Researchers Database

OGURA Yasunori

    Faculty Division of Human Life and Environmental Sciences Research Group of Food Science and Nutrition Professor
Contact:
oguracc.nara-wu.ac.jp
Last Updated :2021/07/07

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Research Areas

  • Life sciences, Immunology
  • Life sciences, Bacteriology
  • Life sciences, Cell biology
  • Life sciences, Molecular biology

Research Experience

  • 2008 - 2011, 琉球大学大学院医学研究科病原細菌学分野 助教
  • 2011, 奈良女子大学生活環境学部食物栄養学科 教授
  • 2004 - 2008, Section of Immunobiology, School of Medicine, Yale University Research fellow
  • 1999 - 2004, Department of Pathology, Medical school, University of Michigan Research fellow
  • 1998 - 2002, 徳島大学分子酵素学研究センター分子細胞学部門 助手

Education

  • 1994, - 1998, Kyoto University, Graduate School, Division of Medicine, 分子医学系専攻
  • 1986, - 1993, Kanazawa University, Faculty of Medicine, 医学科

Awards

  • University of Michigan Inventor Recognition, Yasunori Ogura, University of Michigan, 2002
  • Crohn’s and Colitis Foundation of America, Research Fellowship Award, Yasunori Ogura, Crohn’s and Colitis Foundation of America, 2001

Published Papers

  • PI3K/AKT/PTEN pathway as a target for Crohn's disease therapy.

    OGURA Yasunori; Tokuhira N; Kitagishi Y; Suzuki M; Minami A; Nakanishi A; Ono Y; Kobayashi K; Matsuda S; Ogura Y

    2015, Int J Mol Med, 35 (1), 10-16

  • Function of α-synuclein and PINK1 in Lewy body dementia.

    OGURA Yasunori; Minami A; Nakanishi A; Matsuda S; Kitagishi Y; Ogura Y

    2015, Int J Mol Med, 35 (1), 3-9

  • Neuron membrane trafficking and protein kinases involved in autism and ADHD.

    OGURA Yasunori; Kitagishi Y; Minami A; Nakanishi A; Ogura Y; Matsuda S

    2015, Int J Mol Sci, 16 (2), 3095-3115

  • The tumor suppressor PTEN interacts with p53 in hereditary cancer.

    OGURA Yasunori; Nakanishi A; Kitagishi Y; Ogura Y; Matsuda S

    2014, Int J Oncol, 44 (6), 1813-1819

  • Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease.

    OGURA Yasunori; Kitagishi Y; Nakanishi A; Ogura Y; Matsuda S

    2014, Alzheimers Res Ther, 6 (3), 35

  • Atherosclerosis and tumor suppressor molecules.

    OGURA Yasunori; Suzuki M; Minami A; Nakanishi A; Kobayashi K; Matsuda S; Ogura Y; Kitagishi Y

    2014, Int J Mol Med, 34 (4), 934-340

  • Certain Diet and Lifestyle May Contribute to Islet β-cells Protection in Type-2 Diabetes via the Modulation of Cellular PI3K/AKT Pathway.

    OGURA Yasunori; Kitagishi Y; Nakanishi A; Minami A; Asai Y; Yasui M; Iwaizako A; Suzuki M; Ono Y; Ogura Y; Matsuda S

    2014, Open Biochem J, 8, 74-82

  • Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair.

    OGURA Yasunori; Minami A; Nakanishi A; Ogura Y; Kitagishi Y; Matsuda S

    2014, Front Oncol, 4, 318

  • Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection.

    OGURA Yasunori; Sukumaran B; Ogura Y; Pedra JH; Kobayashi KS; Flavell RA; Fikrig E

    2012, FEMS Immunol Med Microbiol, 66 (2), 211-219

  • Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality.

    OGURA Yasunori; Kim YG; Shaw MH; Warner N; Park JH; Chen F; Ogura Y; N??ez G

    2011, J Immunol, 187, 2849-52

  • Detergents enhance EspB secretion from Escherichia coli strains harboring the locus for the enterocyte effacement (LEE) gene.

    OGURA Yasunori; Nakasone N; Toma C; Higa N; Koizumi Y; Ogura Y; Suzuki T

    2011, FEMS Microbiology Letters, 315, 109-114

  • Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling.

    OGURA Yasunori; Toma C; Higa N; Koizumi Y; Nakasone N; Ogura Y; McCoy AJ; Franchi L; Uematsu S; Sagara J; Taniguchi S; Tsutsui H; Akira S; Tschopp J; N??ez G; Suzuki T

    2010, J Immunol, 184, 5287-5297

  • Inflammasome recognition of influenza virus is essential for adaptive immune responses.

    OGURA Yasunori; Ichinohe T; Lee HK; Ogura Y; Flavell R; Iwasaki A

    2009, J Exp Med, 206, 79-87

  • The NLR gene family: a standard nomenclature.

    OGURA Yasunori; Ting JP; Lovering RC; Alnemri ES; Bertin J; Boss JM; Davis BK; Flavell RA; Girardin SE; Godzik A; Harton JA; Hoffman HM; Hugot JP; Inohara N; Mackenzie A; Maltais LJ; Nunez G; Ogura Y; Otten LA; Philpott D; Reed JC; Reith W; Schreiber S; Steimle V; Ward PA

    2008, Immunity, 28, 285-287

  • Maturation modulates Caspase-1 independent responses of dendritic cells to Anthrax Lethal Toxin.

    OGURA Yasunori; Reig N; Jiang A; Couture R; Sutterwala FS; Ogura Y; Flavell RA; Mellman I; Gisou van; der Goot F

    2008, Cell Microbiol, 10, 1190-1207

  • Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome.

    OGURA Yasunori; Sutterwala FS; Mijares L; Li L; Ogura Y; Kazmierczak B; Flavelll RA

    2007, J Exp Med, 204, 3235-3245

  • ASC/PYCARD and Caspase-1 Regulate the IL-18/IFN-γ Axis During Anaplasma phagocytophilum Infection.

    OGURA Yasunori; Pedra JHF; Sutterwala FS; Sukumaran B; Ogura Y; Qian F; Montgomery RR; Flavell RA; Fikrig E

    2007, J Immunol, 179, 4783-4791

  • MDP-induced interleukin-1b processing requires Nod2 and CIAS1/NALP3.

    OGURA Yasunori; Pan Q; Mathison J; Fearns C; Kravchenko VV; Correia JD; Hoffman HM; Kobayashi KS; Bertin J; Grant EP; Coyle AJ; Sutterwala FS; Ogura Y; Flavell RA; Ulevitch RJ

    2007, J Leukocyte Biol, 82, 177-183

  • The inflammasome in pathogen recognition and inflammation.

    OGURA Yasunori; Sutterwala FS; Ogura Y; Flavell RA

    2007, J Leukocyte Biol 2007 82:259-64, 82, 259-264

  • Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.

    OGURA Yasunori; Lara-Tejero M; Sutterwala FS; Ogura Y; Grant EP; Bertin J; Coyle AJ; Flavell RA; Galan JE

    2006, J Exp Med, 203, 1407-1412

  • Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.

    OGURA Yasunori; Sutterwala FS; Ogura Y; Szczepanik M; Lara-Tejero M; Lichtenberger GS; Grant EP; Bertin J; Coyle AJ; Galan JE; Askenase PW; Flavell RA

    2006, Immunity, 24, 317-327

  • The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.

    OGURA Yasunori; Zamboni DS; Kobayashi KS; Kohlsdorf T; Ogura Y; Long EM; Vance RE; Kuida K; Mariathasan S; Dixit VM; Flavell RA; Dietrich WF; Roy CR

    2006, Nat Immunol, 7, 318-325

  • NALP3: a key player in caspase-1 activation.

    OGURA Yasunori; Sutterwala FS; Ogura Y; Zamboni DS; Roy CR; Flavell RA

    2006, J Endotoxin Res, 12, 251-256

  • The inflammasome: first line of the immune response to cell stress.

    OGURA Yasunori; Ogura Y; Sutterwala FS; Flavell RA

    2006, Cell, 126, 659-662

  • A role for erbin in the regulation of NOD2-dependent NF-kappa B signaling.

    OGURA Yasunori; McDonald C; Chen FF; Ollendorff V; Ogura Y; Marchetto S; Lecine P; Borg JP; Nunez G

    2005, J Biol Chem, 280, 40301-40309

  • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.

    OGURA Yasunori; Kobayashi KS; Chamaillard M; Ogura Y; Henegariu O; Inohara N; Nunez G; Flavell RA

    2005, Science, 307, 731-734

  • Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.

    OGURA Yasunori; Tanabe T; Chamaillard M; Ogura Y; Zhu L; Qiu S; Masumoto J; Ghosh P; Moran A; Predergast MM; Tromp G; Williams CJ; Inohara N; Nunez G

    2004, EMBO J, 23, 1587-1597

  • Expression of NOD2 in Paneth Cells: A Possible Link to Crohn's Ileitis.

    OGURA Yasunori; Ogura Y; Lala S; Xin W; Smith E; Dowds TA; Chen FF; Zimmermann E; Tretiakova M; Cho JH; Hart J; Greenson JK; Keshav S; Nunez G

    2003, Gut, 52, 1591-1597

  • Crohn's disease and the NOD2 gene: A role for paneth cells.

    OGURA Yasunori; Lala S; Ogura Y; Osborne C; Hor SY; Bromfield A; Davies S; Ogunbiyi O; Nunez G; Keshav S

    2003, Gastroenterology, 125, 47-57

  • An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.

    OGURA Yasunori; Chamaillard M; Hashimoto M; Horie Y; Masumoto J; Qiu S; Saab L; Ogura Y; Kawasaki A; Fukase K; Kusumoto S; Valvano MA; Foster SJ; Mak TW; Nunez G; Inohara N

    2003, Nat Immunol, 4, 702-707

  • ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis.

    OGURA Yasunori; Masumoto J; Dowds TA; Schaner P; Chen FF; Ogura Y; Li M; Zhu L; Katsuyama T; Sagara J; Taniguchi S; Gumucio DL; Nunez G; Inohara N

    2003, Biochem Bioph Res Co, 303, 69-73

  • Regulation of Cryopyrin/Pypaf1 Signaling by Pyrin, the Familial Mediterranean Fever Gene Product.

    OGURA Yasunori; Dowds TA; Masumoto J; Chen FF; Ogura Y; Inohara N; N??ez G

    2003, Biochem Bioph Res Co, 302, 575-580

  • Genetic Variation and Activity of Mouse Nod2, a Susceptibility Gene for Crohn's Disease.

    OGURA Yasunori; Ogura Y; Saab L; Chen FF; Benito A; Inohara N; Nu?ez G

    2003, Genomics, 81, 369-377

  • Crohn's disease-associated Nod2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.

    OGURA Yasunori; Bonen DK; Ogura Y; Nicolae DL; Inohara N; Saab L; Tanabe T; Chen FF; Foster SJ; Duerr RH; Brant SR; Cho JH; Nu?ez G

    2003, Gastroenterology, 124, 140-146

  • Induction of Nod2 in myelomonocytic and intestinal Epithelial cells via nuclear factor-kB activation.

    OGURA Yasunori; Gutierrez O; Pipaon C; Inohara N; Fontalba A; Ogura Y; Prosper F; Nunez G; Fernandez-Luna JL

    2002, J Biol Chem, 277, 41701-41705

  • Lack of common NOD2 variants in Japanese patients with Crohn's disease.

    OGURA Yasunori; Inoue N; Tamura K; Kinouchi Y; Fukuda Y; Takahashi S; Ogura Y; Inohara N; Nunez G; Kishi Y; Koike Y; Shimosegawa T; Shimoyama T; Hibi T

    2002, Gastroenterology, 123, 86-91

  • Nods: a family of cytosolic proteins that regulate the host response to pathogens.

    OGURA Yasunori; Inohara N; Ogura Y; Nunez G

    2002, Curr Opin Microbiol, 5, 76-80

  • 炎症性腸疾患と遺伝子異常

    OGURA Yasunori

    2002, Bio Clinica, (1)

  • Lack of association between NOD2 3020InsC frameshift mutation and psoriasis.

    OGURA Yasunori; Nair RP; Stuart P; Ogura Y; Inohara N; Chia NV; Young L; Henseler T; Jenisch S; Christophers E; Voorhees JJ; Nunez G; Elder JT

    2001, J Invest Dermatol, 117, 1671-1672

  • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.

    OGURA Yasunori; Ogura Y; Bonen DK; Inohara N; Nicolae DL; Chen FF; Ramos R; Britton H; Moran T; Karaliuskas R; Duerr RH; Achkar JP; Brant SR; Bayless TM; Kirschner BS; Hanauer SB; Nunez G; Cho JH

    2001, Nature, 411, 603-606

  • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.

    OGURA Yasunori; Ogura Y; Inohara N; Benito A; Chen FF; Yamaoka S; Nunez G

    2001, J Biol Chem, 276, 4812-4818

  • Human Nod1 confers responsiveness to bacterial lipopolysaccharides.

    OGURA Yasunori; Inohara N; Ogura Y; Chen FF; Muto A; Nunez G

    2001, J Biol Chem 2001 276:2551-2554., 276, 2551-2554

  • クローン病感受性遺伝子IBD1/Nod2の同定

    OGURA Yasunori

    2001, 実験医学, (8), 1542-1544

  • An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways.

    OGURA Yasunori; Inohara N; Koseki T; Lin J; del Peso L; Lucas PC; Chen FF; Ogura Y; Nunez G

    2000, J Biol Chem 2000 275:27823-27831., 275, 27823-27831

  • Essential role of platelet-derived growth factor receptor alpha in the development of the intraplacental yolk sac/sinus of Duval in mouse placenta.

    OGURA Yasunori; Ogura Y; Takakura N; Yoshida H; Nishikawa SI

    1998, Biol Reprod, 58, 65-72

  • PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5.

    OGURA Yasunori; Takakura N; Yoshida H; Ogura Y; Kataoka H; Nishikawa S; Nishikawa SI

    1997, J Histochem Cytochem, 45, 883-893

MISC

  • BRCA1 and p53 tumor suppressor molecules in Alzheimer's disease.

    OGURA Yasunori; Nakanishi A; Minami A; Kitagishi Y; Ogura Y; Matsuda S

    2015, Int J Mol Sci, 16 (2), 1879-2892

  • Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn's disease.

    OGURA Yasunori; Inohara N; Ogura Y; Fontalba A; Gutierrez O; Pons F; Crespo J; Fukase K; Inamura S; Kusumoto S; Hashimoto M; Foster SJ; Moran AP; Fernandez-Luna JL; Nunez G

    2003, J Biol Chem, 278, 5509-5512

Presentations

  • 香辛料抽出物による炎症性サイトカインIL-1βの分泌抑制について

    OGURA Yasunori

    日本家政学会関西支部第36回研究発表会, Oct. 2016

  • ウシグソヒトヨタケの子実体形成について

    OGURA Yasunori

    日本家政学会関西支部第36回研究発表会, Oct. 2014, 京都市

  • 香辛料抽出液が炎症性サイトカインIL?1βの産生に与える影響

    OGURA Yasunori

    日本家政学会第66回大会, May 2014, 福岡県北九州市

  • 栄養と免疫?特に自然免疫に関連して―

    OGURA Yasunori

    第10回日本栄養改善学会近畿支部学術総会, Dec. 2011, 日本栄養改善学会近畿支部, 奈良

  • インフラマソームによる炎症制御

    OGURA Yasunori

    第152 回日本獣医学会学術集会日本比較薬理・毒性学会, Sep. 2011, 日本獣医学会, 大阪

  • Purification of multifunctional repeat-in-toxin (RTX) of Vibrio chlerae O1

    OGURA Yasunori

    第83回日本細菌学会総会, Mar. 2010, 横浜

  • The TLRP3- and NLRC4-mediated inflammasome activation by the infection of Vibrio parahaemolyticus

    OGURA Yasunori

    第83回日本細菌学会総会, Mar. 2010, 横浜

  • Caspase-1 activation by environmentally isolated bacteria

    OGURA Yasunori

    第83回日本細菌学会総会, Mar. 2010, 横浜

  • Mechanism of macrophage infection by Leptospira interrogans

    OGURA Yasunori

    第83回日本細菌学会総会, Mar. 2010, 横浜

  • Activation of the NLRP3 inflammasome by pathogenic Vibrios is mediated via pore-forming toxins and differentially regulated by Toll-like receptor signaling.

    OGURA Yasunori

    第39回日本免疫学会総会, Dec. 2009, 大阪

  • Vibrio vulnificus activates Nalp3 inflammasome via the synergistic action of pore forming toxins

    OGURA Yasunori

    第38回日本免疫学会総会, Dec. 2008, 京都

  • The NOD Protein Family: Role in Innate Immunity and Inflammatory Disease

    OGURA Yasunori

    第78回日本生化学会大会, Oct. 2005, 神戸

  • Systematic functional analysis of NOD2 reveals regulatory mechanisms and critical residues involved in muramyl dipeptide recognition.

    OGURA Yasunori; Chamaillard M; Tanabe T; Ogura Y; Zhu L; Qiu S; Masumoto J; Ghosh P; Moran A; Predergast MM; Tromp G; Williams CJ; Inohara N; Nunez G

    The 105th Annual Meeting of the American Gastroenterolgical Association, May 2004, New Orleans, LA, USA

  • クローン病感受性遺伝子Nod2の小腸パネート細胞における発現

    OGURA Yasunori

    第33回日本免疫学会総会, Dec. 2003, 福岡、2003年12月

  • Crohn's disease and the NOD2 gene: A role for Paneth cells.

    OGURA Yasunori; Lala SG; Ogura Y; Hor SK; Abeya M; Osborne C; Davies S; Ogunbiyi O; Nunez G; Keshav S

    The 2003 Annual Meeting of the British Society of Gastroenterology, Mar. 2003, Birmingham, UK

  • Genetic Variation and Activity of Mouse Nod2.

    OGURA Yasunori; Ogura Y

    The 3rd International Meeting on Inflammatory Bowel Diseases in Capri, 2003, Capri, Italy

  • Functional and genetic characterization of major CD-associated Nod2 variants.

    OGURA Yasunori; Bonen DK; Ogura Y; Nicolae DL; Moran T; Karaliukas R; Ramos R; Turkyilmaz MA; Brant SR; Duerr RH; Cho JH; Nunez G

    The 103rd Annual Meeting of the American Gastroenterolgical Association, May 2002, San Francisco, CA, USA

  • Ethnic specific differences in Nod2 associations to Crohn's disease. \nEthnic specific differences in Nod2 associations to Crohn's disease.

    OGURA Yasunori; Bonen DK; Ogura Y; Duerr RH; Brant SR; Nunez G; Cho JH

    The American Society of Human genetics, 51st Annual Meeting, Oct. 2001, San Diego, CA, USA

  • アポトーシス・NF-κB活性化調節因子の構造と機能の共通性

    OGURA Yasunori

    第59回日本癌学会総会, Oct. 2000, 横浜

  • アポトーシス・NF-κB活性化調節因子の構造と機能の共通性

    OGURA Yasunori

    第73回日本生化学会大会, Oct. 2000, 横浜

  • Intraplacental yolk sacにおけるPDGF受容体α鎖の発現とその発生における役割

    OGURA Yasunori

    第30回日本発生生物学会, May 1997, 筑波

Association Memberships

  • 日本発生生物学会

  • 日本免疫学会

  • American Association for the Advancement of Science

  • 日本細菌学会

  • 日本家政学会

  • 日本栄養改善学会



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