子; 石原淳子, 第62回日本栄養改善学会学術集会, ＩＣＴによる自動式24時間思い出しシステムの開発－秤量法に基づく料理データベースを活用して－, 2015年09月, その他
• 中舘美佐子; 石原淳子; 加藤恵梨香; 横山悠太; 髙地リベカ, 第62回日本栄養改善学会学術総会, 家庭調味モニタリング介入の効果～対象者特性別層別解析～, 2015年09月, その他
• 石井有里; 髙地リベカ; 篠澤有里江; 鬼頭久美子; 石原淳子, 第61回日本栄養改善学会学術総会, 食事記録調査における調査員スキル標準化に向けての取り組み（第2報）～模擬献立を用いた推定摂取量～, 2014年08月, 日本語, 国内会議
• 髙地リベカ; 石井有里; 篠澤有里江; 鬼頭久美子; 石原淳子, 第61回日本栄養改善学会学術総会, 食事記録調査における調査員スキル標準化に向けての取り組み（第１報）～模擬調査票を用いた確認事項達成度～, 2014年08月, 日本語, 国内会議
• 横山悠太; 髙地リベカ; 石原淳; 岩崎基; 澤田典絵; 笹月静; 加藤恵梨香; 中村和利; 津金昌一郎, 第24回 日本疫学会学術総会, 簡易版食物摂取頻度調査票開発のための予備的検討－食品群・栄養素等の摂取量推定・妥当性検証－, 2014年01月, その他
• 伊藤弘明; 岩崎基; 澤田典絵; 髙地リベカ; 春日好雄; 横山史朗; 小沼博; 西村秀紀; 草間律; 横山和仁; 津金昌一郎, 第84回 日本衛生学会学術総会, カドミウム摂取量と乳がんリスクの関連：ホルモン受容体を考慮した解析, 2014年05月, その他
• Sawada N; Iwasaki M; Inoue M; Takachi R; Sasazuki S; Yamaji T; Shimazu T; Tsugane S, The 72nd Annual Meeting of the Japanese Cancer Association, Dietary arsenic intake and subsequent risk of cancer: the Japan Public Health Center-based (JPHC) Prospective Study., 2013年09月, その他
• 中村和利; 髙地リベカ; 北村香織; 斎藤トシ子; 小林量作; 押木利英子; 佐々木綾子; 山崎理; 伊木雅之, 第72回 日本公衆衛生学会総会, 加齢性運動器疾患の分子疫学コホート研究（村上鮭で元気プロジェクト）, 2013年10月, その他
• Nakamura K; Kitamura K; Saito T; Kobayashi R; Oshiki R; Takachi R; Sasaki A; Yamazaki O, IOF Regionals 4th Asia-Pacific Osteoporosis Meeting, Serum 25-hydroxyvitamin D levels in a population-based cohort in Japan: Murakami Cohort Study., 2013年12月, その他
• 高地リベカ, 第689回 新潟医学会（特別講演）, 栄養疫学と曝露評価の意義, 2013年, その他
• 髙地リベカ; 坪野吉孝; 井上真奈美; 笹月静; 岩崎基; 津金昌一郎, 第22回 日本疫学会学術総会, 赤肉・加工肉摂取量と大腸がん罹患との関連; JPHC Study, 2012年01月, その他
• 石原淳子; 髙地リベカ; 細井聖子; 石井有里; 岩崎基; 津金昌一郎, 第22回 日本疫学会学術総会, 料理画像を用いた栄養素摂取量推定の精度の検討－生体指標との比較, 2012年01月, その他
• Ishihara J; Takachi R; Ishii Y; Shinozawa Y; Inoue M; Imai T; Tsugane S, 8th International Conference on Diet and Activity Methods., Development of a recipe-based database for the assessment of dietary intake in Japanese populations: Part I – framework and strategy., 2012年05月, その他
• Takachi R; Ishihara J; Ishii Y; Shinozawa Y; Inoue M; Imai T; Tsugane S, 8th International Conference on Diet and Activity Methods., Development of a recipe-based database for the assessment of dietary intake in Japanese populations: Part II – basic results., 2012年05月, その他
• 石原淳子; 髙地リベカ; 石井有里; 篠澤友里江; 鬼頭久美子; 君羅満; 今井具子, 第59回 日本栄養改善学会学術総会, 食事評価のための料理データベース開発（第1報）～データベースの基本情報について～, 2012年09月, その他
• 石井有里; 髙地リベカ; 篠澤友里江; 鬼頭久美子; 君羅満; 石原淳子, 第59回 日本栄養改善学会学術総会, 食事評価のための料理データベース開発（第2報）～１食あたり料理の大きさについて～, 2012年09月, その他
• Sawada N; Iwasaki M; Inoue M; Takachi R; Sasazuki S; Yamaji T; Shimazu T; Tsugane S, The 71st Annual Meeting of the Japanese Cancer Association, Long-term Dietary Cadmium Intake and Cancer Incidence: the Japan Public Health Center-based Prospective Study., 2012年09月, その他
• 伊藤弘明; 岩崎基; 澤田典絵; 髙地リベカ; 春日好雄; 横山史朗; 小沼博; 西村秀紀; 草間律; 横山和仁; 津金昌一郎, 第77回 日本民族衛生学会総会, カドミウム摂取による乳がん罹患リスク －長野県における症例対照研究－, 2012年11月, その他
• 高地リベカ, 第35回 高血圧学会学術総会コメディカル・メディカル合同シンポジウム, にいがた減塩ルネサンス運動, 2012年, その他
• 髙地リベカ; 石原淳子; 岩崎基; 津金昌一郎, 第21回 日本疫学会学術総会, 検診受診者における質問紙による「みそ汁の味付け」とみそ汁濃度実測値及び食事記録法による食塩摂取量と関連, 2011年01月, その他
• Takachi R; Ishihara J; Hosoi S; Iwasaki M; Tsugane S, The joint scientific meeting of the International Epidemiological Association Western Pacific Region and the 20th JEA, Validity of using digital photographic images of meals as a tool for assessing nutrient intake in middle-aged Japanese., 2010年01月, その他
• 髙地リベカ; 石原淳子, 第57回 日本栄養改善学会学術総会, 日本人における塩・塩蔵食品と全がん及び循環器疾患との関連: JPHC Study, 2010年09月, その他
• 鬼頭久美子; 石原淳子; 君羅満; 髙地リベカ; 細井聖子; 石井有里, 第57回 日本栄養改善学会学術総会, 料理単位による食品群・栄養素等摂取量推定の妥当性の検討, 2010年09月, その他
• Ishihara J; Takachi R; Hosoi S; Iwasaki M; Tsugane S, The joint scientific meeting of the International Epidemiological Association Western Pacific Region and the 20th JEA, Validity of using digital photographic images of meals as a tool for assessing food group intake in middle-aged Japanese., 2010年01月, その他
• 髙地リベカ; 石原淳子; 岩崎基; 津金昌一郎, 第19回 日本疫学会学術総会, 検診受診者における自記式半定量食物摂取頻度調査票による食品群・栄養素等摂取量推定の妥当性・再現性の検討, 2009年01月, その他
• 髙地リベカ; 井上真奈美; 倉橋典江; 岩崎基; 笹月静; 石原淳子; 坪野吉孝; 津金昌一郎, 第56回 日本栄養改善学会学術総会, 日本人男性における野菜・果物摂取と前立腺がんとの関連：JPHC Study, 2009年09月, その他
• 鬼頭久美子; 石原淳子; 君羅満; 髙地リベカ, 岩崎基, 第56回 日本栄養改善学会学術総会, 食事記録調査における料理別摂取頻度と食品数：料理を基本とする食事調査データベース構築のための予備検討, 2009年09月, その他
• 高地リベカ, 第56回 日本栄養改善学会学術総会（奨励賞受賞講演）, 実践的な料理データベース作成のための標本サイズと妥当性, 2009年09月, その他
• 髙地リベカ; 井上真奈美; 石原淳子; 倉橋典江; 岩崎基; 笹月静; 磯博康; 坪野吉孝; 津金昌一郎, 第18回 日本疫学会学術総会, 野菜・果物摂取と全がん・循環器疾患罹患との関連；JPHC Study, 2008年01月, その他
• 大滝直人; 馬場麻里子; 宮﨑絵里子; 羽場亮太; 君羅満; 髙地リベカ; 上杉宰世; 井沢正利; 工藤陽子, 第13回 日本健康体力栄養学会総会, 食事バランスガイドに則した中高年女性の食事の検討, 2006年03月, その他
• 工藤陽子; 髙地リベカ; 関千代子; 大滝直人; 君羅満, 第53回 日本栄養改善学会学術総会, 骨密度と尿中Ca・Na排泄量との関連～閉経後期間が及ぼす影響～, 2006年09月, その他
• 髙地リベカ; 上杉宰世; 大内和幸; 工藤陽子; 君羅満; 渡邊昌, 第15回 日本疫学会学術総会, 閉経後女性における血小板凝集能と食生活・脂肪酸について, 2005年01月, その他
• 大滝直人; 髙地リベカ; 羽場亮太; 君羅満; 渡邊昌, 第15回 日本疫学会学術総会, 24時間尿中ミネラル排泄によるスポット尿の有効性に関する検討, 2005年01月, その他
• 君羅満; 髙地リベカ; 馬場麻里子; 宮崎絵里子; 百瀬小夜; 木村一恵; 千葉歌織; 大滝直人; 工藤陽子; 渡辺昌, 第12回 日本健康体力栄養学会総会, 簡易な食事調査"料理単位法"における料理データベースの標本サイズと信頼性, 2005年03月, その他
• 工藤陽子; 髙地リベカ; 大滝直人; 上杉宰世; 羽場亮太; 君羅満, 第52回 日本栄養改善学会学術総会, 簡易食事調査『料理単位法』による栄養摂取状況の把握と生活習慣病の有病数との関連, 2005年09月, その他
• 君羅満; 工藤陽子; 髙地リベカ; 羽場亮太; 倉永ひさ; 関円香; 知念多美; 藤川聡子; 渡辺昌, 第14回 日本疫学会学術総会, 尿中ナトリウム, カリウム排泄量による食事調査法「料理単位法」の検討, 2004年01月, その他
• 髙地リベカ; 相木浩子; 石川千尋; 石田美保子; 上杉宰世; 大内和幸; 君羅満; 渡辺昌, 第14回 日本疫学会学術総会, 一般住民における血小板凝集能検査と関連する要因について, 2004年01月, その他
• 髙地リベカ; 工藤陽子; 相木浩子; 倉永ひさ; 知念多美; 君羅満, 第11回 健康体力栄養研究会総会, 簡易栄養調査法（料理単位法）の検討について: 料理成分値の妥当性, 2004年03月, その他
• 君羅満; 髙地リベカ; 工藤陽子; 石川千尋; 石田美保子; 関円香; 藤川聡子, 第11回 健康体力栄養研究会総会, 簡易栄養調査法（料理単位法）の検討について ～料理ポーションサイズの検討～, 2004年03月, その他
• 髙地リベカ; 工藤陽子; 菅野英子; 君羅満; 渡邊昌, 第51回 日本栄養改善学会学術総会, 簡易栄養調査法（料理単位法）の検討: 料理データベースの標本サイズ, 2004年09月, その他
• 工藤陽子; 羽場亮太; 髙地リベカ; 君羅満; 渡辺昌, 第50回 日本栄養改善学会学術総会, 主要ミネラルの1日摂取量と尿中排泄量の検討, 2003年09月, その他
• 荒井裕介; 谷本典隆; 八束リベカ; 高橋博子; 岩瀬靖彦; 君羅満; 高橋東生; 飯樋洋二; 赤羽正之; 五島孜郎, 第3回 日本健康体力栄養研究会, 地方都市における食生活と運動の状況について, 1996年02月, その他
• 荒井裕介; 谷本典隆; 高橋博子; 八束リベカ; 岩瀬靖彦; 君羅満; 飯樋洋二; 赤羽正之, 第42回 日本栄養改善学会, 岩手県の一地域における栄養状態の経年比較について, 1995年10月, その他
• Takachi R; Ishihara J; Maruya S; Tanaka J; Yatsuya H; Aoyama A; Hirakawa Y; Chiang C; Konta T; Kayama Y; Inoue M; Sawada N; Tsugane S, International Conference on Diet and Activity Methods 2020, eICDAM 2021, Automated Web-based Assessment system using Recipe-Data for Japanese (AWARDJP) – a pilot study for the middle and old age population-base cohort studies in Japan., 2021年02月, 英語

  共同研究・競争的資金等URL
• 藤原紗音; 丸谷幸子; 小川冬華; 松野友香; 高地リベカ, 第67回日本栄養改善学会学術総会, 適塩ソング」BGM 放送の食塩摂取行動への影響―特定給食施設における非無作為化比較試験―, 2020年09月, その他
• 鬼頭久美子; 石原淳子; 山本純平; 小手森綾香; 草野幹太; 小野澤桃子; 村岡志桜里; 丸山広達; 岡田知佳; 高地リベカ; 中村和利; 田中純太; 山地太樹; 島津太一; 石井有里; 澤田典絵; 岩崎基; 磯博康; 津金昌一郎, 第30回日本疫学会学術総会, 食事由来のトランス脂肪酸摂取量～2012-13年の摂取状態及び食物摂取頻度調査票の妥当性検証, 2020年02月, その他
• 鬼頭久美子; 石原淳子; 山本純平; 細田享恒; 小手森綾香; 高地リベカ; 中村和利; 田中純太; 山地太樹; 島津太一; 澤田典絵; 岩崎基; 津金昌一郎; 磯博康; 祖父江友孝, 日本疫学会学術総会講演集(Web), 食事由来のアクリルアミド曝露量推定におけるFFQの妥当性検証, 2019年, 2019年, 2019年, その他
• 金原里恵子; 金原里恵子; 後藤温; 砂見綾香; 森渚; 中村有里; 澤田典絵; 石原淳子; 石原淳子; 高地リベカ; 高地リベカ; 川野因; 岩崎基; 津金昌一郎, 日本疫学会学術総会講演集(Web), 食物摂取頻度調査票による単純糖質摂取量の妥当性および再現性に関する研究, 2018年, 2018年, 2018年, その他
• Kabasawa K; Matsushita K; Takachi R; Nakamura K; Ito Y; Tanaka J; Narita I., 国際, American Society of Nephrology, Kidney Week 2021., Associations of urinary and dietary sodium-to-potassium ratios with albuminuria in community-dwelling Japanese adults: a cross-sectional study, 英語
• Suzuki A, Matsuno T, Takachi R, Ishihara J, Ishii Y, Kito K, Maruya S, Iwasaki M, Tsugane S, Sawada N, 国際, 22ND IUNS-ICN, International Congress of Nutrition in Tokyo, Validity of the Food Frequency Questionnaire- and the 12-day weighed food records-estimated, intakes of sodium, potassium, and sodium-to-potassium ratio for screening in Japanese adults, 英語
• 石井 有里; 高地 リベカ; 石原 淳子; 山地 太樹; 岩崎 基; 井上 真奈美; 津金 昌一郎; 澤田 典絵, 第34回日本疫学会学術総会, がん診断前後を含む５年間の食事摂取量変化について がん診断なし群との比較 JPHC研究より, 2024年02月, 日本語

  共同研究・競争的資金等URL
• 山岸 万里菜; 高地 リベカ; 石原 淳子; 丸谷 幸子; 石井 有里; 鬼頭 久美子; 中村 和利; 田中 純太; 山地 太樹; 磯 博康; 岩崎 基; 津金 昌一郎; 澤田 典絵, 第34回日本疫学会学術総会, 重回帰法を用いたNa排泄量・Na/K比の予測式開発と内的妥当性の検証(JPHC-NEXT妥当性研究), 2024年02月, 日本語

  共同研究・競争的資金等URL
• 鈴木 碧; 高地 リベカ; 石原 淳子; 丸谷 幸子; 石井 有里; 鬼頭 久美子; 中村 和利; 田中 純太; 山地 太樹; 磯 博康; 岩崎 基; 津金 昌一郎; 澤田 典絵, 第34回日本疫学会学術総会, 尿中カリウム排泄量による野菜類・果実類の習慣的摂取量のスクリーニング, 2024年02月, 日本語

  共同研究・競争的資金等URL
• 村井 詩子; 石原 淳子; 高地 リベカ; 小手森 綾香; 石井 有里; 中村 和利; 田中 純太; 磯 博康; 津金 昌一郎; 澤田 典絵, 第34回日本疫学会学術総会, 食品成分表(八訂)を用いた食物摂取頻度調査票の妥当性ー総食物繊維摂取量に着目して, 2024年02月, 日本語
• 高地リベカ; 水谷天咲; 鈴木亜希子; 山岸万里菜; 丸谷幸子; 中館美佐子; 石原淳子, 第22回日本栄養改善学会近畿支部会学術総会, モバイル型Web食事評価システムの開発と概要, 2023年12月, 日本語

  共同研究・競争的資金等URL
• 荻野 麻子; 高地 リベカ; 石原 淳子; 菅原 詩緒理; 保科 由智恵; 鬼頭 久美子; 中舘 美佐子; 丸谷 幸子; 鈴木 碧; 小原 拓; 石黒 真美; 上野 史彦; 野田 あおい; 相澤 美里; 高橋 一平; 米沢 祐大; 山下 貴宏; 鈴木 重徳; 村上 慶子; 栗山 進一, 第, 複数回のFFQによる栄養素等摂取量推定の妥当性 東北メディカル・メガバンク計画コホート調査妥当性研究, 2023年02月, 日本語
• 中舘 美佐子; 石原 淳子; 高地 リベカ; 菅原 詩緒理; 保科 由智恵; 鬼頭 久美子; 小手森 綾香; 丸谷 幸子; 荻野 麻子; 鈴木 碧; 小原 拓; 石黒 真美; 野田 あおい; 相澤 美里; 高橋 一平; 米沢 祐大; 山下 貴宏; 鈴木 重徳; 村上 慶子; 栗山 進一, 第33回日本疫学会学術総会, 一般成人における24時間思い出しWeb食事調査による栄養素等摂取量推定の妥当性, 2023年02月, 日本語

  共同研究・競争的資金等URL
• 山岸 万里菜; 高地 リベカ; 石原 淳子; 小川 冬華; 丸谷 幸子; 石井 有里; 鬼頭 久美子; 中村 和利; 田中 純太; 山地 太樹; 磯 博康; 岩崎 基; 津金 昌一郎; 澤田 典絵, 第33回日本疫学会学術総会, 秤量食事記録によるナトリウム摂取源と24時間尿中ナトリウム排泄量との関連, 2023年02月, 日本語

  共同研究・競争的資金等URL

Works（作品等）

• 多目的コホートに基づくがん予防など健康の維持・増進に役立つエビデンスの構築に関する研究－次世代コホート（新潟県地域）における栄養摂取量把握の妥当性に関する研究, 2012年04月

受賞

• 優秀演題, 2015年, 日本国
• 奨励賞, 2009年, 日本国

共同研究・競争的資金等の研究課題

• 基盤（B）, 2022年04月01日, 2027年03月31日, 22H03360, 研究分担者, AI画像解析を活用した集団レベルの食事評価を目的とする調査法の開発・検証
• 学術指導, 2021年10月, 2022年03月31日, 研究代表者, 食事調査に関する学術指導, サントリーMONOZUKURIエキスパート（株）
• 共同研究, 2019年08月, 2024年03月, 研究分担者, 妊婦および一般成人を対象とした食物摂取頻度調査票および24時間思い出しWeb食事調査の妥当性・再現性の検証, カゴメ株式会社
• 令和４年度農林水産研究推進事業委託プロジェクト研究, 2021年05月, 2026年03月, 研究分担者, 健康寿命延伸に向けた食品・食生活実現プロジェクト, 農林水産省, 令和４年度農林水産研究推進事業委託プロジェクト研究
• 基盤（B）, 2021年04月01日, 2025年03月31日, 21H03208, 研究分担者, 食事を含む生活習慣とがん・循環器疾患生存者の予後に関するコホート研究
• 基盤（B）, 2020年04月01日, 2025年03月31日, 20H01615, 研究代表者, 画像・音声認識と料理データベースによる食事記録システム開発、及び疫学研究での応用
• 基盤研究(B), 2018年04月, 2022年03月, 18H03199, 二重標識水法を活用した料理ベースICT食事調査システムの精度の検討, 石原 淳子, 日本学術振興会, 科研費基盤（B）, 麻布大学, 0, 0, 0, 本研究は、日本人に適した新たな食事評価法として開発した料理単位ICT（Information and Communication Technology：情報通信技術）食事調査システムについて、その精度・妥当性を検証することを目的とし、この方法を用いて得られた推定摂取量をバイオマーカー（尿・血液）と比較した。バイオマーカーには、エネルギー摂取量の厳密な指標として国際的に活用の広がる二重標識水法を用いた。 研究の方法は、健康な男女50名程度を募集し、ベースライン調査（採尿、身長・体重測定）と同時に安定同位体を含む二重標識水を投与し、以降2週間の尿中安定同位体を測定することでエネルギー消費量の測定を行う。対象者は期間中、通常の生活を続けながら、期間中に7回の採尿を実施する。加えて、指定された日程に、ICT食事調査システムを用いた24時間思い出し法による食事調査（４回）、24時間蓄尿（24時間思い出し法と同日２回）を自宅にて行う。このICT食事調査システムは、前日の食事を対象者自身が入力、または調査員による電話聞き取り調査によって実施される。2週間後に、調査会場にて尿検体の回収、および身体測定、および採血を実施し、システムに入力された食事データを用いて、エネルギーおよび栄養素摂取量の推定を行い、生体指標を用いて推定したエネルギーおよび栄養素（たんぱく質、ナトリウム、ビタミン類など）の摂取量と比較を行う。 2020年度は、2019年度に新型コロナウイルス感染症拡大の影響で延期となった神奈川県近郊における冬の調査および愛媛県大洲市における夏の調査を実施した。二重標識水法など、生体試料を含むデータ収集は完了したが、延期に伴ってフォローアップによる食事調査が次年度にずれ込んだ。, 競争的資金, kaken

  対象リソースIRI
• 2018年04月, 2022年03月, 写真法で客観測定した食事時刻・栄養摂取とサーカディアンリズムに関する疫学研究, 石塚 理香, 科研費基盤（C）, 0, 0, 0, 競争的資金, rm:published_papers

  対象リソースIRI
• 2012年, 多目的コホートに基づくがん予防など健康の維持・増進に役立つエビデンスの構築に関する研究－次世代コホートにおける栄養摂取量把握の妥当性に関する研究, 津金昌一郎; 国立がん研究セ, 国立がん研究センター研究開発事業委託費, 0, 0, 0, 競争的資金, rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:presentations;rm:presentations;rm:presentations;rm:presentations

  対象リソースIRI
• 基盤（B）, 2020年04月01日, 2025年03月31日, 20H01615, 研究代表者, 画像・音声認識と料理データベースによる食事記録システム開発、及び疫学研究での応用
• 2018年04月, 2022年03月, 写真法で客観測定した食事時刻・栄養摂取とサーカディアンリズムに関する疫学研究, 石塚 理香, 科研費基盤（C）, 0, 0, 0, 競争的資金, rm:published_papers

  対象リソースIRI
• 2018年04月, 2022年03月, 二重標識水法を活用した料理ベースICT食事調査システムの精度の検討, 石原 淳子, 科研費基盤（B）, 0, 0, 0, 競争的資金
• 2012年, 多目的コホートに基づくがん予防など健康の維持・増進に役立つエビデンスの構築に関する研究－次世代コホートにおける栄養摂取量把握の妥当性に関する研究, 津金昌一郎; 国立がん研究セ, 国立がん研究センター研究開発事業委託費, 0, 0, 0, 競争的資金, rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers

  対象リソースIRI
• 2016年04月, 2019年03月, 日本人におけるがんの原因の寄与度：最新推計と将来予測, 井上 真奈美; 国立がん研究セ, 科研費基盤（B）, 0, 0, 0, 競争的資金, rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers;rm:published_papers

  対象リソースIRI
• 2015年04月, 2019年03月, 研究代表者, 新たな食生活評価システムの大規模疫学研究への導入と活用に関する研究, 髙地 リベカ, 科研費基盤（B）, 0, 0, 0, 競争的資金, rm:published_papers;rm:presentations;rm:presentations;rm:presentations

  対象リソースIRI
• 2015年04月, 2018年03月, 日本人の食生活様式に適した再現可能な減塩方法を提示する無作為化比較試験, 石原 淳子, 科研費基盤（C）, 0, 0, 0, 競争的資金, rm:presentations;rm:presentations;rm:presentations;rm:presentations

  対象リソースIRI
• 2015年, Development of automated self-administered 24hour recall system for Japanese diet., 0, 0, 0, 競争的資金
• 2012年04月, 2015年03月, 研究代表者, 生体試料を用いた、塩味嗜好性の変容による定量的な減塩効果に関する研究, 髙地 リベカ, 科研費基盤（C）, 0, 0, 0, 競争的資金
• 基盤研究(C), 2011年04月, 2014年03月, 23500993, 料理単位法を用いた食事評価のための標準化データベース開発, 石原 淳子, 日本学術振興会, 科研費基盤（C）, 相模女子大学, 0, 0, 0, 多様な地域対象者集団の観察データから得られた食事記録データをもとに、約7,000料理の料理単位データベース（使われた食品名と重量を料理の種類毎に整理したデータベース）の整備を行い、単食材料理と複合料理の出現頻度、種類数を検討した結果、多岐にわたる種類の複合料理データベースが整備される必要性が明らかになった。また、当該データベースを用いた食事評価の応用可能性についての検証では、料理単位での食事評価（料理単位法）の妥当性が担保されていることを明らかにし、ポーションサイズについて、男女差が顕著な料理群を明らかにした。本研究の成果により、料理単位法の実施を可能にする基盤が構築された。, 競争的資金, kaken

  対象リソースIRI
• 研究活動スタート支援, 2010年04月, 2012年03月, 22800069, 研究代表者, 料理データベースによる食生活調査の外的妥当性と食塩摂取量把握精度向上の検討, 髙地 リベカ, 日本学術振興会, 科研費研究活動スタート支援, 新潟大学, 0, 0, 0, 「料理」を主に摂取する日本人の食習慣に適した食事評価ツールとして、既存の実測による食事記録データを収集し、料理名・食材・重量によって構成される料理データベース(DB)として再構成した。料理DB適用による食事評価の外的妥当性の検討を行い、開発地域外にも応用できる可能性が示唆された。さらに、味付けの自己回答が総塩分摂取量推定の補助指標となり得ることを確認し、料理DBによる評価システムへの反映により塩分把握精度の向上が期待できた。, 競争的資金, kaken

  対象リソースIRI
• 令和３年度農林水産研究推進事業委託プロジェクト研究, 2021年05月, 2026年03月, 研究分担者, 健康寿命延伸に向けた食品・食生活実現プロジェクト, 農林水産省, 令和３年度農林水産研究推進事業委託プロジェクト研究
• 基盤（B）, 2021年04月01日, 2025年03月31日, 21H03208, 研究分担者, 食事を含む生活習慣とがん・循環器疾患生存者の予後に関するコホート研究
• 基盤（B）, 2020年04月01日, 2025年03月31日, 20H01615, 研究代表者, 画像・音声認識と料理データベースによる食事記録システム開発、及び疫学研究での応用
• 2012年, 多目的コホートに基づくがん予防など健康の維持・増進に役立つエビデンスの構築に関する研究－次世代コホートにおける栄養摂取量把握の妥当性に関する研究, 国立がん研究センター研究開発事業委託費
• 2012年, 多目的コホートに基づくがん予防など健康の維持・増進に役立つエビデンスの構築に関する研究－次世代コホートにおける栄養摂取量把握の妥当性に関する研究, 国立がん研究センター研究開発事業委託費
• 2012年, 多目的コホートに基づくがん予防など健康の維持・増進に役立つエビデンスの構築に関する研究－次世代コホートにおける栄養摂取量把握の妥当性に関する研究, 国立がん研究センター研究開発事業委託費
• 学術指導, 2022年07月, 2023年03月31日, 研究代表者, 食経験推定のための食事調査の手法獲得のための学術指導, サントリーホールディングス（株）
• 2016年04月, 2019年03月, 日本人におけるがんの原因の寄与度：最新推計と将来予測, 科研費基盤（B）
• 2018年04月, 2022年03月, 二重標識水法を活用した料理ベースICT食事調査システムの精度の検討, 科研費基盤（B）
• 2018年04月, 2022年03月, 二重標識水法を活用した料理ベースICT食事調査システムの精度の検討, 科研費基盤（B）
• 2018年04月, 2022年03月, 写真法で客観測定した食事時刻・栄養摂取とサーカディアンリズムに関する疫学研究, 科研費基盤（C）
• 2018年04月, 2022年03月, 写真法で客観測定した食事時刻・栄養摂取とサーカディアンリズムに関する疫学研究, 科研費基盤（C）
• 2015年04月, 2019年03月, 研究代表者, 新たな食生活評価システムの大規模疫学研究への導入と活用に関する研究, 科研費基盤（B）
• 挑戦的萌芽研究, 2016年04月01日, 2019年03月31日, 16K12747, 画像の自動診断による食事調査方法の日本食への応用, 高田 和子; 高地 リベカ; 香川 雅春; 別所 京子, 日本学術振興会, 科学研究費助成事業, 国立研究開発法人医薬基盤・健康・栄養研究所, 3510000, 2700000, 810000, 海外で開発された画像の自動診断による食事調査方法が日本で活用可能かを検討することを目的とした。初年度の開発者らとのディスカッションにより、日本人のための料理単位の成分表の作成、写真撮影のルールの国内での活用の検証を行った。 国民健康・栄養調査データを活用し、日本における料理単位のデータベースを構築した。自動判別ためのルールに従った写真は、規定の撮影角度が日本の食事に適用しにくいことが明らかになった。, kaken

  対象リソースIRI
• 基盤研究(B), 2015年04月01日, 2019年03月31日, 15H04782, 加齢性運動器疾患の大規模分子疫学コホート研究５年後フォローアップ, 中村 和利; 伊木 雅之; 渡邊 裕美; 北村 香織; 高地 リベカ; 小林 量作, 日本学術振興会, 科学研究費助成事業, 新潟大学, 15860000, 12200000, 3660000, 本研究により、2011年に開始した加齢性運動器疾患の大規模コホート研究の5年後フォローアップを完了した。具体的には、40から74歳の13,816人を対象として生活習慣等のアンケート調査を行い、8,487（61.4%）より回答を得た。また、追跡期間中に死亡373人、骨粗鬆症性骨折284人、変形性膝関節症429人が観察された。これらの資料より、死亡、骨粗鬆症性骨折、変形性膝関節症、慢性疼痛のリスク要因を解析することができた。また、5年間の生活習慣等の情報を比較することにより、ベースラインにおける曝露情報の再評価を行うことができた。, kaken

  対象リソースIRI
• 基盤研究(B), 2022年04月01日, 2027年03月31日, 22H03360, AI画像解析を活用した集団レベルの食事評価を目的とする調査法の開発・検証, 石原 淳子; 澤田 典絵; 高地 リベカ; 井上 真奈美; 川崎 良; 小手森 綾香; 高田 和子, 日本学術振興会, 科学研究費助成事業, 麻布大学, 17160000, 13200000, 3960000, kaken

  対象リソースIRI
• 基盤研究(C), 2022年04月01日, 2026年03月31日, 22K02137, スポット尿を用いた食塩摂取量とナトリウム・カリウム比評価法の再構築, 丸谷 幸子; 高地 リベカ; 大滝 直人; 前田 晃宏; 澤田 典絵, 日本学術振興会, 科学研究費助成事業, 奈良女子大学, 4160000, 3200000, 960000, kaken

  対象リソースIRI
• 基盤研究(B), 2021年04月01日, 2025年03月31日, 21H03208, 食事を含む生活習慣とがん・循環器疾患生存者の予後に関するコホート研究, 澤田 典絵; 山岸 良匡; 中谷 友樹; 石原 淳子; 高地 リベカ; 伊藤 ゆり; 石井 有里, 日本学術振興会, 科学研究費助成事業, 国立研究開発法人国立がん研究センター, 17160000, 13200000, 3960000, わが国では、がん罹患率、循環器疾患受療者が増えているが、死亡率が減少していることから、がん生存者、循環器疾患生存者が増加していることが予測される。しかし、がん生存者、循環器疾患生存者の、罹患後の予後を改善する生活習慣・食習慣については、いまだエビデンスが少ない。 1990年開始の全国11保健所地域住民14万人（研究開始当時年齢40－69歳）の多目的コホート研究では、複数回の食習慣・生活習慣に関するアンケート調査を行うとともに、がん・循環器疾患罹患を把握しており、疾病罹患前、罹患後の生活習慣の変化と予後の関係を検討することが可能である。そこで、本研究では、罹患前の食事や生活習慣を考慮したうえで、食事や生活習慣の罹患前後の変化と、がん・循環器疾患罹患生存者の、予後との関連を明らかにすることを目的としている。 令和3年度は、多目的コホート研究の追跡調査により得られたデータを整理し、罹患情報の精査により罹患データベースの作成を行った。また、死亡データの取得により追跡情報を追加し、がん・循環器疾患生存者データベースの作成を行った。繰り返し調査の比較が可能な5年後調査と10年後調査を用いて、アンケート情報、食事・栄養摂取情報を付与し、がん生存者解析データベースの作成を行い、がん罹患前後の食事・栄養素摂取量の変化について検討を行った。その結果、5年後調査と10年後調査の両方に回答した73,192名のうち、その間に診断されたがん罹患者は、男性886人、女性646人であった。がん罹患者の診断前の食事と比較したところ、男性の診断後の食事において、エネルギー摂取と飲酒量において、より多くの減少がみられたが、そのほかの摂取量変化に差は見られなかった。, kaken;rm:published_papers;rm:presentations

  対象リソースIRI
• 基盤研究(B), 2020年04月01日, 2025年03月31日, 20H01615, 画像・音声認識と料理データベースによる食事記録システム開発、及び疫学研究での応用, 高地 リベカ; 澤田 典絵; 丸山 広達; 石原 淳子; 井上 真奈美; 川崎 良, 日本学術振興会, 科学研究費助成事業, 奈良女子大学, 17550000, 13500000, 4050000, 〇Web型自己回答操作の食事調査システムの疫学研究で広く実施してもらうための課題を整理した。〇モバイル型で料理画像の撮影及び料理名と目安量を入力・情報収集するシステムを開発した。料理名は音声入力も可能な仕様とした。一方で、複数キーワードを音声入力する際の問題点が明らかになった。摂取量の入力システムにおいて、写真撮影には共通のスケールを用いるよう依頼することと、料理データベースの「量」を「目安量」として言語化しそれと比して入力するシステムとした。２４時間思い出し法とは異なり、食事をしている際に記録していく方法を採用した。また、料理名を検索しやすくするために、料理データベースのキーワードを見直して拡充した。ここで収集した画像は研究事務局から提供するスケールと共に撮影されること、料理名（レシピデータベース）に紐づけられることが特徴である。〇二重標識水及び生体指標を用いた妥当性研究を開始し20名から協力を得た。当該対象者においてシステムの使用感についてアンケートを実施したところ、90%はシステム操作がやや難しい・難しいと回答したものの、今後の利用について利用しても良い、利用したいと積極的な回答をした者が90%にのぼった。また、約80%以上の者は入力したい料理データが概ね選択肢に含まれており、90%以上の者は自分の食べた量を概ね正しく入力できたと回答した。料理データベースの「量」を「目安量」として言語化した摂取量の入力システムは対象者側では大きな問題にはなっていない。調査開始前の汎用的説明資料の改善点及びテスト環境の付与等の課題が明らかになった。, kaken;rm:presentations;rm:presentations

  対象リソースIRI
• 基盤研究(C), 2008年, 2010年, 20500738, バイオマーカーを用いた写真撮影法による食事評価の妥当性とその応用, 石原 淳子; 岩崎 基; 津金 昌一郎; 高地 リベカ; 君羅 満, 日本学術振興会, 科学研究費助成事業, 東京農業大学, 4550000, 3500000, 1050000, 撮影法(撮影された食事の画像データから栄養素等摂取量を推定)を、生体指標(血液、尿中の栄養素成分値)および秤量法食事記録法と比較(妥当性の検討)したところ、撮影法による推定で、摂取量を順位付けすることの精度は、ほとんどの食品や栄養素で比較的高いものの、食塩や調味料類など味付けについては正確な推定が困難であることが明らかになった。また、順位付けの精度が高くても、絶対値の推定が困難な食品群があり、写真撮影法による絶対値推定には注意が必要であることが明らかになった。, kaken

  対象リソースIRI
• 基盤（B）, 2020年04月01日, 2025年03月31日, 20H01615, 研究代表者, 画像・音声認識と料理データベースによる食事記録システム開発、及び疫学研究での応用
• 基盤（B）, 2021年04月01日, 2025年03月31日, 21H03208, 研究分担者, 食事を含む生活習慣とがん・循環器疾患生存者の予後に関するコホート研究
• 基盤（B）, 2022年04月01日, 2027年03月31日, 22H03360, 研究分担者, AI画像解析を活用した集団レベルの食事評価を目的とする調査法の開発・検証
• 令和５年度農林水産研究推進事業委託プロジェクト研究, 2021年05月, 2026年03月, 研究分担者, 健康寿命延伸に向けた食品・食生活実現プロジェクト, 農林水産省, 令和４年度農林水産研究推進事業委託プロジェクト研究
• 2012年, 多目的コホートに基づくがん予防など健康の維持・増進に役立つエビデンスの構築に関する研究－次世代コホートにおける栄養摂取量把握の妥当性に関する研究, 国立がん研究センター研究開発事業委託費