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(Faculty Division of Engineering Research Group of Engineering)｜Researchers' Profile Teacher performance management system

SHIBASAKI Manabu

Faculty Division of Engineering Research Group of EngineeringProfessor
Last Updated :2025/06/13

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Profile Information

  • Name (Japanese)

    Shibasaki

  • Name (Kana)

    Manabu

Degree

  • Ph.D, Kobe University
  • MS, Kobe University

Research Areas

  • Life sciences, Biomedical engineering
  • Life sciences, Physiology
  • Humanities & social sciences, Home economics, lifestyle science
  • Life sciences, Physical and health education

Research History

  • Apr. 2021 - Present, 奈良女子大学研究院工学系工学領域
  • Apr. 2017 - Mar. 2021, 奈良女子大学研究院生活環境科学系
  • Apr. 2012 - Mar. 2017, 奈良女子大学研究院生活環境科学系准教授
  • Apr. 2009 - Mar. 2012, 奈良女子大学大学院人間文化研究科准教授
  • Mar. 2008 - Mar. 2009, 奈良女子大学生活環境学部生活健康・衣環境学科准教授
  • Apr. 2007 - Feb. 2008, 奈良女子大学生活環境学部生活健康・衣環境学科助教
  • Apr. 1999 - Mar. 2007, 奈良女子大学生活環境学部生活環境学科生活健康学講座助手
  • Mar. 2004 - Mar. 2005, University of Texas Southwestern Medical center at Dallas, Visiting Scientist
  • Aug. 1998 - Mar. 1999, Institute for Exercise & Environmental Medicine, Presbyterian Hospital of Dallas, Research Associate
  • Apr. 1998 - Mar. 1999, Research Fellow of the Japan Society for the Promotion of Science

Education

  • Apr. 1995 - Mar. 1998, Kobe University, Graduate School, Division of National Science and Technology (except Gakushuin University, Konan University), 知能科学
  • Apr. 1993 - Mar. 1995, 神戸大学大学院教育学研究科
  • Apr. 1989 - Mar. 1993, Kobe University, Faculty of Education, 初等教育

Teaching Experience

  • Oct. 2023 - Present
  • Apr. 2023 - Present
  • 諸学への誘い, Nara Women's University, 2022 - Present
  • General Bionics, Nara Women's University, 2022 - Present
  • Human Body Science, Nara Women's University, 2022 - Present
  • 温熱生理学演習, Nara Women's University, Present
  • Present
  • Present
  • 温熱生理学, Nara Women's University, Present
  • Present
  • Present
  • Oct. 2023
  • Feb. 2022
  • 2022
  • 2021
  • 2021
  • 2021
  • 2021
  • 2019
  • 2019

Media Coverage

  • <チーム池上が行く！＞日本初！女子大工学部の取組, BSテレビ東京, 日経ニュース プラス９, 22 Sep. 2023, Media report, 46107499, rm:research_project_id
    対象リソースIRI
  • 理系育成へ企業とタッグ 奈良女子大、キャリア学ぶ, 北海道新聞、河北新聞、北日本新聞、下野新聞、静岡新聞、中部経済新聞、山陰中央新報、西日本新聞、琉球新聞、伊勢新聞、日本海新聞, Sep. 2023, 46107499, rm:research_project_id
    対象リソースIRI
  • 奈良女子大 技術者の仕事紹介 女子中高生対象ワークショップ, NHK, 大阪県域ほっと関西、奈良県域ならナビ, 29 Mar. 2023, Media report, 46107499, rm:research_project_id
    対象リソースIRI

■Ⅱ．研究活動実績

Published Papers

  • Clinical Neurophysiology Practice, Elsevier BV, Changing characteristics of somatosensory evoked potentials in adolescents, Aoi Mase; Manabu Shibasaki; Hiroki Nakata, 2025, 10, 141, 149, Scientific journal, 10.1016/j.cnp.2025.03.004
    DOI URL
  • Refereed, Journal of Applied Physiology, American Physiological Society, Do changes in cerebral blood flow modulate the amplitudes of P300 during cognitive task?, Shigehiko Ogoh; Hiroki Nakata; Hiroko Kubo; Manabu Shibasaki, A single session of aerobic or resistance training transiently enhances cognitive function, but the precise mechanism behind this exercise-induced cognitive improvement remains unknown. We investigated the effect of altered cerebral blood flow (CBF) on brain neural activity originating from motor executive and inhibitory processing using electroencephalographic event-related potentials. Exercise-induced improvement in cognitive function could not be explained by an increase in CBF, whereas a decrease in CBF did not affect cognitive function., 01 Nov. 2024, 137, 5, 1106, 1116, Scientific journal, 10.1152/japplphysiol.00351.2024
    URLDOI URL
  • Somatosensory & motor research, Effects of inter-stimulus and inter-trial intervals on somatosensory gating., Aoi Mase; Manabu Shibasaki; Hiroki Nakata, AIM OF THE STUDY: Sensory gating is a human higher cognitive function that serves to suppress excessive sensory information and prevent brain overactivity. To elucidate this function, a paired-pulse stimulation paradigm has been used while recording electroencephalography (EEG), and evaluated as an amplitude ratio of responses to a second stimulus (S2) over responses to the first stimulus (S1). The present study investigated the effects of the inter-stimulus interval (ISI) and inter-trial interval (ITI) on somatosensory gating using somatosensory-evoked potentials (SEPs). METHODS: In Experiment 1, ISI was set at five conditions: 200, 400, 600, 800, and 1000 ms. In Experiment 2, ITI was set at four conditions: 1, 2, 4, and 8 s. RESULTS: ISI affected the S2/S1 amplitude ratios of P22 and N27 at C3' and N30 at Fz, and these S2/S1 amplitude ratios decreased the most under the 200 and 400-ms conditions. ITI affected the S2/S1 amplitude ratios of P22, N27, and N60 at C3', and especially, the somatosensory gating did not work under the 1-s condition. These results suggest that not all SEP components are modulated in the same manner with changing ISI and ITI. The effects of ISI and ITI independently affected the somatosensory gating. CONCLUSIONS: Based on our findings, preferable parameters are 200-400 ms for ISI and 4 s or longer for ITI to evaluate the functional mechanisms on somatosensory gating in SEPs., 28 May 2024, 1, 6, Scientific journal, True, 10.1080/08990220.2024.2358516
    DOI URL
  • Refereed, Spinal Cord, Springer Science and Business Media LLC, Observations of cold-induced vasodilation in persons with spinal cord injuries, Yasuhisa Fujita; Yoshi-ichiro Kamijo; Tokio Kinoshita; Takamasa Hashizaki; Kouta Murai; Tatsuya Yoshikawa; Yasunori Umemoto; Chikako Kaminaka; Manabu Shibasaki; Fumihiro Tajima; Yukihide Nishimura, Abstract

    Study design

    Acute experimental study.

    Objectives

    Cold-induced vasodilation is a local mechanism of protection against frostbite in non-injured persons. We assessed whether an increase in skin blood flow (SkBF) during local cooling (LC) was observed in individuals with spinal cord injuries (SCIs) and if the response patterns differed between region levels or sites.

    Setting

    Laboratory of Wakayama Medical University and the affiliated clinics, Japan.

    Methods

    A local cooler device (diameter 4 cm) was placed on the chest (sensate) and right thigh (non-sensate) in persons with cervical (SCIC; n = 9) and thoracolumbar SCIs (SCITL; n = 9). After the surface temperature under the device was controlled at 33 °C for 10 min (baseline), LC (−0.045 °C/s) was applied and the skin temperature was maintained at 15 and 8 °C for 15 min of each stage. SkBF (laser Doppler flowmetry) was monitored using a 1-mm needle-type probe inserted into its center.

    Results

    The percent change in SkBF (%ΔSkBF) on the chest remained unchanged until the end of 15 °C stage; thereafter, it increased to a level at least 70% greater than the baseline during the 8 °C stage in both groups. The %ΔSkBF on the thigh in both SCIC and SCITL notably increased from 8 and 6 min respectively, during the 8°C stage, compared to 1 min before the stage; however, it did not exceed the baseline level.

    Conclusions

    An increase in SkBF during LC was observed both in the sensate and non-sensate areas in SCIs, although the magnitude was larger in the sensate area., 22 Feb. 2024, 62, 4, 170, 177, Scientific journal, 10.1038/s41393-024-00960-3
    URLDOI URL
  • Refereed, Jpn. J. Biometeor., The effects of the differences in motor tasks on cerebral hemodynamics at the start of exercise, Keiko Yamamoto; Minami Hirai; Manabu Shibasaki, Jun. 2023, 60, 1, 23, 30, Scientific journal, 10.11227/seikisho.60.23
    DOI URL
  • Neuroscience Research, Elsevier BV, Effects of hypocapnia and hypercapnia on human somatosensory processing, Hiroki Nakata; Ryusuke Kakigi; Hiroko Kubo; Manabu Shibasaki, May 2023, 190, 29, 35, Scientific journal, 10.1016/j.neures.2022.11.007
    DOI URL
  • Refereed, Scientific Reports, Springer Science and Business Media LLC, Synesthesia has specific cognitive processing during Go/No-go paradigms, Yu Aoki; Manabu Shibasaki; Hiroki Nakata, Abstract

    Grapheme-color synesthesia is a consistent and automatic perception of non-physical color when presented with a grapheme. Many previous studies focused on the synesthetic visual system, but other cognitive functions in grapheme-color synesthetes have remained unclear. Therefore, the objective of the present study was to investigate the characteristics of cognitive processing for motor execution and inhibition during Go/No-go paradigms in grapheme-color synesthesia using event-related potentials (ERPs). Six grapheme-color synesthetes and 24 non-synesthetes performed visual, auditory, and somatosensory Go/No-go paradigms. Omission errors were higher in grapheme-color synesthetes than non-synesthetes. Group-trial interactions (i.e., synesthetes–non-synesthetes × Go–No-go) were observed for the latency of the visual N2 component and amplitude of the somatosensory N2 component. Latencies of auditory and somatosensory P3 components were shorter in grapheme-color synesthetes than non-synesthetes. These findings suggest that grapheme-color synesthetes have specific cognitive processing in motor execution and inhibition as well as synesthetic color perception. Our data advance understanding of cognitive processing in grapheme-color synesthesia., 15 Apr. 2023, 13, 1, Scientific journal, 10.1038/s41598-023-32389-8
    URLDOI URL
  • Refereed, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, American Physiological Society, Quantification of catecholamine neurotransmitters released from cutaneous vasoconstrictor nerve endings in men with cervical spinal cord injury, Tomonori Nakata; Manabu Shibasaki; Yukihide Nishimura; Tokio Kinoshita; Takamasa Hashizaki; Yoshi-ichiro Kamijo; Ken Kouda; Yasunori Umemoto; Fumihiro Tajima, Control of cutaneous circulation is critically important to maintain thermoregulation, especially in individuals with cervical spinal cord injury (CSCI) who have no or less central thermoregulatory drive. However, the peripheral vasoconstrictor mechanism and capability have not been fully investigated after CSCI. Post- and presynaptic sensitivities of the cutaneous vasoconstrictor system were investigated in 8 CSCI and 7 sedentary able-bodied (AB) men using an intradermal microdialysis technique. Eight doses of norepinephrine (NE, 10−8 to 10−1 M) and five doses of tyramine (TY, 10−8, 10−5 to 10−2 M) were administered into the anterior right and left thigh, respectively. Endogenous catecholamines, noradrenaline, and dopamine, collected at the TY site, were determined by high-performance liquid chromatography with electrochemical detection. Regardless of vasoconstrictor agents, cutaneous vascular conductance decreased dose-dependently and responsiveness was similar between the groups (NE: Group P = 0.255, Dose P = 0.014; TY: Group P = 0.468, Dose P < 0.001), whereas the highest dose of each drug induced cutaneous vasodilation. Administration of TY promoted the release of noradrenaline and dopamine in both groups. Notably, the amount of noradrenaline released was similar between the groups ( P = 0.819), although the concentration of dopamine was significantly greater in individuals with CSCI than in AB individuals ( P = 0.004). These results suggest that both vasoconstrictor responsiveness and neural functions are maintained after CSCI, and dopamine in the skin is likely to induce cutaneous vasodilation., 01 Mar. 2023, 324, 3, R345, R352, Scientific journal, 10.1152/ajpregu.00063.2022
    URLDOI URL
  • Refereed, American journal of physiology. Regulatory, integrative and comparative physiology, Altered cardiac β1 responsiveness in hyperthermic older adults., Mads Fischer; Gilbert Moralez; Satyam Sarma; James P MacNamara; Matthew N Cramer; Mu Huang; Steven A Romero; Michinari Hieda; Manabu Shibasaki; Shigehiko Ogoh; Craig G Crandall, Compared with younger adults, passive heating induced increases in cardiac output are attenuated by ∼50% in older adults. This attenuated response may be associated with older individuals' inability to maintain stroke volume through ionotropic mechanisms and/or through altered chronotropic mechanisms. The purpose of this study was to identify the interactive effect of age and hyperthermia on cardiac responsiveness to dobutamine-induced cardiac stimulation. Eleven young (26 ± 4 yr) and 8 older (68 ± 5 yr) participants underwent a normothermic and a hyperthermic (baseline core temperature +1.2°C) trial on the same day. In both thermal conditions, after baseline measurements, intravenous dobutamine was administered for 12 min at 5 µg/kg/min, followed by 12 min at 15 µg/kg/min. Primary measurements included echocardiography-based assessments of cardiac function, gastrointestinal and skin temperatures, heart rate, and mean arterial pressure. Heart rate responses to dobutamine were similar between groups in both thermal conditions (P > 0.05). The peak systolic mitral annular velocity (S'), i.e., an index of left ventricular longitudinal systolic function, was similar between groups for both thermal conditions at baseline. While normothermic, the increase in S' between groups was similar with dobutamine administration. However, while hyperthermic, the increase in S' was attenuated in the older participants with dobutamine (P < 0.001). Healthy, older individuals show attenuated inotropic, but maintained chronotropic responsiveness to dobutamine administration during hyperthermia. These data suggest that older individuals have a reduced capacity to increase cardiomyocyte contractility, estimated by changes in S', via β1-adrenergic mechanisms while hyperthermic., 01 Oct. 2022, 323, 4, R581-R588, Scientific journal, True, 10.1152/ajpregu.00040.2022
    DOI URL
  • Refereed, PLOS ONE, Public Library of Science (PLoS), Modality differences in ERP components between somatosensory and auditory Go/No-go paradigms in prepubescent children, Hiroki Nakata; Miho Takezawa; Keita Kamijo; Manabu Shibasaki, We investigated modality differences in the N2 and P3 components of event-related potentials (ERPs) between somatosensory and auditory Go/No-go paradigms in eighteen healthy prepubescent children (mean age: 125.9±4.2 months). We also evaluated the relationship between behavioral responses (reaction time, reaction time variability, and omission and commission error rates) and amplitudes and latencies of N2 and P3 during somatosensory and auditory Go/No-go paradigms. The peak latency of No-go-N2 was significantly shorter than that of Go-N2 during somatosensory paradigms, but not during auditory paradigms. The peak amplitude of P3 was significantly larger during somatosensory than auditory paradigms, and the peak latency of P3 was significantly shorter during somatosensory than auditory paradigms. Correlations between behavioral responses and the P3 component were not found during somatosensory paradigms. On the other hand, in auditory paradigms, correlations were detected between the reaction time and peak amplitude of No-go-P3, and between the reaction time variability and peak latency of No-go-P3. A correlation was noted between commission error and the peak latency of No-go-N2 during somatosensory paradigms. Compared with previous adult studies using both somatosensory and auditory Go/No-go paradigms, the relationships between behavioral responses and ERP components would be weak in prepubescent children. Our data provide findings to advance understanding of the neural development of motor execution and inhibition processing, that is dependent on or independent of the stimulus modality., 08 Nov. 2021, 16, 11, e0259653, e0259653, Scientific journal, 10.1371/journal.pone.0259653
    URLDOI URL
  • Refereed, PLOS ONE, Public Library of Science (PLoS), Effects of passive heat stress and recovery on human cognitive function: An ERP study, Hiroki Nakata; Ryusuke Kakigi; Manabu Shibasaki, Using event-related potentials (ERPs), we investigated the effects of passive heat stress and recovery on the human cognitive function with Flanker tasks, involving congruent and incongruent stimuli. We hypothesized that modulation of the peak amplitude and latency of the P300 component in ERP waveforms would differ with task difficulty during passive heat stress and recovery. Subjects performed the Flanker tasks before (Pre), at the end of whole body heating (Heat: internal temperature increase of ~1.2°C from the pre-heat baseline), and after the internal temperature had returned to the pre-heat baseline (Recovery). The internal temperature was regulated by a tube-lined suit by perfusing 50°C water for heat stress and 25°C water for recovery immediately after the heat stress. Regardless of task difficulty, the reaction time (RT) was shortened during Heat rather than Pre and Recovery, and standard deviations of RT (i.e., response variability) were significantly smaller during Heat than Pre. However, the peak amplitudes of the P300 component in ERPs, which involved selective attention, expectancy, and memory updating, were significantly smaller during Heat than during Pre, suggesting the impairment of neural activity in cognitive function. Notably, the peak amplitudes of the P300 component were higher during Recovery than during Heat, indicating that the impaired neural activity had recovered after sufficient whole-body cooling. An indicator of the stimulus classification/evaluation time (peak latency of P300) and the RT were shortened during Heat stress, but such shortening was not noted after whole-body cooling. These results suggest that hyperthermia affects the human cognitive function, reflected by the peak amplitude and latency of the P300 component in ERPs during the Flanker tasks, but sufficient treatment such as whole-body cooling performed in this study can recover those functions., 20 Jul. 2021, 16, 7, e0254769, e0254769, Scientific journal, 10.1371/journal.pone.0254769
    URLDOI URL
  • Refereed, The Journal of Physiological Sciences, Springer Science and Business Media LLC, An assessment of hypercapnia-induced elevations in regional cerebral perfusion during combined orthostatic and heat stresses, Manabu Shibasaki; Kohei Sato; Ai Hirasawa; Tomoko Sadamoto; Craig G. Crandall; Shigehiko Ogoh, We investigated that the effects of hypercapnia-induced elevations in cerebral perfusion during a heat stress on global cerebrovascular responses to an orthostatic challenge. Seven volunteers completed a progressive lower-body negative pressure (LBNP) challenge to presyncope during heat stress, with or without breathing a hypercapnic gas mixture. Administration of the hypercapnic gas mixture increased the partial pressure of end-tidal CO2 greater than pre-heat stress alone, and increased both internal carotid artery (ICA) and vertebral artery (VA) blood flows (P < 0.05). During LBNP, both ICA and VA blood flows with the hypercapnic gas mixture remained elevated relative to the control trial (P < 0.05). However, at the end of LBNP due to pre-syncopal symptoms, both ICA and VA blood flows decreased to similar levels between trials. These findings suggest that hypercapnia-induced cerebral vasodilation is insufficient to maintain cerebral perfusion at the end of LBNP due to pre-syncope in either the anterior or posterior vascular beds., May 2020, 70, 1, 25, 25, Scientific journal, False, 10.1186/s12576-020-00751-4
    DOI URL
  • Refereed, Apr. 2020, 61, 4, 308, 316, Scientific journal
  • Refereed, NeuroReport, Ovid Technologies (Wolters Kluwer Health), Differences in characteristics of somatosensory evoked potentials between children and adults, Miho Takezawa; Keita Kamijo; Manabu Shibasaki; Hiroki Nakata, The present study examined the characteristics of somatosensory processing in healthy prepubescent children (mean age: 124.9 ± 3.8 months) compared with young adults. Somatosensory evoked potentials at the frontal (Fz) and centroparietal (C3') electrodes were recorded by delivering an electrical stimulus to the right median nerve at a rate of 3 Hz. The characteristics of somatosensory evoked potential waveforms at C3' were markedly different between the two groups, while those at Fz were similar. Specifically, the waveforms at C3' in the children involved not only standard P12, N18, P22, N27, P45, and N60 components, but also additional positive (P3) and negative (N3) components between N27 and P45, which were not found in adults. The amplitude of P22 at C3' was significantly larger in the children than adults, indicating hyper-excitability/responsiveness of neural activity on somatosensory processing. In contrast, the amplitudes of N15 at Fz and N27 at C3' were smaller in the children than adults, suggesting an immature somatosensory system in the children. The peak latencies of P12, N15, and P18 at Fz, and P12 and N18 at C3' were significantly shorter in the children than adults, which was dependent on the height. These results indicate the developing somatosensory processing with hyper- and hypo-excitability of neural activity in prepubescent children., Dec. 2019, 30, 18, 1284, 1288, Scientific journal, True, 10.1097/wnr.0000000000001355
    DOI URL
  • Refereed, Oct. 2019, 56, 1, 3, 11, Scientific journal
  • Refereed, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, American Physiological Society, Effects of whole body skin cooling on human cognitive processing: a study using SEPs and ERPs, Hiroki Nakata; Fumino Kobayashi; Justin S. Lawley; Ryusuke Kakigi; Manabu Shibasaki, The present study investigated the effect of whole body skin cooling on somatosensory ascending processing by utilizing somatosensory-evoked potentials (SEPs) and motor execution, as well as inhibitory processing by event-related potentials (ERPs). Fourteen healthy participants wearing a water-perfused suit performed two sessions ( sessions 1 and 2) consisting of SEPs and ERPs with somatosensory Go/No-go paradigms under two conditions (cold stress and control) on different days. In session 2, under the cold stress condition, whole body skin cooling was achieved by circulating 20°C water through the suit for 40 min, whereas 34°C water was perfused in the other sessions. The mean skin temperature decreased from 35.0 ± 0.5°C ( session 1) to 30.4 ± 0.9°C ( session 2) during whole body skin cooling, but the internal temperature was maintained. Whole body skin cooling delayed the peak latencies of N20, P25, and P45 components at C4′ of SEPs (all: P < 0.05). Moreover, the peak latencies of P14, N18, and P22 components at Fz of SEPs and the Go-P300 component of ERPs were delayed (all: P < 0.05). In contrast, the peak amplitudes of all individual components of SEPs as well as N140 and P300 of ERPs remained unchanged. These results suggest that passive whole body skin cooling delays neural activities on somatosensory processing and higher cognitive function., 01 Sep. 2019, 317, 3, R432, R441, Scientific journal, 10.1152/ajpregu.00087.2019
    URLDOI URL
  • Refereed, Physiological Reports, Wiley, Effects of repetitive exercise and thermal stress on human cognitive processing, Manabu Shibasaki; Mari Namba; Yoshi-Ichiro Kamijo; Tomoyuki Ito; Ryusuke Kakigi; Hiroki Nakata, Feb. 2019, 7, 4, e14003, e14003, Scientific journal, 10.14814/phy2.14003
    URLDOI URL
  • Refereed, International Journal of Hyperthermia, Informa UK Limited, Differences in serum IL-6 response after 1 °C rise in core body temperature in individuals with spinal cord injury and cervical spinal cord injury during local heat stress, Takamasa Hashizaki; Yukihide Nishimura; Kenzo Teramura; Yasunori Umemoto; Manabu Shibasaki; C. A. Leicht; Ken Kouda; Fumihiro Tajima, 31 Dec. 2018, 35, 1, 541, 547, Scientific journal, 10.1080/02656736.2018.1511838
    URLDOI URL
  • Refereed, European Journal of Pain, Wiley, Warm-, hot- and pain-related neural activities depending on baseline skin temperatures, H. Nakata; R. Kakigi; M. Shibasaki, Nov. 2018, 22, 10, 1791, 1799, Scientific journal, 10.1002/ejp.1275
    URLDOI URL
  • Not Refereed, Jul. 2018, 68, 7, 519, 525, In book
  • Refereed, Journal of Applied Physiology, American Physiological Society, Dynamic cerebral autoregulation during cognitive task: effect of hypoxia, Shigehiko Ogoh; Hiroki Nakata; Tadayoshi Miyamoto; Damian Miles Bailey; Manabu Shibasaki, Changes in cerebral blood flow (CBF) subsequent to alterations in the partial pressures of oxygen and carbon dioxide can modify dynamic cerebral autoregulation (CA). While cognitive activity increases CBF, the extent to which it impacts CA remains to be established. In the present study we determined whether dynamic CA would decrease during a cognitive task and whether hypoxia would further compound impairment. Fourteen young healthy subjects performed a simple Go/No-go task during normoxia and hypoxia (inspired O2 fraction = 12%), and the corresponding relationship between mean arterial pressure (MAP) and mean middle cerebral artery blood velocity (MCA Vmean) was examined. Dynamic CA and steady-state changes in MCA V in relation to changes in arterial pressure were evaluated with transfer function analysis. While MCA Vmean increased during the cognitive activity ( P < 0.001), hypoxia did not cause any additional changes ( P = 0.804 vs. normoxia). Cognitive performance was also unaffected by hypoxia (reaction time, P = 0.712; error, P = 0.653). A decrease in the very low- and low-frequency phase shift (VLF and LF; P = 0.021 and P = 0.01) and an increase in LF gain were observed ( P = 0.037) during cognitive activity, implying impaired dynamic CA. While hypoxia also increased VLF gain ( P < 0.001), it failed to cause any additional modifications in dynamic CA. Collectively, our findings suggest that dynamic CA is impaired during cognitive activity independent of altered systemic O2 availability, although we acknowledge the interpretive complications associated with additional competing, albeit undefined, inputs that could potentially distort the MAP-MCA Vmean relationship.

    NEW & NOTEWORTHY During normoxia, cognitive activity while increasing cerebral perfusion was shown to attenuate dynamic cerebral autoregulation (CA) yet failed to alter reaction time, thereby questioning its functional significance. No further changes were observed during hypoxia, suggesting that impaired dynamic CA occurs independently of altered systemic O2 availability. However, impaired dynamic CA may reflect a technical artifact, given the confounding influence of additional inputs that could potentially distort the mean arterial pressure-mean middle cerebral artery blood velocity relationship., 01 Jun. 2018, 124, 6, 1413, 1419, Scientific journal, True, 10.1152/japplphysiol.00909.2017
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  • May 2018, 39, 84, 93
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  • Refereed, Spinal Cord, Springer Science and Business Media LLC, A comparison of static and dynamic cerebral autoregulation during mild whole-body cold stress in individuals with and without cervical spinal cord injury: a pilot study, Jan W. van der Scheer; Yoshi-Ichiro Kamijo; Christof A. Leicht; Philip J. Millar; Manabu Shibasaki; Victoria L. Goosey-Tolfrey; Fumihiro Tajima, May 2018, 56, 5, 469, 477, Scientific journal, 10.1038/s41393-017-0021-7
    DOI URL
  • Refereed, American Journal of Physiology-Heart and Circulatory Physiology, Effect of increases in cardiac contractility on cerebral blood flow in humans, Shigehiko Ogoh; Gilbert Moralez; Takuro Washio; Satyam Sarma; Michinari Hieda; Steven A. Romero; Matthew N. Cramer; Manabu Shibasaki; Craig G. Crandall, 01 Dec. 2017, 313, 6, H1155, H1161, Scientific journal, 10.1152/ajpheart.00287.2017
    DOI URL
  • Refereed, Journal of Applied Physiology, Effects of acute hypoxia on human cognitive processing: a study using ERPs and SEPs, Hiroki Nakata; Tadayoshi Miyamoto; Shigehiko Ogoh; Ryusuke Kakigi; Manabu Shibasaki, 01 Nov. 2017, 123, 5, 1246, 1255, Scientific journal, 10.1152/japplphysiol.00348.2017
    DOI URL
  • Refereed, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, American Physiological Society, Effects of face/head and whole body cooling during passive heat stress on human somatosensory processing, Hiroki Nakata; Mari Namba; Ryusuke Kakigi; Manabu Shibasaki, We herein investigated the effects of face/head and whole body cooling during passive heat stress on human somatosensory processing recorded by somatosensory-evoked potentials (SEPs) at C4′ and Fz electrodes. Fourteen healthy subjects received a median nerve stimulation at the left wrist. SEPs were recorded at normothermic baseline (Rest), when esophageal temperature had increased by ~1.2°C (heat stress: HS) during passive heating, face/head cooling during passive heating (face/head cooling: FHC), and after HS (whole body cooling: WBC). The latencies and amplitudes of P14, N20, P25, N35, P45, and N60 at C4′ and P14, N18, P22, and N30 at Fz were evaluated. Latency indicated speed of the subcortical and cortical somatosensory processing, while amplitude reflected the strength of neural activity. Blood flow in the internal and common carotid arteries (ICA and CCA, respectively) and psychological comfort were recorded in each session. Increases in esophageal temperature due to HS significantly decreased the amplitude of N60, psychological comfort, and ICA blood flow in the HS session, and also shortened the latencies of SEPs (all, P < 0.05). While esophageal temperature remained elevated, FHC recovered the peak amplitude of N60, psychological comfort, and ICA blood flow toward preheat baseline levels as well as WBC. However, the latencies of SEPs did not recover in the FHC and WBC sessions. These results suggest that impaired neural activity in cortical somatosensory processing during passive HS was recovered by FHC, whereas conduction velocity in the ascending somatosensory input was accelerated by increases in body temperature., 01 Jun. 2017, 312, 6, R996, R1003, Scientific journal, 10.1152/ajpregu.00039.2017
    URLDOI URL
  • Refereed, Scientific Reports, Suppression of cognitive function in hyperthermia; From the viewpoint of executive and inhibitive cognitive processing, Manabu Shibasaki; Mari Namba; Misaki Oshiro; Ryusuke Kakigi; Hiroki Nakata, Apr. 2017, 7, 1, Scientific journal, 10.1038/srep43528
    DOI URL
  • Refereed, Jan. 2017, 58, 1, 50, 54, Scientific journal
  • Refereed, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Effects of aerobic exercise under different thermal conditions on human somatosensory processing, Hiroki Nakata; Misaki Oshiro; Mari Namba; Manabu Shibasaki, 01 Oct. 2016, 311, 4, R629, R636, Scientific journal, 10.1152/ajpregu.00153.2016
    DOI URL
  • Refereed, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, The effect of elevations in internal temperature on event-related potentials during a simple cognitive task in humans, Manabu Shibasaki; Mari Namba; Misaki Oshiro; Craig G. Crandall; Hiroki Nakata, 01 Jul. 2016, 311, 1, R33, R38, Scientific journal, 10.1152/ajpregu.00086.2016
    DOI URL
  • 2016, 57, 11, 858, 858, 10.11419/senshoshi.57.11_858
    DOI URL
  • Refereed, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Effects of passive heat stress on human somatosensory processing, Hiroki Nakata; Misaki Oshiro; Mari Namba; Manabu Shibasaki, 01 Dec. 2015, 309, 11, R1387, R1396, Scientific journal, 10.1152/ajpregu.00280.2015
    DOI URL
  • Oct. 2015, 52, 3, S32, S32
  • Refereed, American Journal of Physiology-Heart and Circulatory Physiology, The role of cardiac sympathetic innervation and skin thermoreceptors on cardiac responses during heat stress, Manabu Shibasaki; Yasunori Umemoto; Tokio Kinoshita; Ken Kouda; Tomoyuki Ito; Takeshi Nakamura; Craig G. Crandall; Fumihiro Tajima, 01 Jun. 2015, 308, 11, H1336, H1342, Scientific journal, True, 10.1152/ajpheart.00911.2014
    DOI URL
  • Refereed, EXPERIMENTAL PHYSIOLOGY, Blood flow in internal carotid and vertebral arteries during graded lower body negative pressure in humans, Shigehiko Ogoh; Kohei Sato; Kazunobu Okazaki; Tadayoshi Miyamoto; Ai Hirasawa; Tomoko Sadamoto; Manabu Shibasaki, Mar. 2015, 100, 3, 259, 266, Scientific journal, 10.1113/expphysiol.2014.083964
    DOI URL
  • Abstracts of Annual Congress of The Japan Society of Home Economics, The Japan Society of Home Economics, Local thermal sensation during repeated thermal stimuli, Shibasaki Manabu, 2015, 67, 137, 137, 10.11428/kasei.67.0_137
    DOI URL
  • Dec. 2014, 51, 4, 70, 70
  • Dec. 2014, 63, 6, 579, 579
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Hyperthermia modulates regional differences in cerebral blood flow to changes in CO2, Shigehiko Ogoh; Kohei Sato; Kazunobu Okazaki; Tadayoshi Miyamoto; Ai Hirasawa; Manabu Shibasaki, Jul. 2014, 117, 1, 46, 52, Scientific journal, 10.1152/japplphysiol.01078.2013
    DOI URL
  • Refereed, EXPERIMENTAL PHYSIOLOGY, Effects of acute hypoxia on cerebrovascular responses to carbon dioxide, Shigehiko Ogoh; Hidehiro Nakahara; Shinya Ueda; Kazunobu Okazaki; Manabu Shibasaki; Andrew W. Subudhi; Tadayoshi Miyamoto, Jun. 2014, 99, 6, 849, 858, Scientific journal, 10.1113/expphysiol.2013.076802
    DOI URL
  • 2014, 63, 1, 111, 111, 10.7600/jspfsm.63.111
    DOI URL
  • Refereed, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Blood flow distribution during heat stress: cerebral and systemic blood flow, Shigehiko Ogoh; Kohei Sato; Kazunobu Okazaki; Tadayoshi Miyamoto; Ai Hirasawa; Keiko Morimoto; Manabu Shibasaki, Dec. 2013, 33, 12, 1915, 1920, Scientific journal, 10.1038/jcbfm.2013.149
    DOI URL
  • Refereed, The Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sports Medicine, Aging and thermoregulation, Manabu Shibasaki; Kazunobu Okazaki; Yoshimitsu Inoue, Global warming is now recognized worldwide. Thermoregulation is critical for human survival when exposed to a severely hot environment. Thermoregulation is closely related to physical fitness, but fitness decreases with advancing age. Thus, thermoregulatory functions also decline with age. In fact, several major heat waves have occurred around the world in the last 10 years, and the mortality ratio was further elevated in elderly people. We encourage exercise training in the elderly to maintain physical fitness, but we should also recognize how human thermoregulation alters with aging. The primary role of thermoregulatory functions is to maintain the internal body temperature within a narrow range. Internal body temperature is regulated by the thermal balance between heat production and heat dissipation. Older individuals have relatively low heat production, impaired thermal perception, and reduced autonomic and behavioral thermoregulatory responses. However, these diminished thermoregulatory functions can be improved, although the gain is lower or limited relative to their younger counterparts. We summarize thermoregulatory functioning in elderly people based on recent publications and our findings., Apr. 2013, 2, 1, 37, 47, Scientific journal, 10.7600/jpfsm.2.37
    DOI URL
  • Refereed, JOURNAL of the JAPAN RESEARCH ASSOCIATION for TEXTILE END-USES, The Japan Research Association for Textile End-Uses, 那智勝浦町における被災地支援活動, SHIBASAKI Manabu,

    Nachi-katsuura town in Wakayama prefecture had a big disaster on September 3, 2011 by typhoon No.12. Medical staffs in Nachi-katsuura municipal hospital and health nurses in the town started support services at the disaster area immediately after the typhoon. Through the support service activities, we have learned some problems in the disaster area. The poor condition of evacuation centers made some health damage to the sufferers. In addition, the lack of underwear, socks and pants for men became a problem at evacuation centers.

    , Mar. 2013, 54, 3, 37-40, 246, 10.11419/senshoshi.54.3_243
    DOI URL
  • Refereed, JOURNAL OF PHYSIOLOGICAL SCIENCES, Blood flow response to carbon dioxide in human internal and external carotid arteries during hyperthermic condition, Ai Hirasawa; Manabu Shibasaki; Rio Sakamoto; Kohei Sato; Kazunobu Okazaki; Tadayoshi Miyamoto; Shigehiko Ogoh, 2013, 63, S264, S264, Scientific journal
  • Oct. 2012, 49, 3, S50, S50
    Permalink
  • Oct. 2012, 49, 3, S74, S74
    Permalink
  • Refereed, FASEB JOURNAL, Release of acetylcholine during whole-body heating in aged skin, Manabu Shibasaki; Hiroko Negishi; Hiroko Kubo; Kazunobu Okazaki; Craig G. Crandall, Apr. 2012, 26, Scientific journal
  • Refereed, CLINICAL AUTONOMIC RESEARCH, Muscle sympathetic responses during orthostasis in heat-stressed individuals, Jian Cui; Manabu Shibasaki; David A. Low; David M. Keller; Scott L. Davis; Craig G. Crandall, Dec. 2011, 21, 6, 381, 387, Scientific journal, 10.1007/s10286-011-0126-6
    DOI URL
  • Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Modelflow underestimates cardiac output in heat-stressed individuals, Manabu Shibasaki; Thad E. Wilson; Morten Bundgaard-Nielsen; Thomas Seifert; Niels H. Secher; Craig G. Crandall, Feb. 2011, 300, 2, R486, R491, Scientific journal, 10.1152/ajpregu.00505.2010
    DOI URL
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Skin blood flow and local temperature independently modify sweat rate during passive heat stress in humans, Jonathan E. Wingo; David A. Low; David M. Keller; R. Matthew Brothers; Manabu Shibasaki; Craig G. Crandall, Nov. 2010, 109, 5, 1301, 1306, Scientific journal, 10.1152/japplphysiol.00646.2010
    DOI URL
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Heat stress attenuates the increase in arterial blood pressure during the cold pressor test, Jian Cui; Manabu Shibasaki; David A. Low; David M. Keller; Scott L. Davis; Craig G. Crandall, Nov. 2010, 109, 5, 1354, 1359, Scientific journal, 10.1152/japplphysiol.00292.2010
    DOI URL
  • Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Insufficient cutaneous vasoconstriction leading up to and during syncopal symptoms in the heat stressed human, C. G. Crandall; M. Shibasaki; T. E. Wilson, Oct. 2010, 299, 4, H1168, H1173, Scientific journal, 10.1152/ajpheart.00290.2010
    DOI URL
  • Refereed, Frontiers in Bioscience - Scholar, Mechanisms and controllers of eccrine sweating in humans, Manabu Shibasaki; Craig G. Crandall, 01 Jan. 2010, 2, 2, 685, 696, Scientific journal
  • Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Plasma hyperosmolality elevates the internal temperature threshold for active thermoregulatory vasodilation during heat stress in humans, Manabu Shibasaki; Ken Aoki; Keiko Morimoto; John M. Johnson; Akira Takamata, Dec. 2009, 297, 6, R1706, R1712, Scientific journal, 10.1152/ajpregu.00242.2009
    DOI URL
  • Refereed, BRITISH JOURNAL OF DERMATOLOGY, Botulinum toxin abolishes sweating via impaired sweat gland responsiveness to exogenous acetylcholine, M. Shibasaki; S. L. Davis; J. Cui; D. A. Low; D. M. Keller; C. G. Crandall, Oct. 2009, 161, 4, 757, 761, Scientific journal, 10.1111/j.1365-2133.2009.09248.x
    DOI URL
  • Refereed, Clinical physiology and functional imaging, Early activation of the coagulation system during lower body negative pressure, SHIBASAKI Manabu; Zaar M; Johansson PI; Nielsen LB; Crandall CG; Shibasaki M; Hilsted L; Secher NH, Oct. 2009, 29, 6, 427-430
  • Refereed, Journal of Burn Care and Research, Sustained impairments in cutaneous vasodilation and sweating in grafted skin following long-term recovery, Scott L. Davis; Manabu Shibasaki; David A. Low; Jian Cui; David M. Keller; Jonathan E. Wingo; Gary F. Purdue; John L. Hunt; Brett D. Arnoldo; Karen J. Kowalske; Craig G. Crandall, Jul. 2009, 30, 4, 675, 685, Scientific journal, 10.1097/BCR.0b013e3181abfd43
    DOI URL
  • Refereed, JOURNAL OF PHYSIOLOGY-LONDON, Neural and non-neural control of skin blood flow during isometric handgrip exercise in the heat stressed human, Manabu Shibasaki; Peter Rasmussen; Niels H. Secher; Craig G. Crandall, May 2009, 587, 9, 2101, 2107, Scientific journal, 10.1113/jphysiol.2009.169201
    DOI URL
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Whole body heat stress attenuates baroreflex control of muscle sympathetic nerve activity during postexercise muscle ischemia, Jian Cui; Manabu Shibasaki; Scott L. Davis; David A. Low; David M. Keller; Craig G. Crandall, Apr. 2009, 106, 4, 1125, 1131, Scientific journal, 10.1152/japplphysiol.00135.2008
    DOI URL
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Effect of elevated local temperature on cutaneous vasoconstrictor responsiveness in humans, Jonathan E. Wingo; David A. Low; David M. Keller; R. Matthew Brothers; Manabu Shibasaki; Craig G. Crandall, Feb. 2009, 106, 2, 571, 575, Scientific journal, 10.1152/japplphysiol.91249.2008
    DOI URL
  • Refereed, Global Environmental Research, Thermoregulatory adaptation in humans and its modifying factors, SHIBASAKI Manabu; Kondo N; Taylor NAS; Shibasaki M; Aoki K; Muhamed AMC, 2009, 13, 1, 35-41
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Nitric oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine, Manabu Shibasaki; David A. Low; Scott L. Davis; Craig G. Crandall, Nov. 2008, 105, 5, 1504, 1508, Scientific journal, 10.1152/japplphysiol.91017.2008
    DOI URL
  • Refereed, MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, Cutaneous and hemodynamic responses during hot flashes in symptomatic postmenopausal women, David A. Low; Scott L. Davis; David M. Keller; Manabu Shibasaki; Craig G. Crandall, Mar. 2008, 15, 2, 290, 295, Scientific journal, 10.1097/gme.0b013e3180ca7cfa
    DOI URL
  • Refereed, Journal of Burn Care & Research, Cutaneous vasoconstriction during whole-body and local cooling in grafted skin 5-9 months post-surgery, SHIBASAKI Manabu; Davis SL; Shibasaki M; Low DA; Cui J; Keller DM; Purdue GF; Hunt JL; Arnoldo BD; Kowalske KJ; Crandall CG, Jan. 2008, 29, 1, 36-41
  • Refereed, JOURNAL OF PHYSIOLOGY-LONDON, Endogenous nitric oxide attenuates neutrally mediated cutaneous vasoconstriction, Manabu Shibasaki; Sylvain Durand; Scott L. Davis; Jian Cui; David A. Low; David M. Keller; Craig G. Crandall, Dec. 2007, 585, 2, 627, 634, Scientific journal, 10.1113/jphysiol.2007.144030
    DOI URL
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Does local heating-induced nitric oxide production attenuate vasoconstrictor responsiveness to lower body negative pressure in human skin?, David A. Low; Manabu Shibasaki; Scott L. Davis; David M. Keller; Craig G. Crandall, May 2007, 102, 5, 1839, 1843, Scientific journal, 10.1152/japplphsiol.01181.2006
    DOI URL
  • Refereed, JOURNAL OF BURN CARE & RESEARCH, Impaired cutaneous vasodilation and sweating in grafted skin during whole-body heating, Scott L. Davis; Manabu Shibasaki; David A. Low; Jian Cui; David M. Keller; Gary F. Purdue; John L. Hunt; Brett D. Arnoldo; Karen J. Kowalske; Craig G. Crandall, May 2007, 28, 3, 427, 434, Scientific journal, 10.1097/BCR.0B013E318053D312
    DOI URL
  • Refereed, JOURNAL OF BURN CARE & RESEARCH, Skin grafting impairs postsynaptic cutaneous vasodilator and sweating responses, Scott L. Davis; Manabu Shibasaki; David A. Low; Jian Cui; David M. Keller; Gary F. Purdue; John L. Hunt; Brett D. Arnoldo; Karen J. Kowalske; Craig G. Crandall, May 2007, 28, 3, 435, 441, Scientific journal, 10.1097/BCR.0B013E318053d32E
    DOI URL
  • Refereed, JOURNAL OF PHYSIOLOGY-LONDON, Carotid baroreceptor stimulation alters cutaneous vascular conductance during whole-body heating in humans, David M. Keller; Scott L. Davis; David A. Low; Manabu Shibasaki; Peter B. Raven; Craig G. Crandall, Dec. 2006, 577, 3, 925, 933, Scientific journal, 10.1113/jphysiol.2006.116905
    DOI URL
  • Refereed, JOURNAL OF PHYSIOLOGY-LONDON, Neurally mediated vasoconstriction is capable of decreasing skin blood flow during orthostasis in the heat-stressed human, Manabu Shibasaki; Scott L. Davis; Jian Cui; David A. Low; David M. Keller; Sylvain Durand; Craig G. Crandall, Sep. 2006, 575, 3, 953, 959, Scientific journal, 10.1113/jphysiol.2006.112649
    DOI URL
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Neural control and mechanisms of eccrine sweating during heat stress and exercise, M Shibasaki; TE Wilson; CG Crandall, May 2006, 100, 5, 1692, 1701, 10.1152/japplphysiol.01124.2005
    DOI URL
  • Refereed, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Spectral characteristics of skin sympathetic nerve activity in heat-stressed humans, J Cui; M Sathishkumar; TE Wilson; M Shibasaki; SL Davis; CG Crandall, Apr. 2006, 290, 4, H1601, H1609, Scientific journal, 10.1152/ajpheart.00025.2005
    DOI URL
  • Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, Mechanisms of cutaneous vasoconstriction during orthostasis in heat stressed individuals, Shibasaki Manabu; Davis Scott L.; Cui Jian; Durand Sylvain; Crandall Craig G., 01 Feb. 2006, 55, 1, 20, 20, 10.7600/jspfsm.55.20
    DOI URL
  • Refereed, JOURNAL OF PHYSIOLOGY-LONDON, Central command and the cutaneous vascular response to isometric exercise in heated humans, M Shibasaki; NH Secher; JM Johnson; CG Crandall, Jun. 2005, 565, 2, 667, 673, Scientific journal, 10.1113/jphysiol.2005.083535
    DOI URL
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Muscle mechanoreceptor modulation of sweat rate during recovery from moderate exercise, M Shibasaki; M Sakai; M Oda; CG Crandall, Jun. 2004, 96, 6, 2115, 2119, Scientific journal, 10.1152/japplphysiol.01370.2003
    DOI URL
  • Refereed, JOURNAL OF PHYSIOLOGY-LONDON, Central command is capable of modulating sweating from non-glabrous human skin, M Shibasaki; NH Secher; C Selmer; N Kondo; CG Crandall, Dec. 2003, 553, 3, 999, 1004, Scientific journal, 10.1113/jphysiol.2003.051102
    DOI URL
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Exercise throughout 6 degrees head-down tilt bed rest preserves thermoregulatory responses, M Shibasaki; TE Wilson; J Cui; BD Levine; CG Crandall, Nov. 2003, 95, 5, 1817, 1823, Scientific journal, 10.1152/japplphysiol.00188.2003
    DOI URL
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Prolonged head-down tilt exposure reduces maximal cutaneous vasodilator and sweating capacity in humans, CG Crandall; M Shibasaki; TE Wilson; J Cui; BD Levine, Jun. 2003, 94, 6, 2330, 2336, Scientific journal, 10.1152/japplphysiol.00790.2002
    DOI URL
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Effects of 14 days of head-down tilt bed rest on cutaneous vasoconstrictor responses in humans, TE Wilson; M Shibasaki; J Cui; BD Levine; CG Crandall, Jun. 2003, 94, 6, 2113, 2118, Scientific journal, 10.1152/japplphysiol.00067.2002
    DOI URL
  • Refereed, EXERCISE AND SPORT SCIENCES REVIEWS, Non-thermoregulatory modulation of sweating in humans, M Shibasaki; N Kondo; CG Crandall, Jan. 2003, 31, 1, 34, 39
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Acetylcholine released from cholinergic nerves contributes to cutaneous vasodilation during heat stress, M Shibasaki; TE Wilson; J Cui; CG Crandall, Dec. 2002, 93, 6, 1947, 1951, Scientific journal, 10.1152/japplphysiol.00036.2002
    DOI URL
  • Refereed, ACTA PHYSIOLOGICA SCANDINAVICA, Sweating responses to a sustained static exercise is dependent on thermal load in humans, N Kondo; N Horikawa; K Aoki; M Shibasaki; Y Inoue; T Nishiyasu; CG Crandall, Aug. 2002, 175, 4, 289, 295, Scientific journal
  • Refereed, Acta Physiologica Scandinavica, Sweating response to sustained handgrip exercise in physically trained men, Jan. 2002, 174, 1, 31-39, Scientific journal, True, 10.1046/j.1365-201x.2002.00921.x
    DOI URL
  • Refereed, JOURNAL OF PHYSIOLOGY-LONDON, Evidence that the human cutaneous venoarteriolar response is not mediated by adrenergic mechanisms, CG Crandall; M Shibasaki; TC Yen, Jan. 2002, 538, 2, 599, 605, Scientific journal, 10.1013/jphysiol.2001.013060
    DOI URL
  • Refereed, ACTA PHYSIOLOGICA SCANDINAVICA, Sweating response in physically trained men to sustained handgrip exercise in mildly hyperthermic conditions, S Yanagimoto; K Aoki; N Horikawa; M Shibasaki; Y Inoue; T Nishiyasu; N Kondo, Jan. 2002, 174, 1, 31, 39, Scientific journal
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Baroreflex modulation of muscle sympathetic nerve activity during posthandgrip muscle ischemia in humans, J Cui; TE Wilson; M Shibasaki; NA Hodges; CG Crandall, Oct. 2001, 91, 4, 1679, 1686, Scientific journal
  • Refereed, JOURNAL OF PHYSIOLOGY-LONDON, Evidence for metaboreceptor stimulation of sweating in normothermic and heat-stressed humans, M Shibasaki; N Kondo; CG Crandall, Jul. 2001, 534, 2, 605, 611, Scientific journal
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Function of human eccrine sweat glands during dynamic exercise and passive heat stress, N Kondo; M Shibasaki; K Aoki; S Koga; Y Inoue; CG Crandall, May 2001, 90, 5, 1877, 1881, Scientific journal
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Effect of local acetylcholinesterase inhibition on sweat rate in humans, M Shibasaki; CG Crandall, Mar. 2001, 90, 3, 757, 762, Scientific journal
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Effect of muscle mass on Vo(2) kinetics at the onset of work, S Koga; TJ Barstow; T Shiojiri; T Takaishi; Y Fukuba; N Kondo; M Shibasaki; DC Poole, Feb. 2001, 90, 2, 461, 468, Scientific journal
  • Refereed, Journal of Applied Physiology, Effects of exercise intensity on the sweating response to a sustained static exercise, SHIBASAKI Manabu; Kondo N; Tominaga H; Shibasaki M; Aoki K; Okada S; Nishiyasu T, Mar. 2000, 88, 3, 1590-1596
  • Refereed, ACTA PHYSIOLOGICA SCANDINAVICA, Relationship between skin blood flow and sweating rate in prepubertal boys and young men, M Shibasaki; Y Inoue; N Kondo; K Aoki; K Hirata, Oct. 1999, 167, 2, 105, 110, Scientific journal
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Kinetics of oxygen uptake during supine and upright heavy exercise, S Koga; T Shiojiri; M Shibasaki; N Kondo; Y Fukuba; TJ Barstow, Jul. 1999, 87, 1, 253, 260, Scientific journal
  • Refereed, JOURNAL OF PHYSIOLOGY-LONDON, Modulation of the thermoregulatory sweating response to mild hyperthermia during activation of the muscle metaboreflex in humans, N Kondo; H Tominaga; M Shibasaki; K Aoki; S Koga; T Nishiyasu, Mar. 1999, 515, 2, 591, 598, Scientific journal
  • Refereed, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, Mechanisms underlying the age-related decrement in the human sweating response, Y Inoue; M Shibasaki; H Ueda; H Ishizashi, Jan. 1999, 79, 2, 121, 126, Scientific journal
  • Refereed, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, Relationship between skin blood flow and sweating rate, and age related regional differences, Y Inoue; M Shibasaki; K Hirata; T Araki, Dec. 1998, 79, 1, 17, 23, Scientific journal
  • Refereed, The Japanese journal of ergonomics, 赤外線透過ファイバを用いた非接触型鼓膜体温計の開発, SHIBASAKI Manabu, Oct. 1998, 34, 5, 247-253, 253
  • Refereed, JOURNAL OF APPLIED PHYSIOLOGY, Continuous measurement of tympanic temperature with a new infrared method using an optical fiber, M Shibasaki; N Kondo; H Tominaga; K Aoki; E Hasegawa; Y Idota; T Moriwaki, Sep. 1998, 85, 3, 921, 926, Scientific journal
  • Refereed, ACTA PHYSIOLOGICA SCANDINAVICA, Regional differences in the effect of exercise intensity on thermoregulatory sweating and cutaneous vasodilation, N Kondo; S Takano; K Aoki; M Shibasaki; H Tominaga; Y Inoue, Sep. 1998, 164, 1, 71, 78, Scientific journal
  • Refereed, JAPANESE JOURNAL OF PHYSIOLOGY, Control of circadian variation in skin blood flow response to heat stress, K Aoki; N Kondo; M Shibasaki; S Takano; T Katsuura; K Hirata, Feb. 1998, 48, 1, 95, 98, Scientific journal
  • Refereed, PHYSIOLOGY & BEHAVIOR, Circadian variation in skin blood flow responses to passive heat stress, K Aoki; N Kondo; M Shibasaki; S Takano; T Katsuura, Dec. 1997, 63, 1, 1, 5, Scientific journal
  • Refereed, ACTA PHYSIOLOGICA SCANDINAVICA, Circadian variation of sweating responses to passive heat stress, K Aoki; N Kondo; M Shibasaki; S Takano; H Tominaga; T Katsuura, Nov. 1997, 161, 3, 397, 402, Scientific journal
  • Refereed, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, Mechanisms of underdeveloped sweating responses in prepubertal boys, M Shibasaki; Y Inoue; N Kondo, Oct. 1997, 76, 4, 340, 345, Scientific journal
  • Refereed, Journal of Thermal Biology, Sweating responses to passive and active limb movements, SHIBASAKI Manabu; Kondo N; Tominaga H; Shiojiri T; Shibasaki M; Aoki K; Takano S; Koga S; Nishiyasu T, Oct. 1997, 22, 4/5, 351-356
  • Refereed, ACTA PHYSIOLOGICA SCANDINAVICA, Effects of reduced muscle temperature on the oxygen uptake kinetics at the start of exercise, T Shiojiri; M Shibasaki; K Aoki; N Kondo; S Koga, Apr. 1997, 159, 4, 327, 333, Scientific journal
  • Refereed, INTERNATIONAL JOURNAL OF BIOMETEOROLOGY, The effect of change in skin temperature due to evaporative cooling on sweating response during exercise, N Kondo; M Nakadome; KR Zhang; T Shiojiri; M Shibasaki; K Hirata; A Iwata, Apr. 1997, 40, 2, 99, 102, Scientific journal
  • Refereed, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, Thermoregulatory responses of prepubertal boys and young men during moderate exercise, M Shibasaki; Y Inoue; N Kondo; A Iwata, Mar. 1997, 75, 3, 212, 218, Scientific journal
  • Refereed, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, Regional differences in age-related decrements of the cutaneous vascular and sweating responses to passive heating, Y Inoue; M Shibasaki, Aug. 1996, 74, 1-2, 78, 84, Scientific journal
  • Refereed, JAPANESE JOURNAL OF PHYSIOLOGY, The influence of work loads on regional differences in sweating rates, S Takano; N Kondo; M Shibasaki; K Aoki; Y Inoue; A Iwata, Apr. 1996, 46, 2, 183, 186, Scientific journal
  • Refereed, RESPIRATION PHYSIOLOGY, Kinetics of oxygen uptake and cardiac output at onset of arm exercise, S Koga; T Shiojiri; M Shibasaki; Y Fukuba; Y Fukuoka; N Kondo, Feb. 1996, 103, 2, 195, 202, Scientific journal
  • Refereed, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, THE EFFECT OF DIURNAL-VARIATION ON THE REGIONAL DIFFERENCES IN SWEATING AND SKIN BLOOD-FLOW DURING EXERCISE, K AOKI; T SHIOJIRI; M SHIBASAKI; S TAKANO; N KONDO; A IWATA, Aug. 1995, 71, 2-3, 276, 280, Scientific journal
  • 1994, 31, 3, 139, 139, 10.11227/seikisho1966.31.139
    DOI URL
  • Refereed, 2023, 60, 1, 23, 30
  • Refereed, 2023, 62, 4, 170, 177
  • Refereed, 2023, 190, 35, 29, 35, 10.1016/j.neures.2022.11.007
  • Refereed, 2023, 13, 1, 10.1038/s41598-023-32389-8
  • Refereed, 01 Mar. 2023, 324, 3, R345, R352, 10.1152/ajpregu.00063.2022
  • Refereed, 01 Oct. 2022, 323, 4, R581, R588, 10.1152/ajpregu.00040.2022
  • Refereed, e0259653
  • Refereed, e0254769
  • Jul. 2014, 64, 7, 475, 480

MISC

  • MEDICINE & SCIENCE IN SPORTS & EXERCISE, Effect Of Exercise Strategy On Brain Activity At The Start Of Exercise, Keiko Yamamoto; Madoka Nomura; Minami Hirai; Hiroko Kubo; Manabu Shibasaki, Sep. 2022, 54, 9, 556, 556, Summary international conference
  • Not Refereed, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Cognitive Task Impairs Dynamic Cerebral Autoregulation During Normoxia And Hypoxia., Shigehiko Ogoh; Hiroaki Nakata; Tadayoshi Miyamoto; Manabu Shibasaki, May 2017, 49, 5, 65, 65, Summary international conference, 10.1249/01.mss.0000517005.35311.00
    DOI URL
  • Not Refereed, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Human Cognitive Function During Acute Hypoxic Exposure, Manabu Shibasaki; Shigehiko Ogoh; Tadayoshi Miyamoto; Hiroki Nakata, May 2017, 49, 5, 241, 241, Summary international conference, 10.1249/01.mss.0000517512.21510.9d
    DOI URL
  • Human Cognitive Functions During Exercise under Different Thermal Conditions, May 2017, 38, 17, 27
  • Not Refereed, MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, Human Cognitive Function During Acute Hypoxic Exposure, Manabu Shibasaki; Shigehiko Ogoh; Tadayoshi Miyamoto; Hiroki Nakata, May 2015, 47, 5, 241, 241, Summary international conference
  • Not Refereed, FASEB JOURNAL, The effect of hyperthermia on cognitive and auditory processing, Manabu Shibasaki; Mari Nanba; Keiko Morimoto; Hiroki Nakata, Apr. 2015, 29, Summary international conference
  • Not Refereed, 加齢に伴う体温調節機能の変化と衣服への提案, SHIBASAKI Manabu, Mar. 2015, 58, 2, 60, 70
  • Not Refereed, 体温調節に関する研究の動向 ?子どもと高齢者?, SHIBASAKI Manabu, Aug. 2014, 67, 8, 475-480, 480
  • Not Refereed, 暑熱環境下における体温調節, SHIBASAKI Manabu, Jul. 2014, 64, 7, 461-465, 465
  • Not Refereed, 発汗研究の新たなツール, SHIBASAKI Manabu, Apr. 2013, 20, 1, 21-24
  • Not Refereed, 高齢者の発汗反応, SHIBASAKI Manabu, Dec. 2012, 19, 2, 52-55
  • Not Refereed, JAPANESE JOURNAL OF BIOMETEOROLOGY, Japanese Society of Biometeorology, 若手から見た生気象学－生理学分野から－, SHIBASAKI Manabu, Biometeorology is a global research field following one of Hippocrates's concepts "Man-Environment. As a young scientist studying temperature regulation, for continuing and growing of Japanese society of biometeorology (JSB), this paper offers what young biometeorologists should do and what JSB should do for them, and how JSB contributes to society and local communities.
    , Mar. 2012, 59-61, 61, 10.11227/seikisho.Suppl..59
    DOI URL
  • 01 Sep. 2010, 47, 3, S67
  • Not Refereed, 運動時の発汗反応－皮内マイクロダイアリシスと発汗に関する研究への応用－, SHIBASAKI Manabu, Dec. 2009, 16, 2, 58-62
  • 01 Oct. 2007, 44, 3, S65
  • 01 Dec. 2006, 55, 6, 678, 678
  • 01 Oct. 2006, 43, 3, S40
  • 2006, 22nd
  • 01 Dec. 2003, 52, 6, 910, 910
  • 01 Oct. 2003, 40, 3, S56
  • 2001, 22, 14, 22
  • 01 Dec. 2000, 49, 6, 899, 899
  • 01 Dec. 2000, 49, 6, 897, 897
  • 01 Dec. 2000, 49, 6, 898, 898
  • 2000, 21, 51, 58
  • 2000, 21, 85, 94
  • Not Refereed, 人における運動時の熱放散反応, SHIBASAKI Manabu, 2000, 9, 1-13
  • Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 382.Pharmacological assessment of acetylcholinesterase effect using intradermal microdialysis, 01 Dec. 1999, 48, 6, 903, 903
  • 1999, 20, 177, 183
  • 01 Dec. 1998, 47, 6, 951, 951
  • 01 Dec. 1998, 47, 6, 880, 880
  • Applied human science : journal of physiological anthropology, Japan Society of Physiological Anthropology, P-10 Control of Circadian Variation in Skin Blood Flow Response during Hot Water Immersion (Proceedings of the 38th Meeting of Japan Society of Physiological Anthropology) :, AOKI Ken; KONDO Narihiko; SHIBASAKI Manabu; TAKANO Seiji; KATSUURA Tetsuo; HIRATA Kozo, 1998, 17, 2, 86, 86
  • Applied human science : journal of physiological anthropology, Japan Society of Physiological Anthropology, P-8 Sweating Response to an Isometric Hand Grip Exercise (Proceedings of the 38th Meeting of Japan Society of Physiological Anthropology) :, Tominaga Hirotaka; Shibasaki Manabu; Horikawa Naoki; Kondo Narihiko, 1998, 17, 2, 86, 86
  • Applied human science : journal of physiological anthropology, Japan Society of Physiological Anthropology, P-7 Effects of Density of Activated Sweat Glands and Sweat Output per Gland on Change in Sweating Rate (Proceedings of the 38th Meeting of Japan Society of Physiological Anthropology) :, KONDO Narihiko; SHIBASAKI Manabu; TOMINAGA Hirotaka; HORIKAWA Naoki, 1998, 17, 2, 86, 86
  • Applied human science : journal of physiological anthropology, Japan Society of Physiological Anthropology, P-9 Continuous Measurement of Tympanic Temperature using Infrared Thermometer with Optical Fiber (Proceedings of the 38th Meeting of Japan Society of Physiological Anthropology) :, SHIBASAKI Manabu; KONDO Narihiko; TOMINAGA Hirotaka; HORIKAWA Naoki; IDOTA Yoshiyuki; MORIWAKI Toshimichi, 1998, 17, 2, 86, 86
  • 01 Dec. 1997, 46, 6, 910, 910
  • 01 Dec. 1997, 46, 6, 906, 906
  • 01 Dec. 1997, 46, 6, 857, 857
  • 1995, 2, 1, 48, 48
  • 1995, 2, 1, 45, 45
  • Human sciences research, Kobe University, The characteristic of thermoregulation in children, Shibasaki Manabu; Kondo Narihiko; Inoue Yoshimitu, 1995, 3, 1, 99, 108
  • 01 Dec. 1994, 43, 6, 684, 684
  • 01 Dec. 1994, 43, 6, 685, 685

Books etc

  • Apr. 2024, 559p, 9784867980194
    CiNii Books URL
  • May 2023, 2, 8, 337, 10p, 図版 21p, 9784860438302
    CiNii Books URL
  • 20 Apr. 2021
  • 25 Dec. 2020, 649p, 9784861048197
    CiNii Books URL
  • Mar. 2020, xvi, 262p, 9784524240296
    CiNii Books URL
  • Oct. 2016, ix, 490p, 図版 [4] p, 9784254620153
    CiNii Books URL
  • Fluid Balance, Hydration, and Athletic Performance, CRC Press, SHIBASAKI Manabu; Manabu Shibasaki; Scott L. Davis, Jan. 2016, 33-58, Not Refereed, 9781482223286
  • Sep. 2014, 冊, 9784880038865
    CiNii Books URL
  • Apr. 2011, ix, 295p, 9784808260316
    CiNii Books URL
  • Nov. 2010, 462p, 9784880038469
    CiNii Books URL
  • Nov. 2010, xiii, 304p, 9784931411005
    CiNii Books URL
  • Sep. 2009, xxii, 724p, 9784621081723
    CiNii Books URL
  • Nonthermoregulatory modification of sweating and skin blood flow Exercise, Nutrition, and Environmental Stress Vol. 4, Cooper Publishing Group, SHIBASAKI Manabu, 2005, 227-243頁, Not Refereed
  • Pulmonary and muscle oxygen uptake kinetics at the onset of exercise Exercise, Nutrition, and Environmental Stress Vol. 3, Cooper Publishing Group, SHIBASAKI Manabu, 2003, 63-84頁, Not Refereed
  • Sep. 2002, x, 251p, 9784931411319
    CiNii Books URL
  • Jun. 2002, viii, 173p, 4061531182
    CiNii Books URL
  • Strategy for preventing heat illness in children and in the elderly Exercise, Nutrition, and Environmental Stress Vol. 2, Cooper Publishing Group, SHIBASAKI Manabu, 2002, 239-271頁, Not Refereed
  • 2001, 2冊, 4880036692
    CiNii Books URL
  • The effect of density of activated sweat glands and sweat output per gland on the change in sweating rate The 1997 Nagano symposium on sports sciences, Cooper Publishing Group, SHIBASAKI Manabu, 1998, Not Refereed
  • Oct. 1996, 631p, 4765500292
    CiNii Books URL
  • 978-4-7644-1219-4
  • ISBN：978-4-86104-819-7

Works

  • Sep. 2006 - Oct. 2010
  • Neural and non-neural modulators of skin blood flow and sweating in humans., Sep. 2006 - Oct. 2010
  • Jun. 2006 - Jul. 2006
  • Sep. 2003 - Oct. 2003
  • Effect of mechanoreflex on sweating and skin blood flow during recovery of dynamic exercise, Sep. 2003 - Oct. 2003
  • May 2002 - Jul. 2002
  • Effect of central command on sweating and skin blood flow during isometric handgrip exercise in the heat stressed human, May 2002 - Jul. 2002
  • Aug. 2000 - Sep. 2000
  • Modulation of cutaneous vasodilation during heat stress due to acetylcholine released from cholinergic nerves, Aug. 2000 - Sep. 2000
  • Aug. 1999 - Sep. 1999
  • Effect of metaboreflex on sweating during isometric handgrip exercise, Aug. 1999 - Sep. 1999

Awards

  • 久野寧記念賞, 2006

Research Projects

  • Mar. 2023 - Feb. 2028, Principal investigator, 次世代生体情報によるヒト・モノ共生型支援システムを創造する女性エンジニアの養成, 住友電工グループ社会貢献基金 大学寄付講座, 奈良女子大学工学部, rm:media_coverage
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (B), 01 Apr. 2022 - 31 Mar. 2026, 22H00951, Human centerd engineering study of the impact of life monitoring technology on the optimization of the living environment of the elderly, 久保 博子; 才脇 直樹; 芝崎 学; 東 実千代; 佐々 尚美; 磯田 則生; 安在 絵美, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Nara Women's University, 17420000, 13400000, 4020000, kaken
    対象リソースIRI
  • Apr. 2019 - Mar. 2022, Principal investigator, 機能性ウェアへの水分散布による蒸発性熱放散促進および紫外線散乱による温熱的快適性向上, 石本記念デサントスポーツ科学振興財団, 奈良女子大学
  • Grant-in-Aid for Scientific Research (B), Apr. 2019 - Mar. 2022, 19H01616, Coinvestigator, Universal specifications in clothing design to extend healthy life expectancy in a super-aging society: Using physiological measurement data as an indicator, MOROOKA Harumi, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Kyoto Women's University, 17810000, 13700000, 4110000, The purpose of this study is to design "universal specifications in clothing" that can maintain and improve activities of daily living (ADL) and quality of life (QOL) even in circumstances where physical functions are restricted due to aging or disability. This basic study involved the measurement and analysis of the physiology and physical functions of elderly and disabled individuals. Further, to develop specific clothing design guidelines for assisting their physical function, we conducted developmental research from thermal, pressure, and tactile perspectives using physiological measurement data as an indicator., kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (B), Apr. 2018 - Mar. 2022, 18H03166, Principal investigator, Effects of central and peripheral fatigue on muscle output regulation and circulatory regulation during exercise in a hot environment, Shibasaki Manabu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Nara Women's University, 17160000, 13200000, 3960000, We investigated the effects of central and peripheral fatigues on motor control and cardiovascular responses during exercise in a hot environment using electroencephalographic event-related potentials, near-infrared spectroscopy, and middle cerebral artery blood velocity. In addition, to investigate the motor skill with muscle fatigue, we examined the interlocking of upper and lower limbs movements. The results of hyperthermia-induced central fatigue showed that the mode of exercise is capable of modulating the central motor command. Also, the peripheral fatigue affects the output of the central motor command, which is brain activity. Finally, "how to relax" due to muscle fatigue was numerically presented., kaken
    対象リソースIRI
  • Apr. 2020 - Mar. 2021, Coinvestigator, 暑熱環境下における皮質脊髄路の興奮性の検討, 石本記念デサントスポーツ科学振興財団, 奈良女子大学
  • Apr. 2018 - Mar. 2019, Coinvestigator, 暑熱環境下の運動による脱水がヒト脳認知機能に及ぼす影響, 石本記念デサントスポーツ科学振興財団, 奈良女子大学
  • Apr. 2017 - Mar. 2018, Principal investigator, 高体温時の認知機能低下の機能的磁気共鳴画像法による空間的神経ネットワーク評価, 石本記念デサントスポーツ科学振興財団, 奈良女子大学
  • Grant-in-Aid for Scientific Research (B), Apr. 2015 - Mar. 2018, 15H02889, Coinvestigator, Development of the device which simulates infant's perspiration and sweating -For constructing baby sweating thermal manikin in the future-, Takako Fukazawa; KUKLANE Kalev; TOURULA Marjo, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Kyoto University of Education, 17550000, 13500000, 4050000, Two devices have been developed to simulate perspiration and sweating from infant’s body surface in terms of constructing in the future baby sweating thermal manikin, which simulates not only baby’s body shape but also heat production and release. Both the devices consisted of mainly two parts, which of the one was a simulating skin and the other was a water supplier. The evaporated water vapour from the device of simulating perspiration was resulted in the rate of approximately 8 g/m2h, whose rate was in good agreement with infant’s perspiration from the body. In baby, sweat evaporates entirely and quickly because of a smaller amount of sweat rate, e.g. 25 g/m2h, even if he/she is exposed to a hot environment. Its phenomenon was also seen in the developed device of simulating infant’s sweating with several sweat rate conditions. Therefore, these results indicate that techniques of simulating perspiration and sweating can be able to apply into constructing a baby thermal manikin., url
    対象リソースIRI
  • Apr. 2016 - Mar. 2017, Coinvestigator, 暑熱環境の違いが運動時のヒト認知機能に及ぼす影響, 石本記念デサントスポーツ科学振興財団, 奈良女子大学
  • Apr. 2015 - Mar. 2016, Principal investigator, 暑熱環境下における聴覚情報処理および高次認知機能の評価, 石本記念デサントスポーツ科学振興財団, 奈良女子大学
  • Grant-in-Aid for Challenging Exploratory Research, Apr. 2012 - Mar. 2015, 24650468, Principal investigator, Development of the preventive medical clothes based upon spurious thermal sensation, SHIBASAKI Manabu; NEGISHI Hiroko; KUBO Hiroko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Nara Women's University, 3770000, 2900000, 870000, A simulated thermal sensation due to evoked TRP (Transient Receptor Potential) channels could be contribute to improve living environment and to prevent heat-related illness. For an objective approach for evaluating thermal sensation, we attempted to develop a suitable protocol for one of brain imaging techniques, fNIRS (functional Near Infrared Spectroscopy). The developed periodic thermal stimulation clearly modulates thermal sensation. We confirmed that the stimulation of Aδfibers combined with menthol administration enhanced brain activity estimated by EEG (electroencephalography) and that thermal sensation during the periodic thermal stimulation was further evoked by menthol., url
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (B), Apr. 2011 - Mar. 2014, 23300265, Principal investigator, Evaluation of physiological responses during thermal stimuli: For development of advanced wear(s), SHIBASAKI Manabu; MORIMOTO Keiko, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Nara Women's University, 17550000, 13500000, 4050000, We proposed a research project for development of advanced wear(s) prevented heat-related illness. In this study, we measured thermal sensation and skin blood flow responses to infrared and/or ultraviolet stimuli and regional blood flow responses during heat stress. In the process of this project, we proposed a linear model of thermal scale using visual analogue scale, and tested the validity of the scale during several thermal stimuli., url
    対象リソースIRI
  • R01, Sep. 2006 - Aug. 2012, Coinvestigator, Neural and non-neural modulators of skin blood flow and sweating in humans., Principal Investigator: Craig G. Crandall, National Heart, Lung, and Blood Institute, National Institutes of Health, Univ. Texas, Southwestern Medical Center at Dallas & IEEM Presbyterian Hospital of Dallas
  • Grant-in-Aid for Young Scientists (B), Apr. 2009 - Mar. 2011, 21790225, Principal investigator, Orthostatic tolerance and blood flow during a heat stress, SHIBASAKI Manabu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Nara Women's University, 4290000, 3300000, 990000, This study was focused on control of lower leg blood flow during an orthostatic challenge of heat-stressed individuals. Cutaneous vasoconstrictor responsiveness was assessed by multiple doses of exogenous norepinephrine and veno-arteriolar reflex on dorsal forearm and lower leg. Venous compliance and microvascular filtration coefficient were measured by strain-gauge plethysmography during 10mmHg pressure step test and during 20mmHg lower body negative pressure. These variables were reduced in the hyperthermic condition. In luteal phase, venous compliance and microvascular filtration were increased and orthostatic tolerance was reduced., url
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (A), Apr. 2008 - Mar. 2011, 20247035, Coinvestigator, Elucidation of the aging process of human heat adaptability and strategies for delaying it, INOUE Yoshimitsu; KOGA Syunsaku; KONDO Narihiko; UEDA Hiroyuki; ISHIZASHI Hiromichi; SHIBASAKI Manabu; OUMI Masato, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Osaka International University, 46150000, 35500000, 10650000, This research project addressed the ways in which human heat adaptability changes with aging from the viewpoint of whole body coordination. Our findings suggest that in men and women, age-related decrement in thermoregulatory function may involve the input system, effector system, output system, and central system in that order, and the decrement in sweat gland function in the lower limbs may proceed from the lower legs to thigh and from posterior to anterior areas. Our results suggest that non-thermal heat loss response to combined input and sex differences in heat loss responses in young adults tended to decrease with aging. They also suggest that the enhancement of peripheral sweat function toward summer was delayed with aging, the contribution of the skin blood flow adjustment to orthostatic tolerance during the summer heat is smaller in older people, and older people are more prone to thrombogenesis in the summer. Although we failed to find a strategy to delay aging of input and output systems of the thermoregulatory function, the establishment of an exercise habit is effective for the effector system., url
    対象リソースIRI
  • Apr. 2008 - Mar. 2009, Principal investigator, 妊娠・授乳期の健康管理ポータブルデバイスの開発, JST, 地域イノベーション創出総合支援事業「シーズ発掘試験」, 奈良女子大学
  • Apr. 2007 - Mar. 2008, Principal investigator, 暑熱環境下における運動時の循環・体温・体液調節の相互作用に関する研究, (財)中冨健康科学財団, 国際研究交流助成, 奈良女子大学
  • Grant-in-Aid for Young Scientists (B), Apr. 2005 - Mar. 2007, 17790162, Principal investigator, 暑熱環境下における起立性ストレス時の皮膚血管調節, 芝崎 学, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Nara Women's University, 3400000, 3400000, 起立性ストレスを負荷すると、内臓や筋または皮膚などの血管は収縮し、血圧の維持に貢献する。暑熱環境下では、深部体温の上昇によって皮膚血管が拡張する。深部体温がかなり上昇した場合、心拍出量の約50%が末梢皮膚循環へ分配されることが報告されている。そのため、暑熱環境下における起立性ストレス時の血圧維持に対して、皮膚血管の収縮は非常に大きな役割を担っていることが考えられる。先行研究によって、暑熱環境下における皮膚血管収縮反応には、皮膚血管拡張神経活動の低下と皮膚血管収縮神経活動の亢進の両方が関与していることが報告されている。しかし、後者のメカニズムは、減弱されている可能性が示唆されている。
    本研究の目的は、暑熱環境下における皮膚血管収縮反応の減弱メカニズムを明らかにすることである。被験者は健康な若年男性または女性、約10名を対象とする。実験1では、局所加温によって皮膚血管を拡張させ、実験2では、血管拡張性物質を皮内マイクロダイアリシスより投与する。
    実験1:局所温度制御装置によって、皮膚温を40℃にコントロールし、1つのマイクロダイアリシスプローブにはリンゲル液を、もう1つにはL-NAMEと血管拡張物質であるアデノシンを投与する。血流量が安定した後、ノルエピネフリンによる用量作用テストを行う。
    実験2:一酸化窒素ドナーであるニトロプルシッドをマイクロダイアリシスプローブより、別のもう1つのプローブよりニトロプルシッドとL-NAMEを、さらに別のプローブよりアデノシンを連続的に投与する。血流量が安定した後、ノルエピネフリンによる用量作用テストを行う。
    実験1では、局所加温にともなうNO由来の皮膚血管拡張の個人差が大きく、L-NAMEによってNO由来の血管拡張を抑制した分をアデノシンで補うことを試みたが、皮膚血流量をクランプすることが困難であったために、途中で断念した。実験2では、アデノシンによる皮膚血管拡張レベルを基準としてニトロプルシッドの濃度を変化させたため、安定したベースラインが得られた。ノルエピネフリンによる用量曲線は、アデノシン投与側よりもニトロプルシッド側でノルエピネフリンの高濃度側へ移動した。, kaken
    対象リソースIRI
  • Grant-in-Aid for Scientific Research (B), Apr. 2003 - Mar. 2006, 15300245, Coinvestigator, The Study on Thermal Environment for Elderly and Cold Proof Person-Study on Physiological Responses on Daily Life Using Heater and Cooler-, KUBO Hiroko; ISODA Norio; SHIBASAKI Manabu, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Nara Women's University, 13600000, 13600000, The purpose of this study is to investigate the optimal thermal environment for the elderly. We carried out two experiments in a climate chamber as follows. Experiment 1: the direct determination of preferred air temperature. The subjects regulated air temperature for 120 minutes. We explained individual variations of thermal comfort for the elderly, and whether it's a good condition for the elderly health. During the experiments, we measured the skin temperatures, heart rate, thermal comfort vote, thermal sensation vote, and so on. And, we measured metabolic rate and heat loss, and we considered heat balance under several thermal environment. The subjects were 30 healthy elderly women. The subjects sat on a chair during the experiments in summer clothes (0.4clo). Experiment 2: exposure to established air temperature (23℃, 25℃, 31℃, 33℃). The subjects were exposed to established air temperature for 60 minutes. We explained the effect of established thermal environment on physiological and psychological responses. On Experiment 2, 19 subjects were extracted from Experiment 1. By these experiments, we determine an extant of comfort temperatures for the elderly that has several preferred temperatures in summer. The results were as follows;
    Preferred air temperature were from 24.4℃ to 29.3℃. The average of preferred air temperature was 27℃, and standard deviation of mat was 1.3℃. On that conditions, almost subjects voted 'comfortable'-'very comfortable'. But under 25℃, some elderly cooled their core temperatures a little, and their heart rate declined. This indicates that the elderly decrease in ability to control the skin temperature., kaken
    対象リソースIRI
  • Grant-in-Aid for Exploratory Research, Apr. 2003 - Mar. 2005, 15650151, Principal investigator, 入眠を促進する足踵温度コントロール-湯たんぽの効果を生理学的に見直す-, 久保 博子; 芝崎 学; 磯田 則生; 久保 博子, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Exploratory Research, Nara Women's University, 3300000, 3300000, 本プロジェクトは、医・工学系ではなく生活科学系から、製品開発の新しいコンセプトの提供とその可能性を示しうるデータの収集を第一の目的とする。入眠に焦点をおき、入眠時の生理学的および物理学的パラメータから、入眠を促進するパラメータを評価し、どうすれば入眠を促進することができるのか、そこに新しい製品開発コンセプトを見出すことを試みる。昨今見直されてきつつある湯たんぽは、足踵を効果的に暖めるため、これに注目して入眠を促進する製品の開発に役立てることを目的とした。
    昨年度行った予備実験として行った昼寝実験より求めた、実際的な快適な足部加温条件をもとにして、終夜睡眠実験をおこなった。
    健康な青年女子(大学生)6名を被験者として採用して、冬期の寝具・寝衣条件で、冬期の室内環境として、入床前安静時18℃、入床前60分より起床時まで15℃50%で夜間の睡眠実験を行った。寝床内暖房条件として、条件1:加温なし、条件2:湯たんぽ湯温55℃、条件3:電気あんか低温で終夜使用、条件4:電気あんか高温で足底皮膚温が30℃になるまで使用の4条件とした。睡眠時には、脳波、心拍数、体動量、直腸温、皮膚温などを測定し、入床前後には心理申告を求めた。
    その結果、(1)足底部加温器具による加温は、足部皮膚温が速やかに上昇し、直腸温の低下を促し、入眠促進効果があることが示唆された。(2)足部が適切に加温器具接触してない場合は足部皮膚温の上昇が速やかではなかったが、入眠時に高めの温度設定条件であった条件2、4においては、比較的安定した入眠促進効果がみられた。その後の温度低下の影響はほとんどみられなかった。(3)足部加温器の使用では、寝床内温度が既往の報告にある快適温度範囲に達する前に置いても速やかな入眠効果がみられた。, kaken
    対象リソースIRI
  • Grant-in-Aid for Young Scientists (A), Apr. 2002 - Mar. 2004, 14704020, Principal investigator, 動的運動初期の体温調節反応に関与する筋からの求心性入力, 芝崎 学, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Nara Women's University, 15600000, 12000000, 3600000, これまでの研究において、運動時の発汗反応には、セントラルコマンドや筋の代謝受容器からの入力が影響することを報告してきた。しかし、これまでの研究アプローチは、静的な運動を対象としており、動的な運動時における発汗反応に対しては不明な点が残されている。特に、筋の機械受容器からの入力が発汗反応に影響するか否かについては、静的な運動時においても明らかにされていない。本研究では、昨年度に引き続き、動的運動時の発汗反応に影響する非温熱性要因に注目し、その中でも本年は機械受容器反射の役割について検討した。
    健康な男性被験者を対象として、20分間で心拍数が毎分135拍程度になるような運動を実施した後に、今回開発した仰臥位で受動的な運動が可能なタンデム自転車を用いた受動的運動回復と、無運動の安静回復をそれぞれ異なる日に実施し、その運動回復期間中の発汗および皮膚血管反応を比較検討した。実験は、本学環境制御室内で実施され、被験者は事前に運動負荷テストを実施し、そのデータをもとに運動負荷を設定した。また、本実験は2日に分けて実施され、体温調節の日内リズムを考慮して、2日とも同時間帯に実施した。
    受動的運動を確認するために、左右の大腿直筋の筋電図を測定した。20分間の運動前にOWの能動的な自転車運動を実施し、運動回復期の受動的運動時の筋電図に能動的運動時のようなバーストが確認されると被験者にリラックスするように指示した。運動回復期の食道温および皮膚温の変化に両回復モードによる差はみられなかった。受動的運動時の発汗量は、安静回復のそれよりも高い値を示したが、皮膚血管コンダクタンスは両回復に差はみられなかった。これらの結果より、運動回復期において筋からの機械的刺激は発汗反応を促進するが、皮膚血管反応には影響しないことが示唆された。, kaken
    対象リソースIRI
  • Apr. 2001 - Mar. 2002, Principal investigator, 異なる被服圧が有酸素運動能力に及ぼす影響, 石本記念デサントスポーツ科学振興財団, 奈良女子大学
  • Grant-in-Aid for Scientific Research (B), Apr. 2000 - Mar. 2002, 12554039, Coinvestigator, Integration of measurement techniques for human adaptability, KOGA Shyunsaku; KOUDO Narihiko; FUKUBA Yoshiyuki; INOUE Yoshimitsu; SHIBASAKI Manabu; SHIOJIRI Tomoyuki, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Kobe Design University, 13100000, 13100000, Pulmonary and muscle oxygen uptake kinetics during exercise have been investigated intensely as a new criterion for the evaluation of aerobic work capacity, since a non-steady state is the more usual condition in organisms. From rigorous analysis of both steady- and non-steady state Vo2 responses to exercise, we are able to gain a deeper insight into the fundamental mechanisms of metabolic control and aerobic work capacity, it is of critical importance toclarify both the precise features of the Vo2 response across the rest- exercise transition and whether O2 delivery and/or utilization is the rate-limiting factor in Vo2 response following the onset of exercise. We investigated the above issues and, in particular, designed to alter (increase/decrease) O2 delivery and/or utilization systematically and to determine the effect of such perturbations on the kinetic response of Vo2 to moderate exercise (where end- exercise Vo2 is below the lactate threshold (LT)) and heavy exercise (where it is above LT)., kaken
    対象リソースIRI
  • Grant-in-Aid for Encouragement of Young Scientists (A), Apr. 2000 - Mar. 2002, 12780024, Principal investigator, 運動時の発汗神経活動における非温熱要因の影響, 芝崎 学, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A), Nara Women's University, 2100000, 2100000, 動的運動時に深部体温や皮膚温などの温熱性要因の上昇に先行して、発汗量が増大することが報告されている。動的運動時における神経性の入力として、セントラルコマンドと筋からの求心性入力が挙げられ、おそらくこれらのいずれかもしくは両方が運動初期の発汗反応に関与しているものと考えられる。本年度の研究では、咋年度の研究結果を踏まえて、動的運動時の発汗反応に影響する非温熱要因の中でも、特に筋からの求心性入力の影響について注目して検討した。
    健康な男女の若年成人の被験者を対象とし、3強度の自転車運動負荷、および中強度運動時の両大腿部への加圧(60mmHg)および無加圧時の発汗反応を検討した。実験は、環境制御室内で実施され、本実験前の簡易テストで、各被験者の無毛部の発汗が軽運動では発現するが、安静状態で発現しない環境温度を確認し、制御室内の温度を調節した。
    いずれの実験においても、運動中、深部体温および皮膚温は上昇しなかった。3強度の運動負荷実験では、前腕部および手掌部の発汗量は、運動強度の増加に伴い、心拍数や平均血圧と同様に増加した。これに対し、大腿部への加圧・無加圧実験では、加圧することによって、平均動脈血圧と同様に前腕部の発汗量は無加圧時よりもより大きく増加したが、手掌部の発汗量および心拍数は運動中上昇するものの加圧・無加圧による差は認められなかった。
    これらの結果は、動的運動時にも非温熱性要因によって発汗活動は賦活されることを示しており、動的運動時の発汗は運動強度に影響されること、また加圧による筋からの求心性入力増大が無毛部の発汗反応を賦活する可能性が示唆された。, kaken
    対象リソースIRI
  • Apr. 2000 - Mar. 2001, Principal investigator, マイクロダイアリシスを用いた発汗機能の評価, 石本記念デサントスポーツ科学振興財団, 奈良女子大学
  • 基盤研究Ｂ, 2019 - 2022, Coinvestigator, 超高齢者社会の健康寿命を訴求したユニバーサル仕様の衣服設計−生体情報を指標に−
  • 基盤研究Ｂ, 2018 - 2022, Principal investigator, 暑熱環境下運動時の中枢性および末梢性疲労による筋出力調節および循環調節への影響
  • 基盤研究Ｂ, 2015 - 2017, Coinvestigator, 乳児型発汗サーマルマネキンの開発へ向けて　不感蒸散および発汗の同時再現装置の構築
  • 萌芽研究, 2012 - 2014, Principal investigator, 擬似的温冷感による快適性および予防医学的衣料の開発
  • 基盤研究Ｂ, 2011 - 2013, Principal investigator, 熱中症予防を目的とした機能的ウェア開発のための生理機能評価
  • 若手研究B, 2009 - 2010, Principal investigator, 暑熱環境下における起立耐性と血流調節
  • 基盤研究A, 2008 - 2010, Coinvestigator, 温熱的環境適応能の老化過程の解明と老化遅延策の構築
  • 若手研究B, 2005 - 2006, Principal investigator, 暑熱環境下における起立性ストレス時の皮膚血管調節
  • 基盤研究Ｂ, 2003 - 2005, Coinvestigator, 高齢者・冷え症者に配慮した温熱環境に関する研究 −冷暖房使用環境下の日常生活行動と生理量との関連からの検討−
  • 萌芽研究, 2003 - 2004, Principal investigator, 入眠を促進する足踵温度コントロール－湯たんぽの効果を生理学的に見直す－
  • 若手研究Ａ, 2002 - 2003, Principal investigator, 動的運動初期の体温調節反応に関与する筋からの求心性入力
  • 基盤研究Ｂ（展開）, 2000 - 2001, Coinvestigator, ヒトの生理学的適応能力の計測技術の体系化
  • 奨励研究Ａ, 2000 - 2001, Principal investigator, 運動時の発汗神経活動における非温熱要因の影響
  • 日本学術振興会特別研究員　特別研究員奨励費, 1998, Principal investigator, 人間の体温調節に関する研究

■Ⅲ．社会連携活動実績

１．公的団体の委員等（審議会、国家試験委員、他大学評価委員，科研費審査委員等）

  • 日本生気象学会, 理事, Apr. 2017 - Present, Society
  • 日本体力医学会, 近畿地方会理事, Mar. 2017 - Present, Society
  • 日本体力医学会, 将来構想計画委員会, Sep. 2015 - Present, Society
  • 日本体力医学会, 評議員, Aug. 2015 - Present, Society
  • 日本生理学会, 英文誌編集委員, Jan. 2011 - Present, Society
  • 日本運動生理学会, 評議員, Apr. 2008 - Present, Society
  • 日本生理学会, 評議委員, Apr. 2008 - Present, Society
  • 日本生気象学会, 評議委員, Apr. 2008 - Present, Society
  • 日本繊維製品消費科学会, 編集委員, Jan. 2011 - Jun. 2015, Society