Papers
Number of the published data : 58
No. Title of presented paper Journal name Type of journal Authorship Volume/issue/page Publication date Joint authors ISSN DOI Repository
1 Picalm reduction exacerbates tau pathology in a murine tauopathy model.
Acta Neuropathologica
Academic Journal
Joint

2020
Kunie Ando, Robert De Decker, Cristina Vergara, Zehra Yilmaz, Salwa Mansor, Valérie Suain, Kristel Sleegers, Marie-Claude Potier, Charles Duyckaerts, Toshio Watanabe, Luc Buée, Karelle Leroy, Jean-Pierre Brion* and the Brainbank Neuro-CEB Neuropathology Network



2 Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ)
PLOS ONE
Academic Journal
Joint
14, e0217880
2019/06
Naomi Tanga, Kazuya Kuboyama, Ayako Kishimoto, Miho Kihara, Hiroshi Kiyonari, Toshio Watanabe, Akihiro Fujikawa & Masaharu Noda



3 The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice.
GLIA
Academic Journal
Joint
67, 967-984
2019/05
Naomi Tanga, Kazuya Kuboyama, Ayako Kishimoto, Hiroshi Kiyonari, Aki Shiraishi, Ryoko Suzuki, Toshio Watanabe, Akihiro Fujikawa, and Masaharu Noda.



4 The BRCA1-interacting protein OLA1 requires the interaction with BARD1 to regulate centrosome number.
Molecular Cancer Research
Academic Journal
Joint
16, 1499-1511
2018/10
uki Yoshino, Huicheng Qi, Hiroki Fujita, Matsuyuki Shirota, Shun Abe, Yuhei Komiyama, Kazuha Shindo, Masahiro Nakayama, Ayako Matsuzawa, Akihiro Kobayashi, Honami Ogoh, Toshio Watanabe, Chikashi Ishioka and Natsuko Chiba

DOI: 10.1158/1541-7786.

5 Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.
Cancer Science
Academic Journal
Joint
109, 2178-2187
2018/05
Koreyuki, Kurosawa, Yui, Inoue, Yoichiro, Kakugawa, Yoji, Yamashita, Hidekazu, Yamada, Kazuhiro, Kishimoto, Miyuki, Nomura, Yuki, Momoi, Koh, Miura, Ichiro, Sato, Natsuko, Chiba, Mai, Suzuki, Honami, Ogoh, Toshio, Watanabe, Nobuhiro, Tanuma, Masahiro, Tachi and Hiroshi, Shima



6 Pkm1 confers metabolic advantages and promotes cell-autonomous tumor cell growth.
Cancer Cell
Academic Journal
Joint
33, 1-13
2018/03
Mami Morita, Taku Sato, Miyuki Nomura, Yoshimi Sakamoto, Yui Inoue, Ryota Tanaka, Shigemi Ito, Koreyuki Kurosawa, Kazunori Yamaguchi, Yuki Sugiura, Hiroshi Takizaki, Yoji Yamashita, Ryuichi Katakura, Ikuro Sato, Yoshinori Okada, Hitomi Watanabe, Gen Kondoh, Shoko Matsumoto, Ayako Kishimoto, Miki Obata, Masaki Matsumoto, Tatsuro Fukuhara, Hozumi Motohashi, Makoto Suematsu, Masaaki Komatsu, Keiichi Nakayama, Toshio Watanabe, Tomoyoshi Soga, Hiroshi Shima, Makoto Maemondo and Nobuhiro Tanuma



7 ADP-ribosylation factor 1.
Encyclopedia of Signaling Molecules, 2nd Edition
Academic Journal
Only
412-414
2018/01




8 A knockout mouse model reveals a critical role of Af10-dependent H3K79 methylation in midfacial development.
Scientific Reports
Academic Journal
Joint
7/ 1, 11922
2017/09
Honami Ogoh, Kazutsune Yamagata, Tomomi Nakao, Lisa L. Sandell, Ayaka Yamamoto, Aiko Yamashita, Naomi Tanga, Mai Suzuki, Takaya Abe, Issay Kitabayashi, Toshio Watanabe,* and Daisuke Sakai*

10.1038/s41598-017-11745-5.

9 Partial loss of CALM function affects gamma-secretase-mediated A beta42 production and amyloid deposition in vivo.
Human Molecular Genetics
Academic Journal
Joint
25, 3988-3997
2016
Kunihiko Kanatsu, Yukiko Hori, Sho Takatori, Toshio Watanabe, Takeshi Iwatsubo, and Taisuke Tomita



10 The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis.
Mechanisms of Development
Academic Journal
Joint
139, 1-9
2016/02
Honami Ogoh1, Nobuhiro Tanuma2, Yasuhisa Matsui3, Natsuki Hayakawa1, Ayaka Inagaki1, Mami Sumiyoshi1, Yuki Momoi2, Ayako Kishimoto1, Mai Suzuki1, Nozomi Sasaki2, Tsukasa Ohuchi2, Miyuki Nomura2, Yuriko Teruya1, Keiko Yasuda1, Toshio Watanabe1* and Hiroshi Shima2*



11 argeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.
FEBS Letters
Academic Journal
Joint
589, 2754-2762
2015
Rie Kusano, Kousuke Fujita, Yasuharu Shinoda, Yuko Nagaura, Hiroshi Kiyonari, Takaya Abe, Toshio Watanabe, Yasuhisa Matsui, Masahiro Fukaya, Hiroyuki Sakagami, Tatsuya Sato, Jun-ichi Funahashi, Motoko Ohnishi, Shinri Tamura, and Takayasu Kobayashi.



12 脱リン酸化酵素PP6は、皮膚がん抑制遺伝子である 「発がんプロモーター・オカダ酸の標的:25年目のミッシングピースの検証」
生化学
Other
Joint
87/ 5, 1-7
2015/11
島 礼



13 Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality.
FEBS letter
Academic Journal
Joint
589, 2754-2762
2015/09
Mami Sumiyoshi, Narumi Masuda, Nobuhiro Tanuma, Honami Ogoh, Eri Imai, Mizuki Otsuka, Natsuki Hayakawa, Kinuyo Ohno,Yasuhisa Matsui, Kanae Hara, Risa Gotoh, Mai Suzuki, Shinya Rai, Hirokazu Tanaka, Itaru Matsumura, Hiroshi Shima, and Toshio Watanabe

doi: 10.1016/j.febslet.2015.07.050.

14 Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA.
Oncogene
Academic Journal
Joint
34, 4647-55
2015/09
Katsuhisa Hayashi, Yuki Momoi, Nobuhiro Tanuma, Ayako Kishimoto, Honami Ogoh, Hiroyuki Kato, Mai Suzuki, Yoshimi Sakamoto, Yui Inoue, Miyuki Nomura, Hiroshi Kiyonari, Masato Sakayori, Kayoko Fukamachi, Yoichiro Kakugawa, Yoji Yamashita, Shigemi Ito, Ikuro Sato, Akira Suzuki, Miki Nishio, Masami Suganuma, Toshio Watanabe and Hiroshi Shima.



15 Loss of protein phosphatase 6 in mouse keratinocytes increases susceptibility to ultraviolet-B-induced carcinogenesis.
Cancer Letters
Academic Journal
Joint
365, 223-228
2015/09
Hiroyuki Kato, Nobuhiro Tanuma, Katsuhisa Hayashi, Koreyuki Kurosawa, Yuki Momoi, Honami Ogoh, Masato Sakayori, Yoichiro Kakugawa, Yoji Yamashita, Koh Miura, Shigemi Ito, Ikuro Sato, Natsuko Chiba, Toshio Watanabe, and Hiroshi Shima



16 脱リン酸化酵素PP6は皮膚がん抑制遺伝子として働く: 25年目のミッシングピースの発見
細胞工学
Other
Joint
34/ 3, 302-303
2015/03
渡邊利雄、島礼



17 Clathrin assembly protein CALM Plays a Critical Role in KIT Signaling by Regulating Its Cellular Transport from Early to Late Endosomes in Hematopoietic Cells.
PLoS ONE
Academic Journal
Joint
DOI: 10.1371/journal.pone.0109441.
2014
Shinya Rai, Hirokazu Tanaka*, Mai Suzuki , Honami Ogoh, Yasuhiro Taniguchi, Yasuyoshi Morita, Takahiro Shimada, Akira Tanimura, Keiko Matsui, Takafumi Yokota, Kenji Oritani, Kenji Tanabe, Toshio Watanabe, Yuzuru Kanakura, and Itaru Matsumura 



18 The ADP-ribosylation factor 1 gene is indispensable for mouse embryonic development after implantation.
Biochem. Biophys. Res. Commun.
Academic Journal
Joint
453/ 4, 748-753
2014/10
Hayakawa N, Ogoh H, Sumiyoshi M, Matsui Y, Nishikawa S, Miyamoto K, Maede Y, Kiyonari H, Suzuki M, and Watanabe T.



19 The nuclear export signal (NES) within CALM is necessary for CALM-AF10-induced leukemia.
Cancer Science
Academic Journal
Joint
105/ 3, 315-323
2014/03
Mai Suzuki, Kazutsune Yamagata, Mika Shino, Yukiko Aikawa, Koichi Akashi, Toshio Watanabe and Issay Kitabayashi.



20 Decreased CALM expression reduces Aβ42 production ratio through clathrin-mediated endocytosis of γ-secretase.
Nature Communication
Academic Journal
Joint
DOI. 10.1038/ncomms4386.
2014/02
Kunihiko Kanatsu, Yuichi Morohashi, Mai Suzuki, Toshio Watanabe, Taisuke Tomita and Takeshi Iwatsubo



21 The Arf GAP SMAP2 is necessary for organized vesicle budding from the Trans-Golgi-network and subsequent acrosome formation in spermiogenesis.
Molecular Biology of the Cell
Academic Journal
Joint
123, 1123-1137
2013
Tomo Funaki, Shunsuke Kon, Kenji Tanabe, Waka Natsume, Sayaka Sato, Tadafumi Shimizu, Naomi Yoshida, Won Fen Wonga, Atsuo Ogura, Takehiko Ogawa, Kimiko Inoue, Narumi Ogonuki, Hiromi Miki, Keiji Mochida, Keisuke Endoh, Kentarou Yomogida, Manabu Fukumoto, Reiko Horai, Yoichiro Iwakura, Chizuru Ito, Kiyotaka Toshimori, Toshio Watanabe, and Masanobu Satake.



22 SMAP2 regulates retrograde transport from recycling endosomes to the Golgi
PLOS ONE
Academic Journal
Joint
8/ 7, e69145. doi:10.1371/journal.pone.0069145
2013
Tatsuyuki Matsudaira, Yasunori Uchida, Kenji Tanabe, Shunsuke Kon, Toshio Watanabe, Tomohiko Taguchi, and Hiroyuki Arai



23 精子頭部形成を支配するGTPase活性化遺伝子SMAP2:輸送小胞形成不全は受精できない丸頭精子を生み出す。
細胞工学
Other
Joint
32/ 12, 1260-1261
2013/12
船木智、昆俊介、田邊 賢司、佐竹正延



24 SMAP1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia
Journal of Clinical Investigation
Academic Journal
Joint
123/ 3, 1123-1137
2013/03
Shunsuke Kon, Naoko Minegishi, Kenji Tanabe, Toshio Watanabe, Tomo Funaki, Won Fen Wong, Daisuke Sakamoto, Yudai Higuchi, Hiroshi Kiyonari, Katsutoshi Asano, Yoichiro Iwakura, Manabu Fukumoto, Motomi Osato, Masashi Sanada, Seishi Ogawa, Takuro Nakamura and Masanobu Satake



25 クラスリン集合因子CALMはトランスフェリンの取り込みに必要で,遺伝子欠損はマウスに貧血を引き起こす:培養細胞研究での定説を覆す
細胞工学
Other
Joint
31/ 7, 808-809
2012/07
鈴木麻衣



26 The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.
PLoS ONE
Academic Journal
Joint
10.1371/journal.pone.0031854
2012/02
Mai Suzuki1, Hirokazu Tanaka2, Akira Tanimura3, Kenji Tanabe4, Natsuko Oe4, Shinya Rai2, Syunsuke Kon5, Manabu Fukumoto6, Kohji Takei4, Takaya Abe7, Itaru Matsumura2, Yuzuru Kanakura3, and Toshio Watanabe1,



27 Transgene insertion in intronic sequences of Mdga2 gene shows methylation in an imprinted manner in an Acrodysplasia (Adp) mouse line
Biochem. Biophys. Res. Commun.
Academic Journal
Joint
418/ 3, 439-444
2012/02
Mai Suzuki, Davor Solter, and Toshio Watanabe



28 気づいた時が変わるとき-チロシンホスファターゼ研究との出会い-
細胞工学
Other
Only

2011




29 Localization of SMAP2 to the TGN and its Function in the Regulation of TGN Protein Transport
Cell Structure and Function
Academic Journal
Joint
36, 83-95
2011
Tomo Funaki, Shunsuke Kon, Roger E. Ronn, Yuji Henmi, Yuka Kobayashi, Toshio Watanabe, Keiko Nakayama, Kenji Tanabe, and Masanobu Satake



30 The carboxy-terminal region of SMAP2 directs subcellular localization as well as Arf protein specificity
Biochem Biophys Res Commun
Academic Journal
Joint
404, 661-666
2011/01
Ikuko Sakakura, Kenji Tanabeb, Natsumi Noukia, Mai Suzuki, Masanobu Satake, and Toshio Watanabe



31 Human VAPA and the yeast VAP Scs2p with an altered proline distribution can phenocopy amyotrophic lateral sclerosis‐associated VAPB(P56S).
Biochem. Biophys. Res. Commun.
Academic Journal
Joint
404/ 2, 605-609
2011/01
Nakamichi S, Yamanaka K, Suzuki M, Watanabe T, Kagiwada S.



32 コミュニティ―を感じさせるノックアウトマウスの成果-未だ見知らぬ未来の研究仲間へのエール
細胞工学
Other
Only
29/ 8, 824-825
2010/08




33 パキシリンはがん遺伝子でチロシンホスファターゼPTPRTはがん抑制遺伝子である
細胞工学
Other
Joint
29/ 7, 704-705
2010/07




34 Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double negative to double positive stages
Immunology
Academic Journal
Joint
130/ 2, 243-253
2010/06
Won Fen Wong, Megumi Nakazato,, Toshio Watanabe, Kazuyoshi Kohu,Takehiro Ogata, Naomi Yoshida, Yusuke Sotomaru, Mamoru Ito, Kimi Araki, Janice Telfer, Manabu Fukumoto, Daisuke Suzuki, Takehito Sato, Katsuto Hozumi, Sonoko Habu, and Masanobu Satake



35 Filamin Associates with Stress Signaling Kinases MKK7 and MKK4 and Regulates JNK Activation.
Biochemical J
Academic Journal
Joint
427/ 2, 237-245
2010/03
Kentaro Nakagawa, Misato Sugahara, Hiroaki Kajiho, Shinya Takahashi, Tokiwa Yamasaki, Jun Hirayama, Yasutaka Ohta, Toshio Watanabe, Yutaka Hata, Toshiaki Katada and Hiroshi Nishina



36 Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.
Proc. Natl. Acad. Sci., USA
Academic Journal
Joint
107/ 6, 2592-2597
2010/02
Zhao, Y., Zhang, X., Guda, K., Lawrence, E., Watanabe, T., Iwakura, Y., Asano, M., Wei, L., Yang, Z., Sun, Q., Zheng, W., Dawson, D., Willis, J., Markowitz, S., Satake, M. and Wang, Z.



37 Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells.
Biochem. Biophys. Res. Commun.
Academic Journal
Joint
379, 817-823
2009
Shinya Ohata, Makiko Nawa, Takeshi Kasama, Tokiwa Yamasaki, Kenji Sawanoboria, Shoji Hata, Takashi Nakamura, Yoichi Asaoka, Toshio Watanabe, Hitoshi Okamoto, Takahiko Hara, Shuji Terai, Isao Sakaida, Toshiaki Katada, and Hiroshi Nishina



38 A SMAP Gene Family Encoding ARF GTPase-activating Proteins and Its Implication in Membrane Trafficking
Methods in Enzymology
Academic Journal
Joint
438, 155-170
2008
KENJI TANABE, SHUNSUKE KON, NOBUYUKI ICHIJO, TOMO FUNAKI, WAKA NATSUME, TOSHIO WATANABE, and MASANOBU SATAKE



39 Clathrin-dependent endocytosis of E-cadherin is regulated by the ArfGAP isoform SMAP1.
Experimental Cell Research
Academic Journal
Joint
314, 1415-1428
2008
Kon, S., Tanabe, K., Watanabe, T.,Sabe H., Satake, M.



40 エンドサイトーシス制御因子Arf6が関与するがんのシグナル伝達
遺伝子医学MOOK
Academic Journal
Only
6, 18-185
2006
渡邊利雄



41 T細胞分化におけるAML1/Runx1の機能
血液・腫瘍科
Academic Journal
Joint

2006
渡邊利雄、佐竹正延



42 SMAP2, a novel Arf GTPase-activating protein, interacts with clathrin and clathrin assembly protein, and functions on the AP-1-positive early endosome/trans-Golgi-network.
Mol. Biol. Cell
Academic Journal
Joint
17/ 6, 1592-1603
2006
Natsume, W., Tanabe, K., Kon S., Yoshida N., Watanabe, T. Torii, T., and Satake M.



43 Involvement of a novel ArfGAP protein, SMAP, in membrene trafficking: Implication in cancer cell biology.
Cancer Science
Academic Journal
Joint
97/ 9, 801-806
2006
Tnabe K., Kon S., Natsume W., Torii T., Watanabe T. and Satake M.



44 Biological implication of filamin A-bound PEBP2beta/CBFbeta in the cytoplasm
Crit. Rev. Eukaryot. Gene Expr.
Academic Journal
Joint
15/ 3, 197-206
2005
watanabe T., Yoshida N. and Satake M.



45 細胞骨格制御因子filamin Aによる転写因子PEBP2/CBFの転写活性調節機構
細胞工学
Academic Journal
Joint
24, 256-257
2005
吉田尚美, 佐竹正延, 渡邊利雄



46 FilaminA-bound PEBP2b/CBFb is retained in the cytoplasm and prevented from functioning as a partner of the Runx1 transcription factor.
Mol. Cell. Biol.
Academic Journal
Joint
25, 1003-1012
2005
Yoshida, N., Ogata, T., Tanabe, K., Li, S., Nakazato, M., Kohu, K., Ohta, Y., Satake, M. and Watanabe, T.



47 Runx1 promotes angiogenesis by down-regulation of insulin-like growth factor binding protein-3.
Oncogene
Academic Journal
Joint
24, 1129-1137
2005
Iwatsuki, K., Tanaka, K., kaneko, T., Kazama, R., Okamoto, S., Nakayama, Y., Ito, Y., Satake, M., Takahashi, S., Watanabe, T. and Hara T.



48 Over-expression of Runx3 transcription factor increases the mature thymocytes of CD8 single positive lineage.
J. Immunol.
Academic Journal
Joint
174, 2627-2636
2005
Kofu, K., Sato, T., Hayashi, K., Uchino R., Abe, N., Inoue, Y., Nakazato, M., Yoshida, N., Watanabe, T., Habu, S. and Satake, M.



49 A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates the clathrin-dependent endocytosis.
Mol. Biol. Cell
Academic Journal
Joint
16, 1617-1628
2005
Tanabe, K., Torii T., Natsume, W., Braesch-Andesaen, S., Watanabe, T and Satake, M.



50 Reduction of runx transcription factor activity up-regulates Fas and Bim expression and enhances the apoptotic sensitivity of double-positive thymocytes.
J. Immunol.
Academic Journal
Joint
175, 4475-4482
2005
Abe, N., Kohu K., Ohmori H., Hayashi, K., Watanabe T., Hozumi, K., Sato, T., Habu S. and Satake, M.



51 CD148の欠損が引き起こす血管網形成異常:大腸癌感受性遺伝子  (癌抑制遺伝子)と血管網形成の関係
細胞工学
Other
Joint
23, 541-545
2004
渡邊利雄, 高橋孝宗



52 受容体型チロシンホスファターゼCD148の欠損が引き起こす血管網形成異常 :大腸癌感受性遺伝子(癌抑制遺伝子)と血管網形成との関係
加齢医学研究所雑誌
Academic Journal
Only
55, 7-21
2004




53 Angiogenesis-related mouse puromycin-insensitive leucyl-specific aminopeptidase is a molecular target of transcription factor PEBP2 in endothelial cells.
Arch. Biochem. Biophys.
Academic Journal
Joint
424, 63-71
2004
Niizeki, O., Miyashita, H., Yamasaki, T., Akada, T., Abe, M., Yoshida, N., Watanabe, T., Yoshimatsu, N. and Sato, Y.



54 A mutant receptor tyrosine phosphatase CD148 causes defects in vascular development.
Mol. Cell. Biol.
Academic Journal
Joint
23, 1817-1831
2003
Takahashi, T., Takahashi, K., John, P.ST., Fleming, P.A., Tomemori, T., Watanabe, T., Abrahamson, D.R., Drake, C.J., Shirasawa, T. and Daniel. T.O.



55 Hemocytes of Ciona intestinalis express multiple genes involved in innate immune host defense.
B. B. R. C.
Academic Journal
Joint
302, 207-218
2003
Shida, K., Terajima, D., Uchino, R., Ikawa, S., Ikeda, M., Asano, K., Watanabe, T., Azumi, M. Nonaka, K., Satou, Y., Satoh, N., Satake, M., Kawazoe Y. and Kasuya A.



56 The runx1 transcription factor inhibits the differetiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression.
J. Exp. Med.
Academic Journal
Joint
198, 51-61
2003
Komine, O., Hayashi, K., Natsume, W., Watanabe T., Seki, Y., Seki, N., Yagi, R., Suzuki, W., Tamauchi, H., Hozumi, K., Habu, S., Kubo, M. and Satake, M.



57 Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytes.
J. Immunol.
Academic Journal
Joint
171, 3594-3604
2003
Ehlers, E., Laule-Kilian, K., Petter, M., Aldrian, C.J., Gruter, B., Wurch, A., Yoshida, N., Watanabe, T., Satake, M. and Steimle V.



58 SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kB-induced anti-apoptosis.
Dev. Biol.
Academic Journal
Joint
250, 332-347
2002
Watanabe, T., Nakagawa, K., Ohata, S., Kitagawa, D., Nishitai, G., Seo, J., Tanemura, S., Shimizu, N., Kishimoto, H., Wada, T., Aoki, J., Arai, H., Iwatsubo, T., Mochita, M., Watanabe, T., Satake, M., Ito, Y., Matsuyama, T., Mak, T.M, Penninger, J.M., Nishina, H. and Katada T.