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(Faculty Division of Human Life and Environmental Sciences Research Group of Environmental Health)｜Researchers' Profile Teacher performance management system

TAKAMATA Akira

Faculty Division of Human Life and Environmental Sciences Research Group of Environmental HealthProfessor
Laboratory Animal Research CenterDirector, Laboratory Animal Research Center
Last Updated :2025/06/13

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Profile Information

  • Name (Japanese)

    Takamata

  • Name (Kana)

    Akira

Degree

  • Ph. D (Physiology), Kyoto Prefectural University of Medicine

Research Interests

  • female reproductive hormones
  • 生体リズム
  • 摂食行動
  • 体液調節
  • 飲水行動
  • 体温調節
  • 内皮機能
  • アンギオテンシンII
  • 骨格筋血流調節
  • 浮腫

Research Areas

  • Life sciences, Physiology
  • Life sciences, Nutrition and health science
  • Humanities & social sciences, Home economics, lifestyle science

Research History

  • 2007 - Present, Nara Women's University, Faculty of Human Life and Environment
  • 2007 - Present, Professor, Nara Women's University
  • 2016 - 2016, ジョン・ピアス研究所、イェール大学産婦人科学・生殖科学 客員教授
  • 2016 - 2016, Visiting Professor, John B. Pierce Laboratory, and Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine
  • 2002 - 2007, Nara Women's University, Faculty of Human Life and Environment
  • 2002 - 2007, Associate Professor, Nara Women's University
  • 1994 - 2002, Kyoto Prefectural University of Medicine
  • 1994 - 2002, Assistant Professor, Department of Physiology, Kyoto Prefectural University of Medicine
  • 1991 - 1994, ジョン ピアス研究所、イェール大学医学部 博士研究員
  • 1991 - 1994, Postdoctoral Associate, John B. Pierce Laboratory, and Yale University School of Medicine

Professional Memberships

  • 日本繊維製品消費科学学会
  • JAPANESE SOCIETY OF BIOMETEOROLOGY
  • JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE
  • 米国生理学会
  • THE PHYSIOLOGICAL SOCIETY OF JAPAN
  • The Japan Research Association for Textile End-Users
  • American Physiological Society

■Ⅱ．研究活動実績

Published Papers

  • Refereed, European Journal of Pharmacology, Elsevier BV, Estradiol Replacement Enhances Sweet Taste Preference in Ovariectomized Rats: Interaction with Energy Intake Regulation, Natsumi Kosugi; Konomi Kanamori; Sayaka Kondo; Aoi Takahashi; Nanako Sakagawa; Mio Nishimaki; Keiko Morimoto; Akira Takamata, May 2025, 177719, 177719, Scientific journal, 10.1016/j.ejphar.2025.177719
    DOI URL
  • Refereed, European journal of nutrition, Effect of fluid replacement with green tea on body fluid balance and renal responses under mild thermal hypohydration: a randomized crossover study., Akira Takamata; Ayano Oka; Mayuna Nagata; Natsumi Kosugi; Sayaka Eguchi; Nanako Sakagawa; Aoi Takahashi; Yuki Nishimoto; Mio Nishimaki; Keiko Morimoto; Takanobu Takihara, PURPOSE: Maintaining an appropriate hydration level by ingesting fluid in a hot environment is a measure to prevent heat-related illness. Caffeine-containing beverages, including green tea (GT), have been avoided as inappropriate rehydration beverages to prevent heat-related illness because caffeine has been assumed to exert diuretic/natriuretic action. However, the influence of caffeine intake on urine output in dehydrated individuals is not well documented. The aim of the present study was to examine the effect of fluid replacement with GT on body fluid balance and renal water and electrolyte handling in mildly dehydrated individuals. METHODS: Subjects were dehydrated by performing three bouts of stepping exercise for 20 min separated by 10 min of rest. They were asked to ingest an amount of water (H2O), GT, or caffeinated H2O (20 mg/100 ml; Caf-H2O) that was equal to the volume of fluid loss during the dehydration protocol; fluid balance was measured for 2 h after fluid ingestion. RESULTS: The dehydration protocol induced hypohydration by ~ 10 g/kg body weight (~ 1% of body weight). Fluid balance 2 h after fluid ingestion was significantly less negative in all trials, and the fluid retention ratio was 52.2 ± 4.2% with H2O, 51.0 ± 5.0% with GT, and 47.9 ± 6.2% with Caf-H2O; those values did not differ among the trials. After rehydration, urine output, urine osmolality, and urinary excretions of osmotically active substances, sodium, potassium and chloride were not different among the trials. CONCLUSION: The data indicate that ingestion of GT or an equivalent caffeine amount does not worsen the hydration level 2 h after ingestion and can be effective in reducing the negative fluid balance for acute recovery from mild hypohydration. TRIAL REGISTRATION: ISRCTN53057185; retrospectively registered., 18 Aug. 2023, 62, 8, 3339, 3347, Scientific journal, True, 10.1007/s00394-023-03236-3
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  • Refereed, Nutrients, MDPI AG, Endogenous Androgens Diminish Food Intake and Activation of Orexin A Neurons in Response to Reduced Glucose Availability in Male Rats, Akira Takamata; Yuri Nishimura; Ayano Oka; Mayuna Nagata; Natsumi Kosugi; Sayaka Eguchi; Hiroko Negishi; Keiko Morimoto, Sex steroids modify feeding behavior and body weight regulation, and androgen reportedly augments food intake and body weight gain. To elucidate the role of endogenous androgens in the feeding regulation induced by reduced glucose availability, we examined the effect of gonadectomy (orchiectomy) on food intake and orexin A neuron’s activity in the lateral hypothalamic/perifornical area (LH/PFA) in response to reduced glucose availability (glucoprivation) induced by 2-deoxy-d-glucose (2DG) administration in male rats. Rats (7W) were bilaterally orchiectomized (ORX group) or sham operated (Sham group). Seventeen days after the surgery, food intake response to 2DG (400 mg/kg, i.v.) was measured for 4 h after the infusion. The same experiment was performed for the immunohistochemical examination of c-Fos-expressing orexin A neurons in the LH/PFA and c-Fos expression in the arcuate nucleus (Arc). Food intake induced by glucoprivation was greater in the ORX group than the Sham group, and the glucoprivation-induced food intake was inversely correlated with plasma testosterone concentration. Glucoprivation stimulated c-Fos expression of the orexin A neurons at the LH/PFA and c-Fos expression in the dorsomedial Arc. The number and percentage of c-Fos-expressing orexin A neurons in the LH/PFA and c-Fos expression in the dorsomedial Arc were significantly higher in the ORX group than the Sham group. This indicates that endogenous androgen, possibly testosterone, diminishes the food intake induced by reduced glucose availability, possibly via the attenuated activity of orexin A neuron in the LH/PFA and neurons in the dorsomedial Arc., 15 Mar. 2022, 14, 6, 1235, 1235, Scientific journal, True, True, 10.3390/nu14061235
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  • Refereed, Physiological reports, Estradiol replacement improves high-fat diet-induced insulin resistance in ovariectomized rats., Naoko Yokota-Nakagi; Sayo Omoto; Shoko Tazumi; Mizuho Kawakami; Akira Takamata; Keiko Morimoto, The role of 17β-estradiol (E2) in high-fat diet (HFD)-induced alteration of the protein kinase B (Akt) signaling pathway in ovariectomized (OVX) rats is unclear. Therefore, we examined whether chronic estrogen replacement restores HFD-induced impairment in insulin sensitivity by its effects concomitant with alterations in the Akt isoform 2 (Akt2) and Akt substrate of 160 kDa (AS160) phosphorylation in muscles of OVX rats. Nine-week-old female Wistar rats underwent ovariectomy under anesthesia; after 4 weeks, subcutaneous implantation of either E2 or placebo (PL) pellets was performed, and HFD feeding was initiated. Intravenous glucose tolerance tests were performed to assess insulin sensitivity. Following insulin injection into rats' portal vein, the liver and gastrocnemius muscle were dissected for insulin signaling analysis. We observed that HFD increased energy intake and body weight in the PL group; however, it was temporarily decreased in the E2 group. Adipose tissue accumulation was larger in HFD-fed rats than in normal chow diet (NCD)-fed rats in the PL group; however, this difference was not observed in the E2 group. HFD reduced insulin sensitivity in the PL group only. In vivo insulin stimulation increased Akt2 phosphorylation in the muscles of NCD-fed rats in both groups. In contrast, HFD affected insulin-stimulated phosphorylation of Akt2 and AS160 in the muscles of rats in the PL group but not in the E2 group. Our data suggest that E2 replacement improves HFD-induced insulin resistance, and this effect is accompanied by the alterations in the Akt2 and AS160 phosphorylation in insulin-stimulated muscles of OVX rats., Mar. 2022, 10, 5, e15193, Scientific journal, True, 10.14814/phy2.15193
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  • Refereed, Nutrients, Estradiol Replacement Improves High-Fat Diet-Induced Obesity by Suppressing the Action of Ghrelin in Ovariectomized Rats., Naoko Yokota-Nakagi; Haruka Takahashi; Mizuho Kawakami; Akira Takamata; Yuki Uchida; Keiko Morimoto, This study aims to investigate the effects of estradiol replacement on the orexigenic action of ghrelin in ovariectomized (OVX) obese rats fed with a high-fat diet (HFD). Four weeks after OVX at 9 weeks of age, Wistar rats were subcutaneously implanted with either 17β-estradiol (E2) or placebo (Pla) pellets and started on HFD feeding. After 4 weeks, growth hormone-releasing peptide (GHRP)-6, a growth hormone secretagogue receptor (GHSR) agonist injected intraperitoneally, induced changes in HFD intake, and c-Fos-positive neurons in the hypothalamic arcuate nucleus (ARC) were measured in both groups. The ghrelin protein and mRNA levels, as well as GHSR protein in stomach, were analyzed by Western blotting and real-time PCR. HFD increased energy intake and body weight in the Pla group, while it temporarily reduced these in the E2 group. GHRP-6 enhanced HFD intake and activated neurons in the ARC only in the Pla group. Furthermore, gastric ghrelin and GHSR protein levels were lower in the E2 group than in the Pla group, but plasma acyl ghrelin levels were similar in both groups. Our results suggest that E2 replacement improves obesity by inhibiting the orexigenic action of ghrelin via downregulation of ghrelin and its receptor in stomach in HFD-fed OVX rats., 26 Mar. 2020, 12, 4, Scientific journal, True, 10.3390/nu12040907
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  • Refereed, Nutrients, MDPI AG, Fluoxetine Mimics the Anorectic Action of Estrogen and Its Regulation of Circadian Feeding in Ovariectomized Female Rats, Yuri Nishimura; Kaori Mabuchi; Natsumi Omura; Ayako Igarashi; Megumi Miura; Nanako Mima; Hiroko Negishi; Keiko Morimoto; Akira Takamata, Our previous study demonstrated that chronic estrogen replacement in ovariectomized rats reduces food intake and augments c-Fos expression in the suprachiasmatic nucleus (SCN), specifically during the light phase. Here, we hypothesized that serotonergic neurons in the central nervous system (CNS), which have anorectic action and play a role in regulating circadian rhythm, mediate the light phase-specific anorectic action of estrogen, and that selective serotonin reuptake inhibitors (SSRIs) mimic the hypophagic action of estrogen. Female Wistar rats were ovariectomized and treated with estradiol (E2) or cholesterol by subcutaneously implanting a silicon capsule containing E2 or cholesterol. Then, half of the cholesterol-treated rats were injected with the SSRI fluoxetine (5 mg/kg) (FLX group), while the remaining rats in the cholesterol-treated group (CON group) and all those in the E2 group were injected with saline subcutaneously twice daily at the onsets of the light and dark phases. Both E2 and FLX reduced food intake during the light phase but not the dark phase, and reduced body weight gain. In addition, both E2 and FLX augmented the c-Fos expression in the SCN, specifically during the light phase. These data indicate that FLX exerts estrogen-like antiobesity and hypophagic actions by modifying circadian feeding patterns, and suggest that estrogen regulates circadian feeding rhythm via serotonergic neurons in the CNS., 22 Mar. 2020, 12, 3, 849, 849, Scientific journal, True, True, 10.3390/nu12030849
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  • Refereed, The journal of physiological sciences : JPS, Endurance running exercise is an effective alternative to estradiol replacement for restoring hyperglycemia through TBC1D1/GLUT4 pathway in skeletal muscle of ovariectomized rats., Mizuho Kawakami; Naoko Yokota-Nakagi; Akira Takamata; Keiko Morimoto, Menopause is a risk factor for impaired glucose metabolism. Alternative treatment of estrogen for postmenopausal women is required. The present study was designed to investigate the effects of 5-week endurance running exercise (Ex) by treadmill on hyperglycemia and signal pathway components mediating glucose transport in ovariectomized (OVX) placebo-treated rats, compared with 4-week 17β-estradiol (E2) replacement or pair-feeding (PF) to the E2 group. Ex improved the hyperglycemia and insulin resistance index in OVX rats as much as E2 or PF did. However, Ex had no effect on body weight gain in the OVX rats. Moreover, Ex enhanced the levels of GLUT4 and phospho-TBC1D1 proteins in the gastrocnemius of the OVX rats, but E2 or PF did not. Instead, the E2 increased the Akt2/AS160 expression and activation in the OVX rats. This study suggests that endurance Ex training restored hyperglycemia through the TBC1D1/GLUT4 pathway in muscle by an alternative mechanism to E2 replacement., Nov. 2019, 69, 6, 1029, 1040, Scientific journal, False, 10.1007/s12576-019-00723-3
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  • Not Refereed, Jul. 2019, 10, 15, 22
  • Refereed, The journal of physiological sciences : JPS, The effect of menstrual cycle phase on foot skin temperature during mild local cooling in young women., Yuki Uchida; Koyuki Atsumi; Akira Takamata; Keiko Morimoto, Japanese women can experience a sensation of cold feet in daily life. It is possible that this sensation of coldness in feet may be associated with female hormones, but to date the effect of menstrual cycle phase on the skin temperature (Tsk) of the foot during local cooling is unknown. We therefore examined Tsk and partial cutaneous blood flow in the foot during the follicular (F) and luteal (L) phases of the menstrual cycle in women experiencing local cooling. Tsk was measured in the toes and the dorsum of the left foot using infrared thermography, while cutaneous blood flow was evaluated in the big toe of the left foot using laser Doppler flowmetry (LDF), both at 28 °C. Mild local cooling (24.7 °C) was then applied for 30 min to the right foot. During cooling of the right foot, no significant differences in Tsk were observed between the F and L phases in either the toes of the left foot or the dorsum of the left foot of all subjects. However, cutaneous blood flow determined by LDF in the big toe of the left foot was greater in the F phase than in the L phase. These results suggest that the menstrual cycle phase did not affect Tsk in the foot, but it did affect cutaneous blood flow in the big toe during mild local cooling., Jan. 2019, 69, 1, 151, 157, Scientific journal, False, 10.1007/s12576-018-0629-1
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  • Refereed, American journal of physiology. Endocrinology and metabolism, Estrogen replacement enhances insulin-induced AS160 activation and improves insulin sensitivity in ovariectomized rats., Mizuho Kawakami; Naoko Yokota-Nakagi; Masami Uji; Ken-Ichi Yoshida; Shoko Tazumi; Akira Takamata; Yuki Uchida; Keiko Morimoto, Menopause predisposes women to impaired glucose metabolism, but the role of estrogen remains unclear. In this study, we examined the effects of chronic estrogen replacement on whole body insulin sensitivity and insulin signaling in ovariectomized rats. Female Wistar rats aged 9 wk were ovariectomized under anesthesia. After 4 wk, pellets containing either 17β-estradiol (E2) or placebo (Pla) were subcutaneously implanted in the rats. After 4 wk of treatment, the intra-abdominal fat accumulation was greater in the Pla group than that in the E2 group. Hyperinsulinemic-euglycemic clamp analysis and intravenous glucose tolerance test revealed that insulin sensitivity was significantly lower in the Pla group than in the E2 group. In addition, Western blotting showed that in vivo insulin stimulation increased protein kinase B (Akt) phosphorylation to a similar degree in the gastrocnemius and liver of both groups, but phosphorylated Akt2 Ser474 was enhanced in the muscle of the E2 group compared with the Pla group. Moreover, insulin-stimulated phosphorylation of Akt substrate of 160 kDa (AS160) Thr642 was observed only in the E2 group, resulting in the difference between the two groups. Additionally, AS160 protein and mRNA levels were higher in muscle of the E2 group than the Pla group. In contrast, E2 replacement had no effect on glucose transporter 4 protein levels in muscle and glycogen synthase kinase-3β in muscle and liver. These results suggest that estrogen replacement improves insulin sensitivity by activating the Akt2/AS160 pathway in the insulin-stimulated muscle of ovariectomized rats., 01 Dec. 2018, 315, 6, E1296-E1304, E1304, Scientific journal, True, 10.1152/ajpendo.00131.2018
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  • Refereed, American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Blood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women, Tessa E. Adler; Charlotte W. Usselman; Akira Takamata; Nina S. Stachenfeld, Hypertension, obesity, and endothelial function predict cardiovascular disease in women, and these factors are interrelated. We hypothesized that hypertension and obesity are associated with endothelial dysfunction in young women and that short-term ethinyl estradiol exposure mitigates this dysfunction. We examined flow-mediated dilation (FMD) responses before and during 7 days of oral ethinyl estradiol (30 µg/day) in 19 women (25 ± 5, 18–35 yr). We divided our sample into two groups based on two criteria: blood pressure and obesity. Women were divided into normal blood pressure (NBP; mean arterial pressure range: 78–91 mmHg, n = 7) and high blood pressure (HBP; mean arterial pressure range: 95–113 mmHg, n = 9) groups. We also stratified our subjects by body composition (lean: 18–31%, n = 8; obese: 38–59%, n = 9). We evaluated brachial FMD after two distinct shear stress stimuli: occlusion alone and occlusion with ischemic handgrip exercise. Obesity was unrelated to both FMD responses. Before ethinyl estradiol administration, the HBP group had blunted ischemic exercise responses relative to the NBP group (8.0 ± 3.5 vs. 12.3 ± 3.2%, respectively, P = 0.05). However, during ethinyl estradiol administration, ischemic exercise responses increased in the HBP group (12.8 ± 6.1%, P = 0.04) but decreased in the NBP group (5.6 ± 2.4%, P = 0.01). Standard FMD did not reveal differences between groups. In summary, 1) moderate HBP predicted endothelial impairment, 2) ethinyl estradiol administration had divergent effects on FMD in women with NBP versus HBP, and 3) enhanced FMD (ischemic handgrip exercise) revealed differences in endothelial function, whereas standard FMD (occlusion alone) did not.

    NEW & NOTEWORTHY We are the first to show that mild hypertension is a stronger predictor of endothelial dysfunction than obesity in healthy women without overt cardiovascular dysfunction. Importantly, the standard 5-min flow-mediated vasodilation stimulus did not detect endothelial dysfunction in our healthy population; only an enhanced ischemic handgrip exercise shear stress stimulus detected endothelial impairment. Estradiol administration increased flow-mediated dilation in women with high blood pressure, so it may be a therapeutic intervention to improve endothelial function., 01 Oct. 2018, 315, 4, H925, H933, Scientific journal, True, True, 10.1152/ajpheart.00188.2018
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  • Refereed, American journal of physiology. Heart and circulatory physiology, Estrogen replacement attenuates stress-induced pressor responses through vasorelaxation via β2-adrenoceptors in peripheral arteries of ovariectomized rats., Shoko Tazumi; Sayo Omoto; Yu Nagatomo; Mariko Kawahara; Naoko Yokota-Nakagi; Mizuho Kawakami; Akira Takamata; Keiko Morimoto, We examined whether chronic estrogen replacement has an inhibitory effect on stress-induced pressor responses via activation of β2-adrenoceptor (AR) in peripheral arteries of ovariectomized rats. Female Wistar rats aged 9 wk were ovariectomized. After 4 wk, pellets containing either 17β-estradiol (E2) or placebo (Pla) were subcutaneously implanted into the rats. After 4 wk of treatment, rats underwent cage-switch stress, and, in a separate experiment, a subset received an infusion of isoproterenol (ISO) with or without pretreatment with the β1-AR blocker atenolol or the β2-AR blocker butoxamine. In addition, the isolated mesenteric artery was used to assess the concentration-related relaxing responses to ISO and the β1- or β2-AR mRNA level. The cage-switch stress-induced pressor response was significantly attenuated in the E2-treated group compared with the Pla-treated group. Pretreatment with atenolol reduced blood pressure responses in both groups. However, butoxamine enhanced the pressor response only in the E2-treated group, resulting in no difference between the two groups. In addition, the intravenous ISO-induced depressor response was significantly enhanced in the E2-treated group compared with the Pla-treated group. Furthermore, the difference in the depressor response was abolished by pretreatment with butoxamine but not by atenolol. In the isolated mesenteric artery, butoxamine caused a rightward shift in ISO-induced concentration-related relaxation in the E2-treated group. The β2-AR mRNA level in the mesenteric artery was higher in the E2-treated group than in the Pla-treated group. These results suggest that estrogen replacement attenuated the stress-induced pressor response probably by suppressing vasoconstriction via activation of β2-ARs in peripheral arteries of ovariectomized rats. NEW & NOTEWORTHY In this study, we show, for the first time, that estrogen replacement has an inhibitory effect on the psychological stress-induced pressor response through vasorelaxation via β2-adrenoceptors, probably due to overexpression of β2-adrenoceptor mRNA, in peripheral arteries of ovariectomized rats., 01 Feb. 2018, 314, 2, H213-H223, Scientific journal, True, 10.1152/ajpheart.00148.2017
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  • Refereed, Frontiers in Endocrinology, S-equol Exerts Estradiol-Like Anorectic Action with Minimal Stimulation of Estrogen Receptor-α in Ovariectomized Rats, Yuri Nishimura; Kaori Mabuchi; Azusa Takano; Yayoi Hara; Hiroko Negishi; Keiko Morimoto; Tomomi Ueno; Shigeto Uchiyama; Akira Takamata, 19 Oct. 2017, 8, Scientific journal, True, 10.3389/fendo.2017.00281
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  • Not Refereed, 2017, 35, 6, 945, 950
  • Refereed, Jpn J Biometeor, Body fluid regulation and female reproductive steroids, TAKAMATA Akira, 2017, 54, 2, 57, 64, 10.11227/seikisho.54.57
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  • Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Effects of estrogen replacement on stress-induced cardiovascular responses via renin-angiotensin system in ovariectomized rats, Shoko Tazumi; Naoko Yokota; Mizuho Kawakami; Sayo Omoto; Akira Takamata; Keiko Morimoto, Nov. 2016, 311, 5, R898, R905, Scientific journal, 10.1152/ajpregu.00415.2015
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  • Refereed, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, Target intensity and interval walking training in water to enhance physical fitness in middle-aged and older women: a randomised controlled study, Shuichi Handa; Shizue Masuki; Takuya Ohshio; Yoshi-ichiro Kamijo; Akira Takamata; Hiroshi Nose, Jan. 2016, 116, 1, 203, 215, Scientific journal, 10.1007/s00421-015-3267-9
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  • Not Refereed, 2015, 56, 1, 8, 9, 10.11419/senshoshi.56.1_8
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  • Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats, Yuri Nishimura; Kaori Mabuchi; Sayumi Taguchi; Saori Ikeda; Eri Aida; Hiroko Negishi; Akira Takamata, May 2014, 64, 3, 203, 211, Scientific journal, 10.1007/s12576-014-0312-0
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  • Not Refereed, 2014, 55, 10, 722, 723, 10.11419/senshoshi.55.10_722
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  • Not Refereed, 2014, 55, 10, 723, 723, 10.11419/senshoshi.55.10_722
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  • Mar. 2013, 75, 2, 96, 96
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  • Refereed, Contrast Media and Molecular Imaging, Mn-citrate and Mn-HIDA: Intermediate-affinity chelates for manganese-enhanced MRI, Yoshiteru Seo; Keitaro Satoh; Hironobu Morita; Akira Takamata; Kazuto Watanabe; Takashi Ogino; Tooru Hasebe; Masataka Murakami, Mar. 2013, 8, 2, 140, 146, Scientific journal, 10.1002/cmmi.1510
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  • Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, Diffusion of manganese chelates in the rat brain measured by T-1-weighted MRI, Yoshiteru Seo; Akira Takamata; Takashi Ogino; Hironobu Morita; Masataka Murakami, 2013, 63, S137, S137
  • Not Refereed, 2012, 19, 18, 23
  • Not Refereed, 2012, 106
  • Refereed, J Phys Fitness Sports Med, The Japanese Society of Physical Fitness and Sports Medicine, Modification of thermoregulatory response to heat stress by body fluid regulation., TAKAMATA Akira, The thermoregulatory system interacts vitally with the body fluid regulatory system. Thermoregulatory response during heat stress, such as sweating and cutaneous vasodilation, stimulates body fluid regulatory response by elevating plasma osmolality and reducing central blood volume. Isotonic hypovolemia, or baroreceptor unloading, and plasma hyperosmolality, in turn, inhibit thermoregulatory response to heat stress, suggesting that body fluid regulation is given priority over thermoregulation. On the other hand, osmoregulatory vasopressin secretion and thirst are augmented by elevated body core temperature. Heat acclimation enhances thermoregulatory response to heat stress. Adaptation of the body fluid regulatory system, such as increased plasma volume and reduced osmotic inhibition of thermoregulatory response, is possibly involved in the mechanism for the enhancement of thermoregulatory response to heat stress by heat acclimation. In this review, we discuss the interaction between body fluid regulation, especially osmoregulation, and thermoregulation mainly in humans., 2012, 1, 3, 479, 489, 10.7600/jpfsm.1.479
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  • Refereed, 2012, 19, 2, 56, 59, Scientific journal
  • Not Refereed, 2012, 62, 12, 942, 945
  • Refereed, BRITISH JOURNAL OF NUTRITION, Chronic oestrogen replacement in ovariectomised rats attenuates food intake and augments c-Fos expression in the suprachiasmatic nucleus specifically during the light phase, Akira Takamata; Kayo Torii; Kana Miyake; Keiko Morimoto, Oct. 2011, 106, 8, 1283, 1289, Scientific journal, 10.1017/S0007114511001607
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  • Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, Lateral diffusion of manganese in the rat brain determined by T-1 relaxation time measured by H-1 MRI, Yoshiteru Seo; Akira Takamata; Takashi Ogino; Hironobu Morita; Masataka Murakami, May 2011, 61, 3, 259, 266, Scientific journal, 10.1007/s12576-011-0143-1
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  • Refereed, MAGNETIC RESONANCE IN MEDICINE, Mn-bicine: A Low Affinity Chelate for Manganese Ion Enhanced MRI, Yoshiteru Seo; Keitaro Satoh; Kazuto Watanabe; Hironobu Morita; Akira Takamata; Takashi Ogino; Masataka Murakami, Apr. 2011, 65, 4, 1005, 1012, Scientific journal, 10.1002/mrm.22680
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  • Refereed, JOURNAL of the JAPAN RESEARCH ASSOCIATION for TEXTILE END-USES, The Japan Research Association for Textile End-Uses, Gravity/sexual cycle, body fluid, circulation and thermoregulatory function, 2011, 52, 1, 32, 36, Scientific journal, 10.11419/senshoshi.52.1_32
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  • Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Plasma hyperosmolality elevates the internal temperature threshold for active thermoregulatory vasodilation during heat stress in humans, Manabu Shibasaki; Ken Aoki; Keiko Morimoto; John M. Johnson; Akira Takamata, Dec. 2009, 297, 6, R1706, R1712, Scientific journal, 10.1152/ajpregu.00242.2009
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  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Involvement of central angiotensin II type 1 receptors in LPS-induced systemic vasopressin release and blood pressure regulation in rats, Fumihiro Shimizu; Toshihiro Kasai; Akira Takamata, Jun. 2009, 106, 6, 1943, 1948, Scientific journal, 10.1152/japplphysiol.90516.2008
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  • Not Refereed, 2009, 26, 60, 66
  • Not Refereed, 2009, 26, 264, 271
  • Not Refereed, LIFE SCIENCES, Mental stress induces sustained elevation of blood pressure and lipid peroxidation in postmenopausal women, Keiko Morimoto; Mayuko Morikawa; Hiroko Kimura; Nobuko Ishii; Akira Takamata; Yasuko Hara; Masami Uji; Ken-ichi Yoshida, Jan. 2008, 82, 1-2, 99, 107, Scientific journal, 10.1016/j.lfs.2007.10.018
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  • Not Refereed, Stress, Neurotransmitters, and Hormones: Neuroendocrine and Genetic Mechanisms, Effects of Estrogen on Stress-induced Activation of Peptide Neurons in PVN of Ovariectomized Rats, Yasuko Hara; Tomomi Kohno; Akira Takamata; Takashi Ueyama; Keiko Morimoto, 2008, 1148, 99, 105, Scientific journal, 10.1196/annals.1410.042
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  • Not Refereed, STRESS, NEUROTRANSMITTERS, AND HORMONES: NEUROENDOCRINE AND GENETIC MECHANISMS, Estrogen Replacement Suppresses Pressor Response and Oxidative Stress Induced by Cage-switch Stress in Ovariectomized Rats, Keiko Morimoto; Masami Uji; Takashi Ueyama; Hiroko Kimura; Tomomi Kohno; Akira Takamata; Shigenobu Yano; Ken-Ichi Yoshida, 2008, 1148, 213, 218, Scientific journal, 10.1196/annals.1410.045
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  • Not Refereed, JAPANESE JOURNAL OF BIOMETEOROLOGY, Japanese Society of Biometeorology, Effect of calf heating and muscle injury on calf venous compliance and capillary filtration coefficient, FUKUI Yoko; YAMAMOTO Kana; TAKAMATA Akira, To gain better insights into the hydrostatic effect on blood pooling and edema formation in the lower limbs, we examined the effect of local calf heating and muscle injury on venous compliance and capillary filtration coefficient (Kf). Ten young female subjects participated in this study. After 60 min supine rest, a cuff on the thigh was inflated to 50 mmHg in 10 mmHg steps every 7-minute, and we measured calf volume and cardiovascular variables. We conducted the same experiment with local calf heating. After the first-day experiment, subjects performed calf raise exercise (4* 100 times). All subjects claimed muscle soreness on the next day, and we conducted the same experiment as the first day experiment on the second day. We determined the venous compliance and Kf from the relationships between blood volume change (first phase of calf volume change) and cuff pressure, and between transcapillary fluid movement (second phase of calf volume change) and cuff pressure, respectively. Venous compliance was not influenced by calf heating or muscle injury. Kf on the second day was higher than that on the first day, and Kf was increased with calf heating on the second day. These suggest that muscle injury increases Kf, and local calf heating enhances the effect of muscle injury on Kf.
    , 2007, 44: 13-39, 1, 13, 39, 10.11227/seikisho.44.13
    DOI URL
  • Not Refereed, 2006, 47, 12, 712, 718, 10.11419/senshoshi1960.47.712
    DOI URL
  • Not Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Acute hypoosmolality attenuates the suppression of cutaneous vasodilation with increased exercise intensity, H Mitono; H Endoh; K Okazaki; T Ichinose; S Masuki; A Takamata; H Nose, Sep. 2005, 99, 3, 902, 908, Scientific journal, 10.1152/japplphysiol.00156.2005
    DOI URL
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Plasma hyperosmolality augments peripheral vascular response to baroreceptor unloading during heat stress, T Ito; T Itoh; T Hayano; K Yamauchi; A Takamata, Aug. 2005, 289, 2, R432, R440, Scientific journal, 10.1152/ajpregu.00027.2004
    DOI URL
  • Not Refereed, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Effect of environmental conditions on tear dynamics in soft contact lens wearers, K Maruyama; N Yokoi; A Takamata; S Kinoshita, Aug. 2004, 45, 8, 2563, 2568, Scientific journal, 10.1167/iovs.03-1185
    DOI URL
  • Not Refereed, AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, Sequence of forebrain activation induced by intraventricular injection of hypertonic NaCl detected by Mn2+ contrasted T-1-weighted MRI, H Morita; T Ogino; N Fujiki; K Tanaka; TM Gotoh; Y Seo; A Takamata; S Nakamura; M Murakami, Jun. 2004, 113, 1-2, 43, 54, Scientific journal, 10.1016/j.autneu.2004.05.005
    DOI URL
  • Not Refereed, ANESTHESIOLOGY, Effect of amino acid infusion on central thermoregulatory control in humans, Y Nakajima; A Takamata; T Matsukawa; DI Sessler; Y Kitamura; H Ueno; Y Tanaka; T Mizobe, Mar. 2004, 100, 3, 634, 639, Scientific journal, 10.1097/00000542-200403000-00025
    DOI URL
  • Not Refereed, 2004, 54, 43, 47
  • Not Refereed, Japanese journal of biometeorology, Japanese Society of Biometeorology, Prevention of heat stroke by ingesting fluid : its physiological mechanisms, TAKAMATA Akira, Thermoregulatory sweating decreases extracellular fluid (ECF) volume and increases ECF osmaolality. In addition, increased skin blood flow during heat stress decreases venous return to the heart, resulting in cardiopulmonary baroreceptor unloading. Plasma hyperosmolality inhibits both thermally-induced cutaneous vasodilaiton and sweating by elevating the body core temperature (Tc) thresholds for these responses. The decreased ECF volume, or cardiopulmonary baroreceptor unloading, during heat stress inhibits thermoregulatory cutaneous vasodilation and also increases heart rate via cardiopulmonary baroreceptor reflexes/. Therefore, fluid ingestion is necessary to maintain thermoregulatory and cardiovascular function during heat stress. It is necessary to replace sodium for full recovery from thermal dehydration. The optimal sodium concentration in beverage might be dependent on the level of heat acclimation, because heat acclimation reduces sweat sodium concentration. Fluid ingestion before exercise is more beneficial to maintain thermoregulatory and cardiovascular function during exercise in a hot environment than fluid ingestion during exercise. Thus, timing of fluid ingestion influences thermoregulation and cardiovascular regulation during exercise.
    , 2004, 41, 1, 55, 59, 10.11227/seikisho.41.55
    DOI URL
  • Not Refereed, ACTA ANAESTHESIOLOGICA SCANDINAVICA, The vasoconstriction threshold is increased in obese patients during general anaesthesia, T Kasai; M Hirose; T Matsukawa; A Takamata; Y Tanaka, May 2003, 47, 5, 588, 592, Scientific journal, 10.1034/j.1399-6576.2003.00097.x
    DOI URL
  • Not Refereed, SHOCK, Reduced blood-to-tissue albumin movement after plasmapheresis, AM Stahl; CM Gillen; A Takamata; ER Nadel; GW Mack, May 2003, 19, 5, 440, 447, Scientific journal, 10.1097/01.shk.0000051757.08171.58
    DOI URL
  • Not Refereed, ACTA ANAESTHESIOLOGICA SCANDINAVICA, Preoperative blood pressure and catecholamines related to hypothermia during general anesthesia, T Kasai; M Hirose; T Matsukawa; A Takamata; K Yaegashi; Y Tanaka, Feb. 2003, 47, 2, 208, 212, Scientific journal, 10.1034/j.1399-6576.2003.00048.x
    DOI URL
  • Not Refereed, JOURNAL OF PHYSIOLOGY-LONDON, Water permeability of capillaries in the subfornical organ of rats determined by Gd-DTPA(2-) enhanced H-1 magnetic resonance imaging, Y Seo; A Takamata; T Ogino; H Morita; S Nakamura; M Murakami, Nov. 2002, 545, 1, 217, 228, Scientific journal, 10.1113/jphysiol.2002.027227
    DOI URL
  • Not Refereed, ANESTHESIA AND ANALGESIA, Preoperative risk factors of intraoperative hypothermia in major surgery under general anesthesia, T Kasai; M Hirose; K Yaegashi; T Matsukawa; A Takamata; Y Tanaka, Nov. 2002, 95, 5, 1381, 1383, Scientific journal, 10.1213/01.ANE.0000030329.15348.50
    DOI URL
  • Not Refereed, NEUROSCIENCE LETTERS, Detection of hypothalamic activation by manganese ion contrasted T-1-weighted magnetic resonance imaging in rats, H Morita; T Ogino; Y Seo; N Fujiki; K Tanaka; A Takamata; S Nakamura; M Murakami, Jun. 2002, 326, 2, 101, 104, Scientific journal, 10.1016/S0304-3940(02)00330-0
    DOI URL
  • Not Refereed, ANESTHESIA AND ANALGESIA, Upright posture reduces thermogenesis and augments core hypothermia, Y Nakajima; A Takamata; T Ito; DI Sessler; Y Kitamura; G Shimosato; S Taniguchi; H Matsuyama; Y Tanaka; T Mizobe, Jun. 2002, 94, 6, 1646, 1651, Scientific journal
  • Not Refereed, 2002, 51, 2295, 2296
  • Not Refereed, JAPANESE JOURNAL OF PHYSIOLOGY, Role of blood volume in the age-associated decline in peak oxygen uptake in humans, T Ito; A Takamata; K Yaegashi; T Itoh; T Yoshida; T Kawabata; M Kimura; T Morimoto, Oct. 2001, 51, 5, 607, 612, Scientific journal, 10.2170/jjphysiol.51.607
    DOI URL
  • Not Refereed, JAPANESE JOURNAL OF PHYSIOLOGY, Effects of pCO(2) on the CSF turnover rate in rats monitored by Gd-DTPA enhanced T-1-weighted magnetic resonance imaging, A Takamata; Y Seo; T Ogino; K Tanaka; N Fujiki; H Morita; M Murakami, Oct. 2001, 51, 5, 555, 562, Scientific journal, 10.2170/jjphysiol.51.555
    DOI URL
  • Not Refereed, ACTA ANAESTHESIOLOGICA SCANDINAVICA, Preoperative blood pressure and intraoperative hypothermia during lower abdominal surgery, T Kasai; M Hirose; T Matsukawa; A Takamata; M Kimura; Y Tanaka, Sep. 2001, 45, 8, 1028, 1031, Scientific journal, 10.1034/j.1399-6576.2001.450817.x
    DOI URL
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Relationship of osmotic inhibition in thermoregulatory responses and sweat sodium concentration in humans, A Takamata; T Yoshida; N Nishida; T Morimoto, Mar. 2001, 280, 3, R623, R629, Scientific journal
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Baroreflex modulation of peripheral vasoconstriction during progressive hypothermia in anesthetized humans, Y Nakajima; T Mizobe; A Takamata; Y Tanaka, Oct. 2000, 279, 4, R1430, R1436, Scientific journal
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Effect of acute hypoxia on vasopressin release and intravascular fluid during dynamic exercise in humans, A Takamata; H Nose; T Kinoshita; M Hirose; T Itoh; T Morimoto, Jul. 2000, 279, 1, R161, R168, Scientific journal
  • Jun. 2000, 49, 3, 441, 441
  • Not Refereed, BRAIN RESEARCH, LPS-induced Fos expression in oxytocin and vasopressin neurons of the rat hypothalamus, W Matsunaga; S Miyata; A Takamata; H Bun; T Nakashima; T Kiyohara, Mar. 2000, 858, 1, 9, 18, Scientific journal, 10.1016/S0006-8993(99)02418-X
    DOI URL
  • Not Refereed, 2000, 42, 332, 339
  • Not Refereed, 2000, 6, 6, 62, 66
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Effect of an exercise-heat acclimation program on body fluid regulatory responses to dehydration in older men, A Takamata; T Ito; K Yaegashi; H Takamiya; Y Maegawa; T Itoh; JE Greenleaf; T Morimoto, Oct. 1999, 277, 4, R1041, R1050, Scientific journal
  • Not Refereed, JAPANESE JOURNAL OF PHYSIOLOGY, Comparison between tail skin blood flow measurements by ultrasonic Doppler flowmetry and plethysmography during heating in anesthetized rats, Y Nakajima; H Nose; A Takamata, Feb. 1999, 49, 1, 121, 124, Scientific journal, 10.2170/jjphysiol.49.121
    DOI URL
  • Jan. 1999, 61, 1, 56, 57
  • Dec. 1998, 47, 6, 834, 834
    Permalink
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Plasma hyperosmolality and arterial pressure regulation during heating in dehydrated and awake rats, Y Nakajima; H Nose; A Takamata, Nov. 1998, 275, 5, R1703, R1711, Scientific journal
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Role of plasma osmolality in the delayed onset of thermal cutaneous vasodilation during exercise in humans, A Takamata; K Nagashima; H Nose; T Morimoto, Jul. 1998, 275, 1, R286, R290, Scientific journal
  • Not Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Effect of continuous negative-pressure breathing on skin blood flow during exercise in a hot environment, K Nagashima; H Nose; A Takamata; T Morimoto, Jun. 1998, 84, 6, 1845, 1851, Scientific journal
  • Not Refereed, BRAIN FUNCTION IN HOT ENVIRONMENT, Thermoregulation and body fluid in hot environment, T Morimoto; T Itoh; A Takamata, 1998, 115, 499, 508
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Osmoregulatory inhibition of thermally induced cutaneous vasodilation in passively heated humans, A Takamata; K Nagashima; H Nose; T Morimoto, Jul. 1997, 273, 1, R197, R204, Scientific journal
  • Not Refereed, INTERNATIONAL JOURNAL OF BIOMETEOROLOGY, Integrative regulations of body temperature and body fluid in humans exercising in a hot environment, H Nose; A Takamata, Feb. 1997, 40, 1, 42, 49, Scientific journal
  • JJSCA, THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA, Anesthesia and operation and body fluid metabolism. Effect of the body fluid osmotic change on the circulation regulation., 1997, 17, 10, 585, 588, 10.2199/jjsca.17.585
    DOI URL
  • Not Refereed, THERMOREGULATION, Negative pressure breathing and the control of skin blood flow during exercise in a hot environment, K Nagashima; T Yoshida; H Nose; A Takamata; T Morimoto, 1997, 813, 604, 609, Scientific journal, 10.1111/j.1749-6632.1997.tb51752.x
    DOI URL
  • Not Refereed, 1997, 14, 18, 21
  • Not Refereed, 1997, 14, 721, 727
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Thirst and fluid regulatory responses to hypertonicity in older adults, NS Stachenfeld; GW Mack; A Takamata; L DiPietro; ER Nadel, Sep. 1996, 271, 3, R757, R765, Scientific journal
  • Not Refereed, 1996, 6, 403, 409
  • Not Refereed, 1996, 13, 68, 73
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, BODY-TEMPERATURE MODIFICATION OF OSMOTICALLY INDUCED VASOPRESSIN SECRETION AND THIRST IN HUMANS, A TAKAMATA; GW MACK; NS STACHENFELD; ER NADEL, Oct. 1995, 269, 4, R874, R880, Scientific journal
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, OSMOREGULATORY MODULATION OF THERMAL SWEATING IN HUMANS - REFLEX EFFECTS OF DRINKING, A TAKAMATA; GW MACK; CM GILLEN; AC JOZSI; ER NADEL, Feb. 1995, 268, 2, R414, R422, Scientific journal
  • Not Refereed, JOURNAL OF APPLIED PHYSIOLOGY, RIGHT ATRIAL PRESSURE AND ANP RELEASE DURING PROLONGED EXERCISE IN A HOT ENVIRONMENT, H NOSE; A TAKAMATA; GW MACK; T KAWABATA; Y ODA; S HASHIMOTO; M HIROSE; E CHIHARA; T MORIMOTO, May 1994, 76, 5, 1882, 1887, Scientific journal
  • Not Refereed, AMERICAN JOURNAL OF PHYSIOLOGY, SODIUM APPETITE, THIRST, AND BODY-FLUID REGULATION IN HUMANS DURING REHYDRATION WITHOUT SODIUM REPLACEMENT, A TAKAMATA; GW MACK; CM GILLEN; ER NADEL, May 1994, 266, 5, R1493, R1502, Scientific journal
  • Not Refereed, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, INFLUENCE OF EXERCISE INTENSITY AND PLASMA-VOLUME ON ACTIVE CUTANEOUS VASODILATION IN HUMANS, GW MACK; H NOSE; A TAKAMATA; T OKUNO; T MORIMOTO, Feb. 1994, 26, 2, 209, 216, Scientific journal
  • Not Refereed, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, RIGHT ATRIAL PRESSURE AND FOREARM BLOOD-FLOW DURING PROLONGED EXERCISE IN A HOT ENVIRONMENT, H NOSE; A TAKAMATA; GW MACK; Y ODA; T KAWABATA; S HASHIMOTO; M HIROSE; E CHIHARA; T MORIMOTO, Feb. 1994, 426, 3-4, 177, 182, Scientific journal
  • Not Refereed, JOURNAL OF APPLIED PHYSIOLOGY, MEASUREMENT OF PLASMA-VOLUME IN RATS WITH USE OF FLUORESCENT-LABELED ALBUMIN MOLECULES, CM GILLEN; A TAKAMATA; GW MACK; ER NADEL, Jan. 1994, 76, 1, 485, 489
  • Not Refereed, JAPANESE JOURNAL OF PHYSIOLOGY, EFFECT OF VAGOTOMY ON CARDIOVASCULAR ADJUSTMENT TO HYPERTHERMIA IN RATS, A TAKAMATA, 1992, 42, 4, 641, 652, Scientific journal, 10.2170/jjphysiol.42.641
    DOI URL
  • Not Refereed, 1992, 101, 625, 633
  • Not Refereed, JOURNAL OF APPLIED PHYSIOLOGY, WATER AND ELECTROLYTE BALANCE IN THE VASCULAR SPACE DURING GRADED-EXERCISE IN HUMANS, H NOSE; A TAKAMATA; GW MACK; Y ODA; T OKUNO; DH KANG; T MORIMOTO, Jun. 1991, 70, 6, 2757, 2762, Scientific journal
  • Refereed, Journal of Applied Physiology, Water and electrolyte balance in the vascular space during graded exercise in humans, H. Nose; A. Takamata; G. W. Mack; Y. Oda; T. Okuno; D. H. Kang; T. Morimoto, 1991, 70, 6, 2757, 2762, Scientific journal
  • Not Refereed, JOURNAL OF APPLIED PHYSIOLOGY, CONTROL OF TOTAL PERIPHERAL RESISTANCE DURING HYPERTHERMIA IN RATS, A TAKAMATA; H NOSE; GW MACK; T MORIMOTO, Sep. 1990, 69, 3, 1087, 1092, Scientific journal
  • Refereed, Journal of Applied Physiology, Control of total peripheral resistance during hyperthermia in rats, A. Takamata; H. Nose; G. W. Mack; T. Morimoto, 1990, 69, 3, 1087, 1092, Scientific journal
  • Not Refereed, 1988, 7, 85, 93
  • Not Refereed, Eiyo To Shokuryo, Japan Society of Nutrition and Food Science, Role of contents in stomach to the circadian variation of plasma ethanol concentration in the rat., TACHIYASHIKI Kaoru; IMAIZUMI Kazuhiko; TODA Noriko; TAKAMATA Akira; UESUGI Kuniko; OGITA Zen-Ichi, To investigate the mechanism responsible for the circadian variation of elimination processes of ethanol (EtOH), EtOH (100mg/100g B.W.) was orally administered to female Sprague-Dawley rats at 8: 00 and 20: 00 under non-fasting conditions, and EtOH concentration in plasma prepared from tail venous blood was determined with gaschromatograph at constant intervals. The intakes of feed and water 12 hours before oral administration of EtOH were also measured to elucidate the relationship between feed intake or water intake and each parameter obtained from the time course of plasma EtOH concentration (p [EtOH]). Immediately after EtOH was disappeared in Plasma, the rats were decapitated. Concentration of EtOH in stomach and the content in stomach for each rat were measured, and specific activity of alcohol dehydrogenase (ADH) in liver was determined spectrophotometrically at 37°C and pH 9. Solid feed and water were given to rats ad libitum during the light period (8: 00-20: 00) and the dark period (20: 00-8: 00). The feed intakes from 20: 00 to 8: 00 and from 8: 00 to 20: 00 were 5.7±1.6mg·g-1 B.W. ·hr-1 and 1.6±0.7mg·g-1 B.W. ·hr-1, respectively. The former was bigger than the latter. The water intake during the dark period was 2.2 times bigger than that during the light period. Therefore, the feed and water intakes during the dark period were higher than those during the light period. The max. p [EtOH] (A), the time to reach max. p [EtOH] (B), the time of pEtOH disappearance (C) and integration value of pEtOH (D) obtained from the dark period were 2.0, 1.5, 1.6 and 3.2 times bigger than those obtained from the light period, respectively. This means that there is the diurnal rhythm of the time course of p [EtOH]. Liver ADH activity showed nonsignificant change between the light period and the dark period. The remaining rates of EtOH in the stomach (= (Content of EtOH in stomach/total content of EtOH administered) ×100) were 25.8±10.7% for the light period, and 0.3±0.4% for the dark period, the former was 86 times higher than the latter. Therefore, A, B, C and D showed the diurnal variation under the non-fasting conditions. However, apparent decay rate constant (k) of EtOH showed no diurnal variation in both groups. There was bigh negative correlation (γ≅ -0.8) between each parameter (A, B, C and D) except k value and the remaining rate of EtOH in stomach. From these results, it is likely that the diurnal rhythm of p [EtOH] under non-fasting conditions is controlled by the remaining rate of EtOH in stomach and independent of the change of liver ADH activity., 1987, 40, 1, 35, 42, 10.4327/jsnfs.40.35
    DOI URL
  • Not Refereed, 1987, 6, 66, 74
  • Not Refereed, 1986, 5, 242, 250

MISC

  • Not Refereed, FASEB JOURNAL, Estradiol-modification of Blood Pressure Regulatory Response to Systemic and Central Angiotensin II Administration in Rats, Akira Takamata; Natsumi Omura; Yuri Nishimura; Ayako Igarashi; Keiko Morimoto, Apr. 2015, 29, Summary international conference
  • Not Refereed, FASEB JOURNAL, Estradiol Replacement Attenuates Central Body Fluid Regulatory Responses to Hyperosmolality and Central Angiotensin II in Ovariectomized Rats, Natsumi Omura; Yuri Nishimura; Ayako Igarashi; Akira Takamata, Apr. 2015, 29, Summary international conference
  • Not Refereed, FASEB JOURNAL, Effect of Estradiol Replacement on Diurnal Sleep/Wake Pattern in Ovariectomized Rats Measured with a Subcutaneously Implanted Acceleration Sensor, Ayako Igarashi; Natsumi Omura; Megumi Miura; Nanako Mima; Yuri Nishimura; Kaori Mabuchi; Akira Takamata, Apr. 2015, 29, Summary international conference
  • Not Refereed, FASEB JOURNAL, The effects of menstrual phase on brachial artery endothelial function after mental stress in young women, Xin Chen; Kyoko Ueshima; Mika Omokute; Akira Takamata; Keiko Morimoto, Apr. 2015, 29, Summary international conference
  • Not Refereed, FASEB JOURNAL, Estradiol replacement attenuates stress-induced pressor response by regulating renin-angiotensin system in ovariectomized rats, Yu Nagatomo; Shoko Tazumi; Risa Itoh; Misa Yoshimoto; Akira Takamata; Keiko Morimoto, Apr. 2015, 29, Summary international conference
  • Not Refereed, FASEB JOURNAL, Serotonin is possibly involved in the anorexigenic and antidepressant effects of estrogen in ovariectomized rats, Yuri Nishimura; Kaori Mabuchi; Hiroko Negishi; Keiko Morimoto; Akira Takamata, Apr. 2013, 27, Summary international conference
  • Not Refereed, FASEB JOURNAL, Orchiectomy increases food intake and perifornical orexin A neuron's activity during glucoprivation, Akira Takamata; Kana Miyake; Kaori Mabuchi; Keiko Morimoto, Apr. 2013, 27, Summary international conference
  • Not Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, Removal of photic stimulation impairs estrogen-induced anorexia in rats, Kaori Mabuchi; Azusa Takano; Yayoi Hara; Keiko Morimoto; Akira Takamata, 2013, 63, S255, S255, Summary international conference
  • Not Refereed, FASEB JOURNAL, Orexigenic and obesity effects of estrogen deficiency can be attenuated by half-day food deprivation either during the light phase or the dark phase, Sayumi Taguchi; Kaori Mabuchi; Azusa Takano; Yayoi Hara; Keiko Morimoto; Akira Takamata, Apr. 2012, 26, Summary international conference
  • Not Refereed, FASEB JOURNAL, Involvement of orexin A and melanin concentrating hormone neurons of the lateral hypothalamic area in the food intake response to reduced glucose availability, Akira Takamata; Sayumi Taguchi; Saori Ikeda; Eri Aida; Keiko Morimoto, Apr. 2012, 26, Summary international conference
  • Not Refereed, EUROPEAN JOURNAL OF ANAESTHESIOLOGY, Effect of central angiotensin II receptor antagonist and endogenous vasopressin on blood pressure regulation during normotension endotoxemia in rats, F. Shimizu; T. Kasai; S. Inoue; A. Takamata, Jun. 2010, 27, 1, 171, 171, Summary international conference
  • Not Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, Estrogen attenuates food intake and hypothalamic c-Fos expression in response to reduced glucose availability during light phase, Akira Takamata; Kana Miyake; Kotomi Ueda; Mami Miyake; Megumu Hasegawa; Yuko Nakamura; Yoko Fujita; Keiko Morimoto, 2010, 60, S181, S181, Summary international conference
  • Not Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, Roles of oxidative stress on the reduction of forearm blood flow induced by mental stress in postmenopausal women, Keoko Morimoto; Kozue Ohyama; Mai Motohiro; Shigenobu Yano; Akira Takamata, 2010, 60, S58, S58, Summary international conference
  • Not Refereed, FASEB JOURNAL, Role of light in the estrogen deficiency-induced changes in diurnal SCN neural activity and food intake, Kana Miyake; Keiko Morimoto; Akira Takamata, Apr. 2009, 23, Summary international conference
  • Not Refereed, FASEB JOURNAL, Estrogen attenuates food intake and perifornical orexinergic neuron's activity during glucoprivation in ovariectomized rats, Akira Takamata; Kana Miyake; Keiko Morimoto, Apr. 2009, 23, Summary international conference
  • Not Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, EFFECTS OF ESTROGEN REPLACEMENT ON OXIDATIVE STRESS IN VASCULATURE RELATED TO PSYCHOLOGICAL STRESS IN OVARIECTOMIZED RATS, Ai Ikehata; Mizuho Kawakami; Sumire Ohkawa; Asumi Yoshida; Masami Uji; Akira Takamata; Ken-ichi Yoshida; Keiko Morimoto, 2009, 59, 497, 497, Summary international conference
  • Not Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, EFFECTS OF ESTROGEN ON STRESS-INDUCED ACTIVATION OF NITRIC OXIDE PRODUCING NEURONS IN PARAVENTRICULAR HYPOTHALAMIC NUCLEUS OF RATS, Yurina Omuro; Tomoko Hata; Yasuko Hara; Akira Takamata; Takashi Ueyama; Keiko Morimoto, 2009, 59, 333, 333, Summary international conference
  • Not Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, ESTROGEN DEFICIENCY MODIFIES DIURNAL RHYTHMS OF SCN ACTIVITY AND BEHAVIORS BY CHANGING THE RESPONSE TO LIGHT, Kana Miyake; Yuka Kobayashi; Keiko Morimoto; Akira Takamata, 2009, 59, 333, 333, Summary international conference
  • Not Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, PEAK OXYGEN UPTAKE DOES NOT CORRELATE WITH BLOOD VOLUME IN PERSONS WITH CERVICAL SPINAL CORD INJURY, Tomoyuki Ito; Yukiharu Higuchi; Yumi Koike; Kazunobu Okazaki; Sumiko Shiba; Takahiro Miyake; Hiroyasu Uenishi; Akira Takamata; Hiromitsu Kimura; Fumihiro Tajima, 2009, 59, 455, 455, Summary international conference
  • Not Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, ESTROGEN ATTENUATES RESPONSES OF FOOD INTAKE AND PERIFORNICAL OREXINERGIC NEURON'S ACTIVITY TO GLUCOPRIVATION, Akira Takamata; Kana Miyake; Yoko Fujita; Yuko Nakamura; Yuka Kobayashi; Keiko Morimoto, 2009, 59, 458, 458, Summary international conference
  • 01 Dec. 2006, 55, 6, 658, 658
  • Not Refereed, FASEB JOURNAL, Effect of estrogen on stress-induced c-Fos expression in catecholaminergic neurons of ovariectomized rat brain, Y Hara; M Matuoka; T Kouno; A Takamata; T Ueyama; K Morimoto, Mar. 2006, 20, 4, A355, A355, Summary international conference
  • 2006, 22nd
  • 01 Dec. 2005, 54, 6, 496, 496
  • 01 Dec. 2005, 54, 6, 496, 496
  • 01 Dec. 2005, 54, 6, 512, 512
  • Not Refereed, FASEB JOURNAL, Effect of estrogen replacement on food intake and hypothalamic c-Fos expression in ovariectomized rats, A Takamata; Y Saito; R Kobayashi; K Torii; K Morimoto, Mar. 2005, 19, 5, A1647, A1647, Summary international conference
  • Not Refereed, FASEB JOURNAL, Effect of estrogen replacement on water intake and hypothalamic c-Fos expression induced by plasma hyperosmolality or central angiotensin II in ovariectomized rats, K Torii; Y Kitamura; K Morimoto; A Takamata, Mar. 2005, 19, 5, A1647, A1648, Summary international conference
  • Not Refereed, 2005, 24, 95, 102
  • 01 Dec. 2004, 53, 6, 736, 736
  • Not Refereed, FASEB JOURNAL, Cardiovascular and ventilatory responses during and after exercise in persons with cervical spinal cord injuries, T Ito; Y Higuchi; H Banno; T Mizushima; A Takamata; H Kimura; F Tajima, Mar. 2003, 17, 5, A941, A941, Summary international conference
  • Dec. 2002, 51, 6, 602, 602
  • Human sciences research, Kobe University, Interrelationship between osmoregulation and thermoregulation : Effect of physical training, heat acclimation and aging(Project of Environment Study for Supporting Development of Aged People(3)), Takamata Akira, Nov. 2002, 10, 1, 141, 158
  • 01 Dec. 2001, 50, 6, 802, 802
  • 01 Dec. 2000, 49, 6, 741, 741
  • 01 Dec. 2000, 49, 6, 749, 749
  • Not Refereed, FASEB JOURNAL, Relationship between osmotic inhibition of thermoregulatory responses and sweat sodium concentration., A Takamata; T Yoshida; T Morimoto, Mar. 2000, 14, 4, A321, A321, Summary international conference
  • 29 Jan. 1999, 35, 3, S69
  • 01 Dec. 1998, 47, 6, 881, 881
  • Not Refereed, ANESTHESIOLOGY, Cardiopulmonary baroreceptor modulation of perioperative hypothermia, Y Nakajima; T Mizobe; K Hayashi; Y Kitamura; K Shigemi; A Takamata; Y Tanaka, Sep. 1998, 89, 3A, U296, U296, Summary international conference
  • Jul. 1998, 9, 118, 118
  • Not Refereed, FASEB JOURNAL, Effect of heat acclimation on body fluid regulation in older subjects., A Takamata; T Ito; K Yaegashi; H Takamiya; Y Maegawa; T Itoh; T Morimoto; JE Greenleaf, Mar. 1998, 12, 4, A125, A125, Summary international conference
  • Not Refereed, 1998, 19, 19, 116, 123
  • 01 Dec. 1997, 46, 6, 914, 914
  • Not Refereed, 宇宙利用シンポジウム, The Modification of Venous Return by Continuous Negative Pressure Breathing and its Effect on Skin Blood Flow., 森本武利; 永島計; 能勢博; 鷹股亮, Sep. 1996, 13th, 55, 58
    URL
  • Not Refereed, 長崎大学熱帯医学研究所共同研究報告集, Central venous pressure and thermoregulatory reaction. (Nagasaki Univ., Inst. for Tropical Medicine S), 永島計; 能勢博; 鷹股亮; 森本武利, 30 Jun. 1996, 1995, 136
    URL
  • Not Refereed, FASEB JOURNAL, Effect of plasma osmolality on thermoregulatory responses to passive heating in humans, A Takamata; K Nagashima; H Nose; T Morimoto, Mar. 1996, 10, 3, 681, 681, Summary international conference
  • Not Refereed, 1996, 4, 109, 122
  • 01 Dec. 1995, 44, 6, 732, 732
  • Not Refereed, FASEB JOURNAL, BODY-TEMPERATURE INFLUENCE ON OSMOTICALLY INDUCED VASOPRESSIN SECRETION IN HUMANS, GW MACK; A TAKAMATA; NS STACHENFELD; ER NADEL, Mar. 1995, 9, 4, A632, A632, Summary international conference
  • Not Refereed, FASEB JOURNAL, ACUTE RECOVERY OF OSMOTICALLY INHIBITED SWEATING IN HUMANS BY DRINKING, A TAKAMATA; GW MACK; CM GILLEN; AC JOZSI; ER NADEL, Mar. 1994, 8, 4, A65, A65, Summary international conference
  • Not Refereed, FASEB JOURNAL, FLUID REGULATION DURING EXTREME CELL DEHYDRATION IN OLDER ADULTS, N STACHENFELD; G MACK; A TAKAMATA; L DIPIETRO; E NADEL, Mar. 1994, 8, 5, A588, A588, Summary international conference
  • Not Refereed, FASEB JOURNAL, BIPHASIC THIRST RESPONSE IN HUMANS FOLLOWING THERMAL EXERCISE SWEATING WITHOUT SODIUM REPLENISHMENT, A TAKAMATA; GW MACK; CM GILLEN; ER NADEL, Feb. 1993, 7, 3, A444, A444, Summary international conference
  • Not Refereed, FASEB JOURNAL, MEASUREMENT OF PLASMA-VOLUME IN RATS USING FLUORESCENT-LABELED ALBUMIN MOLECULES, CM GILLEN; A TAKAMATA; GW MACK; ER NADEL, Feb. 1993, 7, 3, A444, A444, Summary international conference
  • Not Refereed, FASEB JOURNAL, CHANGE IN RIGHT ATRIAL PRESSURE DURING EXERCISE AND THE EFFECT ON THERMAL AND CIRCULATORY REGULATIONS, H NOSE; A TAKAMATA; G MACK; Y ODA; S HASHIMOTO; M HIROSE; E CHIHARA; T MORIMOTO, Mar. 1991, 5, 5, A1400, A1400, Summary international conference
  • Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, TEMPERATURE DEPENCE OF SWIMMING EXERCISE-INDUCED CHANGES IN ETHANOL METABOLISM AND THERMOREGULATORY RESPONSES IN RATS, TAKAMATA Akira; TACHIYASHIKI Kaoru; IMAIZUMI Kazuhiko, 01 Dec. 1990, 39, 6, 804, 804
  • Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, Water and electrolyte balance in the vascular space during graded exercise in humans, NOSE HIROSHI; TAKAMATA AKIRA; Gary W Mack; ODA YSHINOBU; OKUNO TADASHI; KANG DUK-HO; MORIMOTO TAKETOSHI, 01 Dec. 1990, 39, 6, 792, 792
  • Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, Role of central venous pressure on circulatory adjustment to hyperthermia, Takamata Akira; Nose Hiroshi; Morimoto Taketoshi, 01 Dec. 1989, 38, 6, 305, 305

Books etc

  • Apr. 2021
  • Jan. 2020, ix, 179p, 9784065166352
    CiNii Books URL
  • 2015, Not Refereed
  • 2010, Not Refereed
  • 2010, Not Refereed
  • 2010, Not Refereed
  • 2009, Not Refereed
  • 2007, Not Refereed
  • Environmental Physiology, 2007, Not Refereed
  • 2005, Not Refereed
  • 2005, Not Refereed
  • 2002, Not Refereed
  • 2002, Not Refereed
  • 2001, Not Refereed
  • 2001, Not Refereed
  • 2001, Not Refereed
  • Merits of diluted sweat with training on arterial pressure and body temperature regulation in heat stress. In: Thermotherapy for Neoplasia, Inflammation, and Pain., Springer-Verlag, Tokyo, 2001, Not Refereed
  • 2000, Not Refereed
  • Interrelationship between osmoregulation and thermoregulation in a hot engvironment and during exercise. In: Exercise, Nutrition, and Environmental Stress., Cooper Publishing Group, LLC, Camel, IN, 2000, Not Refereed
  • 1999, Not Refereed
  • 1998, Not Refereed
  • 1998, Not Refereed
  • 1998, Not Refereed
  • 1998, Not Refereed
  • Body fluid osmolality, blood volume and thermoregulation. In: The 1997 Nagano Symposium on Sports Sciences., Cooper Publishing Group, LLC, Carmel, IN, 1998, Not Refereed
  • The role of plasma osmolality in exercise-induced inhibition of cutaneous vasodilation. In: The 1997 Nagano Symposium on Sports Sciences., Cooper Publishing Group, LLC, Carmel, IN, 1998, Not Refereed
  • Effects of hypovolemia and hyperosmolality on cardiovascular responses to heat in awake rats.. In: The 1997 Nagano Symposium on Sports Sciences., Cooper Publishing Group, LLC, Carmel, IN, 1998, Not Refereed
  • Near infrared spectrophotometric monitoring of rhythmic fluctuation in oxygenated hemoglobin and myoglobin during muscular exercise. In: The 1997 Nagano Symposium on Sports Sciences., Cooper Publishing Group, LLC, Carmel, IN, 1998, Not Refereed
  • 1997, Not Refereed
  • Osmotic inhibition of thermally induced cutatneous vasodilation in humans and its role in the inhibition of cutaneous vasodilation during exercise. In: Thermal Physiology 1997. Proceedings of the International Symposium on Thermal Physiology., The August Krogh Institute, Copenhagen, 1997, Not Refereed
  • 1996, Not Refereed
  • 1996, Not Refereed
  • Central venous pressure and cardiovascular responses to hyperthermia. In Temperature Regulation: Advances in Pharmacological Sciences, Birk-hauser Verlag, Basel, 1996, Not Refereed
  • Cardiovascular response to exercise in a hot environment. In Physiological Basis of Occupational Health: Stressful Environment. Progress in Biometeorology vol. 11., SPB Academic Publishing bv, Amsterdam, The Netherlands, 1996, Not Refereed
  • 1994, Not Refereed
  • Central venous pressure and cardiovascular responses to hyperthermia. In Temperature Regulation: Advances in Pharmacological Sciences, Birk-hauser Verlag, Basel, 1994, Not Refereed
  • 1993, Not Refereed
  • Thirst, Exercise and Thermoregulation: Interrelationships. In Perspective in Exercise Science and Sports Medicine Volume 6, Exercise, Heat and Thermoregulation, Benchmark Press, Carmel, IN, 1993, Not Refereed
  • 1992, Not Refereed
  • Effect of heat load on body fluid and circulation. In: Hyperthermic Oncology in Japan '91, Shinohara, 1992, Not Refereed
  • 9784764412194

Presentations

  • Others, 17 Mar. 2025 - 19 Mar. 2025
  • Oral presentation, 24 May 2024 - 26 May 2024
  • Poster presentation, 28 Mar. 2024 - 30 Mar. 2024
  • Poster presentation, 28 Mar. 2024 - 30 Mar. 2024
  • Poster presentation, 28 Mar. 2024 - 30 Mar. 2024
  • Oral presentation, 17 Nov. 2023 - 19 Nov. 2023
  • Poster presentation, 12 May 2023 - 14 May 2023
  • Poster presentation, 14 Mar. 2023 - 16 Mar. 2023
  • Oral presentation, 11 Nov. 2022 - 13 Nov. 2022
  • Oral presentation, 11 Nov. 2022 - 13 Nov. 2022
  • Oral presentation, 28 Nov. 2020 - 29 Nov. 2020
  • Nominated symposium, 28 Nov. 2020 - Dec. 2201

Works

  • 2005 - 2005
  • 2004 - 2004
  • 2003 - 2003
  • Feb. 2002 - Mar. 2002
  • 2002 - 2002
  • 2001 - 2001

Awards

  • 1999, Japan

Research Projects

  • Grant-in-Aid for Scientific Research (C), 01 Apr. 2024 - 31 Mar. 2027, 24K14650, Effect of sex difference and sex hormone on hedonic and homeostatic regulation of ingestive behavior, 鷹股 亮; 森本 恵子, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Nara Women's University, 4550000, 3500000, 1050000, kaken
    対象リソースIRI
  • 基盤研究(C), 01 Apr. 2021 - 31 Mar. 2025, 21K10650, 女性看護師における手の冷たさのメカニズム解明と交感神経活動に着目した改善策の開発, 鈴木 みゆき; 鷹股 亮; 土田 敏恵; 徳重 あつ子; 伊部 亜希, 日本学術振興会, 科学研究費助成事業, 兵庫医療大学, 4030000, 3100000, 930000, 本研究は、３つのステップから構成している。ステップ１は、病院での観察研究、ステップ２は、人工気象室での実験研究、ステップ３は、手の冷たさの改善策の開発と予備研究である。手の冷たさに関するテーマであり、季節の影響について考慮が必要なため、いずれも冬季に限定して実施予定である。
    2021年度は、本来病院での観察研究を実施予定であったが、冬季に新型コロナウイルス感染症の流行期と重複し、病院でのデータ収集を見合わせた。そのため、ステップ1を2022年度に実施する予定に変更し、2021年度は、測定機器の選定、デモ機器を用いた動作の確認、測定方法の検討を行うなど、次年度に向けた研究計画の洗練化に努めた。
    洗練化した実施計画の概要としては、研究協力病院において、冷えの有無に関わらず、実際の就労中の女性看護師を対象とし、2022年12月-2023年2月に調査を実施する予定である。データは、属性について、手の冷たさについて、交感神経活動について、主観について収集する予定で、それらについての具体的な研究計画案、デモ機器を用いた測定方法案を見直した。2021年度に立案した内容に基づいて、2022年度はデータ収集を行う予定である。, kaken
    対象リソースIRI
  • 基盤研究(C), 01 Apr. 2021 - 31 Mar. 2024, 21K11723, 口腔内脂肪酸感受性による“舌－脳－腸軸”を介した脂肪摂食調節機構の解明, 森本 恵子; 鷹股 亮; 中木 直子, 日本学術振興会, 科学研究費助成事業, 京都光華女子大学, 4160000, 3200000, 960000, 近年の味蕾味細胞における脂肪酸受容体の発見は、舌における食事由来の脂肪酸感受性は脂質摂取量を調節する因子である可能性を示した。しかし、舌（口腔内）脂肪酸感受性が脂質摂取量にどのようなメカニズムで、どのような影響を与えるのかは未解明である。
    (1)2021年度のヒトを対象とした研究では、食事中に脂肪酸感受性が変化する可能性、その変化が食事全体の脂質摂取量と関連がある可能性について検討を加えた。実験では、健康な若年男女大学生（11-13名）を対象とし、オリーブオイル、スクロースによる舌刺激を行い、その後のオレイン酸感受性の変化を測定した。その結果、男性では、コントロールと比較して、舌の脂肪・スクロース刺激後にオレイン酸閾値の有意な上昇が見られた。女性（月経期）においてもオレイン酸閾値は脂肪刺激後に上昇する傾向が観察された。なお、舌刺激前後のオレイン酸閾値に有意な性差は見られなかった。一方、男性では舌脂肪刺激後のオレイン酸閾値と自由選択摂食によるエネルギー摂取量との間には、正の相関関係が認められた。
    (2)ウィスター系雌性ラットを使用した動物実験では、卵巣摘出後に高脂肪食(HFD)を与え、HFD誘発性肥満モデルを作成した。このモデルを用いて脂肪乳剤による口腔内・胃内刺激実験を実施し、口腔内、胃内への脂肪乳剤投与後のHFD摂食量の経時変化を測定するとともに、血漿消化管ペプチド濃度の変化を測定した。血漿グルカゴン様ペプチド-1、コレシストキニン濃度は脂肪乳剤の口腔内および胃内投与後に肥満モデルでははっきりした変化が見られなかったが、エストラジオール（E2）補充を行った群では、これら消化管ペプチドの血漿濃度が上昇した。以上より、卵巣摘出・HFD誘発性肥満モデルでは口腔・胃内の脂肪センシングから消化管ぺプチド分泌に至る経路の障害が存在する可能性が示唆された。, kaken
    対象リソースIRI
  • 基盤研究(C), 01 Apr. 2020 - 31 Mar. 2023, 20K11604, エストロゲンによる快楽性糖摂取行動促進作用のメカニズムと恒常性摂食調節との連関, 鷹股 亮; 森本 恵子, 日本学術振興会, 科学研究費助成事業 基盤研究(C), 奈良女子大学, 4290000, 3300000, 990000, 本年度は、エストロゲンの恒常性と快楽性エネルギー摂取調節に及ぼす相互作用について明らかにするため、エストロゲンによるスクロース摂取亢進のメカニズムにおける血漿グルコースレベルの影響を亮にする実験を行った。すなわち血漿グルコースレベルが10%スクロース摂取量に及ぼす影響に対するエストロゲンの作用を検討した。
    雌ラットの卵巣摘出し、エストロゲンを補充したエストロゲン補充群と補充しないエストロゲン欠乏群を対象として、静脈内グルコース注入により血漿グルコースレベルを上昇させた条件と2-Deoxy-D-glucose（2DG）を投与してグルコース利用を低下させた条件で10%スクロース溶液の摂取量を測定し、両群で比較した。その結果、エストロゲン補充群では10%スクロース摂取量は血漿グルコース濃度の上昇により有意に減少し、血漿グルコース利用低下により有意に減少したが、エストロゲン欠乏群では有意な差が認められなかった。したがって、エストロゲンは血漿グルコース濃度の変化に対する感度を上昇させ、恒常性のエネルギー摂取調節メカニズムを介してスクロース摂取量を調節したと考えられる。また、本研究室のこれまでの研究より2DG投与後の餌の摂取量はエストロゲンにより抑制されることを示して来たが、２DG投与後のスクロース溶液を介したエネルギー摂取量にエストロゲンの影響は見られなかった。これは、エストロゲンはすクロースからのエネルギー摂取を増加させることを示す結果であり、エネルギー欠乏時にエストロゲンは嗜好性の高い甘味に対して摂取量を増加させる作用があることを示した。さらに、免疫組織化学的c-Fos発現の検討より、エストロゲンによる甘味摂取量亢進における恒常性調節と快楽性調節の相互作用に視床下部外側野のオレキシンニューロン、扁桃体中心核の活動が関与していることが示唆された。, kaken
    対象リソースIRI
  • 基盤研究(C), 01 Apr. 2018 - 31 Mar. 2021, 18K10991, 女性のライフステージによる女性ホルモン変動が脂質嗜好性に及ぼす影響とその作用機序, 森本 恵子; 鷹股 亮; 内田 有希, 日本学術振興会, 科学研究費助成事業 基盤研究(C), 奈良女子大学, 4290000, 3300000, 990000, 2019年度は、若年女性9名と若年男性11名を対象として、口腔内脂肪酸感受性・脂質嗜好性・脂質摂取量を測定し、唾液の口腔由来細胞の脂肪酸受容体mRNA発現について検討した。2018年度と2019年度を合わせた若年女性20名と男性24名の測定結果について、性差や女性の月経周期性変化を評価した。一方、動物実験では、雌性ラットにおけるエストラジオ―ル（E2）の脂質摂取量への作用だけでなく、プロゲステロン（Pro）の作用およびE2とProの併用が脂質摂取量に与える影響についても検討を加えた。また、慢性の社会的心理ストレス（chronic psychosocial stress：CPS）下での雌性ラットの摂食及び体重変化にE2が影響を与える可能性について検討を開始した。
    （1）口腔内オレイン酸感受性に性差はないことが確認された。また、若年女性では排卵前期にオレイン酸感受性が高いという月経周期依存性変化があることが判明した。一方、脂肪嗜好性には月経周期性変化は見られず、オレイン酸感受性との間にも明確な関連は認められなかった。しかし、舌への脂肪刺激後にはオレイン酸感受性と脂肪嗜好性との間に相関関係が見られた。なお、血漿エストロゲン・プロゲステロン濃度と脂肪嗜好性との関には相関関係は認められなかった。
    （2）閉経モデルである卵巣摘出（OVX）ラットへのPro補充は経時的な高脂肪食摂取量や体重増加量に影響を与えなかった。一方、絶食後の高脂肪食摂取量はE2補充群では抑制されたが、Pro補充群やE2・Pro併用補充群では抑制されなかった。したがって、Proは長期の摂食調節には関与しないものの、短期的にはE2の摂食抑制作用を阻害する可能性が示唆された。また、OVXラットにおけるCPS下のエネルギー摂取量および体重増加量の減少をE2補充は抑制するとの結果を得た。, kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (B), 01 Apr. 2016 - 31 Mar. 2020, 16H03026, Mechanism for the environmental light-induced, Takamata Akira, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Nara Women's University, 17420000, 13400000, 4020000, Estrogen deficiency induced hyperphagia/obesity and increased depression-like behavior, which is possibly cause by the attenuated photosensitivity, and consequently the diminished biological rhythm regulation. At least some of these symptoms were reversed by exposure to high-intensity light during the light phase or adjusting diurnal feeding patterns in estrogen-deficiency rats.
    In addition, it has been shown that hyperphagia/obesity and increased depression-like behavior due to estrogen deficiency may be cased by a declined serotonergic function, and the antidepressant fluoxetine may improve these health disorders., url
    対象リソースIRI
  • Grant-in-Aid for Challenging Exploratory Research, 01 Apr. 2015 - 31 Mar. 2017, 15K12355, Development of countermeasure against postmenopausal hyperphagia and obesity by controlling light environment and feeding rhythm pattern., Takamata Akira, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Nara Women's University, 3640000, 2800000, 840000, Hyperphagia and obesity induced by estrogen (E2) deficiency accompanies disorder of circadian feeding rhythm. We have shown that E2 regulates food intake in light dependent manner. In this study, we investigated whether E2 deficiency-induced hyperphagia and obesity can be attenuated by adjusting light environment and feeding rhythm.
    We found that E2 deficiency could weaken light-induced suppression of feeding and obesity. In addition, high intensity light stimulus suppressed food intake and body weight gain even in the E2 deficient state. We also found that forced feeding rhythm formation attenuated hyperphagia and obesity even in the E2 deficient state. Thus, appropriate lifestyle considering the light environment and feeding rhythm could be a countermeasure against postmenopausal hyperphagia and obesity., url
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (C), 01 Apr. 2014 - 31 Mar. 2017, 26350118, Study of functional foods as incretin effects for metabolic syndrome, Negishi Hiroko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Mukogawa Women's University, 4810000, 3700000, 1110000, SHRSP.Z-Lepr fa /IzmDmcr rats (SPZF) show hypertension, hyperphagia, obesity, dyslipidemia, and insulin resistance. Many reports have suggested that glucagon-like peptide-1 (GLP-1) and dipeptidyl peptidase-4 (DPP-4) affect various organs. We observed the expression of GLP-1 and DPP-4 in SPZF rats.In this study, we have shown the effects of incretin may relate to the phenotype in metabolic syndrome status in SPZF.
    There are many reports that natural products have numerous health benefits, including protection against cardiovascular disease. Treatment with sake lees significantly increased the GLP-1 receptor expression than in control. Serum active GLP-1 level in peptide fraction of sake lees group was significantly increased than in control. Sake lees attenuated the development of renal damage through GLP-1 and antioxidant activities in SHRSP.
    Further studies are needed in order to clarify the effects of the fuctional foods through the incretin, url
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (C), 01 Apr. 2012 - 31 Mar. 2015, 24500975, Involvement of circadian feeding rhythm regulation in the mechanism for estrogen-induced hypophagia, TAKAMATA AKIRA, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Nara Women's University, 5200000, 4000000, 1200000, Estrogen attenuates food intake and enhances c-Fos expression in the suprachiasmatic nucleus specifically during the light phase. In the present study, we found that light exposure during the light phase is required to elicit an anorectic effect of estrogen. We also found that estrogen attenuates food intake and orexin A neuron’s responses to reduced glucose availability, which was possibly mediated by serotonergic neurons. Thus, estrogen enhances serotonergic neurons response to light, and the serotonergic neurons attenuate orexin-A neuron’s activity, which is, at least in part, a mechanism for the estrogen-induced hypophagia., url
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  • Grant-in-Aid for Scientific Research (B), 01 Apr. 2011 - 31 Mar. 2014, 23300275, The suppressive effects of estrogen on stress-induced cardiovascular responses in female and complementary nutrients for postmenopausal women, MORIMOTO Keiko; KOJO Shosuke; TAKAMATA Akira; NEGISHI Hiroko; YOSHIDA Ken-ichi; YANO Shigenobu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Nara Women's University, 17940000, 13800000, 4140000, Menopause or mental stress is a risk factor for cardiovascular events. We examined the mechanisms accounting for suppressive effects of estrogen on stress-induced cardiovascular responses in ovariectomized (OVX) rats and complementary nutrients for postmenopausal women.
    In animal model, estrogen replacement attenuated pressor response to the cage-switch stress by suppressing the renin-angiotensin system in OVX rats. However, Kudzu root extracts had no effects on the stress-induced pressor responses in OVX rats.
    In human experiments, mental stress evoked by the Color Word Test induced the elevation in the vascular resistance of brachial artery in postmenopausal women compared with middle-aged premenopausal women. In addition, basal endothelial function was impaired in postmenopausal women compared with premenopausal women. However, the oral pretreatment of vitamin C restored these impairments in the postmenopausal women., url
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  • Grant-in-Aid for Scientific Research (C), 2008 - 2010, 20590230, Mechanisms of inhibitory effects of estrogens on psychological stress-induced pressor response via suppression of oxidative stress, MORIMOTO Keiko; TAKAMATA Akira; UEYAMA Takashi; KIMURA Hiroko; YOSHIDA KenーIchi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Nara Women's University, 4940000, 3800000, 1140000, The findings of experiments with volunteers or ovariectomized rats suggested that the menopause enhanced forearm vascular resistance to mental stress, and estrogen replacement attenuated pressor responses through its anti-oxidative activity., url
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  • Grant-in-Aid for Scientific Research (C), 2005 - 2006, 17590202, Mechanisms responsible for the attenuating effects of estrogen on cardiovascular responses to psychological stress in the central nervous system and the peripheral vessels, MORIMOTO Keiko; TAKAMATA Akira; UEYAMA Takashi; KIMURA Hiroko; YOSHIDA Ken-ichi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Nara Women's University, 3600000, 3600000, (1) Sex difference in norepinephrine surge in response to psychological stress through nitric oxide in rats
    A mild psychological stress induced by a cage-switch evoked a norepinephrine surge in the male, but not in the female rats. There was a sex difference in the norepinephrine surge in response to psychological stress through nitric oxide (NO), in association with pressor response.
    (2) Effects of estrogen on plasma catecholamine, NO metabolites (NOx) and 4-hydroxy-2-nonena1 during cage-switch stress
    Estrogen replacement tended to suppress plasma norepinephrine elevation induced by the stress in ovariectomized rat. Additionally, the NO synthase (NOS) inhibitor decreased this effect of estrogen. By Western blotting analysis, estrogen replacement enhanced basal endothelial NOS expression in mesenteries. Furthermore, estrogen replacement attenuated a basal level of plasma 4-hydroxy-2-nonenal, a marker for oxidative stress, and tended to enhance plasma NOx level.
    Our results suggest that estrogen attenuates the stress-induced pressor response by suppressing oxidative stress and enhancing NO bioavailability
    (3) Effects of estrogen replacement on neuronal activation induced by cage-switch stress in ovariectomized rat brain
    The stress-induced elevations in c-Fos expressions, a marker for neuronal activation, were detected in the following brain areas : lateral septal nucleus, paraventricular hypothalamic nucleus (PVN), dorsomedial hypothalamic nucleus (DMD), arcuate hypothalamic nucleus, paraventricular thalamic nucleus, and locus coeruleus (LC). Estrogen replacement suppressed stress-induced c-Fos expressions in PVN, DMD and LC. In addition, estrogen replacement enhanced the activation of NO-producing neurons in PVN. These findings suggest that estrogen replacement attenuates neuronal activation in these brain areas, at least partly by NO.
    These results suggest that estrogen replacement suppresses cardiovascular responses to psychological stress at least partly through its anti-oxidative effect on the periphery and through its inhibitory effect on neuronal activation in the brain of ovariectomized rats., kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (C), 2004 - 2005, 16590174, The central effect of estrogen on the regulation of food intake and osmoregulation., TAKAMATA Akira; MORIMOTO Keiko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Nara Women's University, 3700000, 3700000, 1.Effect of estrogen replacement on food intake behavior in ovariectomized rats.
    Seven-week-old rats were ovariectomized and were assigned into estradiol- (E2-T) and placebo-treated (Pla-T) groups. The daily food intake and increase in body weight in the E2-T group were significantly lower than the Pla-T group. Food intake during both light and dark phases in the Pla-T group was larger than the E2-T group, and the difference between the two groups was more prominent during light phase. The number of c-Fos ir cells in suprachiasmatic nucleus (SCN) in the Pla-T group was not different from the E2-T group at the beginning of dark phase, but was lower than the E2-T group at the beginning of light phase. The c-Fos expressing cell number at the arcuate nucleus (ARC) in E2-T rats was lower than Pla-T rats in both light and dark phases. The responses of feeding and c-Fos expression at ARC were not different between the two groups. These results suggest that 1)estrogen tonically inhibits ARC neuronal activity and feeding, 2)estrogen might play a role in the production of circadian SCN neuronal activity rhythm and attenuation of feeding during light phase, and 3)estrogen modulates spontaneous feeding but does not influence fasting-induced feeding response.
    2.Effect of estrogen replacement on osmoregulation in ovariectomized rats.
    To clarify the effect of estrogen on osmotically-induced water intake and its central mechanism, we examined the responses of water intake and hypothalamic neuronal activation (c-Fos expression) to plasma hyperosmolality and central angiotensin II (ANGII) administration. Ovariectomized rats were assigned into E2-T and Pla-T groups. Two weeks after the ovariectomy, rats were infused with hypertonic saline (1.5 M;0.33 ml/100g/BW ; i.v.). Access to water was provided 30-min after the infusion, and water intake was measured for 30 min. A few days later, we also examined c-Fos expression immunohistochemically. The same protocols were employed in other rats to examine the responses to central ANGII injection (5ng ; i.c.v.). E2-T rats drank significantly less amount of water than Pla-T rats in response to both hyperosmotic challenge and to central ANGII administration. The number of c-Fos ir cells in the OVLT in response to either osmotic or ANGII stimulations was not different between the E2- and Pla-T groups. The E2-T group showed lower number of c-Fos ir cells in the lateral part of the PVN after osmotic challenge compared to the Pla-T group. E2 treatment decreased AngII-induced c-Fos expression in the SFO and the SON as compared to Pla treatment. Thus, estrogen attenuates osmoregulatory water intake, and the site of this inhibitory action might be located on the pathway between the osmoreceptors and hypothalamic nuclei related to body fluid regulation. Central ANGII might be involved in the estrogen effect on osmoregulatory drinking., kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (C), 2003 - 2004, 15590208, The effect of estrogen on blood pressure regulation during psychological stress and its mechanism, MORIMOTO Keiko; TAKAMATA Akira; YOSHIDA Ken-ichi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Nara Women's University, 3600000, 3600000, We obtained the following results on the effect of estrogen on stress-induced pressor responses and its mechanism.
    (1)Estrogen attenuates pressor responses induced by psychological stresses through endothelial nitric oxide synthase(eNOS) overexpression in rats.
    Pressor response to the cage-switch stress tended to be suppressed in the female (F) group compared with the male (M) group in free moving rats using the telemetry system. Furthermore, these responses to the cage-switch and restraint stresses were attenuated significantly in the ovariectomized estrogen-treated (E) group compared with the placebo-treated (P) group. However, pretreatment of NOS inhibitor diminished the difference of the stress-induced pressor response between the P and E groups. Moreover, the expression of eNOS in the mesentery enhanced significantly in the E group compared with the M and P groups. These results suggest that estrogen attenuates psychological stress-induced pressor responses and the mesenteric eNOS overexpression could explain the mechanism for its effect in rats.
    (2)Pressor response to mental stress varies during menstrual cycle depending on plasma estradiol levels in women.
    The resting blood pressure(BP) was not different between the menstrual (M) and the pre-ovulatory (O) phases of menstrual cycle in young women(YW). The elevations of systolic BP(SBP) and diastolic BP(DBF) induced by the Color Word Test(CWT) were slightly, but not significantly attenuated in O-phase compared with M-phase. In addition, the resting plasma norepinephrine(NE) was higher in O-phase, and its CWT-induced elevation tended to be attenuated in O-phase. Furthermore, the resting DBF was higher in postmenopausal women(PM) than YW. The significant and immediate elevation of DBP during the CWT was greater in PM than in YW and continued until about 15 min of the recovery period. These findings suggest that estrogen may attenuate the DBP elevations induced by the mental stress in women., kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (C), 2002 - 2003, 14570064, Interactive effect of osmoregulatory and volume regulatory stimuli on thermoregulation., TAKAMATA Akira; MORIMOTO Keiko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Nara Women's University, 3500000, 3500000, To gain better insights into the interaction between fluid regulatory and thermoregulatory systems, we examined the effect of body fluid regulatory stimuli on thermoregulatory responses in human subjects.
    Upright posture reduced thermogenesis in response to body core cooling, compared with supine position. In contrast, upright posture enhanced peripheral vasoconstriction. Therefore, the thermoregulatory response to cold stress is influenced by volume regulatory system. The results also suggest that the mechanisms controlling peripheral vasoconstriction and thermogenesis during cold stress are appeared to be independent. We also examined the effect of plasma hyperosmolality on baroreceptor unloading-induced peripheral vasoconstriction. Plasma hyperosmolality augmented the reduction of forearm vascular conductance induced by lower body negative pressure during heat stress but not during normothermia. Therefore, there. apparently exists an interactive effect of plasma hyperosmolality and central hypovoloemia on the peripheral vascular response during heat stress, but not during normothermia. Our findings suggest that plasma hyperosmolality enhances baroreceptor-mediated reduction of thermal active peripheral vasodilation, but does not enhance the vasoconstrictor system.
    In a series of animal experiments, we examined the central mechanisms of the body fluid regulatory system. We quantified the permeability of capillaries in the subfornical organ of rat by a nuclear magnetic resonance method in combination with a venous injection of a relaxation reagent, Gd-DTPA^<2-> which could not pass through the blood-brain barrier (BBB). The proposed value may be 10-100 times larger than that of the blood-barrier in the cortex. We conclude that the capillaries in the SFO have one of the highest water permeability values among all of the capillaries in the brain, and this site may play an important role in osmoreception. In another animal experiment, we suggest that Mn^<2+> MRI is a useful technique for identifying in vivo the active brain region in the hypothalamus in response to various stimuli., kaken
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  • Grant-in-Aid for Scientific Research (C), 2002 - 2003, 14571683, Basic study of the effects of environmental conditions on tear dynamics using an environmental chamber, YOKOI Norihiko; TAKAMATA Akira, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Kyoto Prefectural University of Medicine, 3500000, 3500000, Tears on soft contact lens (SCL) are very thin and this is thought to serve as a model system for the evaluation of the effect of environment on tears. Using an artificial chamber and this model system, we tried to examine the effect of environment on tears by evaluating tear dynamics and the symptom of dryness in contact lens wearers, under different temperature and humidity conditions. The results were that the thin tear film on the SCL got thinner and more unstable at a lower temperature and a lower humidity, the effect being more prominent at a lower temperature. Moreover, this tendency was found to depend on the water content of SCL and increases in SCLs with a higher water content. Also, the tear film on SCL is affected by the wind ; an increase in wind velocity was found to make the tear film on SCL thinner and more unstable, resulting in the production of a dry symptom., kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (C), 2001 - 2002, 13670047, Water permeability of capillaries in the subfornical organ of rats determined by Gd-DTPA^<2-> enhanced ^1H magnetic resonance imaging, SEO Yoshiteru; MURAKAMI Masataka; TAKAMATA Akira; ITOH Toshiyuki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Kyoto Prefectural University of Medicine, 2900000, 2900000, The water permeability of capillaries in the subfomical organ (SFO) of rat was measured by a ^1H nuclear magnetic resonance method in combination with a venous injection of a relaxation reagent: gadolinium-diethylene triamine-N,N,N',N",N"-pentaacetic acid (Gd-DTPA^2), which could not pass through the blood-brain barrier (BBB). Judging from results of Gd-DTPA^2 dose dependency in the intact brain and the BBB permeabilized brain, Gd-DTPA^2 could not have leaked out from the capillaries in the cortex,thalamus or SFO, but it could have been extravasated in the posterior lobe of the pituitary gland. The longitudinal (T_1) relaxation time of water in the SFO region was measured by inversion-recovery magnetic resonance imaging at 4.7 T. The T_1 relaxation rates (1/T_1) before and after Gd-DTPA^2 infusion were 0.70 ^^+__-0.02s^<-1> (mean ^^+__- SEM, n=9) and 1.53 ^^+__- 0.11s^<-1> (n=9), respecitively. The rate constant for water influx to the capillaries was estimated to be 0.84 ^^+__- 0.11s^<-1> (n=9) which corresponds with a diffusive membrane permeability (Pd) of 3.7 x 10^<-3> cm s^<-1>. Compared with values found in the literature available on this subject, this Pd value of the capillaries in SFO was the same order as that of transmembrane permeability of water of the vasa recta, and it may be 10 - 100 times larger than that of the blood-brain barrier in the cortex. Areas of the cortex and thalamus showed minimal changes in T_1 relaxation rate (ca. 0.09s^<-1>), but these were not statistically significant, which corresponds to Pd values much smaller than that found in the SFO. From these results, we conclude that the capillaries in SFO have one of the highest water permeability values among all of the capillaries in SFO have one of the highest water permeability values among all of the capillaries in the brain. It is also suggested that this magnetic resonance imaging, based on T_1 relaxation rate, is a useful method to detect local water permeability in situ, kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (C), 2000 - 2001, 12670065, Interaction of stress defending system, thermoregulation and osmoregulation in the systemic vasopressin release, TAKAMATA Akira; ITO Tomoyuki; ITOH Toshiyuki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Kyoto Prefectural University of Medicine, 3200000, 3200000, To elucidate the interactive effect of thermal and stress stimuli and osmoregulation on systemic vasopressin secretion, we examined the effect of endotoxemia on vasopressin release and its mechanism in rats. We also examined the mechanism of vasopressin release during exercise in humans.
    Endotoxemia, induced by intravenous lipopolysaccharide (IPS) administration, induced vasopressin release and water ingestion behavior in rats without any changes in plasma osmolality or plasma volume. Intracerebroventricular (i. c. v.) administration of losartan (angiotensin II AT1 receptor antagonist) almost completely inhibited these responses, suggesting that the brain angiotensin II is involved in the LPS-induced systemic vasopressin secretion and thirst via AT1 receptor.
    To reveal the mechanism of vasopressin release during exercise in humans, we compared the relationship between plasma vasopressin concentration and plasma osmolality during a graded cycle ergo meter exercise protocol and this relationship during hyper tonic saline infusion at rest. Exercise at lower intensity (< 60 % maximal oxygen uptake (VO_2max)) attenuated osmotic vasopressin secretion, and exercise at higher intensity (> 60 % VO_2max) augmented osmotic vasopressin secretion. Blood pressure and heart rate increased with the increase in exercise intensity, and esophageal temperature, plasma lactate concentration, and plasma ACTH concentration increased above 60 % VO_2max. These responses did not occur during hyper tonic saline infusion. The results suggest that the attenuated osmotic vaspressin secretion at the lower exercise intensity might be due to the increased blood pressure, and that the augmented osmotic vasopressin secretion at the higher exercise intensity might be due to the increased body core temperature and/or stress-induced CRH secretion, CRH has been reported to stimulate vasopressin secretion in dogs. In addition, our results demonstrated that osmotic vasopressin secretion did not stimulate ACTH secretion from the anterior pituitary gland., kaken
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  • 奨励研究(A), 1998 - 1999, 10770031, 浸透圧調節系の体温調節系・循環調節系に対する修飾機構の解析, 鷹股 亮, 日本学術振興会, 科学研究費助成事業 奨励研究(A), 京都府立医科大学, 1800000, 1800000, 1)ヒトにおいて、暑熱馴化により体液調節能が向上し、血漿浸透圧上昇による体温調節反応の抑制が減弱する。
    温熱脱水(体重の約1.5-2.0%)後、被験者に水分の自由摂取を2時間にわたって行なわせた際の水分バランスをみると、暑熱馴化前では脱水量の約50%しか回復しないが、暑熱馴化(7日間)によりその回復は、約80%になり、暑熱馴化が体液調節機能を亢進させることが明らかになった。しかし、この体液調節機能の向上は、同様の暑熱馴化プログラムを行なった高齢者では認められなかった。従って、体液調節系と体温調節系の相互作用に加齢の影響があることが明らかになった。また、暑熱馴化は汗ナトリウム(Na)濃度を低下させることが知られている。汗Na濃度の低下は、発汗時の血漿浸透圧の上昇を増加させる。一方、我々は血漿浸透圧の上昇が体温上昇時の体温調節反応を抑制することを報告して来た。そこで、暑熱馴化が浸透圧上昇による体温調節機能の抑制作用が減弱させるのではないかという仮説を立て、実験を行った。その結果、浸透圧上昇に対する体温調節反応の抑制(発汗および皮膚血管拡張反応の深部体温閾値の上昇)は、汗Na濃度が低い被験者程小さくかった。従って、馴化している個人程浸透圧上昇による体温調節機能の抑制は小さくなることが明らかになった。
    2)エンドトキシン血症時の飲水およびバゾプレッシン分泌に脳内アンギオテンシンIIが関与する
    エンドトキシン血症時には、体温上昇がおこるが血中のバゾプレッシン濃度の上昇および飲水行動が起こる。血漿浸透圧上昇時のバゾプレッシン分泌および飲水は脳内アンギオテンシンIIをブロックすることによって抑制できるが、LPS投与してエンドトキシン血症にしたラットにみられるバゾプレッシン分泌および飲水も脳内アンギオテンシンIIをブロックすることによって抑制できた。体温調節系と浸透圧調節系の相互作用に脳内アンギオテンシンが関与している可能性が示唆された。, kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (B), 1997 - 1998, 09470017, Adaptability of older adults to heat with reference to water balance, MORIMOTO Taketoshi; YAEGASHI Kazuhiro; TAKAMATA Akira; ITOH Toshiyuki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Kyoto Prefectural University of Medicine, 10700000, 10700000, Adaptability of older adults to heat stress was assessed in relation to water balance.
    1. Changes in water balance with heat acclimation in older adults
    Nine oIder and 6 younger adlts were exposed to heat-exercise stress for 8 days, and regulatory responses in body temperature and water balance were compared on the first and 8th day. The results obtained shown lower body fluid volumes, higher losses of water and salts, lower water intake due to the lack of thirst, lower responsiveness of water related hormones, and lesser acclimation to heat in older subject. It is suggested that these factors are relevant to the higher incidences of heat casualty in the elderly (submitted to American Journal of Physiology).
    2. Epidemiology of heat stroke
    Based on the National Death Statistics between 1968 and 1994, the epidemiology of heat stroke death was analyzed. About 150 deaths have been reported in the years with heat waves in Japan, while 589 cases were reported in 1994 with sever heat waves. Out of the heat stroke death, 64% were found in the elderly people (submitted to International Journal of Biometeorology).
    3. The effects of dehydration on body temperature regulation
    The experimental results from our laboratory on the effects of dehydration on body temperature regulation were reviewed dividing the effect of hypovolemia (Progress in Brain Research, Vol. 115, Brain Function Hot Environment) and hyperosmolality (Reviews in Clinical & Basic Pharmacology).
    The experimental findings obtained in this projects suggests that the high incidences of heat casualty in the elderly are related to the lower level of water balance in older subjects., kaken
    対象リソースIRI
  • 奨励研究(A), 1996 - 1996, 08770049, 浸透圧調節系に対する体温調節系からの修飾機構とその生理的意義のの解析, 鷹股 亮, 日本学術振興会, 科学研究費助成事業 奨励研究(A), 京都府立医科大学, 1000000, 1000000, 体温調節系と浸透圧調節系は密接に関連しあって機能している。我々はヒトにおいて体温の上昇が浸透圧調節系の機能を浸透圧依存性に亢進させることを明らかにしてきたが、ラットを用いた実験モデルを作成してそのメカニズムを更に明らかにすることを目的とした。
    ラットを用いた実験モデルを作成するにあたって、先ずラットの浸透圧刺激性飲水パターンを明らかにするための実験を行った。ラットの側脳室内に高張性の人工髄液を持続注入して飲水量を測定した。また、容量刺激による飲水のパターンと浸透圧刺激性の飲水パターンを比較するため、利尿剤であるfurosemideを投与した際のラットの飲水量も測定した。浸透圧刺激は直ちに飲水を惹き起こしたのに対し、容量調節系の飲水の発現は、浸透圧刺激性の飲水に比べて有意に遅れ、更に長時間にわたって持続することが明らかとなった。この実験よりラットの飲水パターンは、イヌ等の動物と比べヒトのそれに近く、実験のモデル動物として妥当であることが明らかになった。しかし、ラットは、浸透圧刺激によりナトリウム利尿が起こって浸透圧調節に働く点はヒトとは異なる反応を示した。
    体温上昇の浸透圧刺激飲水に対する影響を明らかにするためにラットに浸透圧刺激を加えた後の飲水量を高温環環境下(32℃)とラットにおける中性温度域である24℃の環境温下で比較した。室温32℃の環境下でラットの体温は、0.5℃から1℃上昇し、飲水量は体温の上昇により約30%低下した。この結果は、ヒトにおける反応とは異なった。体温の上昇によりラットの行動量が低下したことが飲水行動の抑制を惹き起こしたものと考えられる。現在、血漿バゾプレッシング濃度の測定を行っており、血漿バゾプレッシングの反応よりラットにおける体温上昇による飲水量の低下が、浸透圧調節系に対する抑制なのか行動の抑制であるのかが明らかになると期待される。また、ラットの体温の上昇を環境温の上昇にではなく、thermodeを用いて上昇させる実験も計画中である。, kaken
    対象リソースIRI
  • 一般研究(C), 1995 - 1995, 07670091, 脳内浸透圧受容システムの暑熱脱水時血圧調節における生理的役割, 能勢 博; 鷹股 亮, 日本学術振興会, 科学研究費助成事業 一般研究(C), 信州大学, 2200000, 2200000, 発汗による血漿浸透圧の上昇は発汗と皮膚血管拡張の抑制を引き起こし熱放散を減少させる。温熱脱水時の脳脊髄液の浸透圧上昇が血圧調節に与える影響を検討する目的で、脱水したラットの側脳室内に低張性人口髄液を注入して側脳室内のNa濃度([Na]_)を脱水前の値に回復させた場合の動脈血圧および心拍出量を連続測定した。その結果、[Na]_の低下に比例して動脈血圧、心拍出量は低下した。これらの結果は温熱脱水による[Na]_の上昇は低血液量に起因する低血圧を防止する上で重要な入力信号であることを意味する。次に高[Na]_の高体温時の皮膚血管への影響を検討する目的で、ラットの側脳室内に高張性人口髄液を注入したときの平均動脈血圧(MAP)、中心静脈圧、尾動脈血流量(CBF)を連続測定した。尾動脈の血管コンダクタンス(CVC)はCBF/MAPで算出した。赤外線ランプによって食道温を37℃から40℃まで上昇させると、CBFは2.3±0.4ml/min(平均値±標準誤差,n=14)から3.2±0.4ml/minに上昇した(p<0.001)。一方、MAPは125±5mmHgから95±5mmHgに低下し(p<0.01)、CVCは0.019±0.003から0.034±0.004ml/(min mmHg)に上昇した。
    MAPとCVCの間に高い逆相関関係が観察された(r=-0.94,p<0.001)。体温を40℃に上昇させたラットの側脳室内に高張性人口髄液を注入するとMAPおよびCVCは熱負荷の前の値にまで回復し、その際CVCとMAPの間に熱負荷と同様高い逆相関が観察され(r=-0.93,p<0.001)、回帰係数は熱負荷時とほぼ一致した。
    以上の結果は体温上昇による尾部皮膚血管の拡張は末梢血管抵抗を低下させ動脈血圧の維持を困難にすること、さらに温熱脱水等による髄液浸透圧の上昇は高体温時の過度の皮膚血管拡張を抑制して血圧維持に働くことが明らかになった。, kaken
    対象リソースIRI
  • 奨励研究(A), 1995 - 1995, 07770050, 高温環境下での蒸発性熱放散に対する脳室周囲器官浸透圧受容器からの修飾, 鷹股 亮, 日本学術振興会, 科学研究費助成事業 奨励研究(A), 京都府立医科大学, 1000000, 1000000, 脱水等による血漿浸透圧の上昇は,高温環境下での体温調節反応である発汗や蒸発性熱放散を抑制することが知られている。この浸透圧の体温調節反応抑制のメカニズムを明らかにすることを最終目的として実験を行った。
    第一段階として浸透圧刺激が蒸発性熱放散を特異的に抑制するのか、それとも高温環境下での体温調節反応一般に抑制的に働くのかを明らかにすることを目的として、ヒトの皮膚血管拡張反応に対する血漿浸透圧上昇の影響を検討した。この実験ではさらに、血漿浸透圧上昇の皮膚血管拡張反応に対する影響を定量化するために、血漿浸透圧をいろいろ変化させて皮膚血管拡張がおこる閾値深部体温との関係を求めた。血漿浸透圧は,0.9%,2%,3%の食塩水を静脈内に輸液することによって変化させた。皮膚血管拡張開始の深部体温閾値は血漿浸透圧が上昇する程高温側にシフトし,その結果同じ温熱負荷にも関わらず浸透圧が高い程体温の上昇が大きくなった。この結果より、血漿浸透圧の上昇は、蒸発性熱放散のみならず皮膚血管拡張反応にも抑制作用があることが明らかとなった。即ち,浸透圧刺激が体温調節中枢に影響を及ぼしている可能性が示唆された。更に、その抑制の程度は血漿浸透圧が上昇するほど上昇することが明らかとなった。
    現在ラットを用いた実験モデルを作成し実験を進行している。今後,浸透圧受容器から体温調節中枢に対する影響をラットのモデルでさらに明らかにしていく予定である。, kaken
    対象リソースIRI
  • 共同研究, Jan. 2024 - Mar. 2026, Principal investigator, ミネラル入り炭酸水摂取が軽度脱水後の水分摂取行動と体液バランスに及ぼす影響
  • 31 Mar. 2025, Principal investigator, ミネラル入り炭酸水摂取が軽度脱水後の水分摂取行動と体液バランスに及ぼ す影
  • 基盤研究(C), 01 Apr. 2021 - 31 Mar. 2025, 21K10650, Coinvestigator, 女性看護師における手の冷たさのメカニズム解明と交感神経活動に着目した改善策の開発
  • 基盤研究(C), 01 Apr. 2021 - 31 Mar. 2024, 21K11723, Coinvestigator, 口腔内脂肪酸感受性による“舌－脳－腸軸”を介した脂肪摂食調節機構の解明

■Ⅲ．社会連携活動実績

１．公的団体の委員等（審議会、国家試験委員、他大学評価委員，科研費審査委員等）

  • 日本生気象学会, 理事, 2005 - Present, 日本生気象学会, Society
  • 日本生理学会, 評議員, 日本生理学会, Society