Researchers Database

TAKAMATA Akira

    Faculty Division of Human Life and Environmental Sciences Research Group of Environmental Health Professor
    Laboratory Animal Research Center Director, Laboratory Animal Research Center
Contact:
takamatacc.nara-wu.ac.jp
Last Updated :2021/07/20

researchmap

Degree

  • Ph. D (Physiology), Kyoto Prefectural University of Medicine

Research Interests

  • 浮腫 内皮機能 アンギオテンシンII 骨格筋血流調節 飲水行動 体温調節 体液調節 摂食行動 生体リズム 女性ホルモン edema endothelial function muscle blood flow regulation; angiotensin II drinking behavior thermoregulation body fluid regulation ingestive behavior biological rhythms female reproductive hormones 

Research Areas

  • Life sciences, Nutrition and health science
  • Life sciences, Physiology
  • Humanities & social sciences, Home economics, lifestyle science

Research Experience

  • 2007, Nara Women's University, Faculty of Human Life and Environment
  • 2007, Professor, Nara Women's University
  • 2016 - 2016, ジョン・ピアス研究所、イェール大学産婦人科学・生殖科学 客員教授
  • 2016 - 2016, Visiting Professor, John B. Pierce Laboratory, and Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine
  • 2002 - 2007, Nara Women's University, Faculty of Human Life and Environment
  • 2002 - 2007, Associate Professor, Nara Women's University
  • 1994 - 2002, Kyoto Prefectural University of Medicine
  • 1994 - 2002, Assistant Professor, Department of Physiology, Kyoto Prefectural University of Medicine
  • 1991 - 1994, ジョン ピアス研究所、イェール大学医学部 博士研究員
  • 1991 - 1994, Postdoctoral Associate, John B. Pierce Laboratory, and Yale University School of Medicine

Awards

  • 久野寧記念賞, 1999, JPN

Published Papers

  • Estradiol Replacement Improves High-Fat Diet-Induced Obesity by Suppressing the Action of Ghrelin in Ovariectomized Rats.

    Naoko Yokota-Nakagi; Haruka Takahashi; Mizuho Kawakami; Akira Takamata; Yuki Uchida; Keiko Morimoto

    26 Mar. 2020, Nutrients, 12 (4), True, doi;pubmed

  • Fluoxetine Mimics the Anorectic Action of Estrogen and Its Regulation of Circadian Feeding in Ovariectomized Female Rats.

    Yuri Nishimura; Kaori Mabuchi; Natsumi Omura; Ayako Igarashi; Megumi Miura; Nanako Mima; Hiroko Negishi; Keiko Morimoto; Akira Takamata

    22 Mar. 2020, Nutrients, 12 (3), True, True, doi;pubmed;pmc

  • Endurance running exercise is an effective alternative to estradiol replacement for restoring hyperglycemia through TBC1D1/GLUT4 pathway in skeletal muscle of ovariectomized rats.

    Mizuho Kawakami; Naoko Yokota-Nakagi; Akira Takamata; Keiko Morimoto

    Menopause is a risk factor for impaired glucose metabolism. Alternative treatment of estrogen for postmenopausal women is required. The present study was designed to investigate the effects of 5-week endurance running exercise (Ex) by treadmill on hyperglycemia and signal pathway components mediating glucose transport in ovariectomized (OVX) placebo-treated rats, compared with 4-week 17β-estradiol (E2) replacement or pair-feeding (PF) to the E2 group. Ex improved the hyperglycemia and insulin resistance index in OVX rats as much as E2 or PF did. However, Ex had no effect on body weight gain in the OVX rats. Moreover, Ex enhanced the levels of GLUT4 and phospho-TBC1D1 proteins in the gastrocnemius of the OVX rats, but E2 or PF did not. Instead, the E2 increased the Akt2/AS160 expression and activation in the OVX rats. This study suggests that endurance Ex training restored hyperglycemia through the TBC1D1/GLUT4 pathway in muscle by an alternative mechanism to E2 replacement., Nov. 2019, The journal of physiological sciences : JPS, 69 (6), 1029 - 1040, False, doi;pubmed

  • 水分補給による熱中症予防の生理学的メカニズム

    鷹股 亮

    Jul. 2019, 食と医療, 10, 15 - 22

  • The effect of menstrual cycle phase on foot skin temperature during mild local cooling in young women.

    Yuki Uchida; Koyuki Atsumi; Akira Takamata; Keiko Morimoto

    Japanese women can experience a sensation of cold feet in daily life. It is possible that this sensation of coldness in feet may be associated with female hormones, but to date the effect of menstrual cycle phase on the skin temperature (Tsk) of the foot during local cooling is unknown. We therefore examined Tsk and partial cutaneous blood flow in the foot during the follicular (F) and luteal (L) phases of the menstrual cycle in women experiencing local cooling. Tsk was measured in the toes and the dorsum of the left foot using infrared thermography, while cutaneous blood flow was evaluated in the big toe of the left foot using laser Doppler flowmetry (LDF), both at 28 °C. Mild local cooling (24.7 °C) was then applied for 30 min to the right foot. During cooling of the right foot, no significant differences in Tsk were observed between the F and L phases in either the toes of the left foot or the dorsum of the left foot of all subjects. However, cutaneous blood flow determined by LDF in the big toe of the left foot was greater in the F phase than in the L phase. These results suggest that the menstrual cycle phase did not affect Tsk in the foot, but it did affect cutaneous blood flow in the big toe during mild local cooling., Jan. 2019, The journal of physiological sciences : JPS, 69 (1), 151 - 157, False, doi;pubmed

  • Estrogen replacement enhances insulin-induced AS160 activation and improves insulin sensitivity in ovariectomized rats.

    Mizuho Kawakami; Naoko Yokota-Nakagi; Masami Uji; Ken-Ichi Yoshida; Shoko Tazumi; Akira Takamata; Yuki Uchida; Keiko Morimoto

    Menopause predisposes women to impaired glucose metabolism, but the role of estrogen remains unclear. In this study, we examined the effects of chronic estrogen replacement on whole body insulin sensitivity and insulin signaling in ovariectomized rats. Female Wistar rats aged 9 wk were ovariectomized under anesthesia. After 4 wk, pellets containing either 17β-estradiol (E2) or placebo (Pla) were subcutaneously implanted in the rats. After 4 wk of treatment, the intra-abdominal fat accumulation was greater in the Pla group than that in the E2 group. Hyperinsulinemic-euglycemic clamp analysis and intravenous glucose tolerance test revealed that insulin sensitivity was significantly lower in the Pla group than in the E2 group. In addition, Western blotting showed that in vivo insulin stimulation increased protein kinase B (Akt) phosphorylation to a similar degree in the gastrocnemius and liver of both groups, but phosphorylated Akt2 Ser474 was enhanced in the muscle of the E2 group compared with the Pla group. Moreover, insulin-stimulated phosphorylation of Akt substrate of 160 kDa (AS160) Thr642 was observed only in the E2 group, resulting in the difference between the two groups. Additionally, AS160 protein and mRNA levels were higher in muscle of the E2 group than the Pla group. In contrast, E2 replacement had no effect on glucose transporter 4 protein levels in muscle and glycogen synthase kinase-3β in muscle and liver. These results suggest that estrogen replacement improves insulin sensitivity by activating the Akt2/AS160 pathway in the insulin-stimulated muscle of ovariectomized rats., 01 Dec. 2018, American journal of physiology. Endocrinology and metabolism, 315 (6), E1296-E1304 - E1304, True, doi;pubmed

  • S-equol exerts estradiol-like anorectic action with Minimal stimulation of estrogen receptor-alpha in Ovariectomized rats

    Yuri Nishimura; Kaori Mabuchi; Azusa Takano; Yayoi Hara; Hiroko Negishi; Keiko Morimoto; Tomomi Ueno; Shigeto Uchiyama; Akira Takamata

    FRONTIERS MEDIA SA, Oct. 2017, FRONTIERS IN ENDOCRINOLOGY, 8, 281, doi;web_of_science

    Scientific journal

  • 摂食調節における性差と性ホルモンの役割

    鷹股 亮; 鷹股亮; 森本恵子

    2017, 実験医学, 35 (6), 945 - 950

  • Body fluid regulation and female reproductive steroids

    TAKAMATA Akira

    2017, Jpn J Biometeor, 54 (2), 57 - 64, doi

  • Estrogen replacement attenuates stress-induced pressor responses through vasorelaxation via β2-adrenoceptors in peripheral arteries of ovariectomized rats.

    Shoko Tazumi; Sayo Omoto; Yu Nagatomo; Mariko Kawahara; Naoko Yokota-Nakagi; Mizuho Kawakami; Akira Takamata; Keiko Morimoto

    We examined whether chronic estrogen replacement has an inhibitory effect on stress-induced pressor responses via activation of β2-adrenoceptor (AR) in peripheral arteries of ovariectomized rats. Female Wistar rats aged 9 wk were ovariectomized. After 4 wk, pellets containing either 17β-estradiol (E2) or placebo (Pla) were subcutaneously implanted into the rats. After 4 wk of treatment, rats underwent cage-switch stress, and, in a separate experiment, a subset received an infusion of isoproterenol (ISO) with or without pretreatment with the β1-AR blocker atenolol or the β2-AR blocker butoxamine. In addition, the isolated mesenteric artery was used to assess the concentration-related relaxing responses to ISO and the β1- or β2-AR mRNA level. The cage-switch stress-induced pressor response was significantly attenuated in the E2-treated group compared with the Pla-treated group. Pretreatment with atenolol reduced blood pressure responses in both groups. However, butoxamine enhanced the pressor response only in the E2-treated group, resulting in no difference between the two groups. In addition, the intravenous ISO-induced depressor response was significantly enhanced in the E2-treated group compared with the Pla-treated group. Furthermore, the difference in the depressor response was abolished by pretreatment with butoxamine but not by atenolol. In the isolated mesenteric artery, butoxamine caused a rightward shift in ISO-induced concentration-related relaxation in the E2-treated group. The β2-AR mRNA level in the mesenteric artery was higher in the E2-treated group than in the Pla-treated group. These results suggest that estrogen replacement attenuated the stress-induced pressor response probably by suppressing vasoconstriction via activation of β2-ARs in peripheral arteries of ovariectomized rats. NEW & NOTEWORTHY In this study, we show, for the first time, that estrogen replacement has an inhibitory effect on the psychological stress-induced pressor response through vasorelaxation via β2-adrenoceptors, probably due to overexpression of β2-adrenoceptor mRNA, in peripheral arteries of ovariectomized rats., 01 Feb. 2018, American journal of physiology. Heart and circulatory physiology, 314 (2), H213-H223, True, doi;pubmed

  • Effects of estrogen replacement on stress-induced cardiovascular responses via renin-angiotensin system in ovariectomized rats

    Shoko Tazumi; Naoko Yokota; Mizuho Kawakami; Sayo Omoto; Akira Takamata; Keiko Morimoto

    AMER PHYSIOLOGICAL SOC, Nov. 2016, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 311 (5), R898 - R905, doi;web_of_science

    Scientific journal

  • Target intensity and interval walking training in water to enhance physical fitness in middle-aged and older women: a randomised controlled study

    Shuichi Handa; Shizue Masuki; Takuya Ohshio; Yoshi-ichiro Kamijo; Akira Takamata; Hiroshi Nose

    To determine the target intensity for fast walking during interval walking training (IWT) in water for middle-aged and older people to enhance physical fitness. Thirty-one women [59 +/- 5 (SD) years old] were randomly divided into two groups: IWT on land (LG, N = 15) and in water (WG, N = 16). All subjects were instructed to perform a parts per thousand yen6 sets of fast and slow walking for 3 min each in a day, a parts per thousand yen4 days week(-1), for 8 weeks, at an intensity 35 % higher than the oxygen consumption rate at the gas exchange threshold (O-2GET), with a subjective feeling of 16-18 points of the Borg scale during fast walking in each condition. Before and after IWT, we measured O-2GET, peak aerobic capacity (O-2peak) by graded walking and cycling tests on land and isometric knee extension (F (EXT)) and flexion (F (FLX)) forces. Before IWT, the O-2GET for walking in water was 14 % higher and the heart rate (HR) at a given O-2 was similar to 10 beats min(-1) lower (P=0.001) than on land. During IWT, subjects in both groups performed IWT for similar to 4 days week(-1) (P > 0.9) with a 14 % higher fast walking intensity in WG than in LG (P < 0.05). After IWT, the O-2peak and O-2GET for cycling, F (EXT) and F (FLX) increased more in WG than in LG (all, P < 0.05). Walking in water elevated O-2GET and decreased HR at a given exercise intensity in middle-aged and older women, which enabled them to perform exercise at a higher metabolic rate than on land due to improved subjective feelings, which, for these subjects, resulted in greater gains in physical fitness., SPRINGER, Jan. 2016, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 116 (1), 203 - 215, doi;web_of_science

    Scientific journal

  • ヒトをはかる16話(その14)循環機能をはかる

    鷹股 亮

    2015, 繊維製品消費科学, 56, 8

  • Involvement of orexin-A neurons but not melanin-concentrating hormone neurons in the short-term regulation of food intake in rats

    Yuri Nishimura; Kaori Mabuchi; Sayumi Taguchi; Saori Ikeda; Eri Aida; Hiroko Negishi; Akira Takamata

    SPRINGER JAPAN KK, May 2014, JOURNAL OF PHYSIOLOGICAL SCIENCES, 64 (3), 203 - 211, doi;web_of_science

    Scientific journal

  • ヒトをはかる16話(その9)代謝量をはかる

    鷹股 亮

    2014, 繊維製品消費科学, 55, 722, doi

  • ヒトをはかる16話(その10)酸素消費量をはかる

    鷹股 亮

    2014, 繊維製品消費科学, 55, 723

  • Mn-citrate and Mn-HIDA: Intermediate-affinity chelates for manganese-enhanced MRI

    Yoshiteru Seo; Keitaro Satoh; Hironobu Morita; Akira Takamata; Kazuto Watanabe; Takashi Ogino; Tooru Hasebe; Masataka Murakami

    In this study we investigated two manganese chelates in order to improve the image enhancement of manganese-enhanced MRI and decrease the toxicity of free manganese ions. Since both MnCl2 and a low-affinity chelate were associated with a slow continuous decrease of cardiac functions, we investigated intermediate-affinity chelates: manganese N-(2-hydroxyethyl)iminodiacetic acid (Mn-HIDA) and Mn-citrate. The T1 relaxivity values for Mn-citrate (4.4 m m-1 s-1) and Mn-HIDA (3.3 m m-1 s-1) in artificial cerebrospinal fluid (CSF) were almost constant in a concentration range from 0.5 to 5 m m at 37 °C and 4.7 T. In human plasma, the relaxivity values increased when the concentrations of these Mn chelates were decreased, suggesting the presence of free Mn2+ bound with serum albumin. Mn-HIDA and Mn-citrate demonstrated a tendency for better contractility when employed with an isolated perfused frog heart, compared with MnCl2. Only minimal changes were demonstrated after a venous infusion of 100 m m Mn-citrate or Mn-HIDA (8.3 μmol kg-1 min-1) in rats and a constant heart rate, arterial pressure and sympathetic nerve activity were maintained, even after breaking the blood-brain barrier (BBB). Mn-citrate and Mn-HIDA could not cross the intact BBB and appeared in the CSF, and then diffused into the brain parenchyma through the ependymal layer. The responses in the supraoptic nucleus induced by the hypertonic stimulation were detectable. Therefore, Mn-citrate and Mn-HIDA appear to be better choices for maintaining the vital conditions of experimental animals, and they may improve the reproducibility of manganese-enhanced MRI of the small nuclei in the hypothalamus and thalamus. © 2012 John Wiley & Sons, Ltd., Mar. 2013, Contrast Media and Molecular Imaging, 8 (2), 140 - 146, doi;pubmed

    Scientific journal

  • Diffusion of manganese chelates in the rat brain measured by T-1-weighted MRI

    Yoshiteru Seo; Akira Takamata; Takashi Ogino; Hironobu Morita; Masataka Murakami

    SPRINGER JAPAN KK, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S137 - S137, web_of_science

  • 低体温と全身麻酔と代謝,そして腎機能─低温環境で体温維持に働く非ふるえ熱産生 全身麻酔は褐色脂肪組織などの熱産生を阻害する.

    鷹股 亮

    2012, LISA, 19, 18 - 23

  • 健康と水

    鷹股 亮

    2012, 月刊食生活, 106

  • Modification of thermoregulatory response to heat stress by body fluid regulation.

    TAKAMATA Akira

    2012, J Phys Fitness Sports Med, 1 (3), 479 - 489, doi

  • 温熱発汗に及ぼす体液調節系からの抑制

    鷹股 亮

    2012, 発汗学, 19 (2), 56 - 59

  • 摂食/体重コントロールと性ホルモン

    鷹股 亮

    2012, 体育の科学, 62 (12), 942 - 945

  • Chronic oestrogen replacement in ovariectomised rats attenuates food intake and augments c-Fos expression in the suprachiasmatic nucleus specifically during the light phase

    Akira Takamata; Kayo Torii; Kana Miyake; Keiko Morimoto

    CAMBRIDGE UNIV PRESS, Oct. 2011, BRITISH JOURNAL OF NUTRITION, 106 (8), 1283 - 1289, doi;web_of_science

    Scientific journal

  • Lateral diffusion of manganese in the rat brain determined by T-1 relaxation time measured by H-1 MRI

    Yoshiteru Seo; Akira Takamata; Takashi Ogino; Hironobu Morita; Masataka Murakami

    In order to optimize manganese ion-enhanced MRI in thalamic and hypothalamic nuclei, we analyzed the diffusion of manganese in the brain followed by the intra-cerebroventricular application of manganese-bicine (Mn-bicine). T-1-weighted MRI intensities, with 9-pixel ROIs in the hypothalamus perpendicular to the third ventricle, were measured during continuous infusion of Mn-bicine solution in the lateral cerebroventricle. Using a relationship between the image intensity of T-1-weighted MRI and T-1 relaxation time, the image intensity was converted into the concentration of manganese. Assuming a simple diffusion process, the apparent diffusion coefficient (D-ap) of manganese (4.2 x 10(-5) mm(2) s(-1)) is much lower than that of water (6 x 10(-4) mm(2) s(-1)), and the D-ap tended to decrease when the distance from the third ventricle increased. These results suggest (1) the Mn2+ ion is trapped by neural cells during diffusion and (2) the manganese efflux is discharged from the brain via veins., SPRINGER TOKYO, May 2011, JOURNAL OF PHYSIOLOGICAL SCIENCES, 61 (3), 259 - 266, doi;web_of_science

    Scientific journal

  • Mn-bicine: A Low Affinity Chelate for Manganese Ion Enhanced MRI

    Yoshiteru Seo; Keitaro Satoh; Kazuto Watanabe; Hironobu Morita; Akira Takamata; Takashi Ogino; Masataka Murakami

    The toxicity of free Mn(2+) is a bottleneck for the in vivo application of manganese ion enhanced MRI. To reduce free Mn(2+) concentration ([Mn(2+)]), a low affinity chelate reagent: N,N-bis(2-hydroxyethyl)glycine (bicine) was used. Considering the conditional association constant of Mn-bicine at pH 7.4 (10(2.9) M(-1)), (i) a 100 mM Mn-bicine solution should contain about 10 mM of free manganese ion, but (ii) free manganese will make up 3/4 of the final plasma concentration (0.5 mM) with an intravenous infusion of 100 mM Mn-bicine. The T(1) relaxivity of Mn-bicine in a 5 mM Mn-bicine solution was estimated as 5 mM(-1) sec(-1) at 24 degrees C, 7 T in a pH range of 6.8-7.5. Mn-bicine demonstrated a tendency for better contractility when employed with an isolated perfused frog heart, compared with MnCl(2). A venous infusion of 100 mM Mn-bicine (8.3 mu mol kg(-1) min(-1)) showed a minimal decrease and maintained a constant heart rate level and arterial pressure in rats, while rats infused with 100 mM of MnCl(2) showed a significant suppression of the hemodynamic functions. Thus, Mn-bicine appears to be a better choice for maintaining the vital conditions of experimental animals, and may improve the reproducibility of manganese ion enhanced MRI. Magn Reson Med 65:1005-1012, 2011. (C) 2010 Wiley-Liss, Inc., WILEY-BLACKWELL, Apr. 2011, MAGNETIC RESONANCE IN MEDICINE, 65 (4), 1005 - 1012, doi;web_of_science

    Scientific journal

  • 重力、性周期と体液、循環、体温調節機能

    鷹股 亮; 鷹股 亮

    2011, 繊維製品消費科学, 52, 32 - 36, doi

  • Plasma hyperosmolality elevates the internal temperature threshold for active thermoregulatory vasodilation during heat stress in humans

    Manabu Shibasaki; Ken Aoki; Keiko Morimoto; John M. Johnson; Akira Takamata

    Shibasaki M, Aoki K, Morimoto K, Johnson JM, Takamata A. Plasma hyperosmolality elevates the internal temperature threshold for active thermoregulatory vasodilation during heat stress in humans. Am J Physiol Regul Integr Comp Physiol 297: R1706-R1712, 2009. First published October 7, 2009; doi:10.1152/ajpregu.00242.2009.Plasma hyperosmolality delays the response in skin blood flow to heat stress by elevating the internal temperature threshold for cutaneous vasodilation. This elevation could be because of a delayed onset of cutaneous active vasodilation and/or to persistent cutaneous active vasoconstriction. Seven healthy men were infused with either hypertonic (3% NaCl) or isotonic (0.9% NaCl) saline and passively heated by immersing their lower legs in 42 C water for 60 min (room temperature, 28 C; relative humidity, 40%). Skin blood flow was monitored via laser-Doppler flowmetry at sites pretreated with bretylium tosylate (BT) to block sympathetic vasoconstriction selectively and at adjacent control sites. Plasma osmolality was increased by similar to 13 mosmol/kgH(2)O following hypertonic saline infusion and was unchanged following isotonic saline infusion. The esophageal temperature (T(es)) threshold for cutaneous vasodilation at untreated sites was significantly elevated in the hyperosmotic state (37.73 +/- 0.11 degrees C) relative to the isosmotic state (36.63 +/- 0.12 degrees C, P < 0.001). A similar elevation of the Tes threshold for cutaneous vasodilation was observed between osmotic conditions at the BT-treated sites (37.74 +/- 0.18 vs. 36.67 +/- 0.07 degrees C, P < 0.001) as well as sweating. These results suggest that the hyperosmotically induced elevation of the internal temperature threshold for cutaneous vasodilation is due primarily to an elevation in the internal temperature threshold for the onset of active vasodilation, and not to an enhancement of vasoconstrictor activity., AMER PHYSIOLOGICAL SOC, Dec. 2009, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 297 (6), R1706 - R1712, doi;web_of_science

    Scientific journal

  • Involvement of central angiotensin II type 1 receptors in LPS-induced systemic vasopressin release and blood pressure regulation in rats

    Fumihiro Shimizu; Toshihiro Kasai; Akira Takamata

    Shimizu F, Kasai T, Takamata A. Involvement of central angiotensin II type 1 receptors in LPS-induced systemic vasopressin release and blood pressure regulation in rats. J Appl Physiol 106: 1943-1948, 2009. First published April 9, 2009; doi:10.1152/japplphysiol.90516.2008.-The purpose of this study was to evaluate the involvement of central angiotensin II (ANG II) and ANG II type 1 (AT(1)) receptors in systemic release of arginine vasopressin (AVP) and blood pressure regulation during endotoxemia. LPS (150 mu g/kg) was injected intravenously 30 min after intracerebroventricular (icv) losartan (50 mu g), an AT(1) receptor antagonist, or subcutaneous (sc) captopril (50 mg/kg), an angiotensin-converting enzyme inhibitor. Rats with icv and sc saline injections served as control. LPS administration increased plasma AVP concentration from 2.1 +/- 0.2 to 15.2 +/- 2.5 pg/ml (60 min after LPS injection) without significant changes in plasma osmolality or hematocrit. LPS-induced AVP secretion was significantly attenuated by pretreatment with icv losartan (2.3 +/- 0.5 to 3.7 +/- 0.5 pg/ml) but was not attenuated after peripheral captopril treatment (2.2 +/- 0.6 to 17.6 +/- 4.2 pg/ml). LPS administration significantly decreased systolic blood pressure (SBP) by 22.7 +/- 5.4 mmHg after intravenous LPS injection in icv losartan-treated rats, while SBP remained unchanged in vehicle-treated or sc captopril-treated rats by intravenous LPS. These results indicate that central AT(1) receptors, not responsive to peripheral ANG II, play an important role in systemic AVP secretion and maintenance of blood pressure during endotoxemia., AMER PHYSIOLOGICAL SOC, Jun. 2009, JOURNAL OF APPLIED PHYSIOLOGY, 106 (6), 1943 - 1948, doi;web_of_science

    Scientific journal

  • 運動・スポーツにおける体温調節と水分摂取

    鷹股 亮; 鷹股 亮

    2009, 臨床スポーツ医学 臨時増刊号 スポーツ栄養・食事ガイド, 26, 60 - 66

  • 女性

    鷹股 亮; 鷹股 亮

    2009, 臨床スポーツ医学 臨時増刊号 スポーツ栄養・食事ガイド, 26, 264 - 271

  • Mental stress induces sustained elevation of blood pressure and lipid peroxidation in postmenopausal women

    Keiko Morimoto; Mayuko Morikawa; Hiroko Kimura; Nobuko Ishii; Akira Takamata; Yasuko Hara; Masami Uji; Ken-ichi Yoshida

    Mental stress is thought to underlie cardiovascular events, but there is information on oxidative stress induced by mental stress in association with cardiovascular responses in women. Using a sensitive assay for plasma 4-hydroxy-2-nonenal (HNE), as a marker for oxidative stress, we addressed the relation between pressor responses and oxidative stress induced by mental or physical stress in premenopausal and postmenopausal women. Healthy subjects (7 postmenopausal and 8 premenopausal women, in early and late follicular phases) were subjected to mental and physical stress evoked by a Color Word Test (CWT) and isometric handgrip, respectively. The CWT induced a rapid elevation of diastolic blood pressure (DBP), at a higher level in the postmenopausal than in the premenopausal women (p<0.01), and this higher DBP was sustained during the CWT and recovery (p<0.01). The CWT induced a significant elevation in plasma noradrenaline in premenopausal women in the early follicular phase and in postmenopausal women (p<0.05). Plasma nitric oxide metabolites were higher in postmenopausal than in the premenopausal women in the late follicular phase (p<0.05), but did not change during exposure to the two types of stress in either group. Plasma HNE was increased during recovery from the CWT, but not the handgrip, in postmenopausal women (2.4 times, p<0.05). There was a significant difference in the time course of the CWT-induced HNE response between the postmenopausal and premenopausal women (p<0.05). These findings suggest that mental, but not physical, stress causes sustained diastolic blood pressure elevation in postmenopausal women, accompanied by heightened oxidative stress. (C) 2007 Elsevier Inc. All rights reserved., PERGAMON-ELSEVIER SCIENCE LTD, Jan. 2008, LIFE SCIENCES, 82 (1-2), 99 - 107, doi;web_of_science

    Scientific journal

  • Effects of Estrogen on Stress-induced Activation of Peptide Neurons in PVN of Ovariectomized Rats

    Yasuko Hara; Tomomi Kohno; Akira Takamata; Takashi Ueyama; Keiko Morimoto

    Estrogen has been implicated in brain function related to stress responses. We investigated whether estrogen affects psychological stress-induced activation of peptide-containing or nitric oxide-producing neurons in the paraventricular hypothalamic nucleus (PVN) in ovariectomized (OVX) rats, both placebo-treated (OVX + Pla) and estrogen-treated (OVX + E2) by comparison of c-Fos expression using immunohistochemistry. Cage-switch stress increased activation in oxytocinergic neurons in the parvocellular PVN (pPVN) in OVX + Pla, but not in that of OVX + E2, rats. Moreover, the stress-induced activation in NADPH-diaphorase-positive neurons in the pPVN was larger in the OVX + E2 than in the OVX + Pla group. These findings suggest that estrogen attenuates the activation of oxytocinergic neurons in the pPVN, at least in part via nitric oxide., BLACKWELL PUBLISHING, 2008, Stress, Neurotransmitters, and Hormones: Neuroendocrine and Genetic Mechanisms, 1148, 99 - 105, doi;web_of_science

    Scientific journal

  • Estrogen Replacement Suppresses Pressor Response and Oxidative Stress Induced by Cage-switch Stress in Ovariectomized Rats

    Keiko Morimoto; Masami Uji; Takashi Ueyama; Hiroko Kimura; Tomomi Kohno; Akira Takamata; Shigenobu Yano; Ken-Ichi Yoshida

    We examined the suppressive effects of estradiol on psychological stress-induced cardiovascular responses and oxidative stress in ovariectomized rats, both placebo-treated (OVX+Pla) and estrogen-treated (OVX+E2). The elevations in blood pressure and heart rate induced by cage-switch stress were attenuated in the OVX+E2 as compared with the OVX+Pla group. N(G)-nitro-L-arginine methyl ester, administered via drinking water, reduced the difference in these responses. Furthermore, this stress increased plasma nitrotyrosine and decreased plasma nitric oxide (NO) metabolites only in the OVX+Pla group. We demonstrated that estrogen replacement suppresses cardiovascular responses to psychological stress, at least in part by improving NO bioavailability in ovariectomized rats., BLACKWELL PUBLISHING, 2008, STRESS, NEUROTRANSMITTERS, AND HORMONES: NEUROENDOCRINE AND GENETIC MECHANISMS, 1148, 213 - 218, doi;web_of_science

    Scientific journal

  • 下肢の加温および筋肉痛を惹き起こす運動が下肢静脈コンプライアンス、毛細血管水透過係数に及ぼす影響

    鷹股 亮; 福井洋子; 山本佳奈; 鷹股亮

    2007, 生気象学会雑誌, 44: 13-39, 13 - 39, doi

  • 衣服を用いた運動時の静脈還流量維持と体温・循環反応ーその生理学的背景

    鷹股 亮; 鷹股亮

    2006, 繊維製品消費科学, 47, 712 - 718, doi

  • Acute hypoosmolality attenuates the suppression of cutaneous vasodilation with increased exercise intensity

    H Mitono; H Endoh; K Okazaki; T Ichinose; S Masuki; A Takamata; H Nose

    We examined the hypothesis that elevation of the body core temperature threshold for forearm skin vasodilation (THFVC) with increased exercise intensity is partially caused by concomitantly increased plasma osmolality Eight young male subjects, wearing a body suit perfused with warm water to maintain the mean skin temperature at 34 +/- 1 degrees C (ranges), performed 20-min cycle-ergometer exercise at 30% peak aerobic power ((V) over dot o(2 peak)) under isoosmotic conditions (C), and at 65% (V) over dot o(2 pea)k under isoosmotic (HEXIOS) and hypoosmotic (HEXLos) conditions. In HEXLos, hypoosmolality was attained by hypotonic saline infusion with DDAVP, a V-2 agonist, before exercise. P-osmol (mosmol/kgH(2)O) increased after the start of exercise in both H-EX trials (P < 0.01) but not in C. The average P-osmol at 5 and 10 min in HEXIos was higher than in C (P < 0.01), whereas that in HEXLos was lower than in HEXIos (P < 0.01). The change in THFVC was proportional to that in P-osmol in every subject for three trials. The change in THFVC per unit change in P-osmol (Delta THFVC/Delta P-osmol, degrees C center dot mosmol(-1)center dot kgH(2)O(-1)) was 0.064 +/- 0.012 when exercise intensity increased from C to HEXIOS, similar to 0.086 +/- 0.020 when P-osmol decreased from HEXIOS to HEXLOS (P > 0.1). Moreover, there were no significant differences in plasma volume, heart rate, mean arterial pressure, and plasma lactate concentration around THFVC between HEXIOS and HEXLOS (P > 0.1). Thus the increase in THFVC due to increased exercise intensity was at least partially explained by the concomitantly increased P-osmol., AMER PHYSIOLOGICAL SOC, Sep. 2005, JOURNAL OF APPLIED PHYSIOLOGY, 99 (3), 902 - 908, doi;web_of_science

    Scientific journal

  • Plasma hyperosmolality augments peripheral vascular response to baroreceptor unloading during heat stress

    T Ito; T Itoh; T Hayano; K Yamauchi; A Takamata

    The aim of this study was to elucidate the interactive effect of central hypovolemia and plasma hyperosmolality on regulation of peripheral vascular response and AVP secretion during heat stress. Seven male subjects were infused with either isotonic (0.9%; NOSM) or hypertonic (3.0%; HOSM) NaCl solution and then heated by perfusing 42 degrees C (heat stress; HT) or 34.5 degrees C water (normothermia; NT) through water perfusion suits. Sixty minutes later, subjects were exposed to progressive lower body negative pressure (LBNP) to -40 mmHg. Plasma osmolality (P-osmol) increased by similar to 11 mosmol/kgH(2)O in HOSM conditions. The increase in esophageal temperature before LBNP was much larger in HT-HOSM (0.90 +/- 0.09 degrees C) than in HT-NOSM (0.30 +/- 0.07 degrees C) (P < 0.01) because of osmotic inhibition of thermoregulation. During LBNP, mean arterial pressure was well maintained, and changes in thoracic impedance and stroke volume were similar in all conditions. Forearm vascular conductance (FVC) before application of LBNP was higher in HT than in NT conditions (P < 0.001) and was not influenced by Posmol within the thermal conditions. The reduction in FVC at -40 mmHg in HT-HOSM (-9.99 +/- 0.96 units; 58.8 +/- 4.1%) was significantly larger than in HT-NOSM (-6.02 +/- 1.23 units; 44.7 +/- 8.1%) (P < 0.05), whereas the FVC response was not different between NT-NOSM and NT-HOSM. Plasma AVP response to LBNP did not interact with P-osmol in either NT or HT conditions. These data indicate that there apparently exists an interactive effect of P-osmol and central hypovolemia on the peripheral vascular response during heat stress, or peripheral vasodilated conditions, but not in normothermia., AMER PHYSIOLOGICAL SOC, Aug. 2005, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 289 (2), R432 - R440, doi;web_of_science

    Scientific journal

  • Effect of environmental conditions on tear dynamics in soft contact lens wearers

    K Maruyama; N Yokoi; A Takamata; S Kinoshita

    PURPOSE. Dry eye symptoms are often associated with soft contact lens (SCL) wear and may be affected by environmental conditions. This study was conducted to determine the effects of temperature and humidity on the tear film in SCL wearers. METHODS. All 11 enrolled subjects were males (mean age, 23.5 +/- 5.2 [SD] years), and all wore SCL daily. They were exposed in different sessions to four different conditions in an environmental chamber with the air temperature (AT) and relative humidity (RH) set at 5degreesC/10% (AT/RH), 15degreesC/20%, 25degreesC/40%, or 35degreesC/50%. Two different types of hydrogel SCL (SCL-a and SCL-b; water content 72.0% and 37.5%, respectively) were used. The meniscus tear volume was determined on a video meniscometer by measuring the tear meniscus radius (TMR) with and without SCL. The tear interference patterns on the contact lens (TIPCL) were classified into five grades (the higher the grade, the thinner the film). Using a video interferometer, the non-invasive tear film breakup time (NIBUT) was recorded with and without SCLs; ocular dryness was also scored with and without SCLs. RESULTS. Under the environmental conditions examined, there were no significant differences in the TMR without or with SCL, regardless of their type. As AT and RH decreased, there was a significant increase in the TIPCL grade (CL-a: P = 0.042; CL-b: P = 0.002), a significant decrease in NIBUT (CL-a: P = 0.004; CL-b: P = 0.001), and a significant increase in the dryness score (without SCL P = 0.023; with CL-a P = 0.009; with CL-b P = 0.003). The dryness scores were higher with CL-a than CL-b (P = 0.011 at 15degreesC/20%). Under identical experimental conditions, we observed no significant change in NIBUT in the absence of an SCL. CONCLUSIONS. AT and RH apparently had no effect on the tear volume in the presence of SCLs. As AT and RH decreased, the tear film on the SCL became thinner, NIBUT became shorter, and dryness increased. Dryness was more pronounced in eyes with SCL of the higher water content., ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Aug. 2004, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45 (8), 2563 - 2568, doi;web_of_science

    Scientific journal

  • Sequence of forebrain activation induced by intraventricular injection of hypertonic NaCl detected by Mn2+ contrasted T-1-weighted MRI

    H Morita; T Ogino; N Fujiki; K Tanaka; TM Gotoh; Y Seo; A Takamata; S Nakamura; M Murakami

    In order to define the sequence of forebrain activation involved in osmoregulation, central activation in response to intracerebroventricular injection of NaCl solution (10 mul of 0.15, 0.5, or 1.5 M) was detected using manganese-contrasted magnetic resonance imaging (MRI) in anesthetized rats. Changes in renal sympathetic nerve activity (RNA) were also measured, and the time courses of forebrain activation and RNA changes compared. NaCl injection resulted in rapid activation of the subfornical organ (SFO), organum vasculosum lamina terminalis (OVLT), and periventricular regions and the lateral hypothalamic area (LHA), then of the paraventricular hypothalamic nucleus (PVN) and supraoptic nucleus (SON). The delay in activation in the PVN and SON showed a wide variation from 0 to 5.78 min, and the average delay in the PVN (2.88 +/- 0.34 min) and SON (2.90 +/- 0.39 min) was significantly greater than that in the SFO (0.40 +/- 0.10 min) and OVLT (0.74 +/- 0.13 min). NaCl (1.5 M) injection elicited a rapid, large increase in RNA, which consisted of two components, an early rapid increase at 99 s after injection (160 +/- 27%) and a slower increase at 9 min after injection (209 +/- 34%). These results suggest that the PVN and SON are activated not only by the afferent input from the SFO and OVLT but also by diffusion of the hypertonic stimulus to these regions and probably by their intrinsic osmosensitivity. The PVN might be responsible for the second slower component of the RNA response, but cannot be responsible for the first component. (C) 2004 Elsevier B.V. All rights reserved., ELSEVIER SCIENCE BV, Jun. 2004, AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 113 (1-2), 43 - 54, doi;web_of_science

    Scientific journal

  • Effect of amino acid infusion on central thermoregulatory control in humans

    Y Nakajima; A Takamata; T Matsukawa; DI Sessler; Y Kitamura; H Ueno; Y Tanaka; T Mizobe

    Background. Administration of protein or amino acids enhances thermogenesis, presumably by stimulating oxidative metabolism. However, hyperthermia results even when thermoregulatory responses are intact, suggesting that amino acids also alter central thermoregulatory control. Therefore, the authors tested the hypothesis that amino acid infusion increases the thermoregulatory set point. Methods. Nine male volunteers each participated on 4 study days in randomized order: (1) intravenous amino acids infused at 4 kJ(.)kg(-1.)h(-1) for 2.5 h combined with skin-surface warming, (2) amino acid infusion combined with cutaneous cooling, (3) saline infusion combined with skin-surface warming, and (4) saline infusion combined with cutaneous cooling. Results: Amino acid infusion increased resting core temperature by 0.3 +/- 0.1 degreesC (mean +/- SD) and oxygen consumption by 18 +/- 12%. Furthermore, amino acid infusion increased the calculated core temperature threshold (triggering core temperature at a designated mean skin temperature of 34 degreesC) for active cutaneous vasodilation by 0.3 +/- 0.3 degreesC, for sweating by 0.2 +/- 0.2 degreesC, for thermoregulatory vasoconstriction by 0.3 +/- 0.3 degreesC, and for thermogenesis by 0.4 +/- 0.5 degreesC. Amino acid infusion did not alter the incremental response intensity (i.e., gain) of thermoregulatory defenses. Conclusions: Amino acid infusion increased the metabolic rate and the resting core temperature. However, amino acids also produced a synchronous increase in all major autonomic thermoregulatory defense thresholds; the increase in core temperature was identical to the set point increase, even in a cold environment with amble potential to dissipate heat. in subjects with intact thermoregulatory defenses, amino acid-induced hyperthermia seems to result from an increased set point rather than increased metabolic rate per se., LIPPINCOTT WILLIAMS & WILKINS, Mar. 2004, ANESTHESIOLOGY, 100 (3), 634 - 639, doi;web_of_science

    Scientific journal

  • 運動・ホルモンと水分代謝

    鷹股 亮; 鷹股亮

    2004, 体育の科学, 54, 43 - 47

  • 水分摂取による熱中症予防 その生理学的メカニズム

    鷹股 亮; 鷹股亮

    2004, 日本生気象学会誌, 41, 55 - 59, doi

  • The vasoconstriction threshold is increased in obese patients during general anaesthesia

    T Kasai; M Hirose; T Matsukawa; A Takamata; Y Tanaka

    Background: In anaesthetized patients, body temperature decreases often, but overweight patients become less hypothermic. Obesity in itself protects body heat, and thermoregulatory reflexes may maintain normothermia in obese patients. We tested the hypothesis that even slight obesity increases the vasoconstriction threshold. Methods: Twenty male patients aged 30-65 years scheduled for open abdominal surgery were allocated to two groups: body fat greater than or equal to25% (obese group, n = 10), or <25% (normal weight group, n = 10). Anaesthesia was maintained with 0.4% isoflurane and opioid. The thermoregulatory vasoconstriction threshold was defined by the tympanic membrane temperature at which the skin temperature gradient equalled 0degreesC. Plasma adrenaline, noradrenaline and leptin were measured. Results: Age, height, heart rate and blood pressure did not differ between the two groups of patients. In the obese group the vasoconstriction threshold was higher than that in the normal weight group: 36.0 +/- 0.1 vs. 35.5 +/- 0.2degreesC. Consequently, after 4 h of anaesthesia, the core temperature was highest in the obese patients: 36.4 +/- 0.1 vs. 35.5 +/- 0.2degreesC. Conclusions: These results suggest that core temperature is maintained in obese patients because their vasoconstriction threshold to a low environmental temperature is high., BLACKWELL MUNKSGAARD, May 2003, ACTA ANAESTHESIOLOGICA SCANDINAVICA, 47 (5), 588 - 592, doi;web_of_science

    Scientific journal

  • Reduced blood-to-tissue albumin movement after plasmapheresis

    AM Stahl; CM Gillen; A Takamata; ER Nadel; GW Mack

    We tested the hypothesis that a decrease in the blood-to-tissue movement of albumin contributes to the recovery of plasma albumin and plasma volume after acute plasma protein depletion (plasmapheresis). Awake and unrestrained male Sprague-Dawley rats (220-320 g) fitted with jugular catheters were plasmapheresed, and plasma volume, plasma albumin, and total plasma protein content were measured at 1, 5, 24, and 48 h postplasmapheresis. Plasma volume recovered to baseline within 1 h (4.6 +/- 0.42 vs. 4.7 +/- 0.46 mL/100 g body weight (bw), remained at baseline from 5 h to 24 h but increased to 5.5 +/- 0.57 mL/100 g bw at 48 h (P < 0.05). Plasma albumin and total protein content recovered rapidly but remained below baseline levels at 1 h (10.05 +/- 0.98 vs. 12.33 +/- 1.29 and 19.75 +/- 1.75 vs. 24.73 +/- 2.56 mg/100 g bw, respectively). Plasma protein content returned to baseline by 5 h of recovery. Tissue uptake of I-125-labeled albumin decreased in the heart, skin, skeletal muscle, and small intestines of plasmapheresed rats (P < 0.05). These data support the hypothesis that a reduction in albumin efflux from the vascular space contributes to the recovery of plasma albumin and total protein content during plasma volume recovery and eventual expansion after plasmapheresis., LIPPINCOTT WILLIAMS & WILKINS, May 2003, SHOCK, 19 (5), 440 - 447, doi;web_of_science

    Scientific journal

  • Preoperative blood pressure and catecholamines related to hypothermia during general anesthesia

    T Kasai; M Hirose; T Matsukawa; A Takamata; K Yaegashi; Y Tanaka

    Background: We previously demonstrated that preoperative blood pressure values affect intraoperative hypothermia during general anesthesia. We hypothesized that increased catecholamine secretion could be responsible for the relationship between preoperative blood pressure and hypothermia. Methods: To evaluate the effect of preoperative systolic blood pressure (SBP) and plasma catecholamine levels on core temperature during general anesthesia, 40 male patients who were scheduled for open abdominal surgery were allocated to two groups: those whose preoperative SBP was 140 mmHg or greater (high SBP group, n = 20), and those whose SBP was less than 140 mmHg (normal SBP group, n = 20). Anesthesia was maintained with 0.4% isoflurane and opioids. Results: The average age, height, and weight of the patients in the two groups did not differ. Preoperative SBP, mean blood pressure, diastolic blood pressure and heart rate in the high SBP group were significantly higher than those in the normal SBP group. Plasma norepinephrine concentrations in the high SBP group were significantly greater than those in the normal SBP group before and 1 h after the induction of anesthesia. Tympanic membrane temperatures in the normal SBP group started to decline further just after the induction of anesthesia, more so than that in the high SBP group. The vasoconstriction threshold in the normal SBP group was significantly lower than that in the high SBP group. Conclusion: These results suggest that the higher levels of preoperative catecholamine secretion contributed to the lesser degree of intraoperative hypothermia observed in the high SBP group., BLACKWELL MUNKSGAARD, Feb. 2003, ACTA ANAESTHESIOLOGICA SCANDINAVICA, 47 (2), 208 - 212, doi;web_of_science

    Scientific journal

  • Water permeability of capillaries in the subfornical organ of rats determined by Gd-DTPA(2-) enhanced H-1 magnetic resonance imaging

    Y Seo; A Takamata; T Ogino; H Morita; S Nakamura; M Murakami

    The water permeability of capillaries in the subfornical organ (SFO) of rat was measured by a H-1 nuclear magnetic resonance method in combination with a venous injection of a relaxation reagent, gadolinium-diethylene triamine-N,N,N,N",N"-pentaacetic acid (Gd-DTPA(2-)), which could not pass through the blood-brain barrier (BBB). Judging from results of Gd-DTPA(2-) dose dependency in the intact brain and the BBB-permeabilized brain, Gd-DTPA(2-) could not have leaked out from the capillaries in the cortex, thalamus or SFO, but it could have been extravasated in the posterior lobe of the pituitary gland. The longitudinal (T,) relaxation time of water in the SFO region was measured by inversion-recovery magnetic resonance imaging at 4.7 T. The T-1 relaxation rates (1/T-1) before and after Gd-DTPA(2-) infusion were 0.70 +/- 0.02 s(-1) (mean +/- S.E.M., n = 9) and 1.53 +/- 0.11 s(-1) (n = 9), respectively. The rate constant for water influx to the capillaries was estimated to be 0.84 +/- 0.11 s(-1) (n = 9) which corresponds with a diffusive membrane permeability (P-d) of 3.7 x 10(-3) cm s(-1). Compared with values found in the literature available on this subject, this Pd value for the capillaries in the SFO was the same order of magnitude as that for transmembrane permeability of water for the vasa recta, and it may be 10-100 times larger than that of the blood-brain barrier in the cortex. Areas of the cortex and thalamus showed minimal changes in the T-1 relaxation rate (ca 0.09 s(-1)), but these values were not statistically significant and they corresponded to P-d values much smaller than those found in the SFO. From these results, we conclude that the capillaries in the SFO have one of the highest water permeability values among all of the capillaries in the brain. It is also suggested that this magnetic resonance imaging, based on T-1 relaxation rate, is a useful method to detect local water permeability in situ., CAMBRIDGE UNIV PRESS, Nov. 2002, JOURNAL OF PHYSIOLOGY-LONDON, 545 (1), 217 - 228, doi;web_of_science

    Scientific journal

  • Preoperative risk factors of intraoperative hypothermia in major surgery under general anesthesia

    T Kasai; M Hirose; K Yaegashi; T Matsukawa; A Takamata; Y Tanaka

    Preoperative factors, such as age and body habitus, affect intraoperative hypothermia during general anesthesia. In a preliminary study, we developed a logistic model to retrospectively evaluate predictors of intraoperative hypothermia in patients who received major surgery. The following factors were selected to develop the model: Z = -15.014 + 0.097 x (Age) + 0.263 x (Height) - 0.323 x (Weight) - 0.055 x (Preoperative systolic blood pressure) - 0.121 X (Preoperative heart rate). By using this model, the probability of hypothermia can be estimated by applying the following formula: Probability = 1/(1 + e(-z)). If an estimated probability of hypothermia was >0.5, the sensibility of prediction was 81.5% and the specificity was 83%. In the second study, the model was applied prospectively to other patients, and the validity of the logistic model was evaluated. The core temperature showed a significant decrease in patients with a probability >0.7, who were predicted to be hypothermic, and their thermoregulatory vasoconstriction threshold also showed a significant decrease, compared with the patients with a probability less than or equal to0.3, who were predicted to be normothermic. We concluded that intraoperative hypothermia could be predicted from preoperative characteristics such as age, height, weight, systolic blood pressure, and heart rate., LIPPINCOTT WILLIAMS & WILKINS, Nov. 2002, ANESTHESIA AND ANALGESIA, 95 (5), 1381 - 1383, doi;web_of_science

    Scientific journal

  • Detection of hypothalamic activation by manganese ion contrasted T-1-weighted magnetic resonance imaging in rats

    H Morita; T Ogino; Y Seo; N Fujiki; K Tanaka; A Takamata; S Nakamura; M Murakami

    To examine the usefulness of Mn2+ contrasted magnetic resonance imaging (MRI) in hypothalamic imaging, images obtained using T-1-weighted MRI were compared with Fos expression, which is known to increase after activation of voltage-dependent Ca2+ channels. Intravenous infusion of MnCl2 elicited a rapid increase in the T-1-weighted MRI signal intensity in the vessels and ventricles, but not in the brain parenchyma, suggesting that Mn2+ did not diffuse freely across the blood-brain barrier. When the blood-brain barrier was broken by right intracarotid arterial injection of 25% D-mannitol, an increased signal intensity was seen in the right brain. Intracarotid arterial injection of hypertonic NaCl elicited rapid and striking increases in signal intensity in the paraventricular hypothalamic nucleus, supraoptic nucleus, and preoptic area, which are thought to be involved in central osmotic regulation. These observations were consistent with the Fos expression results. These results indicate that Mn2+ contrasted MRI is a useful technique for investigating the autonomic center in the hypothalamus. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved., ELSEVIER SCI IRELAND LTD, Jun. 2002, NEUROSCIENCE LETTERS, 326 (2), 101 - 104, doi;web_of_science

    Scientific journal

  • Upright posture reduces thermogenesis and augments core hypothermia

    Y Nakajima; A Takamata; T Ito; DI Sessler; Y Kitamura; G Shimosato; S Taniguchi; H Matsuyama; Y Tanaka; T Mizobe

    We recently reported that baroreceptor-mediated reflexes modulate thermoregulatory vasoconstriction during lower abdominal surgery. Accordingly, we examined the hypothesis that postural differences and the related alterations in baroreceptor loading similarly modulate the thermogenic (i.e., shivering) response to hypothermia in humans. In healthy humans (n = 7), cold saline was infused W (30 mL/kg at 4degreesC) for 30 min to decrease core temperature. Each participant was studied on 2 separate days, once lying supine and once sitting uptight. Tympanic membrane temperature and oxygen consumption were monitored for 40 min after each saline infusion. The decrease in core temperature upon completion of the infusion in the upright posture position was 1.24degreesC +/- 0.07degreesC, which was significantly greater than the 1.02degreesC +/- 0.06degreesC seen in the supine position. The core temperature was reduced by 0.59degreesC +/- 0.07degreesC in the upright position but only by 0.37degreesC +/- 0.05degreesC in the supine position when the increase in oxygen consumption signaling thermogenic shivering occurred. Thus, the threshold temperature for thermogenesis was significantly less in the upright than the supine position. The gain of the thermogenic response did not differ significantly between the positions (363 +/- 69 mL.min(-1).degreesC(-1) for upright and 480 +/- 80 mL . min(-1) . degreesC(-1) for supine). The skin temperature gradient was significantly larger in the upright than in the supine posture, suggesting that the peripheral vasoconstriction was augmented by upright posture. Plasma norepinephrine concentrations increased in response to cold saline infusion under both conditions, but the increase was significantly larger in the upright than in the supine posture. Baroreceptor unloading thus augments the peripheral vasoconstrictor and catecholamine response to core hypothermia but simultaneously reduces thermogenesis, which consequently aggravated the core temperature decrease in the upright posture., LIPPINCOTT WILLIAMS & WILKINS, Jun. 2002, ANESTHESIA AND ANALGESIA, 94 (6), 1646 - 1651, web_of_science

    Scientific journal

  • 夏期の作業・運動時における効果的な水分補給

    鷹股 亮

    2002, 綜合臨床, 51, 2295 - 2296

  • Role of blood volume in the age-associated decline in peak oxygen uptake in humans

    T Ito; A Takamata; K Yaegashi; T Itoh; T Yoshida; T Kawabata; M Kimura; T Morimoto

    It has been reported that maximal oxygen uptake ((V) over dot O-2max) is linearly correlated with blood volume (BV) in young people and that there is a reduction in (V) over dot O-2max with aging. To examine the involvement of BV in the reduction of (V) over dot O-2max, we used an incremental cycle ergometer protocol in a semirecumbent position to determine the relationship between peak oxygen uptake ((V) over dot O-2peak) and BV in older subjects (69.1 +/- 1.0 years, n=22), then compared that relationship with that in young subjects (22.3 +/- 0.5 years; n=31). In the present study, (V) over dot O-2peak and BV were significantly lower in the older subjects, compared with those in the young subjects. A linear correlation was demonstrated between the (V) over dot O-2peak and BV in both the older (r=0.705; p<0.001) and the young (r=0.681; p<0.001) subjects within the groups. However, an analysis of covariance with BV as a covariate revealed that (V) over dot O-2peak at a given BV was smaller in the older subjects than in the young subjects (p<0.001), i.e., graphically, the regression line determined for the older subjects showed a downward shift. The decreased peak heart rate as a result of aging (153 +/- 3 beats/min in the older vs. 189 +/- 2 beats/min in the young subjects) contributed partly to this downward shift. These results suggest that the BV is an important determinant factor for (V) over dot O-2peak, especially within an age group, and that the age-associated decline of (V) over dot O-2peak is also, to a relatively larger degree, because of factors other than BV and heart rate., CENTER ACADEMIC PUBL JAPAN, Oct. 2001, JAPANESE JOURNAL OF PHYSIOLOGY, 51 (5), 607 - 612, doi;web_of_science

    Scientific journal

  • Preoperative blood pressure and intraoperative hypothermia during lower abdominal surgery

    T Kasai; M Hirose; T Matsukawa; A Takamata; M Kimura; Y Tanaka

    Background: Preoperative factors including age and body habitus affect intraoperative hypothermia during general anesthesia. We hypothesized that preoperative blood pressure also plays a contributory role in the induction of intraoperative hypothermia. Methods: We evaluated the effect of preoperative systolic blood pressure (SBP) on core temperature during lower abdominal surgery under general anesthesia. In 36 female patients under 65 years of age, patients with a preoperative SBP of 140 mmHg or greater upon arrival in the operating theater were assigned to the high SBP group (n=18), while those with SBP below 140 mmHg were assigned to the normal SBP group (n=18). Anesthesia was maintained with isoflurane and nitrous oxide combined with epidural buprenorphine, and routine thermal care was provided intraoperatively. Results: There were no significant differences in age, height or weight between the two groups. Tympanic membrane temperature in the normal SBP group started to decrease significantly from 15 min after induction of anesthesia compared to that in the high SBP group, and continued to decrease further at two hours after induction. Vasoconstriction threshold, determined to be tympanic membrane temperature at the time when a forearm minus finger skin surface gradient exceeded 0 degreesC, was significantly higher in the high SBP group than in the normal SBP group. Conclusion: These results suggest that preoperative SBP has some preventive effect on the decrease in intraoperative core temperature during lower abdominal surgery under general anesthesia., MUNKSGAARD INT PUBL LTD, Sep. 2001, ACTA ANAESTHESIOLOGICA SCANDINAVICA, 45 (8), 1028 - 1031, doi;web_of_science

    Scientific journal

  • Relationship of osmotic inhibition in thermoregulatory responses and sweat sodium concentration in humans

    A Takamata; T Yoshida; N Nishida; T Morimoto

    Heat acclimatization improves thermoregulatory responses to heat stress and decreases sweat sodium concentration ([Na+](sweat)). The reduced [Na+](sweat) results in a larger increase in plasma osmolality (P-osmol) at a given amount of sweat output. The increase in Posmol inhibits thermoregulatory responses to increased body core temperature. Therefore, we hypothesized that the inhibitory effect of plasma hyperosmolality on the thermoregulatory responses to heat stress should be attenuated with the reduction of [Na+](sweat) due to heat acclimatization. Eleven subjects (9 male and 2 female) were passively heated by immersing their lower legs into water at 42 degreesC (room temperature 28 degreesC and relative humidity 30%) for 50 min following isotonic or hypertonic saline infusion. We determined the increase in the esophageal temperature (T-es) required to elicit sweating and cutaneous vasodilation (CVD) (DeltaT(es) thresholds for sweating and CVD, respectively) in each condition and calculated the elevation of the T-es thresholds per unit increase in P-osmol as the osmotic inhibition of sweating and CVD. The osmotic shift in the DeltaT(es) thresholds for both sweating and CVD correlated linearly with [Na+](sweat) (r = 0.858 and r = 0.628, respectively). Thus subjects with a lower [Na+](sweat) showed a smaller osmotic elevation of the DeltaT(es) thresholds for sweating and CVD. These results suggest the possibility that heat acclimatization attenuates osmotic inhibition of thermoregulatory responses as well as reducing [Na+](sweat)., AMER PHYSIOLOGICAL SOC, Mar. 2001, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 280 (3), R623 - R629, web_of_science

    Scientific journal

  • Effects of pCO(2) on the CSF turnover rate in rats monitored by Gd-DTPA enhanced T-1-weighted magnetic resonance imaging

    A Takamata; Y Seo; T Ogino; K Tanaka; N Fujiki; H Morita; M Murakami

    The cerebrospinal fluid (CSF) secretion of rat was monitored by longitudinal relaxation time-weighted magnetic resonance imaging (T-1-weighted MRI) in combination with a ventricular injection of a T-1-relaxation reagent: gadolinium-diethylene triamine-N,N,N',N",N"-pentaacetic acid (Gd-DTPA). A cannula was inserted in the left lateral ventricle, and 5 mul of 8.5 mm Gd-DTPA was injected as a CSF marker. Changes in the image intensity of the CSF were measured every 30 s, and the turnover rate of CSF (k) in the left lateral ventricle was obtained from the dilution of Gd-DTPA, based on the assumption of a single compartment model. In the control conditions, k was 0.158 +/- 0.009 min(-1) at an arterial blood CO2 tension (pCO(2)) of 38.6 +/- 2.2 mmHg (n=10), which corresponds to the CSF secretion rate of 3.6 mul min(-1). The k value was decreased (0.078 +/- 0.010 min(-1), n=4) by a carbonic-anhydrase inhibitor (acetazolamide). The turnover rate was decreased by hypocapnia (0.094+/-0.019 min(-1), pCO(2)=24.7 +/- 2.9 mmHg, n=4), and it increased gradually and reached a plateau level as a result of hypercapnia (0.194 +/- 0.011 min(-1), pCO(2)=104.5 +/- 7.1 mmHg, n=10). These results suggested that CO2 upregulates the secretion of CSF in the rat., CENTER ACADEMIC PUBL JAPAN, Oct. 2001, JAPANESE JOURNAL OF PHYSIOLOGY, 51 (5), 555 - 562, doi;web_of_science

    Scientific journal

  • Baroreflex modulation of peripheral vasoconstriction during progressive hypothermia in anesthetized humans

    Y Nakajima; T Mizobe; A Takamata; Y Tanaka

    Mild hypothermia is a major concomitant of surgery under general anesthesia. We examined the hypothesis that baroreceptor loading/unloading modifies thermoregulatory peripheral vasoconstriction and, consequently, body core temperature in subjects undergoing lower abdominal surgery with general anesthesia. Thirty-six patients were divided into four groups: control group (C), applied positive end-expiratory pressure (PEEP; 10 cmH(2)O) group (P), applied leg-up position group (L), and a group of leg-up position patients with PEEP starting 90 min after induction of anesthesia (L + P). The esophageal temperature (T-es) and the forearm-fingertip temperature gradient, as an index of peripheral vasoconstriction, were monitored for 3 h after induction of anesthesia. Mean arterial pressure and pulse pressure did not change during the study in any group. The change in right atrial transmural pressure from the baseline value was 0.3 +/- 0.1 mmHg in C, -3.0 +/- 0.5 mmHg in P, and 2.3 +/- 0.4 mmHg in L (P < 0.01). The change in Tes at the end of the study was -1.7 +/- 0.1 (35.1 +/- 0.1)degrees C in C, -1.1 +/- 0.1 (35.7 +/- 0.1)degrees C in P, and -2.7 +/- 0.1 (34.1 +/- 0.1)degrees C in L, showing significant differences (P < 0.01). The Tes threshold for thermal peripheral vasoconstriction was 35.6 +/- 0.1 degrees C in C, 36.2 +/- 0.2 degrees C in P, and 34.8 +/- 0.2 degrees C in L (P, 0.01). Excessive Tes decrease in the leg-up-position operation was attenuated by applying PEEP (L + P group; P < 0.05). Our data indicate that baroreceptor loading augments and unloading prevents perioperative hypothermia in anesthetized and paralyzed subjects by reducing and increasing the body temperature threshold for peripheral vasoconstriction, respectively., AMER PHYSIOLOGICAL SOC, Oct. 2000, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 279 (4), R1430 - R1436, web_of_science

    Scientific journal

  • Effect of acute hypoxia on vasopressin release and intravascular fluid during dynamic exercise in humans

    A Takamata; H Nose; T Kinoshita; M Hirose; T Itoh; T Morimoto

    To test the hypothesis that acute hypoxia does not modify the relationship between plasma vasopressin concentration ([AVP](p)) and plasma osmolality (P-osmol) during exercise and that the increase in [AVP](p) during exercise is due mainly to the exercise intensity-dependent increase in P-osmol, we examined [AVP](p) during a graded exercise in a hypoxic condition (13% O-2, N-2 balance) in seven healthy male subjects. A graded exercise in a normoxic condition on a separate day served as the control. Hypoxia reduced peak aerobic power ((V) over dotO(2 peak)) by 32.4 +/- 2.7%. Blood samples obtained during rest and at around 25, 45, 65, 80, and 100% of (V) over dotO(2) (peak) of each of the respective conditions were used for analyses of intravascular water and electrolyte balance. The pattern of the changes in fluid and electrolyte balance in response to percent (V) over dotO(2 peak) was similar between the two conditions. Plasma volume decreased linearly as percent (V) over dotO(2 peak) increased while P-osmol increased in a curvilinear fashion with a steep increase occurring at above similar to 66% (V) over dotO(2 peak). Above this relative exercise intensity, plasma sodium, potassium, and lactate concentrations also increased, whereas plasma bicarbonate concentration decreased. Thus transvascular fluid movement at above similar to 66% (V) over dotO(2 peak) was due to the net efflux of hypotonic fluid out of the vascular space in both conditions. The relationship between [AVP](p) and P-osmol during exercise in response to relative exercise intensity was similar between the two conditions. The results indicate that acute mild hypoxia itself has no direct effect on vasopressin release, and it does not modify the relationship between [AVP](p) and P-osmol during exercise. The results also support the hypothesis that exercise-induced vasopressin release is primarily stimulated by increased P-osmol produced by hypotonic fluid movement out of the vascular space in a relative exercise intensity-dependent manner., AMER PHYSIOLOGICAL SOC, Jul. 2000, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 279 (1), R161 - R168, web_of_science

    Scientific journal

  • LPS-induced Fos expression in oxytocin and vasopressin neurons of the rat hypothalamus

    W Matsunaga; S Miyata; A Takamata; H Bun; T Nakashima; T Kiyohara

    The aim of this study was to examine the involvement of the hypothalamic oxytocin (OXT) and vasopressin (AVP) neurons in acute phase reaction using quantitative dual-labeled immunostaining with Fos and either OXT and AVP in several hypothalamic regions. Administration of low dose (5 mu g/kg) and high dose (125 mu g/kg) of LPS induced intense nuclear Fos immunoreactivity in many OXT and AVP neurons in all the observed hypothalamic regions. The percentage of Fos-positive nuclei in OXT magnocellular neurons was higher than that of AVP magnocellular neurons in the supraoptic nucleus (SON), the magnocellular neurons in the paraventricular nucleus (magPVN), rostral SON (rSON), and nucleus circularis (NC), whose axons terminate at the posterior pituitary for peripheral release. The percentage of Fos-positive nuclei in AVP parvocellular neurons in the paraventricular nucleus (parPVN) was higher than that of OXT parvocellular neurons, whose axons terminate within the brain for central release. Moreover, the percentage of Fos-positive nuclei in AVP magnocellular neurons of the SON and rSON was significantly higher than that of the magPVN and NC when animals were given LPS via intraperitoneal (i.p.)-injection. This regional heterogeneity was not observed in OXT magnocellular neurons of i.p.-injected rats or in either OXT or AVP magnocellular neurons of intravenous (i.v.)-injected rats. The present data suggest that LPS-induced peripheral release of AVP and OXT is due to the activation of the magnocellular neurons in the SON, magPVN, NC, and rSON, and the central release of those hormones is in part derived from the activation of parvocellular neurons in the PVN. It is also suggested that the activation of AVP magnocellular neurons is heterogeneous among the four hypothalamic regions, but that of OXT magnocellular neurons is homogenous among these brain regions in response to LPS administration. (C) 2000 Elsevier Science B.V. All rights reserved., ELSEVIER SCIENCE BV, Mar. 2000, BRAIN RESEARCH, 858 (1), 9 - 18, doi;web_of_science

    Scientific journal

  • スポーツと水分摂取

    鷹股 亮; 鷹股亮

    2000, 保健の科学, 42, 332 - 339

  • 運動時の水分補給とスポーツ飲料

    鷹股 亮

    2000, FOOD Style 21, 6, 62 - 66

  • Comparison between tail skin blood flow measurements by ultrasonic Doppler flowmetry and plethysmography during heating in anesthetized rats

    Y Nakajima; H Nose; A Takamata

    Tail skin blood flow (TBFu) was directly measured in anesthetized and passively heated rats by ultrasonic Doppler flowmetry during heating, and the values were compared to those (TBFp) simultaneously measured by venous-occlusion plethysmography. TBFp was estimated from the values per unit tissue multiplied by the tail volume, the shape of which was assumed to be a cone. TBFp was highly correlated with TBFu, with a regression equation of TBFp=0.7TBF(u)+0.1 (r(2)=0.94, p<0.001). Although TBFp was slightly lower than TBFu, the equation is useful to estimate the absolute values of tail skin blood flow from the values of plethysmography in awake rats., CENTER ACADEMIC PUBL JAPAN, Feb. 1999, JAPANESE JOURNAL OF PHYSIOLOGY, 49 (1), 121 - 124, doi;web_of_science

    Scientific journal

  • Effect of an exercise-heat acclimation program on body fluid regulatory responses to dehydration in older men

    A Takamata; T Ito; K Yaegashi; H Takamiya; Y Maegawa; T Itoh; JE Greenleaf; T Morimoto

    We examined if an exercise-heat acclimation program improves body fluid regulatory function in older subjects, as has been reported in younger subjects. Nine older (Old; 70 +/- 3 yr) and six younger (Young; 25 +/- 3 yr) male subjects participated in the study. Body fluid regulatory responses to an acute thermal dehydration challenge were examined before and after the B-day acclimation session. Acute dehydration was produced by intermittent light exercise [4 bouts of 20-min exercise at 40% peak rate of oxygen consumption (VO2peak) Separated by 10 min rest] in the heat (36 degrees C; 40% relative humidity) followed by 30 min of recovery without fluid intake at 25 degrees C. During the 2-h rehydration period the subjects drank a carbohydrate-electrolyte solution ad libitum. In the preacclimation test, the Old lost similar to 0.8 kg during dehydration and recovered 31 +/- 4% of that loss during rehydration, whereas the Young lost similar to 1.2 kg and recovered 56 +/- 8% (P < 0.05, Young vs. Old). During the B-day heat acclimation period all subjects performed the same exercise-heat exposure as in the dehydration period. Exercise-heat acclimation increased plasma volume by similar to 5% (P < 0.05) in Young subjects but not in Old. The body fluid loss during dehydration in the postacclimation test was similar to that in the preacclimation in Young and Old. The fractional recovery of lost fluid volume during rehydration increased in Young (by 80 +/- 9%; P < 0.05) but not in Old (by only 34 +/- 5%; NS). The improved recovery from dehydration in Young was mainly due to increased fluid intake with a small increase in the fluid retention fraction. The greater involuntary dehydration (greater fluid deficit) in Old was accompanied by reduced plasma vasopressin and aldosterone concentrations, renin activity, and subjective thirst rating (P < 0.05,Young vs. Old). Thus older people have reduced ability to facilitate body fluid regulatory function by exercise-heat acclimation, which might be involved in attenuation of the acclimation-induced increase in body fluid volume., AMER PHYSIOLOGICAL SOC, Oct. 1999, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 277 (4), R1041 - R1050, web_of_science

    Scientific journal

  • Plasma hyperosmolality and arterial pressure regulation during heating in dehydrated and awake rats

    Y Nakajima; H Nose; A Takamata

    To gain better insights into the effect of dehydration on thermal and cardiovascular regulation during hyperthermia, we examined these regulatory responses during body heating in rats under isosmotic hypovolemia and hyperosmotic hypovolemia. Rats were divided into four groups: normovolemic and isosmotic (C), hypovolemic and isosmotic [L, plasma volume loss (Delta PV) = -20% of control], hypovolemic and less hyperosmotic [HL1, increase in plasma osmolality (Delta P-osm) = 23 mosmol/kgH(2)O, Delta PV = -16%], and hypovolemic and more hyperosmotic (HL2, Delta P-osm = 52 mosmol/kgH(2)O, Delta PV = -17%). Hyperosmolality was attained by subcutaneous injection of hypertonic saline and hypovolemia by intra-arterial injection of furosemide before heating, Then rats were placed in a thermocontrolled box (35 degrees C air temperature, similar to 20% relative humidity) for 1-2 h until rectal temperatures (T-re) reached 40.0 degrees C. Mean arterial pressure in L decreased with rise in T-re (P < 0.001), whereas mean arterial pressure remained constant in the other groups. Maximal tail skin blood flow in L, HL1, and HL2 was decreased to similar to 30% of that in C (P < 0.001). T-re threshold for tail skin vasodilation (TVD) was not changed in L, whereas the threshold shifted higher in the HL groups. T-re threshold for TVD was highly correlated with P-osm (r = 0.94, P < 0.001). Heart rate in the HL groups increased with rise in T-re (P < 0.001), whereas it remained unchanged in C and L. Cardiovascular responses to heating were not influenced by V-1 antagonist in C, L, and HL2. Thus isotonic hypovolemia attenuates maximal tail skin blood flow, whereas hypertonic hypovolemia causes an upward shift of T-re threshold for TVD and an increase in heart rate during hyperthermia. These results suggest that plasma hyperosmolality stimulates presser responses in the hypovolemic condition that subsequently contribute to arterial pressure regulation during heat stress., AMER PHYSIOLOGICAL SOC, Nov. 1998, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 275 (5), R1703 - R1711, web_of_science

    Scientific journal

  • Role of plasma osmolality in the delayed onset of thermal cutaneous vasodilation during exercise in humans

    A Takamata; K Nagashima; H Nose; T Morimoto

    To elucidate the role of increased plasma osmolality (P-osmol), which occurs during exercise in the regulation of cutaneous vasodilation (CVD) during exercise, we determined the relationship between the change in esophageal temperature (Delta T-es) required to elicit CVD (Delta T-es threshold for CVD) and P-osmol during light and moderate exercise (30 and 55% of peak oxygen consumption, respectively) and passive body heating. Then we compared the relationship with the data obtained in our previous study [A. Takamata, K. Nagashima, H. Nose, and T. Morimoto.Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R197-R204, 1997], in which we determined the relationships during passive body heating following isotonic (0.9% NaCl) or hypertonic (2 or 3% NaCl) saline infusions in the same subjects. P-osmol values at 5 min after the onset of exercise were 287.5 +/- 0.9 mosmol/kgH(2)O during light exercise and 293.0 +/- 1.2 mosmol/kgH(2)O during moderate exercise. P-osmol just before passive body heating was 289.9 +/- 1.4 mosmol/kgH(2)O. The Delta T-es threshold for CVD was 0.09 +/- 0.05 degrees C during light exercise, 0.31 +/- 0.09 degrees C during moderate exercise, and 0.10 +/- 0.05 degrees C during passive body heating. The relationship between the Delta T-es threshold for CVD and P-osmol was shown to be on the same regression line both during exercise and during passive body heating with or without infusions [A. Takamata, K. Nagashima, H. Nose, and T. Morimoto. Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R197-R204, 1997]. Our data suggest that the elevated body core temperature threshold for CVD during exercise could be the result of increased P-osmol induced by exercise and is not due to reduced plasma volume or the intensity of the exercise itself., AMER PHYSIOLOGICAL SOC, Jul. 1998, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 275 (1), R286 - R290, web_of_science

    Scientific journal

  • Effect of continuous negative-pressure breathing on skin blood flow during exercise in a hot environment

    K Nagashima; H Nose; A Takamata; T Morimoto

    To assess the impact of continuous negative-pressure breathing (CNPB) on the regulation of skin blood flow, we measured forearm blood flow (FBF) by venous-occlusion plethysmography and laser-Doppler flow (LDF) at the anterior chest during exercise in a hot environment (ambient temperature = 30 degrees C, relative humidity = similar to 30%). Seven male subjects exercised in the upright position at an intensity of 60% peak oxygen consumption rate for 40 min with and without CNPB after 20 min of exercise. The esophageal temperature (T-es) in both conditions increased to 38.1 degrees C by the end of exercise, without any significant differences between the two trials. Mean arterial pressure (MAP) increased by similar to 15 mmHg by 8 min of exercise, without any significant difference between the two trials before CNPB. However, CNPB reduced MAP by similar to 10 mmHg after 24 min of exercise (P < 0.05). The increase in FBF and LDF in the control condition leveled off after 18 min of exercise above a T-es of 37.7 degrees C, whereas in the CNPB trial the increase continued, with a rise in T-es despite the decrease in MAP. These results suggest that CNPB enhances vasodilation of skin above a T-es of similar to 38 degrees C by stretching intrathoracic baroreceptors such as cardiopulmonary baroreceptors., AMER PHYSIOLOGICAL SOC, Jun. 1998, JOURNAL OF APPLIED PHYSIOLOGY, 84 (6), 1845 - 1851, web_of_science

    Scientific journal

  • Thermoregulation and body fluid in hot environment

    T Morimoto; T Itoh; A Takamata

    ELSEVIER SCIENCE PUBL B V, 1998, BRAIN FUNCTION IN HOT ENVIRONMENT, 115, 499 - 508, web_of_science

  • Osmoregulatory inhibition of thermally induced cutaneous vasodilation in passively heated humans

    A Takamata; K Nagashima; H Nose; T Morimoto

    We examined the effect of increased plasma osmolality (P-osm) on cutaneous vasodilatory response to increased esophageal temperature (T-es) in passively heated human subjects (n = 6). To modify P-osm, subjects were infused with 0.9, 2, or 3% NaCl infusions (Inf) for 90 min on separate days. Infusion rates were 0.2, 0.15, and 0.125 ml . min(-1). kg body wt(-1) for 0.9, 2, and 3% Inf, respectively, which produced relatively similar plasma volume expansion. Thirty minutes after the end of infusion, subjects immersed their lower legs in a water bath at 42 degrees C (room temperature 28 degrees C) for 60 min after 10 min of preheating control measurements. Passive heating without infusion (NI) served as time control to account for the effect of volume expansion. P-osm (mosmol/kgH(2)O) values at the onset of passive heating were 289.9 +/- 1.4, 292.1 +/- 0.6, 298.7 +/- 0.7, and 305.6 +/- 0.6 after NI, 0.9% Inf, 2% Inf, and 3% Inf, respectively. The increases in T-es (Delta T-es) at equilibrium during passive heating (mean Delta T-es during 55-60 min) were 0.47 +/- 0.08, 0.59 +/- 0.08, 0.85 +/- 0.13, and 1.09 +/- 0.12 degrees C after NI, 0.9% Inf, 2% Inf, and 3% Inf, respectively, which indicates that T-es at equilibrium increased linearly as P-osm increased. Delta T-es required to elicit cutaneous vasodilation (Delta T-es threshold for cutaneous vasodilation) also increased linearly as P-osm increased as well as the Delta T-es threshold for sweating. The calculated increases in these thresholds per unit rise in P-osm from regression analysis were 0.044 degrees C for the cutaneous vasodilation and 0.034 degrees C for sweating. Thus the Delta T-es thresholds for cutaneous vasodilation and sweating are shifted to higher Delta T-es along with the increase in P-osm, and these shifts resulted in the higher increase in T-es during passive heating., AMER PHYSIOLOGICAL SOC, Jul. 1997, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 273 (1), R197 - R204, web_of_science

    Scientific journal

  • Integrative regulations of body temperature and body fluid in humans exercising in a hot environment

    H Nose; A Takamata

    SPRINGER VERLAG, Feb. 1997, INTERNATIONAL JOURNAL OF BIOMETEOROLOGY, 40 (1), 42 - 49, web_of_science

    Scientific journal

  • Negative pressure breathing and the control of skin blood flow during exercise in a hot environment

    K Nagashima; T Yoshida; H Nose; A Takamata; T Morimoto

    NEW YORK ACAD SCIENCES, 1997, THERMOREGULATION, 813, 604 - 609, doi;web_of_science

    Scientific journal

  • 静脈還流量からみた微少重力下での筋血流調節

    鷹股 亮; 能勢博; 上条義一郎; 竹野欽昭; 柳平担徳; 酒井秋男; 永島計; 鷹股亮; 森本武利

    1997, Space Utilization Research., 14, 18 - 21

  • 運動時の体液調節

    鷹股 亮

    1997, 臨床スポーツ医学, 14, 721 - 727

  • Thirst and fluid regulatory responses to hypertonicity in older adults

    NS Stachenfeld; GW Mack; A Takamata; L DiPietro; ER Nadel

    To assess the fluid regulatory responses in aging adults, we measured thirst perception and renal osmoregulation during and after infusion of hypertonic (3% NaCl) saline in older (72 +/- 2 yr, n = 6) and younger (26 +/- 2 yr, n = 6) subjects. Hypertonic saline was infused at 0.1 ml . min(-1). kg(-1) for 120 min. On a separate day, the same subjects were infused identically with isotonic saline as a control. After infusion and a 30-min equilibration period, the subjects drank water ad libitum for 180 min. Hypertonic saline infusion Zed to graded increases in plasma osmolality (P-osm; 18 +/- 2 and 20 +/- 2 mosmol/kgH(2)O) and percent changes in plasma volume (16.2 +/- 1.9 and 18.0 +/- 1.2%) that were similar in older and younger subjects. Osmotically stimulated increases in thirst (94.8 +/- 18.9 and 88.3 +/- 25.6 mm), assessed on a line rating scale, and plasma arginine vasopressin concentration (6.08 +/- 1.50 and 4.51 +/- 1.37 pg/ml, for older and younger, respectively) were also unaffected by age. Despite subsequent hypervolemia, both groups of subjects drank sufficient water to restore preinfusion levels of P-osm. Renal handling of free water and sodium was also unaffected by age during recovery from hypertonic saline infusion, but was significantly lower in older subjects during recovery from isotonic saline infusion, resulting in net fluid retention and a significant fall in P-osm (6 mosmol/kgH(2)O). In contrast to earlier reports of a blunted thirst response to dehydration and hypertonicity, we found that osmotically stimulated thirst and renal osmoregulation were intact in older adults after hypertonic saline infusion., AMER PHYSIOLOGICAL SOC, Sep. 1996, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 271 (3), R757 - R765, web_of_science

    Scientific journal

  • スポーツが血中イオンに及ぼす影響と循環血液量の変化について

    鷹股 亮

    1996, 日常診療と血液, 6, 403 - 409

  • 運動時の体温調節と水分摂取.

    鷹股 亮

    1996, 臨床スポーツ医学, 13, 68 - 73

  • OSMOREGULATORY MODULATION OF THERMAL SWEATING IN HUMANS - REFLEX EFFECTS OF DRINKING

    A TAKAMATA; GW MACK; CM GILLEN; AC JOZSI; ER NADEL

    To gain better insight into the interaction between thermoregulation and osmoregulation, we examined the thermal sweating response to drinking in cell-dehydrated humans. Cell dehydration (CDH) was induced by infusion of a 3% NaCl solution, at 1.2 ml/kg, for 2 h; infusion of a 0.9% NaCl solution in a separate experiment served as a control (euhydrated condition, EH). After infusion, subjects were heated by immersion of the lower legs in 42 degrees C water at an ambient temperature of 28 degrees C for 90 min. Subjects drank 4.3 ml/kg of H2O (similar to 38 degrees C) at 60 min of heating. The 3% NaCl infusion increased plasma osmolality by 13.6 +/- 0.8 mosmol/kgH(2)O and plasma arginine vasopressin concentration ([AVP]) by 3.3 +/- 0.7 pg/ml. Neither variable was altered with 0.9% NaCl infusion. Before drinking, esophageal temperature (T-es) had increased by 0.91 +/- 0.08 degrees C in CDH and by 0.40 +/- 0.11 degrees C in EH. Local chest sweating rate (SR(ch)) had increased by 0.67 +/- 0.08 and 0.63 +/- 0.07 mg . min(-1) . cm(-2) in CDH and EH, respectively. Thus the change in SR(ch) per unit rise in T-es was much lower in CDH than in EH. Drinking immediately increased SR(ch) and reduced T-es in CDH, with a reduction in plasma [AVP] and thirst rating. Drinking did not change thermoregulatory and osmoregulatory responses in EH. These results suggest that the act of drinking itself eliminates, at least partially, an osmotic inhibitory input to the thermoregulatory center, as well as osmotic AVP secretion and thirst., AMER PHYSIOLOGICAL SOC, Feb. 1995, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 268 (2), R414 - R422, web_of_science

    Scientific journal

  • BODY-TEMPERATURE MODIFICATION OF OSMOTICALLY INDUCED VASOPRESSIN SECRETION AND THIRST IN HUMANS

    A TAKAMATA; GW MACK; NS STACHENFELD; ER NADEL

    We examined the effect of increased body core temperature (T-es) on the plasma arginine vasopressin concentration ([AVP](p)) and thirst responses to increased plasma osmolality (P-osm) induced by 3% NaCl infusion for 120 min in seven healthy humans. T-es was increased by immersion of the lower legs in 41 degrees C water in a 28 degrees C room (passive heating; HT). Immersion of the lower legs in 34.5 degrees C water on a separate day served as the control (thermoneutral; NT). The 120-min hypertonic saline infusion was initiated 30 min after the onset of leg immersion and was followed by a 30-min rehydration period. T-es in HT increased by 0.21 +/- 0.04 degrees C before infusion and by 0.86 +/- 0.08 degrees C at the end of infusion. The change in T-es in NT before and after the infusion was negligible. P-osm was increased by 15.0 +/- 1.0 mosmol/kgH(2)O by infusion in both NT and HT. [AVP](p) increased by 3.48 +/- 0.72 pg/ml in NT and by 7.59 +/- 1.02 pg/ml in HT. Thus the increase in [AVP](p) at a given increase in P-osm was markedly higher in HT than in NT. The plasma renin activity response to hypertonic saline infusion in both conditions was similar. Subjective thirst rating and cumulative water intake during rehydration were higher in HT than in NT. The calculated increase in [AVP](p) per unit rise in T-es at a P-osm of 299 +/- 1 mosmol/kgH(2)O was 4.23 +/- 0.85 pg . ml(-1).degrees C-1, significantly higher than the 1.68 +/- 1.10 pg . ml(-1).degrees C-1 increase at a P-osm of 284 +/- 1 mosmol/kgH(2)O. Our data indicate that the effect of increased T-es and P-osm on [AVP](p) is not simply additive but P-osm dependent. We conclude that increased T-es modulates osmotically induced AVP secretion in a P-osm-dependent manner., AMER PHYSIOLOGICAL SOC, Oct. 1995, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 269 (4), R874 - R880, web_of_science

    Scientific journal

  • RIGHT ATRIAL PRESSURE AND ANP RELEASE DURING PROLONGED EXERCISE IN A HOT ENVIRONMENT

    H NOSE; A TAKAMATA; GW MACK; T KAWABATA; Y ODA; S HASHIMOTO; M HIROSE; E CHIHARA; T MORIMOTO

    To investigate the relationship between right atrial pressure (RAP) and atrial natriuretic peptide (ANP) release during prolonged exercise in a hot environment (30 degrees C, 20% relative humidity), we studied with a Swan-Ganz catheter five male volunteers exercising on a cycle ergometer at 60% of peak aerobic power for 50 min. The ANP level increased from 14 +/- 3 (SE) to 69 +/- 10 pg/ml (P < 0.001) during the first 10 min of exercise as RAP rose from 4.3 +/- 0.8 to 6.9 +/- 1.1 mmHg (P < 0.001). The 10-min ANP level was significantly correlated with RAP (r = 0.88, P < 0.05) but not with heart rate, pulmonary arterial blood temperature, plasma norepinephrine, or plasma epinephrine. The 10-min RAP value was inversely correlated with blood volume (r = -0.98, P < 0.01) and also with stroke volume (r = -0.96, P < 0.01). In the next 20 min of exercise, ANP continued to increase to 101 +/- 12 pg/ml (P < 0.02 vs. 10 min) and remained at this level until 50 min of exercise, whereas RAP decreased and reached a level not significantly different from baseline at 50 min (5.7 +/- 1.0 mmHg; P < 0.01 vs. 10 min). This dissociation of ANP and RAP may have been related to the significant increases from the 10-min values of heart rate, blood temperature, norepinephrine (all P < 0.01), and epinephrine (P < 0.02) during the same period. These results suggest that ANP release is primarily controlled by atrial distension at the onset of exercise but that other stimulators may be involved thereafter. The lower ANP release in subjects with a higher blood volume at 10 min may have been caused by an attenuated increase in RAP due to a larger stroke volume., AMER PHYSIOLOGICAL SOC, May 1994, JOURNAL OF APPLIED PHYSIOLOGY, 76 (5), 1882 - 1887, web_of_science

    Scientific journal

  • RIGHT ATRIAL PRESSURE AND FOREARM BLOOD-FLOW DURING PROLONGED EXERCISE IN A HOT ENVIRONMENT

    H NOSE; A TAKAMATA; GW MACK; Y ODA; T KAWABATA; S HASHIMOTO; M HIROSE; E CHIHARA; T MORIMOTO

    Right atrial pressure (RAP) at rest is known to be reduced by an increase in skin blood flow (SkBF) in a hot environment. However, there is no clear evidence that this is so during exercise. To clarify the effect of the increase in SkBF on RAP during exercise, we measured forearm blood flow (FBF) (as an index of SkBF) and RAP continuously using a Swan-Ganz catheter in five male volunteers exercising on a cycle ergometer at 60% of peak aerobic power for 50 min in a hot environment (30 degrees C, relative humidity 20%). Cardiac output increased from 5.5 +/- 0.2 l/min at rest to 17.9 +/- 1.2 l/min (mean +/- SE, P < 0.01) in the first 10 min of exercise and then remained steady until the end of exercise. FBF did not change significantly during the first 5 min, but then increased from 2.7 +/- 0.5 ml/100 ml per min at rest to 10.8 +/- 1.7 ml/100 ml per min (P < 0.001) by 25 min as pulmonary arterial blood temperature (T-b) rose from 37.0 +/- 0.1 degrees C to 38.1 +/- 0.1 degrees C (P < 0.001). FBF then reached a plateau, despite a continuing increase in T,. RAP increased significantly from 4.3 +/- 0.8 to 7.6 +/- 1.2 mm Hg (P < 0.001) during the first 5 min of exercise and then gradually declined to 6.1 +/- 1.0 mm Hg by 25 min (P < 0.001 vs. 5 min) and further to 5.7 +/- 1.0 mm Hg by 50 min, a value not significantly higher than at rest. This reduction in RAP during exercise was significantly correlated with the increase in FBF (r = -0.97, P < 0.001) with a regression equation of RAP = -0.25XFBF + 8.8. These results suggest that the decrease in RAP after 5 min exercise was caused by an increase in SkBF during exercise in a hot environment., SPRINGER VERLAG, Feb. 1994, PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 426 (3-4), 177 - 182, web_of_science

    Scientific journal

  • MEASUREMENT OF PLASMA-VOLUME IN RATS WITH USE OF FLUORESCENT-LABELED ALBUMIN MOLECULES

    CM GILLEN; A TAKAMATA; GW MACK; ER NADEL

    We describe a method for measuring plasma volume (PV) in small animals that allows small sample sizes but does not require the use of radioisotopes and thus is a convenient approach for making repeated measurements. Texas Red covalently bound to albumin (TR-A) was used in a typical indicator-dilution technique to measure PV. The relative fluorescent intensity of TR-A is linear to its concentration (up to 0.15 mg/ml) at an excitation lambda of 590 nm and an emission lambda of 610 nm. Catheters were inserted through the right jugular vein of anesthetized rats and threaded into the vena cava. A 0.5-ml control blood sample was taken, a measure quantity of TR-A was injected, and the catheter was flushed with saline. A 0.5-ml postinjection sample was taken 5 min after TR-A injection. PV was calculated by comparing the difference between the relative fluorescent intensity of control and postinjection plasma samples to a standard. The PV of 22 rats [362 +/- 14 (SE) g] was 14.1 +/- 0.4 ml (39.6 +/- 0.9 ml/kg body wt) measured by the TR-A method and 12.8 +/- 0.4 ml (35.9 +/- 1.0 ml/kg body wt) measured by a standard radioiodinated albumin method. There was a strong correlation between PV measured by both methods in the same rat (r = 0.90, P < 0.01). Infusion experiments indicated that the TR-A method can detect acute changes in PV, and repeated measurements of PV made on a chronically instrumented rat demonstrated that the method can reliably measure PV on consecutive days., AMER PHYSIOLOGICAL SOC, Jan. 1994, JOURNAL OF APPLIED PHYSIOLOGY, 76 (1), 485 - 489, web_of_science

  • INFLUENCE OF EXERCISE INTENSITY AND PLASMA-VOLUME ON ACTIVE CUTANEOUS VASODILATION IN HUMANS

    GW MACK; H NOSE; A TAKAMATA; T OKUNO; T MORIMOTO

    The influence of dynamic exercise on active cutaneous vasodilation was evaluated in eight male subjects. We measured the increase in internal body temperature (esophageal temperature, T-es) required to elicit active cutaneous vasodilation and the slope of the linear relationship between increases in forearm skin vascular conductance (Delta FVC) and T-es during indirect heating (legs immersed in 44 degrees C water for 30 min), 30 min of light exercise (LEX; 75 +/- 5 W = 30% maximal oxygen uptake, VO2max), and 20 min of moderate exercise (MEX, 149 +/- 7 W = 60% VO2max) Studies were conducted in the supine position at 30 degrees C (RH <30%) and mean skin temperature averaged 35.09 +/- 0.12 degrees C. During indirect heating and LEX, cutaneous vasodilation occurred after a similar increase in T-es, 0.03 +/- 0.02 degrees C and 0.11 +/- 0.02 degrees C, respectively. During MEX, T-es increased 0.42 +/- 0.06 degrees C before the onset of cutaneous vasodilation (P < 0.05, different from rest and LEX). The relationship between the increase in T-es threshold for vasodilation and exercise intensity was nonlinear, indicating that some minimal exercise intensity was required to elicit a delay in active cutaneous vasodilation. That minimal exercise intensity was greater than 30% VO2max (75 +/- 5 W). During MEX the increase in T-es threshold for vasodilation was inversely related to resting plasma volume (ml . kg(-1)) with a larger initial plasma volume associated with a smaller increase in T-es threshold for cutaneous vasodilation (r(2) = 0.67, P = 0.03). In addition, peak cutaneous vasodilation represented as the peak Delta FVC/peak Delta T-es, was directly related to plasma volume (r(2) = 0.64, P = 0.03). We conclude that the influence of exercise on the threshold for active cutaneous vasodilation is dependent on an interaction between exercise intensity and the size of the intravascular compartment. This conclusion is consistent with the hypothesis that blood volume expansion is an important adaptation of exercise training and contributes to improved thermoregulatory control during exercise in the heat., WILLIAMS & WILKINS, Feb. 1994, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 26 (2), 209 - 216, web_of_science

    Scientific journal

  • SODIUM APPETITE, THIRST, AND BODY-FLUID REGULATION IN HUMANS DURING REHYDRATION WITHOUT SODIUM REPLACEMENT

    A TAKAMATA; GW MACK; CM GILLEN; ER NADEL

    After a 7-h H2O and Na+ depletion period (DP), produced by intermittent light exercise (8 bouts) at 35 degrees C, we examined thirst and taste palatability responses to 10 different NaCl solutions during 23 h of rehydration (RH) at 25 degrees C. During DP, net H2O and Na+ loss were 27.2 +/- 2.9 ml/kg and 3.29 +/- 0.45 meq/kg, respectively. Plasma osmolality (P-Osm) and plasma Na+ concentration ([Na+](p)) increased significantly during DP by 3.4 +/- 1.2 mosmol/kgH(2)O and 3.0 +/- 1.0 meq/kgH(2)O, respectively. Plasma volume (PV) decreased by 6.5 +/- 1.9%. Thirst rating, renal fractional reabsorption of H2O, and plasma arginine vasopressin concentration (P-AVP) increased as P-Osm increased. This increased thirst was accompanied by increased palatability ratings to H2O. During RH, subjects drank deionized H2O ad libitum and ate a Na+-free diet for 23 h. P-Osm and [Na+](p) returned to control levels within 1 h RH and remained at or below the control thereafter. PV remained reduced by similar to 5% throughout RH. The increased thirst and P-AVP returned to their respective control levels within 1 h of RH as P-Osm decreased, but thirst rating increased again between 17 and 23 h of RH without an increase in P-Osm or P-AVP. Palatability ratings to a 1 M NaCl solution at and after 3 h RH and palatability ratings to 0.3 M at 17 and 23 h RH were significantly higher than control. Plasma aldosterone concentration (P-Aldo) increased after DP, decreased with drinking, and increased again between 6 and 23 h of RH, accompanied by a marked decrease in fractional Na+ excretion to <0.07%. Thus both Na+ preference and thirst in humans are influenced by body fluid and electrolyte status. The increased Na+ palatability (Na+ appetite) was preceded by osmotically induced thirst, and accompanied by nonosmotically driven thirst [extracellular fluid (ECF) thirst] and increased P-Aldo. The ''Na+ appetite'' and ''ECF thirst'' along with increased renal Na+ retention could contribute to ECF volume regulation after thermally induced H2O and Na+ depletion., AMER PHYSIOLOGICAL SOC, May 1994, AMERICAN JOURNAL OF PHYSIOLOGY, 266 (5), R1493 - R1502, web_of_science

    Scientific journal

  • EFFECT OF VAGOTOMY ON CARDIOVASCULAR ADJUSTMENT TO HYPERTHERMIA IN RATS

    A TAKAMATA

    To elucidate the contribution of cardiopulmonary baroreflexes on the control of total peripheral vascular conductance (TVC) during hyperthermia, alpha-chloralose-anesthetized rats with (VX-groups) or without (C-groups) vagotomy were subjected to body heating raising arterial blood temperature (T(b)) at a rate of 0.1-degrees-C/min. In both the C- and VX-groups, rats were divided into normovolemia (C-NBV and VX-NBV) and furosemide-induced hypovolemia (C-LBV and VX-LBV) and cardiovascular responses to hyperthermia were compared between the four groups. Central venous pressure (CVP) decreased as T(b) rose to 43-degrees-C by 1.92 +/- 0.24, 1.36 +/- 0.28, 0.62 +/- 0.14, and 0.35 +/- 0.23 mmHg in the C-NBV, VX-NBV, C-LBV, and VX-LBV groups, respectively. Mean arterial pressure increased by 35-45 mmHg in the C-groups and by 25-35 mmHg in the VX-groups at T(b) of 42-43-degrees-C in the C-groups and 42-degrees-C in the VX-groups. Heart rate response to increased T(b) was not affected by vagotomy or LBV. Stroke volume correlated with CVP (r = 0.769) and this relationship did not differ among the four groups. TVC was more highly correlated with CVP in the C-groups (r = 0.925) than in the VX-groups (r = 0.757). The slope of TVC vs. CVP (TVC/CVP) for the VX-groups lowered by about 40% from that for the C-groups. These results suggest that during hyperthermia, cardiopulmonary baroreflexes may partly contribute to the control of TVC, and other mechanisms related to decreased BV and increased T(b) play some roles in the control of TVC., CENTER ACADEMIC PUBL JAPAN, 1992, JAPANESE JOURNAL OF PHYSIOLOGY, 42 (4), 641 - 652, doi;web_of_science

    Scientific journal

  • 低酸素負荷による睡眠時血圧動揺の解析

    鷹股 亮; 仲井幹雄; 能勢博; 猪田浩史; 陳勉; 鷹股亮; 池内隆治; 森本武利

    1992, 京都府立医科大学雑誌, 101, 625 - 633

  • WATER AND ELECTROLYTE BALANCE IN THE VASCULAR SPACE DURING GRADED-EXERCISE IN HUMANS

    H NOSE; A TAKAMATA; GW MACK; Y ODA; T OKUNO; DH KANG; T MORIMOTO

    We analyzed the changes in water content and electrolyte concentrations in the vascular space during graded exercise of short duration. Six male volunteers exercised on a cycle ergometer at 20-degrees-C (relative humidity = 30%) as exercise intensity was increased stepwise until voluntary exhaustion. Blood samples were collected at exercise intensities of 29, 56, 70, and 95% of maximum aerobic power (Vo2max). A curvilinear relationship between exercise intensity and Na+ concentration in plasma ([Na+]p) was observed. [Na+]p significantly increased at 70% Vo2max and at 95% Vo2max was approximately 8 meq/kgH2O higher than control. The change in lactate concentration in plasma ([Lac-]p) was closely correlated with the change in [Na+]p (DELTA[Na+]p = 0.687 DELTA[Lac-]p + 1.79, r = 0.99). The change in [Lac-]p was also inversely correlated with the change in HCO3- concentration in plasma (DELTA[HCO3-]p = -0.761 DELTA[Lac-]p + 0.22, r = -1.00). At an exercise intensity of 95% Vo2max, 60% of the increase in plasma osmolality (Posmol) was accounted for by an increase in [Na+]p. These results suggest that lactic acid released into the vascular space from active skeletal muscles reacts with [HCO3-]p to produce CO2 gas and Lac-. The data raise the intriguing notion that increase in [Na+]p during exercise may be caused by elevated Lac-., AMER PHYSIOLOGICAL SOC, Jun. 1991, JOURNAL OF APPLIED PHYSIOLOGY, 70 (6), 2757 - 2762, web_of_science

    Scientific journal

  • CONTROL OF TOTAL PERIPHERAL RESISTANCE DURING HYPERTHERMIA IN RATS

    A TAKAMATA; H NOSE; GW MACK; T MORIMOTO

    AMER PHYSIOLOGICAL SOC, Sep. 1990, JOURNAL OF APPLIED PHYSIOLOGY, 69 (3), 1087 - 1092, web_of_science

    Scientific journal

  • 遊泳運動による摂取エタノールの生体内分布の変動と体温調節反応

    鷹股 亮; 今泉和彦; 立屋敷かおる; 鷹股亮; 荻田善一

    1988, アルコール代謝と肝, 7, 85 - 93

  • 血漿エタノールレベルの日内変動に対する胃内容物の役割―in vivo レベルの検討―

    鷹股 亮; 立屋敷かおる; 今泉和彦; 戸田典子; 鷹股亮; 上杉公仁子; 荻田善一

    1987, 日本栄養・食糧学会誌, 40, 35 - 42, doi

  • エタノールの生体内分布の動的解析

    鷹股 亮; 今泉和彦; 立屋敷かおる; 鷹股亮; 戸田典子; 蒲田直明

    1987, アルコール代謝と肝, 6, 66 - 74

  • 肝エタノール代謝に及ぼす運動の影響

    鷹股 亮; 今泉和彦; 立屋敷かおる; 佐々木友子; 長野肇; 大滝優子; 鷹股亮

    1986, アルコール代謝と肝, 5, 242 - 250

  • Water and electrolyte balance in the vascular space during graded exercise in humans

    H. Nose; A. Takamata; G. W. Mack; Y. Oda; T. Okuno; D. H. Kang; T. Morimoto

    We analyzed the changes in water content and electrolyte concentrations in the vascular space during graded exercise of short duration. Six male volunteers exercised on a cycle ergometer at 20°C (relative humidity = 30%) as exercise intensity was increased stepwise until voluntary exhaustion. Blood samples were collected at exercise intensities of 29, 56, 70, and 95% of maximum aerobic power (V̇O(2 max)). A curvilinear relationship between exercise intensity and Na+ concentration in plasma ([Na+]p) was observed. [Na+]p significantly increased at 70% V̇O(2 max) and at 95% V̇O(2 max) was ~8 meq/kgH2O higher than control. The change in lactate concentration in plasma ([Lac-]p) was closely correlated with the change in [Na+]p (Δ[Na+]p = 0.687 Δ[Lac-]p + 1.79,r = 0.99). The change in [Lac-]p was also inversely correlated with the change in HCO-/3 concentration in plasma (Δ[HCO-/3]p = -0.761 Δ[Lac-]p + 0.22, r = -1.00). At an exercise intensity of 95% V̇O(2 max), 60% of the increase in plasma osmolality (Posmol) was accounted for by an increase in [Na+]p. These results suggest that lactic acid released into the vascular space from active skeletal muscles reacts with [HCO-/3]p to produce CO2 gas and Lac-. The data raise the intriguing notion that increase in [Na+]p during exercise may be caused by elevated Lac-., 1991, Journal of Applied Physiology, 70 (6), 2757 - 2762, pubmed

    Scientific journal

  • Control of total peripheral resistance during hyperthermia in rats

    A. Takamata; H. Nose; G. W. Mack; T. Morimoto

    To elucidate the effect of blood volume on the circulatory adjustment to heat stress, we studied α-chloralose-anesthetized rats at three levels of blood volume: normovolemia (NBV), hypervolemia (HBV +32% plasma volume by isotonic albumin solution infusion), and hypovolemia (LBV -16% plasma volume by furosemide administration). Body surface heating was performed with an infrared lamp to raise arterial blood temperature (T(b)) at the rate of ~0.1°C/min. Before heating, central venous pressure (CVP) was significantly higher in HBV (0.41 ± 0.25 mmHg) and lower in LBV (-1.44 ± 0.22 mmHg) than in NBV (-0.41 ± 0.10 mmHg). The T(b) at which CVP started to decrease was ~40°C in HBV, ~41°C in NBV, and ~42°C in LBV, and it decreased by 1.53 ± 0.14, 1.92 ± 0.24, and 0.62 ± 0.14 mmHg from 37 to 43°C of T(b) in HBV, NBV, and LBV, respectively. Stroke volume was closely correlated with CVP, and this relationship was not affected by T(b). Heart rate responses to the raised T(b) were similar among the three groups. Mean arterial pressure (MAP) was not affected by blood volume modification or CVP and was maintained at preheating (T(b) 37°C) level until T(b) rose to 40°C. Above this T(b), MAP increased until T(b) reached 43°C (+30-40 mmHg) for all three groups. Total peripheral resistance (TPR) was inversely correlated with CVP, and the slope of the linear relationship between TPR and CVP in LBV was three- to fourfold steeper than in NBV or HBV. These results suggest that the control of TPR during severe hyperthermia (T(b) > 40°C) is influenced by T(b) and also by a cardiopulmonary baroreflex in response to a fall in CVP., 1990, Journal of Applied Physiology, 69 (3), 1087 - 1092, pubmed

    Scientific journal

  • Blood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women

    Tessa E. Adler; Charlotte W. Usselman; Akira Takamata; Nina S. Stachenfeld

    Hypertension, obesity, and endothelial function predict cardiovascular disease in women, and these factors are interrelated. We hypothesized that hypertension and obesity are associated with endothelial dysfunction in young women and that short-term ethinyl estradiol exposure mitigates this dysfunction. We examined flow-mediated dilation (FMD) responses before and during 7 days of oral ethinyl estradiol (30 µg/day) in 19 women (25 ± 5, 18–35 yr). We divided our sample into two groups based on two criteria: blood pressure and obesity. Women were divided into normal blood pressure (NBP; mean arterial pressure range: 78–91 mmHg, n = 7) and high blood pressure (HBP; mean arterial pressure range: 95–113 mmHg, n = 9) groups. We also stratified our subjects by body composition (lean: 18–31%, n = 8; obese: 38–59%, n = 9). We evaluated brachial FMD after two distinct shear stress stimuli: occlusion alone and occlusion with ischemic handgrip exercise. Obesity was unrelated to both FMD responses. Before ethinyl estradiol administration, the HBP group had blunted ischemic exercise responses relative to the NBP group (8.0 ± 3.5 vs. 12.3 ± 3.2%, respectively, P = 0.05). However, during ethinyl estradiol administration, ischemic exercise responses increased in the HBP group (12.8 ± 6.1%, P = 0.04) but decreased in the NBP group (5.6 ± 2.4%, P = 0.01). Standard FMD did not reveal differences between groups. In summary, 1) moderate HBP predicted endothelial impairment, 2) ethinyl estradiol administration had divergent effects on FMD in women with NBP versus HBP, and 3) enhanced FMD (ischemic handgrip exercise) revealed differences in endothelial function, whereas standard FMD (occlusion alone) did not. NEW & NOTEWORTHY We are the first to show that mild hypertension is a stronger predictor of endothelial dysfunction than obesity in healthy women without overt cardiovascular dysfunction. Importantly, the standard 5-min flow-mediated vasodilation stimulus did not detect endothelial dysfunction in our healthy population; only an enhanced ischemic handgrip exercise shear stress stimulus detected endothelial impairment. Estradiol administration increased flow-mediated dilation in women with high blood pressure, so it may be a therapeutic intervention to improve endothelial function., American Physiological Society, 01 Oct. 2018, American Journal of Physiology-Heart and Circulatory Physiology, 315 (4), H925 - H933, doi;url

    Scientific journal

MISC

  • 運動時の全身循環および体温調節機能をサポートする下肢圧迫法の開発

    鷹股 亮; 鷹股亮

    2005, デサントスポーツ科学, 24, 95 - 102

  • 運動トレーニングおよび暑熱馴化時の体温調節機能の亢進における浸透圧調節系の役割

    鷹股 亮; 鷹股亮; 芳田哲也

    1998, デサントスポーツ科学, 19, 116 - 123

  • The Modification of Venous Return by Continuous Negative Pressure Breathing and its Effect on Skin Blood Flow.

    森本武利; 永島計; 能勢博; 鷹股亮

    Sep. 1996, 宇宙利用シンポジウム, 13th, 55 - 58, j_global;url

  • Central venous pressure and thermoregulatory reaction. (Nagasaki Univ., Inst. for Tropical Medicine S)

    永島計; 能勢博; 鷹股亮; 森本武利

    30 Jun. 1996, 長崎大学熱帯医学研究所共同研究報告集, 1995, 136, j_global;url

  • 血漿浸透圧の上昇が温熱負荷時の皮膚血流調節に及ぼす影響とその個人差

    鷹股 亮; 鷹股亮; 永島計; 能勢博

    1996, 小野スポーツ科学, 4, 109 - 122

  • Estradiol-modification of Blood Pressure Regulatory Response to Systemic and Central Angiotensin II Administration in Rats

    Akira Takamata; Natsumi Omura; Yuri Nishimura; Ayako Igarashi; Keiko Morimoto

    FEDERATION AMER SOC EXP BIOL, Apr. 2015, FASEB JOURNAL, 29, web_of_science

    Summary international conference

  • Estradiol Replacement Attenuates Central Body Fluid Regulatory Responses to Hyperosmolality and Central Angiotensin II in Ovariectomized Rats

    Natsumi Omura; Yuri Nishimura; Ayako Igarashi; Akira Takamata

    FEDERATION AMER SOC EXP BIOL, Apr. 2015, FASEB JOURNAL, 29, web_of_science

    Summary international conference

  • Effect of Estradiol Replacement on Diurnal Sleep/Wake Pattern in Ovariectomized Rats Measured with a Subcutaneously Implanted Acceleration Sensor

    Ayako Igarashi; Natsumi Omura; Megumi Miura; Nanako Mima; Yuri Nishimura; Kaori Mabuchi; Akira Takamata

    FEDERATION AMER SOC EXP BIOL, Apr. 2015, FASEB JOURNAL, 29, web_of_science

    Summary international conference

  • The effects of menstrual phase on brachial artery endothelial function after mental stress in young women

    Xin Chen; Kyoko Ueshima; Mika Omokute; Akira Takamata; Keiko Morimoto

    FEDERATION AMER SOC EXP BIOL, Apr. 2015, FASEB JOURNAL, 29, web_of_science

    Summary international conference

  • Estradiol replacement attenuates stress-induced pressor response by regulating renin-angiotensin system in ovariectomized rats

    Yu Nagatomo; Shoko Tazumi; Risa Itoh; Misa Yoshimoto; Akira Takamata; Keiko Morimoto

    FEDERATION AMER SOC EXP BIOL, Apr. 2015, FASEB JOURNAL, 29, web_of_science

    Summary international conference

  • Serotonin is possibly involved in the anorexigenic and antidepressant effects of estrogen in ovariectomized rats

    Yuri Nishimura; Kaori Mabuchi; Hiroko Negishi; Keiko Morimoto; Akira Takamata

    FEDERATION AMER SOC EXP BIOL, Apr. 2013, FASEB JOURNAL, 27, web_of_science

    Summary international conference

  • Orchiectomy increases food intake and perifornical orexin A neuron's activity during glucoprivation

    Akira Takamata; Kana Miyake; Kaori Mabuchi; Keiko Morimoto

    FEDERATION AMER SOC EXP BIOL, Apr. 2013, FASEB JOURNAL, 27, web_of_science

    Summary international conference

  • Removal of photic stimulation impairs estrogen-induced anorexia in rats

    Kaori Mabuchi; Azusa Takano; Yayoi Hara; Keiko Morimoto; Akira Takamata

    SPRINGER JAPAN KK, 2013, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S255 - S255, web_of_science

    Summary international conference

  • Orexigenic and obesity effects of estrogen deficiency can be attenuated by half-day food deprivation either during the light phase or the dark phase

    Sayumi Taguchi; Kaori Mabuchi; Azusa Takano; Yayoi Hara; Keiko Morimoto; Akira Takamata

    FEDERATION AMER SOC EXP BIOL, Apr. 2012, FASEB JOURNAL, 26, web_of_science

    Summary international conference

  • Involvement of orexin A and melanin concentrating hormone neurons of the lateral hypothalamic area in the food intake response to reduced glucose availability

    Akira Takamata; Sayumi Taguchi; Saori Ikeda; Eri Aida; Keiko Morimoto

    FEDERATION AMER SOC EXP BIOL, Apr. 2012, FASEB JOURNAL, 26, web_of_science

    Summary international conference

  • Effect of central angiotensin II receptor antagonist and endogenous vasopressin on blood pressure regulation during normotension endotoxemia in rats

    F. Shimizu; T. Kasai; S. Inoue; A. Takamata

    LIPPINCOTT WILLIAMS & WILKINS, Jun. 2010, EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 27 (1), 171 - 171, web_of_science

    Summary international conference

  • Estrogen attenuates food intake and hypothalamic c-Fos expression in response to reduced glucose availability during light phase

    Akira Takamata; Kana Miyake; Kotomi Ueda; Mami Miyake; Megumu Hasegawa; Yuko Nakamura; Yoko Fujita; Keiko Morimoto

    SPRINGER TOKYO, 2010, JOURNAL OF PHYSIOLOGICAL SCIENCES, 60, S181 - S181, web_of_science

    Summary international conference

  • Roles of oxidative stress on the reduction of forearm blood flow induced by mental stress in postmenopausal women

    Keoko Morimoto; Kozue Ohyama; Mai Motohiro; Shigenobu Yano; Akira Takamata

    SPRINGER TOKYO, 2010, JOURNAL OF PHYSIOLOGICAL SCIENCES, 60, S58 - S58, web_of_science

    Summary international conference

  • Role of light in the estrogen deficiency-induced changes in diurnal SCN neural activity and food intake

    Kana Miyake; Keiko Morimoto; Akira Takamata

    FEDERATION AMER SOC EXP BIOL, Apr. 2009, FASEB JOURNAL, 23, web_of_science

    Summary international conference

  • Estrogen attenuates food intake and perifornical orexinergic neuron's activity during glucoprivation in ovariectomized rats

    Akira Takamata; Kana Miyake; Keiko Morimoto

    FEDERATION AMER SOC EXP BIOL, Apr. 2009, FASEB JOURNAL, 23, web_of_science

    Summary international conference

  • EFFECTS OF ESTROGEN REPLACEMENT ON OXIDATIVE STRESS IN VASCULATURE RELATED TO PSYCHOLOGICAL STRESS IN OVARIECTOMIZED RATS

    Ai Ikehata; Mizuho Kawakami; Sumire Ohkawa; Asumi Yoshida; Masami Uji; Akira Takamata; Ken-ichi Yoshida; Keiko Morimoto

    SPRINGER TOKYO, 2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 497 - 497, web_of_science

    Summary international conference

  • EFFECTS OF ESTROGEN ON STRESS-INDUCED ACTIVATION OF NITRIC OXIDE PRODUCING NEURONS IN PARAVENTRICULAR HYPOTHALAMIC NUCLEUS OF RATS

    Yurina Omuro; Tomoko Hata; Yasuko Hara; Akira Takamata; Takashi Ueyama; Keiko Morimoto

    SPRINGER TOKYO, 2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 333 - 333, web_of_science

    Summary international conference

  • ESTROGEN DEFICIENCY MODIFIES DIURNAL RHYTHMS OF SCN ACTIVITY AND BEHAVIORS BY CHANGING THE RESPONSE TO LIGHT

    Kana Miyake; Yuka Kobayashi; Keiko Morimoto; Akira Takamata

    SPRINGER TOKYO, 2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 333 - 333, web_of_science

    Summary international conference

  • PEAK OXYGEN UPTAKE DOES NOT CORRELATE WITH BLOOD VOLUME IN PERSONS WITH CERVICAL SPINAL CORD INJURY

    Tomoyuki Ito; Yukiharu Higuchi; Yumi Koike; Kazunobu Okazaki; Sumiko Shiba; Takahiro Miyake; Hiroyasu Uenishi; Akira Takamata; Hiromitsu Kimura; Fumihiro Tajima

    SPRINGER TOKYO, 2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 455 - 455, web_of_science

    Summary international conference

  • ESTROGEN ATTENUATES RESPONSES OF FOOD INTAKE AND PERIFORNICAL OREXINERGIC NEURON'S ACTIVITY TO GLUCOPRIVATION

    Akira Takamata; Kana Miyake; Yoko Fujita; Yuko Nakamura; Yuka Kobayashi; Keiko Morimoto

    SPRINGER TOKYO, 2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 458 - 458, web_of_science

    Summary international conference

  • Effect of estrogen replacement on food intake and hypothalamic c-Fos expression in ovariectomized rats

    A Takamata; Y Saito; R Kobayashi; K Torii; K Morimoto

    FEDERATION AMER SOC EXP BIOL, Mar. 2005, FASEB JOURNAL, 19 (5), A1647 - A1647, web_of_science

    Summary international conference

  • Effect of estrogen replacement on water intake and hypothalamic c-Fos expression induced by plasma hyperosmolality or central angiotensin II in ovariectomized rats

    K Torii; Y Kitamura; K Morimoto; A Takamata

    FEDERATION AMER SOC EXP BIOL, Mar. 2005, FASEB JOURNAL, 19 (5), A1647 - A1648, web_of_science

    Summary international conference

  • Cardiovascular and ventilatory responses during and after exercise in persons with cervical spinal cord injuries

    T Ito; Y Higuchi; H Banno; T Mizushima; A Takamata; H Kimura; F Tajima

    FEDERATION AMER SOC EXP BIOL, Mar. 2003, FASEB JOURNAL, 17 (5), A941 - A941, web_of_science

    Summary international conference

  • Relationship between osmotic inhibition of thermoregulatory responses and sweat sodium concentration.

    A Takamata; T Yoshida; T Morimoto

    FEDERATION AMER SOC EXP BIOL, Mar. 2000, FASEB JOURNAL, 14 (4), A321 - A321, web_of_science

    Summary international conference

  • Cardiopulmonary baroreceptor modulation of perioperative hypothermia

    Y Nakajima; T Mizobe; K Hayashi; Y Kitamura; K Shigemi; A Takamata; Y Tanaka

    LIPPINCOTT WILLIAMS & WILKINS, Sep. 1998, ANESTHESIOLOGY, 89 (3A), U296 - U296, web_of_science

    Summary international conference

  • Effect of heat acclimation on body fluid regulation in older subjects.

    A Takamata; T Ito; K Yaegashi; H Takamiya; Y Maegawa; T Itoh; T Morimoto; JE Greenleaf

    FEDERATION AMER SOC EXP BIOL, Mar. 1998, FASEB JOURNAL, 12 (4), A125 - A125, web_of_science

    Summary international conference

  • Effect of plasma osmolality on thermoregulatory responses to passive heating in humans

    A Takamata; K Nagashima; H Nose; T Morimoto

    FEDERATION AMER SOC EXP BIOL, Mar. 1996, FASEB JOURNAL, 10 (3), 681 - 681, web_of_science

    Summary international conference

  • BODY-TEMPERATURE INFLUENCE ON OSMOTICALLY INDUCED VASOPRESSIN SECRETION IN HUMANS

    GW MACK; A TAKAMATA; NS STACHENFELD; ER NADEL

    FEDERATION AMER SOC EXP BIOL, Mar. 1995, FASEB JOURNAL, 9 (4), A632 - A632, web_of_science

    Summary international conference

  • ACUTE RECOVERY OF OSMOTICALLY INHIBITED SWEATING IN HUMANS BY DRINKING

    A TAKAMATA; GW MACK; CM GILLEN; AC JOZSI; ER NADEL

    FEDERATION AMER SOC EXP BIOL, Mar. 1994, FASEB JOURNAL, 8 (4), A65 - A65, web_of_science

    Summary international conference

  • FLUID REGULATION DURING EXTREME CELL DEHYDRATION IN OLDER ADULTS

    N STACHENFELD; G MACK; A TAKAMATA; L DIPIETRO; E NADEL

    FEDERATION AMER SOC EXP BIOL, Mar. 1994, FASEB JOURNAL, 8 (5), A588 - A588, web_of_science

    Summary international conference

  • BIPHASIC THIRST RESPONSE IN HUMANS FOLLOWING THERMAL EXERCISE SWEATING WITHOUT SODIUM REPLENISHMENT

    A TAKAMATA; GW MACK; CM GILLEN; ER NADEL

    FEDERATION AMER SOC EXP BIOL, Feb. 1993, FASEB JOURNAL, 7 (3), A444 - A444, web_of_science

    Summary international conference

  • MEASUREMENT OF PLASMA-VOLUME IN RATS USING FLUORESCENT-LABELED ALBUMIN MOLECULES

    CM GILLEN; A TAKAMATA; GW MACK; ER NADEL

    FEDERATION AMER SOC EXP BIOL, Feb. 1993, FASEB JOURNAL, 7 (3), A444 - A444, web_of_science

    Summary international conference

  • CHANGE IN RIGHT ATRIAL PRESSURE DURING EXERCISE AND THE EFFECT ON THERMAL AND CIRCULATORY REGULATIONS

    H NOSE; A TAKAMATA; G MACK; Y ODA; S HASHIMOTO; M HIROSE; E CHIHARA; T MORIMOTO

    FEDERATION AMER SOC EXP BIOL, Mar. 1991, FASEB JOURNAL, 5 (5), A1400 - A1400, web_of_science

    Summary international conference

Books etc

  • ニュー運動生理学

    真興交易(株)医書出版部, 2015

  • からだと温度の事典 脱水時の体温調節

    朝倉書店, 2010

  • からだと温度の事典 運動時の体液調節

    朝倉書店, 2010

  • 運動生理学のニューエビデンス

    真興交易社, 2010

  • 身体トレーニング 運動生理学からみた身体機能の維持・向上 運動時の体液変化とその循環・体温調節への影響

    真興交易(株)医書出版部, 2009

  • 環境生理学

    北海道大学出版会, 2007

  • Environmental Physiology

    2007

  • 人間の許容限界事典 14.体液

    朝倉書店, 2005

  • 人間の許容限界事典 15.浸透圧

    朝倉書店, 2005

  • 体温―運動時の体温調節システムとそれを修飾する因子― 体温調節システムと浸透圧調節

    ナップ, 2002

  • 最新栄養学第8版―専門領域の最新情報ー Chapter 11 水分・電解質バランスー体温調節および高温環境下での身体運動に及ぼす影響

    2002

  • Merits of diluted sweat with training on arterial pressure and body temperature regulation in heat stress. In: Thermotherapy for Neoplasia, Inflammation, and Pain.

    Springer-Verlag, Tokyo, 2001

  • 運動とホルモン 体液調節と液性因子

    ナップ, 2001

  • 新運動生理学(下巻) 環境と体液

    真興交易, 2001

  • Merits of diluted sweat with training on arterial pressure and body temperature regulation in heat stress. In: Thermotherapy for Neoplasia, Inflammation, and Pain.

    Springer-Verlag, Tokyo, 2001

  • Interrelationship between osmoregulation and thermoregulation in a hot engvironment and during exercise. In: Exercise, Nutrition, and Environmental Stress.

    Cooper Publishing Group, LLC, Camel, IN, 2000

  • Interrelationship between osmoregulation and thermoregulation in a hot engvironment and during exercise. In: Exercise, Nutrition, and Environmental Stress.

    Cooper Publishing Group, LLC, Camel, IN, 2000

  • スポーツ医科学 運動・スポーツと体内における反応 体液・血液の働き

    杏林書院, 1999

  • Body fluid osmolality, blood volume and thermoregulation. In: The 1997 Nagano Symposium on Sports Sciences.

    Cooper Publishing Group, LLC, Carmel, IN, 1998

  • The role of plasma osmolality in exercise-induced inhibition of cutaneous vasodilation. In: The 1997 Nagano Symposium on Sports Sciences.

    Cooper Publishing Group, LLC, Carmel, IN, 1998

  • Effects of hypovolemia and hyperosmolality on cardiovascular responses to heat in awake rats.. In: The 1997 Nagano Symposium on Sports Sciences.

    Cooper Publishing Group, LLC, Carmel, IN, 1998

  • Near infrared spectrophotometric monitoring of rhythmic fluctuation in oxygenated hemoglobin and myoglobin during muscular exercise. In: The 1997 Nagano Symposium on Sports Sciences.

    Cooper Publishing Group, LLC, Carmel, IN, 1998

  • Body fluid osmolality, blood volume and thermoregulation. In: The 1997 Nagano Symposium on Sports Sciences.

    Cooper Publishing Group, LLC, Carmel, IN, 1998

  • The role of plasma osmolality in exercise-induced inhibition of cutaneous vasodilation. In: The 1997 Nagano Symposium on Sports Sciences.

    Cooper Publishing Group, LLC, Carmel, IN, 1998

  • Effects of hypovolemia and hyperosmolality on cardiovascular responses to heat in awake rats.. In: The 1997 Nagano Symposium on Sports Sciences.

    Cooper Publishing Group, LLC, Carmel, IN, 1998

  • Near infrared spectrophotometric monitoring of rhythmic fluctuation in oxygenated hemoglobin and myoglobin during muscular exercise. In: The 1997 Nagano Symposium on Sports Sciences.

    Cooper Publishing Group, LLC, Carmel, IN, 1998

  • Osmotic inhibition of thermally induced cutatneous vasodilation in humans and its role in the inhibition of cutaneous vasodilation during exercise. In: Thermal Physiology 1997. Proceedings of the International Symposium on Thermal Physiology.

    The August Krogh Institute, Copenhagen, 1997

  • Osmotic inhibition of thermally induced cutatneous vasodilation in humans and its role in the inhibition of cutaneous vasodilation during exercise. In: Thermal Physiology 1997. Proceedings of the International Symposium on Thermal Physiology.

    The August Krogh Institute, Copenhagen, 1997

  • Central venous pressure and cardiovascular responses to hyperthermia. In Temperature Regulation: Advances in Pharmacological Sciences

    Birk-hauser Verlag, Basel, 1996

  • Cardiovascular response to exercise in a hot environment. In Physiological Basis of Occupational Health: Stressful Environment. Progress in Biometeorology vol. 11.

    SPB Academic Publishing bv, Amsterdam, The Netherlands, 1996

  • Central venous pressure and cardiovascular responses to hyperthermia. In Temperature Regulation: Advances in Pharmacological Sciences

    Birk-hauser Verlag, Basel, 1996

  • Cardiovascular response to exercise in a hot environment. In Physiological Basis of Occupational Health: Stressful Environment. Progress in Biometeorology vol. 11.

    SPB Academic Publishing bv, Amsterdam, The Netherlands, 1996

  • Central venous pressure and cardiovascular responses to hyperthermia. In Temperature Regulation: Advances in Pharmacological Sciences

    Birk-hauser Verlag, Basel, 1994

  • Central venous pressure and cardiovascular responses to hyperthermia. In Temperature Regulation: Advances in Pharmacological Sciences

    Birk-hauser Verlag, Basel, 1994

  • Thirst, Exercise and Thermoregulation: Interrelationships. In Perspective in Exercise Science and Sports Medicine Volume 6, Exercise, Heat and Thermoregulation

    Benchmark Press, Carmel, IN, 1993

  • Thirst, Exercise and Thermoregulation: Interrelationships. In Perspective in Exercise Science and Sports Medicine Volume 6, Exercise, Heat and Thermoregulation

    Benchmark Press, Carmel, IN, 1993

  • Effect of heat load on body fluid and circulation. In: Hyperthermic Oncology in Japan '91

    Shinohara, 1992

  • Effect of heat load on body fluid and circulation. In: Hyperthermic Oncology in Japan '91

    Shinohara, 1992

  • 体温の「なぜ?」がわかる生理学 〜からだで感じる・考える・理解する〜

    (, Range: 26 脱水症と体温の密接な関係とは)

    杏林書院, Mar. 2021

  • 解剖生理学 : 人体の構造と機能

    河田, 光博; 三木, 健寿; 鷹股, 亮

    講談社, Jan. 2020, ix, 179p, cinii_books (ISBN: 9784065166352)

Association Memberships

  • 日本繊維製品消費科学学会

  • JAPANESE SOCIETY OF BIOMETEOROLOGY

  • JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE

  • 米国生理学会

  • THE PHYSIOLOGICAL SOCIETY OF JAPAN

  • The Japan Research Association for Textile End-Users

  • American Physiological Society

Works

  • 自律神経系中枢のMRIによる研究

    2005, - 2005

  • マンガン造影を用いた、容量刺激、血圧変化に対する延髄および視床下部神経活動の解析

    2004, - 2004

  • マンガン造影による浸透圧、容量刺激に対する視床下部神経核活動の解析

    2003, - 2003

  • 経口補液飲料のナトリウム濃度が温熱脱水からの体液量回復に及ぼす影響

    Feb. 2002, Mar. - 2002

  • マイクロイメージング法による脳室周囲器官群および関連する視床下部・延髄の研究

    2002, - 2002

  • T1緩和時間MRI法によるラット脳室周囲器官の測定

    2001, - 2001



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