研究者総覧

白水 倫生Shirozu Michioシロズ ミチオ

所属部署名保健管理センター
職名教授
Last Updated :2022/10/05

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プロフィール情報

  • 白水, シロズ
  • 倫生, ミチオ

学位

  • 医学博士, 京都大学, 1996年

研究分野

  • ライフサイエンス, 内科学一般

経歴

  • 2017年04月, 9999年, 奈良女子大学, 保健管理センター, 所長, 日本国
  • 2016年04月, 2017年03月, 奈良女子大学, 保健管理センター, 専任教員, 日本国
  • 2002年04月, 2016年03月, 医療法人岡谷会おかたに病院, 内科・心療内科, 医師, 日本国
  • 1999年10月, 2008年03月, 京都大学医学部附属病院, 総合診療科, 医師, 非常勤, 日本国
  • 2000年04月, 2002年03月, 医療法人医真会安中診療所, 内科・心療内科, 医師, 日本国
  • 1997年05月, 1999年09月, 京都逓信病院, 健康管理課, 産業医, 日本国
  • 1995年04月, 1997年04月, 京都大学医学部附属病院, 総合診療科, 医員, 日本国
  • 1989年06月, 1991年03月, 神戸市立中央市民病院, 内科, 研修医, 日本国

学歴

  • 1991年04月, 1995年03月, 京都大学大学院, 医学研究科, 医化学, 日本国
  • 1983年04月, 1989年03月, 京都大学, 医学部, 医学科, 日本国

担当経験のある科目(授業)

  • 精神疾患とその治療, 国立大学法人奈良女子大学, 2018年04月99日, 大学の前期講義, 学部専門科目, 日本国
  • 生活と健康, 国立大学法人奈良女子大学, 2016年10月99日, 大学の後期講義, 学部教養科目, 日本国
  • いのちと健康, 国立大学法人奈良女子大学, 2016年04月99日, 大学の前期講義, 学部教養科目, 日本国

Ⅱ.研究活動実績

論文

  • 査読あり, 英語, Biomedical Research, Isoform specific expression of the SDR-1 protein, α and β in subregions of adult rodent brain, Nelson D. Lopez; Ayae Kinoshita; Masafumi Taniwaki; Hideaki Tada; Michio Shirozu; Toru Nakano; Kei Tashiro; Tasuku Honjo, Stromal cell-derived receptor-1 (SDR-1) α and β, also called gp55 and gp65, belong to the immunoglobulin (Ig) superfamily. Rabbit antisera specific to SDR-1 β and those recognizing both α and β forms of SDR-1 were raised to study regional distributions of SDR-1 α and β in the adult rodent brain. Immunohistochemical studies of adult rat brains with either antibodies revealed a granular pattern of staining distributed within neuropils. SDR-1 β form like immunoreactivity (β-LI) was detected in limited regions, namely the glomerulus of the olfactory bulb and the superficial layers (layers II, III) of the cerebral cortex, whereas αβ-LI was found in the olfactory tubercle, cerebral center, hippocampus, thalamus, midbrain, and molecular layer in the cerebellum, suggesting wider distribution of SDR-1α. The SDR1 gene is highly conserved from Xenopus to human. The human SDR-1 cDNA was isolated and the human SDR1 gene was mapped to chromosome 15q22 by fluorescence in situ hybridization., 1999年, 20, 1, 43, 49, 研究論文(学術雑誌)
  • 査読あり, 英語, Genomics, Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method., M Shirozu; H Tada; K Tashiro; T Nakamura; N D Lopez; M Nazarea; T Hamada; T Sato; T Nakano; T Honjo, We recently described a method, called the signal sequence trap (SST) method, to clone cDNAs of secreted proteins and/or type I transmembrane proteins containing N-terminal signal sequences by using an epitope-tagging expression plasmid vector. In this paper we describe the summary of a large-scale screening of approximately 5900 clones of an SST cDNA library constructed from mouse bone marrow stromal cell line ST-2 cells. Of 26 positive clones obtained and sequenced, 11 clones appeared to contain authentic signal sequences. Five of the clones corresponded to the 5' ends of the cDNA of known genes containing N-terminal signal sequences. The full-length cDNA clones of the 6 other unknown clones were isolated and sequenced. One clone, termed SDF3, encoded a mouse counterpart of human pigment epithelium-derived factor. Another clone, termed SDR1, had considerable homology with basigin, a member of the immunoglobulin superfamily. A third clone, termed SDF5, had partial homology with a Drosophila tissue polarity gene frizzled (fz) and its rat homologues, fz-1 and fz-2. The other three clones had no significant homology with sequences in the databases. These results indicate that the SST method is effective and useful for the isolation of secreted and membrane proteins without knowledge of their functions., 1996年11月01日, 37, 3, 273, 80, 研究論文(学術雑誌), 国際誌
  • 査読あり, 英語, Gene, Isolation and characterization of a novel secretory protein, stromal cell-derived factor-2 (SDF-2) using the signal sequence trap method., T Hamada; K Tashiro; H Tada; J Inazawa; M Shirozu; K Shibahara; T Nakamura; N Martina; T Nakano; T Honjo, With use of the signal sequence trap method, we isolated a cDNA encoding a novel secretory protein, SDF-2, from the mouse stromal cell line, ST2. The human homologue of SDF-2 was also isolated. The amino acid (aa) sequences deduced from both the clones were conserved more than 92%. The chromosomal localization of the human SDF-2 gene was mapped to 17q11.2. The aa sequence of SDF-2 shows similarity to those of yeast dolichyl phosphate-D-mannose:protein mannosyltransferases, Pmt1p [Strahl-Bolsinger et al. (1993) Proc. Natl. Acad. Sci. USA 90, 8164-8168] and Pmt2p [Lussier et al. (1995) J. Biol. Chem. 270, 2770-2775], whose activities have not been detected in higher eukaryotes., 1996年10月17日, 176, 1-2, 211, 4, 研究論文(学術雑誌), 国際誌
  • 査読あり, 英語, Genomics, Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene., M Shirozu; T Nakano; J Inazawa; K Tashiro; H Tada; T Shinohara; T Honjo, Stromal cell-derived factors 1 alpha and 1 beta are small cytokines belonging to the intercrine CXC subfamily and originally isolated from a murine bone-marrow stroma cell line by the signal sequence trap method. cDNA and genomic clones of human SDF1 alpha and SDF1 beta (SDF1A and SDF1B) were isolated and characterized. cDNAs of SDF1 alpha and SDF1 beta encode proteins of 89 and 93 amino acids, respectively. SDF1 alpha and SDF1 beta sequences are more than 92% identical to those of the human counterparts. The genomic structure of the SDF1 gene revealed that human SDF1 alpha and SDF1 beta are encoded by a single gene and arise by alternative splicing. SDF1 alpha and SDF1 beta are encoded by 3 and 4 exons, respectively. Ubiquitous expression of the SDF1 gene, except in blood cells, was consistent with the presence of the GC-rich sequence in the 5'-flanking region of the SDF1 gene, as is often the case in the "housekeeping" genes. Although genes encoding other members of the intercrine family are localized on chromosome 4q or 17q, the human SDF1 gene was mapped to chromosome 10q by fluorescence in situ hybridization. Strong evolutionary conservation and unique chromosomal localization of the SDF1 gene suggest that SDF1 alpha and SDF1 beta may have important functions distinct from those of other members of the intercrine family., 1995年08月10日, 28, 3, 495, 500, 研究論文(学術雑誌), 国際誌
  • 査読あり, 英語, The Journal of biological chemistry, The human S mu bp-2, a DNA-binding protein specific to the single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region., Y Fukita; T R Mizuta; M Shirozu; K Ozawa; A Shimizu; T Honjo, We have cloned the cDNA encoding the human homologue of S mu bp-2, which binds to single-stranded DNA with 5'-phosphorylated guanine-rich sequences related to the immunoglobulin mu chain switch (S mu) region. The deduced amino acid sequences of the mouse and human S mu bp-2 are 76.5% homologous and contain motifs conserved among helicases. We have identified a domain essential for DNA binding at residues 638-786. The binding domain is less conserved (63% homologous) than the putative catalytic domain of N-terminal half containing most of the helicase motifs (85% homologous). The human and mouse S mu bp-2 have similar, although slightly different, binding specificities. Although the mouse S mu bp-2 preferentially binds to the mouse S mu motif (GGGGT), the human S mu bp-2 binds equally well to the human (GGGCT) and mouse S mu motifs. The human S mu bp-2 gene was mapped to chromosome 11 q13.2-q13.4 by in situ hybridization., 1993年08月15日, 268, 23, 17463, 70, 研究論文(学術雑誌), 国際誌
  • 査読あり, 英語, Science (New York, N.Y.), Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins., K Tashiro; H Tada; R Heilker; M Shirozu; T Nakano; T Honjo, A method was developed to clone, without the use of specific functional assays, complementary DNAs (cDNAs) that carry specific amino-terminal signal sequences, such as those encoding intercellular signal-transducing molecules and receptors. The vector used in this system directed the cell surface expression of interleukin-2 receptor fusion proteins when inserts with signal sequences were cloned in-frame with the correct orientation. An expression cDNA library was constructed from a bone marrow stromal cell line, which contained 5' portion-enriched cDNAs (the average size was 400 base pairs). Two cDNAs that encoded putative cytokine molecules, stromal cell-derived factor-1 alpha (SDF-1 alpha) and SDF-1 beta, which belong to the intercrine-macrophage inflammatory protein superfamily, were cloned., 1993年07月30日, 261, 5121, 600, 3, 研究論文(学術雑誌), 国際誌

MISC

  • 査読無し, 日本語, 心身医学, (一社)日本心身医学会, 患者の真実を受け容れる 非精神病の幻覚患者の1例, 白水 倫生, 2003年11月, 43, 11, 786, 786
  • 査読無し, 日本語, 逓信医学, (株)郵研社, 定期健康診断における尿潜血検査の意義, 金子 至寿佳; 宮田 學; 白水 倫生; 久萬田 俊明, 2000年03月, 52, 3, 157, 157
  • 査読無し, 日本語, 逓信医学, (株)郵研社, 成人病検診及び健康診断における血清鉄測定の有用性について, 宮田 學; 金子 至寿佳; 白水 倫生; 久萬田 俊明, 2000年03月, 52, 3, 156, 157
  • 査読無し, 日本語, 心身医学, (一社)日本心身医学会, 間主観的観点に基づいたヒステリー様の難治性てんかん患者に対する治療の1例, 白水 倫生; 福井 次矢, 2000年01月, 40, 1, 74, 74
  • 査読無し, 日本語, 逓信医学, (株)郵研社, 定期健康診断有所見者のフォローアップ, 白水 倫生; 宮田 學, 1998年11月, 50, 6, 426, 427
  • 査読無し, 日本語, 総合診療研究会会誌, 日本総合診療医学会, 入院患者でのAdverse Eventsの発生頻度, 白水 倫生; 山本 和利; 前川 宗隆; 福井 次矢, 1998年09月, 3, 1, 30, 30
  • 査読無し, 日本語, 公衆衛生, (株)医学書院, 【成人病から生活習慣病へ】「生活習慣病」でよいのか 臨床医の立場から, 白水 倫生; 福井 次矢, 1998年02月, 62, 2, 102, 104
  • 査読無し, 日本語, 健康医学, (公社)日本人間ドック学会, 人間ドックにおける糖負荷試験及び一回採血法による耐糖能障害の評価 糖負荷試験は必要か, 宮田 學; 白水 倫生; 作本 静枝, 糖負荷試験と一回採血法を対比して検討したところ,HbAlc8.0%以上或いはフルクトサミン300μmole/l以上は要治療群,HbAlc6.0%未満は要観察群とし,これ以外の群については,できれば後日糖負荷試験を施行して糖代謝異常の程度に応じて治療方針を決定するというのが実際的と考えられた, 1997年10月, 12, 3, 268, 274
  • 査読無し, 日本語, からだの科学 増刊, (株)日本評論社, 予防医学はどうして重要か, 白水 倫生; 福井 次矢, 1997年09月, 臨増, 医療改革, 129, 132
  • 査読無し, 日本語, JIM: Journal of Integrated Medicine, (株)医学書院, 転移性骨腫瘍が疑われた患者の鑑別診断, 白水 倫生; 山本 和利; 福井 次矢, 1997年08月, 7, 8, 679, 682
  • 査読無し, 日本語, JIM: Journal of Integrated Medicine, (株)医学書院, 倦怠感(だるさ)の病態, 白水 倫生, 1997年07月, 7, 7, 546, 547
  • 査読無し, 日本語, 生化学, (公社)日本生化学会, シグナルシークエンストラップ法(SST)を用いた分泌蛋白およびI型膜蛋白のクローニング, 白水 倫生, 1995年07月, 67, 7, 746, 746

書籍等出版物

  • 内科学, 朝倉書店, 白水倫生; 福井次矢, 医原性疾患, 1999年10月, xxxix, 2110p, 日本語, その他, 4254321864, cinii_books

講演・口頭発表等

  • 安藤明子, 国内, 第59回全国大学保健管理研究集会, コロナ禍における講義前の5分間瞑想が 大学生に及ぼすエゴグラムの変化について, 口頭発表(一般), 2021年10月05日, 2021年10月06日, 日本語


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