日本語
 Faculty
 Division of Natural Sciences
 Research Group of Biological Sciences
Professor
WATANABE   Toshio
Tel.0742-20-3413
Fax.0742-20-3413

Additional position
"Principal, Attached Secondary School" 

Other faculty or department / position
Faculty of Science Department of Chemistry,Biology, and Environmental Sciences Courses of Biological Sciences
Principal, Attached Secondary School
Graduate School of Humanities and Sciences Master's Course Department of Biological Science
Graduate School of Humanities and Sciences Doctoral Course School of Natural Science and Ecological Awareness

Career
Inst. of Applied Microbiol. University of Tokyo・Jyosyu  1987/08/01-1996/04/14 
Max Planck Inst. of Immunobiol.・Visiting Scientist  1992/05/01-1994/04 
Inst. of Dev., Aging & Cancer, Tohoku University ・Associate Professor  1996/04/15-2006/03/31 
Graduate School of Humanities and Sciences・Professor  2006/04/01-Present 

Graduate school
The University of Tokyo  Master course  Graduate School, Division of Science  Biochemistry and Biophysics  1984/03  Completed  Domestic   
The University of Tokyo  Doctor course  Graduate School, Division of Science  Biochemistry and Biophysics  1987/03  Completed  Domestic   

School
The University of Tokyo  Faculty of Science  Biochemistry and Biophysics  1982/03  Graduated  Domestic   

Academic degrees
Ph D.  The University of Tokyo  1987/03 

Current state of research and teaching activities
Using culture cells and gene modified mice, let's try to reveal mammals physiological function.   

Current research field
Living Organism Molecular Science 
Heredity/Genome Dynamics 
Molecular Biology 
Cell Biology 
Developmental Biology 
General Medical Chemistry 
Immunology 

Research keywords
Cancer Cells, Mouse Development, Cell Differentiation, Molecular Genetics, Biochemistry, Gene Manipulated Mice, Membrane Traffic 

Achievements of joint or funded research
Ptproのコンディショナルノックイン組換えマウスの作出とその機能解析  平成26年度個別共同利用研究  2014/06-2015/03  Domestic joint research within Japan 
Ptprj及びPtproのコンディショナルノックイン組換えマウスの作出とその機能解析  平成25年度個別共同利用研究  2013/07-2014/03  Domestic joint research within Japan 
新規乳癌関連分子のノックアウトマウスの作成とその解析による新たな発癌機構の解明  平成24年度 東北大学加齢医学研究所共同  2012/04-2013/03  Domestic joint research within Japan 
改変型Ptprzノックインマウスの作出とその機能解析  平成24年度個別共同利用研究  2012/04-2013/03  Domestic joint research within Japan 
改変型Ptprzノックインマウスの作出とその機能解析  平成23年度個別共同利用研究  2011/04-2012/03  Domestic joint research within Japan 
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Scientific inquiry expense
ミトコンドリア・ダイナミクスの分子機構の解明と高次生理機能の考察  基盤研究(B)一般  2017-2019 
新規BRCA1結合分子のゲノム安定性維持機構の解明とがん治療法の開発  基盤研究(B)一般  2016-2018 
組織特異的遺伝子欠損法を用いた神経変性疾患における小胞輸送機構関与の検証  基盤研究(C)一般  2016-2018 
哺乳動物におけるミトコンドリア・ダイナミクスの分子基盤解析  基盤研究(B)一般  2014-2016 
新規癌抑制分子の細胞分裂制御能の解析による癌抑制機構の解明と癌治療法の開発  基盤研究(B)一般  2012-2015 
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Research cost, Donation cost, etc.
体重を決める新しい仕組みの解明 ―高脂肪食肥満に耐性な遺伝子欠損マウスの解析からのアプローチ―  Science research expense  平成30年度 奈良女子大学研究推進プロジェクト経費  2018-2019 
培養細胞とマウス個体を用いた新規育毛因子・増強因子の探索  Science research expense  研究助成  2017-2018 
培養細胞とマウス個体を用いた新規育毛因子・増強因子の探索  Science research expense  【大阪市】イノベーション創出支援補助金  2017-2018 
渡邊教授の研究  Donation  研究助成  2016-2017 
渡邊教授の研究  Donation  研究助成  2015-2016 
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Books
史上最強図解 これならわかる!分子生物学  2013/04  ナツメ社  1-296    978-4816353499   
バイオイラストレイテッド すくすく育て細胞培養  1996/07  秀潤社         
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Papers
The BRCA1-interacting protein OLA1 requires the interaction with BARD1 to regulate centrosome number.  Molecular Cancer Research  Academic Journal  Joint    2018  uki Yoshino, Huicheng Qi, Hiroki Fujita, Matsuyuki Shirota, Shun Abe, Yuhei Komiyama, Kazuha Shindo, Masahiro Nakayama, Ayako Matsuzawa, Akihiro Kobayashi, Honami Ogoh, Toshio Watanabe, Chikashi Ishioka and Natsuko Chiba    DOI: 10.1158/1541-7786.   
Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.  Cancer Science  Academic Journal  Joint  109, 2178-2187  2018/05  Koreyuki, Kurosawa, Yui, Inoue, Yoichiro, Kakugawa, Yoji, Yamashita, Hidekazu, Yamada, Kazuhiro, Kishimoto, Miyuki, Nomura, Yuki, Momoi, Koh, Miura, Ichiro, Sato, Natsuko, Chiba, Mai, Suzuki, Honami, Ogoh, Toshio, Watanabe, Nobuhiro, Tanuma, Masahiro, Tachi and Hiroshi, Shima       
Pkm1 confers metabolic advantages and promotes cell-autonomous tumor cell growth.  Cancer Cell  Academic Journal  Joint  33, 1-13  2018/03  Mami Morita, Taku Sato, Miyuki Nomura, Yoshimi Sakamoto, Yui Inoue, Ryota Tanaka, Shigemi Ito, Koreyuki Kurosawa, Kazunori Yamaguchi, Yuki Sugiura, Hiroshi Takizaki, Yoji Yamashita, Ryuichi Katakura, Ikuro Sato, Yoshinori Okada, Hitomi Watanabe, Gen Kondoh, Shoko Matsumoto, Ayako Kishimoto, Miki Obata, Masaki Matsumoto, Tatsuro Fukuhara, Hozumi Motohashi, Makoto Suematsu, Masaaki Komatsu, Keiichi Nakayama, Toshio Watanabe, Tomoyoshi Soga, Hiroshi Shima, Makoto Maemondo and Nobuhiro Tanuma       
ADP-ribosylation factor 1.  Encyclopedia of Signaling Molecules, 2nd Edition  Academic Journal  Only  412-414  2018/01         
A knockout mouse model reveals a critical role of Af10-dependent H3K79 methylation in midfacial development.  Scientific Reports  Academic Journal  Joint  7/ 1, 11922  2017/09  Honami Ogoh, Kazutsune Yamagata, Tomomi Nakao, Lisa L. Sandell, Ayaka Yamamoto, Aiko Yamashita, Naomi Tanga, Mai Suzuki, Takaya Abe, Issay Kitabayashi, Toshio Watanabe,* and Daisuke Sakai*    10.1038/s41598-017-11745-5.   
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Research presentations
Conference presentation  Smap1 and Smap2 doubly-deficient mouse embryos showed abnormalities during gastrulation period  第41回日本分子生物学会年会  2018/11 
Conference presentation  A trial isolating Arf1 and Arf6 double-deficient MEF  第41回日本分子生物学会年会  2018/11 
Conference presentation  Tie2-Cre Induced Tissue Specific Deletion of Ppp6c Caused Abnormalities during Mouse Embryogenesis  第41回日本分子生物学会年会  2018/11 
Conference presentation  Analysis of responses to virus infection in Mul1-KO mice  第41回日本分子生物学会年会  2018/11 
Conference presentation  Elucidation of the function of the small G protein Arf family in B cells.  第41回日本分子生物学会年会  2018/11/28 
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Intellectual property rights
Patent  細胞分化誘導剤  特願昭63-257875  1988/10/30         
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Academic awards
Long-Term-Fellowships by Human Frontier Science Program  1992/03/19  Overseas 
Kato menorial Awords by JMBS  1987/12  Domestic 
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Alloted class
生物学実験Ⅰ 
生物学実験(A) 
生物学実験(B) 
生物学実験(C) 
個体機能学セミナーⅠ 
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Social cooperation and an international exchange activity
NWU-UL Mini-symposium on Bioscience  2013/03/08-2013/03/08     
NWU-UL Mini-symposium on Bioscience  2012/03/08-2012/03/08     
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Memberships of academic societies
KTCC -Present  Domestic
運営委員 2007/06-Present
SUMO研究会 -Present  Domestic
麒麟塾ー血液学若手研究者勉強会ー -Present  Domestic
第3回麒麟塾 塾頭 2006/07-2007/07
日本プロテインホスファターゼ研究会 -Present  Domestic
世話人 監事 2000/04-Present
日本癌学会 -Present  Domestic
日本分子生物学会 -Present  Domestic
幹細胞研究会 -Present  Domestic
日本生化学学会 2012/03/27-Present  Domestic