日本語
 Faculty
 Division of Natural Sciences
 Research Group of Biological Sciences
Professor
WATANABE   Toshio
Tel.0742-20-3413
Fax.0742-20-3413

Additional position
Principal, Attached Secondary School 

Other faculty or department / position
Faculty of Science Department of Chemistry,Biology, and Environmental Sciences Courses of Biological Sciences
Principal, Attached Secondary School
Graduate School of Humanities and Sciences Master's Course Department of Biological Science
Graduate School of Humanities and Sciences Doctoral Course School of Natural Science and Ecological Awareness

Career
Inst. of Applied Microbiol. University of Tokyo・Jyosyu  1987/08/01-1996/04/14 
Max Planck Inst. of Immunobiol.・Visiting Scientist  1992/05/01-1994/04 
Inst. of Dev., Aging & Cancer, Tohoku University ・Associate Professor  1996/04/15-2006/03/31 
Graduate School of Humanities and Sciences・Professor  2006/04/01-Present 

Graduate school
The University of Tokyo  Master course  Graduate School, Division of Science  Biochemistry and Biophysics  1984/03  Completed  Domestic   
The University of Tokyo  Doctor course  Graduate School, Division of Science  Biochemistry and Biophysics  1987/03  Completed  Domestic   

School
The University of Tokyo  Faculty of Science  Biochemistry and Biophysics  1982/03  Graduated  Domestic   

Academic degrees
Ph D.  The University of Tokyo  1987/03 

Current state of research and teaching activities
Using culture cells and gene modified mice, let's try to reveal mammals physiological function.   

Current research field
Living Organism Molecular Science 
Heredity/Genome Dynamics 
Molecular Biology 
Cell Biology 
Developmental Biology 
General Medical Chemistry 
Immunology 

Research keywords
Cancer Cells, Mouse Development, Cell Differentiation, Molecular Genetics, Biochemistry, Gene Manipulated Mice, Membrane Traffic 

Achievements of joint or funded research
Ptproのコンディショナルノックイン組換えマウスの作出とその機能解析  平成26年度個別共同利用研究  2014/06-2015/03  Domestic joint research within Japan 
Ptprj及びPtproのコンディショナルノックイン組換えマウスの作出とその機能解析  平成25年度個別共同利用研究  2013/07-2014/03  Domestic joint research within Japan 
新規乳癌関連分子のノックアウトマウスの作成とその解析による新たな発癌機構の解明  平成24年度 東北大学加齢医学研究所共同  2012/04-2013/03  Domestic joint research within Japan 
改変型Ptprzノックインマウスの作出とその機能解析  平成24年度個別共同利用研究  2012/04-2013/03  Domestic joint research within Japan 
改変型Ptprzノックインマウスの作出とその機能解析  平成23年度個別共同利用研究  2011/04-2012/03  Domestic joint research within Japan 
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Books
史上最強図解 これならわかる!分子生物学  2013/04  ナツメ社  1-296    978-4816353499   
バイオイラストレイテッド すくすく育て細胞培養  1996/07  秀潤社         
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Papers
A knockout mouse model reveals a critical role of Af10-dependent H3K79 methylation in midfacial development.  Scientific Reports  Academic Journal  Joint  7/ 1, 11922  2017/09  Honami Ogoh, Kazutsune Yamagata, Tomomi Nakao, Lisa L. Sandell, Ayaka Yamamoto, Aiko Yamashita, Naomi Tanga, Mai Suzuki, Takaya Abe, Issay Kitabayashi, Toshio Watanabe,* and Daisuke Sakai*    10.1038/s41598-017-11745-5.   
ADP-ribosylation factor 1.  Encyclopedia of Signaling Molecules, 2nd Edition  Academic Journal  Only    2017/03         
argeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.  FEBS Letters  Academic Journal  Joint  in press  2016  Rie Kusano, Kousuke Fujita, Yasuharu Shinoda, Yuko Nagaura, Hiroshi Kiyonari, Takaya Abe, Toshio Watanabe, Yasuhisa Matsui, Masahiro Fukaya, Hiroyuki Sakagami, Tatsuya Sato, Jun-ichi Funahashi, Motoko Ohnishi, Shinri Tamura, and Takayasu Kobayashi.       
Partial loss of CALM function affects gamma-secretase-mediated A beta42 production and amyloid deposition in vivo.  Human Molecular Genetics  Academic Journal  Joint  in press  2016  Kunihiko Kanatsu, Yukiko Hori, Sho Takatori, Toshio Watanabe, Takeshi Iwatsubo, and Taisuke Tomita       
The protein phosphatase 6 catalytic subunit (Ppp6c) is indispensable for proper post-implantation embryogenesis.  Mechanisms of Development  Academic Journal  Joint  139, 1-9  2016/02  Honami Ogoh1, Nobuhiro Tanuma2, Yasuhisa Matsui3, Natsuki Hayakawa1, Ayaka Inagaki1, Mami Sumiyoshi1, Yuki Momoi2, Ayako Kishimoto1, Mai Suzuki1, Nozomi Sasaki2, Tsukasa Ohuchi2, Miyuki Nomura2, Yuriko Teruya1, Keiko Yasuda1, Toshio Watanabe1* and Hiroshi Shima2*       
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Research presentations
Conference presentation  オートファジーによるtype 2A protein phosphataseの制御機構の解明  Consortium of Biological Sciences 2017  2017/12/08 
Conference presentation  The Failure of endocytic pathways in the ArfGAPs, SMAP1 and SMAP2 doubly-deficient mouse embryos.  Consortium of Biological Sciences 2017  2017/12/08 
Conference presentation  制御性T細胞の分化誘導に関わるシグナル伝達経路の解明  Consortium of Biological Sciences 2017  2017/12/08 
Conference presentation  Analysis of how CALM deficiency is involved in the abnormality of the degradation pathway through MVB/Late endosome.  Consortium of Biological Sciences 2017  2017/12/07 
Conference presentation  BRCA1の新規結合分子Ola1のノックアウトマウスの表現型の解析  Consortium of Biological Sciences 2017  2017/12/06 
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Intellectual property rights
Patent  細胞分化誘導剤  特願昭63-257875  1988/10/30         
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Academic awards
Long-Term-Fellowships by Human Frontier Science Program  1992/03/19  Overseas 
Kato menorial Awords by JMBS  1987/12  Domestic 
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Alloted class
Experimental Course for Biological Sciences I 
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Social cooperation and an international exchange activity
NWU-UL Mini-symposium on Bioscience  2013/03/08-2013/03/08     
NWU-UL Mini-symposium on Bioscience  2012/03/08-2012/03/08     
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Memberships of academic societies
KTCC -Present  Domestic
運営委員 2007/06-Present
SUMO研究会 -Present  Domestic
麒麟塾ー血液学若手研究者勉強会ー -Present  Domestic
第3回麒麟塾 塾頭 2006/07-2007/07
日本プロテインホスファターゼ研究会 -Present  Domestic
世話人 監事 2000/04-Present
日本癌学会 -Present  Domestic
日本分子生物学会 -Present  Domestic
幹細胞研究会 -Present  Domestic
日本生化学学会 2012/03/27-Present  Domestic